CN110433240A - A kind of Chinese medicine composition and preparation method thereof for chest enlarge - Google Patents

Abstract

Medicament is made by mixing Chinese medicinal extracts, additive and excipients in the Chinese medicine composition and preparation method thereof that the invention discloses a kind of for chest enlarge, the Chinese medicine composition；The mixing Chinese medicinal extracts include following raw material: Salvia root P.E, yam extract, kudzu root extract, rose extract, papaya extractives, cistanche extracts, Shorthorned Epimedium P.E, Astragalus Root P.E, ginseng extract；The preparation method of the Chinese medicine composition is the following steps are included: S1, weigh each raw materials of mixing Chinese medicinal extracts；S2 mixing Chinese medicinal extracts pre-process to obtain active mixing Chinese medicinal extracts；S3, activation mixing Chinese medicinal extracts are mixed with suitable water, additive and excipients to uniformly to the Chinese medicine composition for being used for chest enlarge.Chinese medicine composition proposed by the present invention, formula rationally, chest enlarge excellent effect, it is without side-effects, non-stimulated to skin, do not rebound.

Description

A kind of Chinese medicine composition and preparation method thereof for chest enlarge

Technical field

The present invention relates to medicament research and development technical fields more particularly to a kind of for the Chinese medicine composition of chest enlarge and its preparation side Method.

Background technique

Breast is that women realizes the important indicator of the beautiful curve and the symbolic characteristic of pubarche or even adult female One of.Being constantly progressive and develop with society, living condition is constantly improved, and people are to health and beautiful requirement It is higher and higher.Breast is not only for lactated infant, the even more pith of women formal beauty.Plentiful, bodybuilding breast has become For the important symbol of woman charm.But since busy life, pregnancy, lactation, weight gain, congenital dysplasia etc. are many Reason, cause the breast of many women it is flat it is small, relaxation is sagging etc., this not only affects female's oomph, but also drops significantly The low confidence of women.

Method currently used for chest enlarge mainly has modus operandi, the method for movement, dietary adjustments method, acupuncture chest enlarge method, massage chest enlarge Method and drug chest enlarge method etc..Wherein, modus operandi is a kind of method of relative maturity, however uses this method pain big, is needed There is operative incision in institute, it may appear that the scar that can not be disappeared；Meanwhile breast prosthesis is located under pectoralis major, feel with Normal breast is different, and breast can be hardened as muscles contract；What is more, and prosthese ulceration, which is impregnated into bodily tissue, to be difficult to thoroughly It removes, certain harm is generated to body, and mammary gland local problem can only be solved.The method of movement, dietary adjustments method and massage chest enlarge Although method has certain chest enlarge effect, but responding time is long, and effect is unobvious.Though acupuncture chest enlarge method is quick, have certain Side effect and pain sensation be easy rebound and there are certain risk.Therefore, at present chest enlarge means use it is more or rich Chest medicine, breast-rounding essential oil and chest enlarge health care product.However, the presently commercially available general effect of chest enlarge product is not satisfactory, especially very much Chest enlarge product all contains hormone, and long-time service can cause endocrine disturbance, damage hepatic and renal function, and chloasma, acne etc. is caused to be damaged U.S. dermatoses.

Therefore, be badly in need of find it is a kind of can match with female pathology, effect is progressive and stablize, do not harm human health, with Based on effecting a permanent cure and with the chest enlarge product of the pure natural ecosystem of the pure green of temporary solution.Based on the deficiencies in the prior art, this hair It is bright to propose a kind of Chinese medicine composition and preparation method thereof for chest enlarge.

Summary of the invention

The purpose of the present invention is to solve Operative risks existing in the prior art greatly, painful, side effect is big, controls Therapeutic effect is unobvious, containing hormone, influence the shortcomings that health, and a kind of Chinese medicine composition for chest enlarge that proposes and its Preparation method.

Medicament is made by mixing Chinese medicinal extracts, additive and excipients in a kind of Chinese medicine composition for chest enlarge；It is described Mixing Chinese medicinal extracts include the raw material of following parts by weight: 2~30 parts of Salvia root P.E, 2~30 parts of yam extract, pueraria lobata mention 2~30 parts of object, 2~30 parts of rose extract, 2~30 parts of papaya extractives, 1~20 part of cistanche extracts, Herba Epimedii is taken to mention Take 1~20 part of object, 1~20 part of Astragalus Root P.E, 2~30 parts of ginseng extract.

Preferably, the mixing Chinese medicinal extracts include the raw material of following parts by weight: 5~20 parts of Salvia root P.E of mixing, 5~20 parts of yam extract, 5~20 parts of kudzu root extract, 5~20 parts of rose extract, 5~20 parts of papaya extractives, meat desert 2~10 parts of Rong's extract, 2~10 parts of Shorthorned Epimedium P.E, 2~10 parts of Astragalus Root P.E, 5~10 parts of ginseng extract.

Preferably, the additive is antioxidant, preservative, pH adjusting agent, wetting agent, moisturizer, fragrance, pigment, ox Sulfonic acid, VC, VE, proline, in lysine at least two mixture.

Preferably, the antioxidant be inorganic sulphide, it is organic sulfur compound, enol class, phenol, any in amino One kind, the inorganic sulphide are sodium hydrogensulfite or sodium metabisulfite, and the organic sulfur compound is thioglycerol or half Guang Propylhomoserin, the enol class is ascorbic acid, acid ascorbyl ester, ascorbate, arabo-ascorbic acid, arabo-ascorbic acid ester, different anti- In any one in bad hematic acid salt, ethylenediamine tetra-acetic acid and its salt, the phenol calls quinhydrones, gallic acid, gallic acid third Ester, tocopherol, any one in D-α-tocopherol acetate, the amino is glycine or phenylalanine；

The preservative is esters preservative, in alcohols preservative, acids preservative, antiseptic mercurials, quaternary ammonium preservative It is a kind of；The esters preservative be methyl p-hydroxybenzoate, ethyl-para-hydroxybenzoate, propylparaben, to hydroxyl One of yl benzoic acid butyl ester, benzyl p-hydroxybenzoate, P-hydroxybenzoic acid phenyl ester, ethyl hydroxy benzoate；The alcohols anti-corrosion Agent is one of Phenoxyethanol, ethyl alcohol, propylene glycol, benzyl alcohol；The acids preservative be benzoic acid, benzoate, formic acid, One of formates, propionic acid, propionate, gentianic acid, gentisate；The antiseptic mercurials are thimerosal, phenylmercuric acetate, boron One of sour benzene mercury；The quaternary ammonium preservative is benzalkonium chloride, benzalkonium bromide, chlorhexidine acetate, chlorhexidine hydrochloride, grape One of saccharic acid chlorohexidene, chlorhexidinium iodine；

The pH adjusting agent be one of acid, alkaloids, buffer solution, the acidic materials be hydrochloric acid, acetic acid, One of lactic acid, citric acid, tartaric acid, caproic acid, adipic acid, malic acid, phosphoric acid, succinic acid, boric acid and its salt, the bases Substance is one of ethanol amine, isopropylamine, sodium carbonate, sodium hydroxide, potassium hydroxide, ammonia solution, and the buffer solution is phosphorus One of phthalate buffer, borate buffer solution, Succinate Buffer, tartrate buffer；

The wetting agent is lecithin, polysorbate, polyoxyethylene alkyl ether, Brij, Emulsifier EL-60, poloxamer One of 188；

The moisturizer is hyaluronic acid, Sodium Hyaluronate, glycerol, propylene glycol, butanediol, sorbierite, polyethylene glycol, xylose One of alcohol, polypropylene glycol, ceramide, collagen, mucopolysaccharide, chitin derivativ, aloe, marine algae extract.

Preferably, the excipient is solvent, solubilizer, cosolvent, suspending agent, stabilizer, emulsifier, thickener, base Material.

Preferably, the solvent is the mixing of water, propylene glycol, glycerol, at least two kinds of substances in cosmetic oil；It is described Solubilizer is Tween 80；The cosolvent is the mixing of acid, alkali, at least two kinds of substances in organic solvent；The suspending agent is table Face activating agent and thickener；The emulsifier be surfactant, surface tension can be reduced high-molecular compound, can Stability Bound The mixture of at least two or more substances in the solid powder of facial mask；The thickener is carbomer；The host material is oil One of property matrix, emulsion-type matrix or aqueous matrix, the oleaginous base includes hydrocarbon base, grease type matrix, lipoid The polymer of class matrix and organosilicon oxide；The hydrocarbon base is one of white oil, vaseline, paraffin, the cream Dosage form substrate includes oil-in and water-in-oil base；The aqueous matrix is polyalcohol, cellulose derivative, glycerol, gelatin One of.

Preferably, the dosage form is solution-type, suspension type, emulsion-type, gel-type, creme, any one in paste.

The invention also provides a kind of preparation methods of Chinese medicine composition for chest enlarge, comprising the following steps:

S1, according to 2~30 parts of Salvia root P.E, 2~30 parts of yam extract, 2~30 parts of kudzu root extract, rose extract 2 ~30 parts, 2~30 parts of papaya extractives, 1~20 part of cistanche extracts, 1~20 part of Shorthorned Epimedium P.E, Astragalus Root P.E 1 2~30 parts of~20 parts, ginseng extract each raw materials of preparation mixing Chinese medicinal extracts, it is spare；

S2, by the weighed Salvia root P.E of step S1, yam extract, kudzu root extract, rose extract, papaya extractives, Cistanche extracts, Shorthorned Epimedium P.E part, Astragalus Root P.E and ginseng extract are uniformly mixed, and take mixing Chinese medicinal extracts, The palmityl tripeptides and suitable water, 10~20min of ultrasonic disperse for being added 0.01~0.02 times of mixing Chinese medicinal extracts quality obtain Mixture A；Take 10~20 times of mixing Chinese medicinal extracts quality ethanol water and mixing Chinese medicinal extracts quality 0.01~ 0.02 times of Calycosin-7-O-BETA-D-glucoside is uniformly mixed to get mixture B；Mixture A is added dropwise in mixture B, ultrasound point It is dissipated to uniformly, is concentrated under reduced pressure up to active mixing Chinese medicinal extracts；The mass concentration of ethyl alcohol is 75% in the ethanol water；

S3, the activation mixing Chinese medicinal extracts that step S2 is prepared are mixed with suitable water, additive and excipients to equal The even Chinese medicine composition to get for chest enlarge.

Chinese medicine composition proposed by the present invention has the advantage that compared with prior art

1, Chinese medicine composition proposed by the present invention, first by Chinese medicine Radix Salviae Miltiorrhizae, Chinese yam, pueraria lobata, rose, pawpaw, Herba Cistanches, excessive sheep The leaves of pulse plants, Radix Astragali, ginseng active component extract mixed and pre-processed, then mixed with additive, excipients；Entire system Preparation Method is easy to operate, obtained mixing Chinese medicinal extracts protein rich in, vitamin, microelement etc., for cream Room development provides required nutrient, and the isoflavones in pueraria lobata has estrogen-like action, can promote female breast development, meat Desert cistanche can enhance the function of Hypothalamus-Pituitary-Ovaries, improve hypophysis to the reactivity and ovary of luteinizing hormone-releasing hormone (LRH) To the reactivity of lutropin, so that mammary development be promoted to increase, while it can also enhance machine after the mixing of plurality of Chinese extract The immunity of body increases red blood cell, hemoglobin and leucocyte, is further conducive to the growth and development of breast, thus short Time reaches the effect of chest enlarge, and it is without side-effects, non-stimulated to skin, do not rebound；

2, in Chinese medicine composition proposed by the present invention, Herba Cistanches are the key medicine of liver and kidney benefiting, replenishing vital essence and blood；Pueraria lobata enters stomach the spleen channel, inspires Stomach Qi uplink, born fluid, to control weakness of the spleen and the stomach panacea, two medicines are ministerial drug altogether；Ginseng positive, liver-kidney tonifying function beneficial to temperature, Promote essence and blood metaplasia and support breast, is adjutant；Rose property is walked to alter, have soothing liver-qi stagnation, row cream in the stagnation of the circulation of vital energy function, help the fluent chest of qi and blood Bear, and keep mammary development plentiful, to make medicine, four kinds of Chinese medicines, which are used in mixed way, has the function of synergy.

3, Chinese medicine composition proposed by the present invention makes with the agents in combination containing nti-freckle ingredient, whitening composition, anti-inflammation components With that can have the function that synergy, Chinese medicine composition proposed by the present invention is independent or use is associated with other active components, It is not single to play the role of chest enlarge, while lobule of mammary gland and reticular connective tissue hyperplasia can also be prevented and treated.

4, mixing Chinese medicinal extracts proposed by the present invention are also needing to carry out pretreatment operation using preceding, and utilize rationally ratio The effect of palmityl tripeptides and Calycosin-7-O-BETA-D-glucoside of example are modified processing, can significantly improve Chinese medicine composition chest enlarge, contracting The treatment time of short patient.

Specific embodiment

Combined with specific embodiments below the present invention is made further to explain.

Embodiment one

A kind of Chinese medicine composition composition for chest enlarge proposed by the present invention:

Auxiliary material	Every liter of supplementary material dosage
		Salvia root P.E	3g
Yam extract	3g
		Kudzu root extract	3g
Rose extract	3g
		Papaya extractives	3g
Cistanche extracts	1g
		Shorthorned Epimedium P.E	1g
Astragalus Root P.E	1g
		Ginseng extract	1g
Taurine	3g
		VC	1g
VE	1g
		Proline	1g
Lysine	1g
		Sodium Hyaluronate	0.5g
Ethyl alcohol	50mL
		PLURONICS F87	0.5g
Phenoxyethanol	2.5 g
		Water	Add to 1L

Preparation method includes the following steps:

S1, according to above-mentioned recipe quantity, weigh Salvia root P.E, yam extract, kudzu root extract, rose extract, pawpaw and mention Object, cistanche extracts, Herba Epimedii is taken to extract part, Astragalus Root P.E, ginseng extract preparation each raw material of mixing Chinese medicinal extracts, It is spare；

S2, by the weighed Salvia root P.E of step S1, yam extract, kudzu root extract, rose extract, papaya extractives, Cistanche extracts, Shorthorned Epimedium P.E part, Astragalus Root P.E and ginseng extract are uniformly mixed, and take mixing Chinese medicinal extracts, The palmityl tripeptides and suitable water, ultrasonic disperse 15min for being added 0.01 times of mixing Chinese medicinal extracts quality obtain mixture A；It takes The ethanol water and 0.01 times of mixing Chinese medicinal extracts quality of Calycosin-7-O-BETA-D-glucoside that 15 times of mixing Chinese medicinal extracts quality mix It closes uniformly to get mixture B；Mixture A is added dropwise in mixture B, ultrasonic disperse is concentrated under reduced pressure up to living to uniform Property mixing Chinese medicinal extracts；The mass concentration of ethyl alcohol is 75% in the ethanol water；

S3, by the ethyl alcohol of recipe quantity, PLURONICS F87, Phenoxyethanol, Sodium Hyaluronate, taurine, proline, lysine, VC And VE, addition 600mL water, stirring and dissolving, the active mixing Chinese medicinal extracts that then addition step S2 is obtained, stirring and dissolving, after Continuous plus water is settled to 1L, mixes to get the Chinese medicine composition aqueous solution for chest enlarge.

Embodiment two

A kind of Chinese medicine composition composition for chest enlarge proposed by the present invention:

Auxiliary material	Every liter of supplementary material dosage
		Salvia root P.E	2g
Yam extract	2g
		Kudzu root extract	2g
Rose extract	2g
		Papaya extractives	2g
Cistanche extracts	2g
		Shorthorned Epimedium P.E	2g
Astragalus Root P.E	2g
		Ginseng extract	2g
Taurine	3g
		VC	1g
VE	1g
		Proline	1g
Lysine	1g
		Sodium Hyaluronate	0.5g
Carbomer	4 g
		Sodium hydroxide	1.6 g
PLURONICS F87	0.5g
		Phenoxyethanol	2.5 g
Glycerol	20 g
		Ethyl alcohol	50mL
Water	Add to 1L

Preparation method includes the following steps:

S1, according to above-mentioned recipe quantity, weigh Salvia root P.E, yam extract, kudzu root extract, rose extract, pawpaw and mention Object, cistanche extracts, Herba Epimedii is taken to extract part, Astragalus Root P.E, ginseng extract preparation each raw material of mixing Chinese medicinal extracts, It is spare；

S2, by the weighed Salvia root P.E of step S1, yam extract, kudzu root extract, rose extract, papaya extractives, Cistanche extracts, Shorthorned Epimedium P.E part, Astragalus Root P.E and ginseng extract are uniformly mixed, and take mixing Chinese medicinal extracts, The palmityl tripeptides and suitable water, ultrasonic disperse 20min for being added 0.01 times of mixing Chinese medicinal extracts quality obtain mixture A；It takes The ethanol water and 0.02 times of mixing Chinese medicinal extracts quality of Calycosin-7-O-BETA-D-glucoside that 10 times of mixing Chinese medicinal extracts quality mix It closes uniformly to get mixture B；Mixture A is added dropwise in mixture B, ultrasonic disperse is concentrated under reduced pressure up to living to uniform Property mixing Chinese medicinal extracts；The mass concentration of ethyl alcohol is 75% in the ethanol water；

S3, by weighed PLURONICS F87, add in 250ml water and dissolve；The ethyl alcohol, glycerol, benzene oxygen second of recipe quantity are weighed respectively Alcohol, Sodium Hyaluronate, proline, lysine, carbomer, sodium hydroxide, VC with and VE, be added 600mL water, stirring and dissolving, so Activity mixing Chinese medicinal extracts made from step S2 are added in the backward solution, mixing mixes, and continues plus water is settled to 1L, mix The even Chinese medicine composition gel to get for chest enlarge.

Embodiment three

A kind of Chinese medicine composition composition for chest enlarge proposed by the present invention:

Auxiliary material	Every liter of supplementary material dosage
		Salvia root P.E	2g
Yam extract	2g
		Kudzu root extract	2g
Rose extract	2g
		Papaya extractives	2g
Cistanche extracts	1g
		Shorthorned Epimedium P.E	1g
Astragalus Root P.E	1g
		Ginseng extract	1g
Taurine	3g
		VC	1g
VE	1g
		Proline	1g
Lysine	1g
		Carbomer	4 g
Sodium hydroxide	1.6 g
		Phenoxyethanol	2.5 g
Glycerol	60 g
		Ethyl hydroxy benzoate	3 g
White oil	50 g
		PLURONICS F87	22.5 g
Tween 80	7.5 g
		Span 80	25 g
Water	Add to 1L

Preparation method includes the following steps:

S1, according to above-mentioned recipe quantity, weigh Salvia root P.E, yam extract, kudzu root extract, rose extract, pawpaw and mention Object, cistanche extracts, Herba Epimedii is taken to extract part, Astragalus Root P.E, ginseng extract preparation each raw material of mixing Chinese medicinal extracts, It is spare；

S2, by the weighed Salvia root P.E of step S1, yam extract, kudzu root extract, rose extract, papaya extractives, Cistanche extracts, Shorthorned Epimedium P.E part, Astragalus Root P.E and ginseng extract are uniformly mixed, and take mixing Chinese medicinal extracts, The palmityl tripeptides and suitable water, ultrasonic disperse 10min for being added 0.02 times of mixing Chinese medicinal extracts quality obtain mixture A；It takes The ethanol water and 0.01 times of mixing Chinese medicinal extracts quality of Calycosin-7-O-BETA-D-glucoside that 10 times of mixing Chinese medicinal extracts quality mix It closes uniformly to get mixture B；Mixture A is added dropwise in mixture B, ultrasonic disperse is concentrated under reduced pressure up to living to uniform Property mixing Chinese medicinal extracts；The mass concentration of ethyl alcohol is 75% in the ethanol water；

S3, the taurine for weighing above-mentioned recipe quantity respectively, VC, VE, proline, lysine, carbomer, sodium hydroxide, Bo Luosha 650mL water is added in nurse 188 and Tween 80, and dissolution mixes, and activity mixing Chinese medicinal extracts made from step S2 are added, and mixing is equal Even mixing, obtains mixture C；The ethyl hydroxy benzoate and Phenoxyethanol for weighing above-mentioned recipe quantity respectively, are added to the sweet of above-mentioned recipe quantity In oil, dissolution is mixed, and is then added in mixture C, is stirred and evenly mixed, stir 20min under the conditions of 60 DEG C of 1000rpm, obtains mixed Close object D；The white oil and Span80 for weighing above-mentioned recipe quantity, stir and evenly mix, and are heated to 60 DEG C, are then added to high-speed stirred In mixture D, continues to stir 20min, water is added to be settled to 1L, the condition then recycled according to 500 bar 5 carries out homogeneous, i.e., It must be used for the Chinese medicine composition nano-emulsion of chest enlarge.

Comparative example one

A kind of Chinese medicine composition composition for chest enlarge proposed by the present invention:

Auxiliary material	Every liter of supplementary material dosage
		Salvia root P.E	3g
Yam extract	3g
		Kudzu root extract	3g
Rose extract	3g
		Papaya extractives	3g
Cistanche extracts	1g
		Shorthorned Epimedium P.E	1g
Astragalus Root P.E	1g
		Ginseng extract	1g
Taurine	3g
		VC	1g
VE	1g
		Proline	1g
Lysine	1g
		Sodium Hyaluronate	0.5g
Ethyl alcohol	50mL
		PLURONICS F87	0.5g
Phenoxyethanol	2.5 g
		Water	Add to 1L

Preparation method includes the following steps:

S1, according to above-mentioned recipe quantity, weigh Salvia root P.E, yam extract, kudzu root extract, rose extract, pawpaw and mention Object, cistanche extracts, Herba Epimedii is taken to extract part, Astragalus Root P.E, ginseng extract preparation each raw material of mixing Chinese medicinal extracts, It is spare；

S2, by the ethyl alcohol of recipe quantity, PLURONICS F87, Phenoxyethanol, Sodium Hyaluronate, VC and VE, 600mL water, stirring is added Then the obtained mixing Chinese medicinal extracts of step S1 are added in dissolution, stirring and dissolving, continues plus water is settled to 1L, mix to get with In the Chinese medicine composition aqueous solution of chest enlarge.

Experiment

(1) guinea pig acute skin irritation test

The test of skin Acute irritation test, Mei Geshi are carried out to the Chinese medicine composition that embodiment one~tri- and comparative example one obtain respectively Applying example selects 5 cavys to be tested, and experimental temperature is 20~24 DEG C, and relative humidity is 60~70%.About for 24 hours will before experiment Experimental animal back backbone two sides coat is cut, unhairing range 3cm*3cm, application area 2.5cm*2.5cm.Take given the test agent 0.5mL is applied on the skin of side, and blank solvent water is smeared as control in the other side, smears 1 time daily, continuous to smear 14 days. Since second day, cropping is answered before smearing every time, tested material is remained with water or nonirritant solvent cleaning, knot is observed after one hour Fruit.Stimulate the reaction evaluation is carried out referring to " cosmetics health specification (2007 editions) " regulation.Evaluation result is as shown in the table:

1 Chinese medicine of table closes the acute skin irritation reaction of object

As can be seen from the results, it is anti-that the Chinese medicine composition that prepared by embodiment one~tri- and comparative example one is showed no acute skin irritation It answers.

(2) experiment of chest enlarge validity and human body irritation test

Female breast standard: 1. plentiful, tall and straight, flexible, hemispherical；2. breast is located at the 2nd to 6 intercostal, nipple is located at the 4th Intercostal；3. breast 10~12cm of basal surface diameter, two teat spacings be greater than 20cm or two shoulders away from 1/2；4. bust is equal to stern It encloses；Breast is flat or less than normal: being 1. less than the 1/3 of fat corrected milk(FCM) foundations basal diameter；2. bust is less than hip circumference 1/3；Under breast relaxation Hang down: 1. breast tension, elastic force reduce；2. if teat placement lower than discount below breast for I degree it is sagging；Breast position is lower than the 6th Rib edge is that II degree is sagging；Breast position is that III degree is sagging up to umbilical region.

The bodybuilding standard of breast is specifically shown in Table 2；Digital representative fraction in table 2,75 points or more represent bodybuilding breast, and total score exists 40~60 points of persons are the nonstandard breast of I degree, and 20~40 points of persons are the nonstandard breast of II degree, and less than 20 points persons are that III degree is nonstandard Breast.

The bodybuilding standard of 2 breast of table

(3) clinical test:

Study subject: women 100 of selection 18~45 years old, medical fitness, Fen≤60 point Zong or less person has breast augmentation and health demand And meet cosmetics normal individual trial subject enrollment standard person in " cosmetics health specification ".It is randomly divided into 5 groups, every group 20.

Subject method: study subject is divided into 5 groups at random, every group 20, gives embodiment one~tri- and comparative example respectively One Chinese medicine composition being prepared and reference substance (i.e. placebo).Example one~tri- and comparative example one take every time once a day It is wiped outside appropriate in breast part, and is massaged from bottom to top, from inside to outside with finger pulp until absorption, continuous 90 days, during which deactivates it Its breast augmentation and diet products.Control group 20 use placebo, usage, dosage, the same using time, points for attention.

Observation index: 1. according to breast fitness standard sight, measurement corresponding index, reciprocal fraction is provided, total score is calculated；② Whether inquiry breast has the abnormal phenomenon such as lump, pain, and whether observation breast has the irritations such as erythema, redness and itch anti- It answers；3. whether there is the physiological changes such as irregular menstruation, the proliferation of mammary gland, it the results are shown in Table 3.

The chest enlarge curative effect and irritation of the different Chinese medicine compositions of table 3 compare

It can be seen from the above result that various Chinese medicine compositions prepared by the present invention all have apparent chest enlarge compared with placebo Effect, agents area does not find obvious irritation, and does not find there is any influence to physiological phenomenon, in addition to this as can be seen that The pretreatment operation of mixing Chinese medicinal extracts can significantly improve the chest enlarge effect of Chinese medicine composition.

The foregoing is only a preferred embodiment of the present invention, but scope of protection of the present invention is not limited thereto, Anyone skilled in the art in the technical scope disclosed by the present invention, according to the technique and scheme of the present invention and its Inventive concept is subject to equivalent substitution or change, should be covered by the protection scope of the present invention.

Claims (8)

1. a kind of Chinese medicine composition for chest enlarge, which is characterized in that be made of mixing Chinese medicinal extracts, additive and excipients Medicament；The mixing Chinese medicinal extracts include the raw material of following parts by weight: 2~30 parts of Salvia root P.E, yam extract 2~30 Part, 2~30 parts of kudzu root extract, 2~30 parts of rose extract, 2~30 parts of papaya extractives, 1~20 part of cistanche extracts, 1~20 part of Shorthorned Epimedium P.E, 1~20 part of Astragalus Root P.E, 2~30 parts of ginseng extract.

2. a kind of Chinese medicine composition for chest enlarge according to claim 1, which is characterized in that the mixing traditional Chinese medicine extraction Object includes the raw material of following parts by weight: 5~20 parts of Salvia root P.E, 5~20 parts of yam extract, 5~20 parts of kudzu root extract, 5~20 parts of rose extract, 5~20 parts of papaya extractives, 2~10 parts of cistanche extracts, 2~10 parts of Shorthorned Epimedium P.E, 2~10 parts of Astragalus Root P.E, 5~10 parts of ginseng extract.

3. a kind of Chinese medicine composition for chest enlarge according to claim 1, which is characterized in that the additive is antioxygen Agent, preservative, pH adjusting agent, wetting agent, moisturizer, fragrance, pigment, taurine, VC, VE, proline, at least two in lysine The mixture of kind.

4. a kind of Chinese medicine composition for chest enlarge according to claim 3, which is characterized in that the antioxidant is inorganic Sulfide, organic sulfur compound, enol class, phenol, any one in amino, the inorganic sulphide is sodium hydrogensulfite Or sodium metabisulfite, the organic sulfur compound are thioglycerol or cysteine, the enol class is ascorbic acid, Vitamin C Appointing in acid esters, ascorbate, arabo-ascorbic acid, arabo-ascorbic acid ester, erythorbate, ethylenediamine tetra-acetic acid and its salt In meaning one, phenol meaning quinhydrones, gallic acid, propylgallate, tocopherol, any one in D-α-tocopherol acetate, The amino is glycine or phenylalanine；

The preservative is esters preservative, in alcohols preservative, acids preservative, antiseptic mercurials, quaternary ammonium preservative It is a kind of；The esters preservative be methyl p-hydroxybenzoate, ethyl-para-hydroxybenzoate, propylparaben, to hydroxyl One of yl benzoic acid butyl ester, benzyl p-hydroxybenzoate, P-hydroxybenzoic acid phenyl ester, ethyl hydroxy benzoate；The alcohols anti-corrosion Agent is one of Phenoxyethanol, ethyl alcohol, propylene glycol, benzyl alcohol；The acids preservative be benzoic acid, benzoate, formic acid, One of formates, propionic acid, propionate, gentianic acid, gentisate；The antiseptic mercurials are thimerosal, phenylmercuric acetate, boron One of sour benzene mercury；The quaternary ammonium preservative is benzalkonium chloride, benzalkonium bromide, chlorhexidine acetate, chlorhexidine hydrochloride, grape One of saccharic acid chlorohexidene, chlorhexidinium iodine；

The pH adjusting agent be one of acid, alkaloids, buffer solution, the acidic materials be hydrochloric acid, acetic acid, One of lactic acid, citric acid, tartaric acid, caproic acid, adipic acid, malic acid, phosphoric acid, succinic acid, boric acid and its salt, the bases Substance is one of ethanol amine, isopropylamine, sodium carbonate, sodium hydroxide, potassium hydroxide, ammonia solution, and the buffer solution is phosphorus One of phthalate buffer, borate buffer solution, Succinate Buffer, tartrate buffer；

The wetting agent is lecithin, polysorbate, polyoxyethylene alkyl ether, Brij, Emulsifier EL-60, poloxamer One of 188；

The moisturizer is hyaluronic acid, Sodium Hyaluronate, glycerol, propylene glycol, butanediol, sorbierite, polyethylene glycol, xylose One of alcohol, polypropylene glycol, ceramide, collagen, mucopolysaccharide, chitin derivativ, aloe, marine algae extract.

5. a kind of Chinese medicine composition for chest enlarge according to claim 1, which is characterized in that the excipient is molten Agent, solubilizer, cosolvent, suspending agent, stabilizer, emulsifier, thickener, host material.

6. a kind of Chinese medicine composition for chest enlarge according to claim 5, which is characterized in that the solvent is water, third The mixing of glycol, glycerol, at least two kinds of substances in cosmetic oil；The solubilizer is Tween 80；The cosolvent be acid, The mixing of at least two kinds of substances in alkali, organic solvent；The suspending agent is surfactant and thickener；The emulsifier is Surfactant, the high-molecular compound that surface tension can be reduced, can be at least two or more in the solid powder of Stability Bound facial mask The mixture of substance；The thickener is carbomer；The host material is in oleaginous base, emulsion-type matrix or aqueous matrix One kind, the oleaginous base includes the polymerization of hydrocarbon base, grease type matrix, lipoidis matrix and organosilicon oxide Object；The hydrocarbon base is one of white oil, vaseline, paraffin, and the emulsion-type matrix includes oil-in and water-in-oil type Matrix；The aqueous matrix is one of polyalcohol, cellulose derivative, glycerol, gelatin.

7. a kind of Chinese medicine composition for chest enlarge according to claim 1, which is characterized in that the dosage form is solution Type, suspension type, emulsion-type, gel-type, creme, any one in paste.

8. a kind of preparation method of the Chinese medicine composition for chest enlarge, which comprises the following steps:

S1, according to 2~30 parts of Salvia root P.E, 2~30 parts of yam extract, 2~30 parts of kudzu root extract, rose extract 2 ~30 parts, 2~30 parts of papaya extractives, 1~20 part of cistanche extracts, 1~20 part of Shorthorned Epimedium P.E, Astragalus Root P.E 1 2~30 parts of~20 parts, ginseng extract each raw materials of preparation mixing Chinese medicinal extracts, it is spare；

S2, by the weighed Salvia root P.E of step S1, yam extract, kudzu root extract, rose extract, papaya extractives, Cistanche extracts, Shorthorned Epimedium P.E part, Astragalus Root P.E and ginseng extract are uniformly mixed, and take mixing Chinese medicinal extracts, The palmityl tripeptides and suitable water, 10~20min of ultrasonic disperse for being added 0.01~0.02 times of mixing Chinese medicinal extracts quality obtain Mixture A；Take 10~20 times of mixing Chinese medicinal extracts quality ethanol water and mixing Chinese medicinal extracts quality 0.01~ 0.02 times of Calycosin-7-O-BETA-D-glucoside is uniformly mixed to get mixture B；Mixture A is added dropwise in mixture B, ultrasound point It is dissipated to uniformly, is concentrated under reduced pressure up to active mixing Chinese medicinal extracts；The mass concentration of ethyl alcohol is 75% in the ethanol water；

S3, the activation mixing Chinese medicinal extracts that step S2 is prepared are mixed with suitable water, additive and excipients to equal The even Chinese medicine composition to get for chest enlarge.