CN108785163B

CN108785163B - Breast enlarging cream and preparation method and application method thereof

Info

Publication number: CN108785163B
Application number: CN201810713836.4A
Authority: CN
Inventors: 刘洪生; 胡晓娟; 张荣培; 李跃克
Original assignee: Bokai Pharmaceutical Co ltd
Current assignee: Bokai Pharmaceutical Co ltd
Priority date: 2018-07-03
Filing date: 2018-07-03
Publication date: 2021-09-14
Anticipated expiration: 2038-07-03
Also published as: CN108785163A

Abstract

The invention provides breast enlarging cream and a preparation method and a using method thereof, and relates to the technical field of medical cosmetics, wherein the breast enlarging cream comprises the following components in parts by mass: the breast enlargement cream provided by the invention not only can stimulate estrogen secretion, activate mammary gland to generate more subcutaneous fat of breast and promote breast enlargement, but also can clear away in-vivo garbage, improve microcirculation, enhance skin elasticity, enable breasts to be firm and full and highlight the curvilinear charm of women by the mutual cooperation of the soybean isoflavone extract, the cowherb seed extract, the radix puerariae extract and the vitamin E.

Description

Breast enlarging cream and preparation method and application method thereof

Technical Field

The invention relates to the technical field of medicines and cosmetics, in particular to breast enlarging cream and a preparation method and a using method thereof.

Background

The breast is an important index for realizing curve beauty of women and is also one of the symbolic characteristics of adolescent and even adult women. The breast is composed of skin, breast, fat, connective tissue and nipple, and defects in any aspect of the breast affect the health and shape integrity of the breast.

Modern medicine and psychology think that female breast is imperfect due to many reasons, including nutrient deficiency or unbalance, unreasonable wearing of bra, lack of exercise, skin relaxation after rapid weight loss, and ovarian function decline, which results in breast skin relaxation, fat loss, connective tissue tension unbalance, mammary gland growth stopping or atrophy, etc.

At present, the breast is enlarged by common operations and oral hormone drugs in the market, and the wounds on the breasts need to be cut for silica gel filling, so that the feeling is unnatural, and the pathogenic factors are generated in the body, thereby bringing serious health hazards. Oral hormone drugs interfere with normal hormone secretion in vivo, even cause endocrine disturbance and damage body health. Therefore, the people skilled in the art need to develop a healthy and safe breast enhancement product to meet the needs of modern women.

In view of the above, the present invention is particularly proposed.

Disclosure of Invention

The invention aims to provide breast enlarging cream to relieve the technical problem that the body health is damaged by breast enlargement by an operation or oral estrogen medicine.

The breast enhancement cream provided by the invention comprises the following components in parts by weight: 5-10 parts of soybean isoflavone extract, 0.5-5 parts of cowherb seed extract, 0.5-5 parts of kudzu root extract and 5-10 parts of vitamin E.

Further, the breast enhancement cream comprises the following components in parts by weight: 6-9 parts of soybean isoflavone extract, 1-3 parts of cowherb seed extract, 1-3 parts of kudzu root extract and 6-9 parts of vitamin E.

Further, the breast enhancement cream comprises the following components in parts by weight: 7-9 parts of soybean isoflavone extract, 1.5-2.5 parts of cowherb seed extract, 1.5-2.5 parts of kudzu root extract and 78-9 parts of vitamin E7.

Further, the breast enhancement cream also comprises 1-3 parts of palmitoyl tripeptide and 1-3 parts of acetyl hexapeptide in parts by mass;

preferably, the composition further comprises 1-3 parts of commiphora mukul resin extract.

Further, the breast enhancement cream also comprises 10-20 parts of auxiliary materials in parts by mass;

preferably, the adjuvant is selected from at least one of a thickener, a humectant, a vegetable oil, and an emulsifier.

Further, the auxiliary materials comprise 1-2 parts of thickening agent, 10-20 parts of humectant, 1-2 parts of vegetable oil and 0.2-0.8 part of emulsifier in parts by mass;

preferably, the thickener is a carbomer;

preferably, the humectant is glycerin;

preferably, the emulsifier is triethanolamine.

Further, the vegetable oil is selected from at least one of coconut oil, tea tree oil, jojoba oil and sweet almond oil;

preferably, the vegetable oil is a mixture of coconut oil and tea tree oil;

further preferably, the mass ratio of the coconut oil to the tea tree oil is 2-3: 1.

Further, the breast enhancement cream also comprises 150-250 parts by mass of solvent, preferably 180-220 parts by mass;

preferably, the solvent is water.

The invention also aims to provide a preparation method of the breast enlargement cream, which comprises the following steps: mixing soybean isoflavone extract, semen Vaccariae extract, radix Puerariae extract, vitamin E, optionally palmitoyl tripeptide, optionally acetyl hexapeptide, optionally commiphora mukul resin extract, optionally adjuvants and optionally solvent to obtain breast enlarging cream.

The invention also aims to provide a use method of the breast enlarging cream, which comprises the following steps: applying the breast enlarging cream on breast, and massaging until absorption;

preferably, the smearing and the massage are performed in a bead-by-bead massage manner.

The breast-enlarging cream provided by the invention has the advantages that through mutual cooperation of the soybean isoflavone extract, the cowherb seed extract, the kudzu root extract and the vitamin E, the breast-enlarging cream can stimulate estrogen secretion, activate mammary glands to generate more breast subcutaneous fat and promote breast enlargement, can also clear away in-vivo garbage, improve microcirculation and enhance skin elasticity, enables breasts to be firm and full, and highlights the curvilinear charm of women.

In addition, the breast enlargement cream provided by the invention is prepared from traditional Chinese medicine extracts, has no toxic or side effect, and can effectively regulate endocrine and promote female health after long-term use.

The preparation method of the breast enlargement cream provided by the invention is simple in process and convenient to operate, and can be suitable for industrial mass production, so that the production efficiency is effectively improved.

The breast enlarging cream provided by the invention is used in a direct smearing mode, is convenient and safe, and provides more convenience for women.

Detailed Description

Embodiments of the present invention will be described in detail below with reference to examples, but it will be understood by those skilled in the art that the following examples are only illustrative of the present invention and should not be construed as limiting the scope of the present invention. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.

According to one aspect of the invention, the invention provides breast enlarging cream which comprises the following components in parts by weight: 5-10 parts of soybean isoflavone extract, 0.5-5 parts of cowherb seed extract, 0.5-5 parts of kudzu root extract and 5-10 parts of vitamin E.

In the present invention, the typical but non-limiting mass fraction of the soybean isoflavone extract is, for example, 5, 5.2, 5.5, 5.8, 6, 6.2, 6.5, 6.8, 7, 7.2, 7.5, 7.8, 8, 8.2, 8.5, 8.8, 9, 9.2, 9.5, 9.8 or 10 parts.

The soybean isoflavone extract is extracted from soybean germs, mainly contains daidzin, daidzein, genistin, genistein, glycitein and glycitein aglycone, can make female skin smooth, fine, tender and tender, and float and elasticity, and activate adipose tissue in breast, so that free fat can be attracted to breast directionally, thereby achieving breast augmentation effect.

Typical but not limiting parts by mass of the cowherb seed extract in the present invention are e.g. 0.5, 0.8, 1, 1.2, 1.5, 1.8, 2, 2.2, 2.5, 2.8, 3, 3.2, 3.5, 3.8, 4, 4.2, 4.5, 4.8 or 5 parts.

The semen Vaccariae extract is extracted from dried and mature seed of Vaccaria segetalis of Caryophyllaceae, contains semen Vaccariae saponin and semen Vaccariae flavonoid glycoside as effective components, and has effects of promoting blood circulation, dredging channels, promoting lactation, relieving swelling, and healing sore.

Typical but not limiting mass fractions of the pueraria lobata extract in the present invention are, for example, 0.5, 0.8, 1, 1.2, 1.5, 1.8, 2, 2.2, 2.5, 2.8, 3, 3.2, 3.5, 3.8, 4, 4.2, 4.5, 4.8 or 5 parts.

The radix Puerariae extract is derived from dried root of Pueraria lobata Ohwi of Leguminosae. The kudzu root extract contains isoflavone, has the effects of plumping and firming mammary gland and reconstructing breast tissue, can quickly activate dormant breast tissue to promote the regrowth of the mammary gland tissue, can promote the health of uterus and ovary, and has the function of preventing cardiovascular diseases.

Typical but not limiting parts by mass of vitamin E in the present invention are e.g. 5, 5.2, 5.5, 5.8, 6, 6.2, 6.5, 6.8, 7, 7.2, 7.5, 7.8, 8, 8.2, 8.5, 8.8, 9, 9.2, 9.5, 9.8 or 10 parts.

Vitamin E is a fat-soluble vitamin, and the hydrolysate thereof is tocopherol, which is one of the most main antioxidants, and can promote the secretion of estrogen, protect body cells from being poisoned by free radicals, prevent organic deterioration, improve blood circulation, protect tissues, reduce cholesterol and prevent hypertension.

In a preferred embodiment of the invention, the breast-enlarging cream further comprises 1-3 parts by mass of palmitoyl tripeptide, 1-3 parts by mass of acetyl hexapeptide and 1-3 parts by mass of commiphora mukul resin extract.

In this preferred embodiment of the invention, typical but not limiting parts by mass of the palmitoyl tripeptide in the breast-enlarging cream are, for example, 1, 1.2, 1.5, 1.8, 2, 2.2, 2.5, 2.8 or 3 parts.

The palmitoyl tripeptide can greatly promote the production of collagen, reduce the generation of wrinkles, enhance the elasticity of skin, promote the activity of cells, improve the water content of the skin and improve the skin color.

In this preferred embodiment of the invention, the typical but non-limiting parts by mass of acetyl hexapeptide in the breast augmentation cream are, for example, 1, 1.2, 1.5, 1.8, 2, 2.2, 2.5, 2.8 or 3 parts.

Acetyl hexapeptide is a bioactive polypeptide which can promote the expression of PGC-1 alpha to stimulate the maturation of fat cells, induce more fat accumulation and promote breast firmness.

In this preferred embodiment of the invention, the typical but non-limiting parts by mass of commiphora mukul resin extract in the breast augmentation cream are, for example, 1, 1.2, 1.5, 1.8, 2, 2.2, 2.5, 2.8 or 3 parts.

The commiphora mukul resin extract can inhibit the activity of lipase for decomposing fat, promote the formation and accumulation of ester, promote the accumulation of fat and inhibit the decomposition of fat, and effectively increase the breast volume.

In a preferred embodiment provided by the invention, the breast-enlarging cream further comprises 10-20 parts of auxiliary materials in parts by mass.

In this preferred embodiment of the invention, typical but not limiting parts by mass of the auxiliary material are, for example, 10, 10.5, 11, 11.5, 12, 12.5, 13, 13.5, 14, 14.5, 15, 15.5, 16, 16.5, 17, 17.5, 18, 18.5, 19, 19.5 or 20 parts.

The auxiliary materials are added into the breast enlarging cream, so that the breast enlarging cream becomes an emulsion, and the breast enlarging cream is more convenient and faster to use.

In a further preferred embodiment of the present invention, the adjuvant is selected from one or more of a thickener, a humectant, a vegetable oil and an emulsifier.

In a preferred embodiment of the invention, the auxiliary material comprises 1-2 parts of thickening agent, 10-20 parts of humectant, 1-2 parts of vegetable oil and 0.2-0.8 part of emulsifier by mass.

Typical but not limiting parts by mass of the thickener in the present invention are e.g. 1, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9 or 2 parts.

Typical but not limiting parts by mass of the humectant are, for example, 10, 10.5, 11, 11.5, 12, 12.5, 13, 13.5, 14, 14.5, 15, 15.5, 16, 16.5, 17, 17.5, 18, 18.5, 19, 19.5 or 20 parts.

Typical but not limiting parts by mass of the vegetable oil are e.g. 1, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9 or 2 parts.

Typical but not limiting mass parts of the emulsifier are e.g. 0.2, 0.25, 0.3, 0.35, 0.4, 0.45, 0.5, 0.55, 0.6, 0.65, 0.7, 0.75 or 0.8 parts.

In a preferred embodiment of the invention, the thickener is a carbomer.

Carbomer is acrylic resin and has strong hygroscopicity, and molecular chains are dispersed and stretched due to the mutual repulsion action of negative charges after carbomer is neutralized to ionize carboxyl, so that the carbomer is in a great swelling state and has viscosity.

In a preferred embodiment of the invention, the humectant is glycerin.

The glycerin has strong hygroscopicity, can prevent moisture on the skin from diffusing too fast, and can absorb moisture from the air properly.

In a preferred embodiment of the invention, the emulsifier is triethanolamine.

The triethanolamine is a common emulsifier in cream, and cream products emulsified by the triethanolamine have the characteristics of fine cream and bright white cream.

In a preferred embodiment of the invention, the vegetable oil is selected from one or more of coconut oil, tea tree oil, jojoba oil and sweet almond oil.

By adding the vegetable oil into the breast enlargement cream, the breast enlargement cream has better skin lubricity and can be directly used for skin massage.

The vegetable oil is a non-volatile oil extracted from seeds, flowers, rhizomes or fruits of plants, and has better affinity with skin when coconut oil, tea tree oil, jojoba oil or sweet almond oil is selected as base oil.

In a further preferred embodiment of the invention, when the vegetable oil is a mixture of coconut oil and tea tree oil, the breast-enlarging cream is more suitable for skin absorption, and especially has better effect when the mass ratio of the coconut oil to the tea tree oil is 2-3: 1.

In a preferred embodiment of the invention, the breast enhancement cream further comprises 150-250 parts by mass of a solvent.

By adding the solvent, various components in the breast enlarging cream are mixed more uniformly and are more suitable for skin absorption.

In a typical but non-limiting embodiment of the invention, the part by mass of the solvent in the breast augmentation cream is, for example, 150, 160, 170, 180, 190, 200, 210, 220, 230, 240 or 250 parts.

In a further preferred embodiment of the invention, the solvent is water.

The water-emulsion-shaped breast-enlarging cream prepared by using water as a solvent is healthier and safer, and is more suitable for skin absorption.

According to a second aspect of the present invention, there is provided a method of preparing a breast augmentation cream, comprising the steps of: mixing soybean isoflavone extract, semen Vaccariae extract, radix Puerariae extract, vitamin E, optionally palmitoyl tripeptide, optionally acetyl hexapeptide, optionally commiphora mukul resin extract, optionally adjuvants and optionally solvent to obtain breast enlarging cream.

According to a third aspect of the invention, the invention provides a use method of the breast enlarging cream, which comprises the following steps: the breast enlarging cream is applied on breast, and massaged until absorption.

The breast enlarging cream provided by the invention is convenient and rapid to use, and is convenient for a user to use at any time.

In a further preferred embodiment of the invention, the application and massage are performed by means of a bead massage.

The breast enlarging cream is more convenient and quicker to use by adopting a bead massage mode and is easier to be absorbed by the skin.

The technical solution provided by the present invention is further described below with reference to examples and comparative examples.

Example 1

The embodiment provides a breast enhancement cream which comprises the following components in parts by weight: 5 parts of soybean isoflavone extract, 5 parts of cowherb seed extract, 0.5 part of kudzu root extract, 10 parts of vitamin E, 12 parts of glycerol, 1.2g of carbomer, 0.5g of triethanolamine, 1g of coconut oil and 0.4g of tea tree oil.

Example 2

The embodiment provides a breast enhancement cream which comprises the following components in parts by weight: 10 parts of soybean isoflavone extract, 0.5 part of cowherb seed extract, 5 parts of kudzu root extract, 5 parts of vitamin E, 12 parts of glycerol, 1.2g of carbomer, 0.5g of triethanolamine, 1g of coconut oil and 0.4g of tea tree oil.

Example 3

The embodiment provides a breast enhancement cream which comprises the following components in parts by weight: 6 parts of soybean isoflavone extract, 3 parts of cowherb seed extract, 1 part of kudzu root extract, 9 parts of vitamin E, 12 parts of glycerol, 1.2g of carbomer, 0.5g of triethanolamine, 1g of coconut oil and 0.4g of tea tree oil.

Example 4

The embodiment provides a breast enhancement cream which comprises the following components in parts by weight: 9 parts of soybean isoflavone extract, 1 part of cowherb seed extract, 3 parts of kudzu root extract, 6 parts of vitamin E, 12 parts of glycerol, 1.2g of carbomer, 0.5g of triethanolamine, 1g of coconut oil and 0.4g of tea tree oil.

Example 5

The embodiment provides a breast enhancement cream which comprises the following components in parts by weight: 8 parts of soybean isoflavone extract, 2 parts of cowherb seed extract, 2 parts of kudzu root extract, 8 parts of vitamin E, 12 parts of glycerol, 1.2g of carbomer, 0.5g of triethanolamine, 1g of coconut oil and 0.4g of tea tree oil.

Example 6

The embodiment provides a breast-enlarging cream, and is different from the embodiment 5 in that the breast-enlarging cream further comprises 2 parts of palmitoyl tripeptide and 2 parts of acetyl hexapeptide in parts by mass.

Example 7

The present example provides a breast augmentation cream, and differs from example 6 in that it further comprises 2 parts by mass of commiphora mukul resin extract.

Example 8

The present example provides a method for preparing breast enhancement cream, and the breast enhancement cream provided in examples 1 to 7 is prepared according to the following steps:

mixing soybean isoflavone extract, semen Vaccariae extract, radix Puerariae extract, vitamin E, optionally palmitoyl trititanium, optionally acetyl hexapeptide, optionally commiphora mukul resin extract, glycerol, carbomer, oleum Cocois, tea tree oil and triethanolamine uniformly to obtain breast enlarging cream.

Comparative example 1

This comparative example provides a breast augmentation cream, which differs from example 5 in that no soy isoflavone extract is added.

Comparative example 2

The comparative example provides a breast augmentation cream, which differs from example 5 in that the cowherb seed extract is not added.

Comparative example 3

The comparative example provides a breast augmentation cream, which differs from example 5 in that no pueraria extract is added.

Comparative example 4

This comparative example provides a breast augmentation cream which differs from example 5 in that vitamin E is not added.

Comparative examples 1-4 provide breast augmentation creams made by the same method as example 5 and are not described in detail herein.

Test example 1

96 SD female rats of 24 days old are taken and randomly divided into 12 groups, which are respectively 1-12 groups, wherein 1-7 groups of the SD female rats are respectively coated with breast enhancing cream provided by massage examples 1-7, 8-11 groups of the SD female rats are respectively coated with breast enhancing cream provided by massage comparative examples 1-4 on the breasts, 12 groups of the SD female rats are blank control groups and are coated with massage glycerin, 12 groups of the SD female rats are respectively applied with two massage administrations at 8:00 am and 20:00 pm and are massaged until the breast enhancing cream is completely absorbed, the SD female rats are treated after two weeks, jugular vein blood is collected to measure the contents of estradiol and progesterone, a pair of mammary glands on the abdomen of the rats are taken and weighed, and the ratio of the weight of the mammary glands to the weight is calculated, and the results are shown in Table 1.

TABLE 1 data table of estradiol and progesterone content in rats

As can be seen from Table 1, the estradiol content and progesterone content of groups 1-7 are significantly higher than those of group 12, which shows that the breast-enlarging cream provided by examples 1-7 can significantly increase the estradiol and progesterone content in rats, while the development of mammary gland is mainly controlled by estrogen and progesterone, estradiol can stimulate the growth of mammary gland, and significantly increase the progesterone receptor number of mammary gland cells, and estradiol and progesterone cooperate to promote the development of mammary acinus, and the estradiol and progesterone content can reflect the development level of mammary gland to some extent.

As can be seen from the comparison of the groups 1 to 7 with the groups 8 to 11, the breast-enlarging creams provided in examples 1 to 7 can significantly increase the estradiol and progesterone content in rats and stimulate the mammary gland growth by the mutual synergy of the soybean isoflavone extract, the cowherb seed extract, the kudzu root extract and the vitamin E.

As can be seen from the comparison of the 6 groups with the 1-5 groups, the breast-enlarging cream provided in example 6 can significantly increase the estradiol and progesterone content in rats by adding palmitoyl tripeptide and acetyl hexapeptide, and stimulate mammary gland growth.

As can be seen from the comparison between the 7 and 6 groups, the breast-enlarging cream provided in example 7 synergistically acts with palmitoyl tripeptide and acetyl hexapeptide by adding commiphora mukul resin extract, and can penetrate into rats to secrete more estradiol and progesterone, so that mammary tissues are increased.

Test example 2

160 women with healthy breasts with B cups are selected, the women are 20-40 years old and have no treatment within one month, the women are randomly divided into 8 groups, 1-8 groups respectively, and 20 people in each group, wherein 1-3 groups use the breast enhancement cream provided by examples 5-7 respectively, 4-7 groups use the breast enhancement cream provided by comparative examples 1-4 respectively, 8 groups use glycerin, the breast enhancement cream is smeared for 2 times every day, and the same breast massage method is used until the cream is completely absorbed for 56 days, and the curative effect is shown in Table 2.

The judgment standard of the curative effect is as follows:

the effect is shown: the breast volume is increased by more than 30 percent;

effective, breast volume increases 25-30%;

improving the breast, and increasing the breast volume by 10-25%;

and (4) invalidation: the breast volume was unchanged.

TABLE 2 Breast enhancement watch

As can be seen from table 2, the effective rates of groups 1-3 were significantly higher than those of group 8, which demonstrates that the breast augmentation creams provided in examples 5-7 can significantly promote the growth of mammary tissue, resulting in an increase in breast volume.

As can be seen from the comparison between the groups 1 and 4-7, the effective rate of the group 1 is significantly higher than that of the group 4-7, which indicates that the breast-enlarging cream provided by the group 1 has a more significant breast-enlarging effect by the mutual synergy of the soybean isoflavone extract, the cowherb seed extract, the kudzu root extract and the vitamin E.

As can be seen from the comparison of the group 2 with the group 1, the effective rate of the group 2 is higher than that of the group 1, which indicates that the breast-enlarging cream provided by the example 6 can remarkably promote the growth of mammary glands and increase the breast volume by adding the palmitoyl tripeptide and the acetyl hexapeptide.

As can be seen from the comparison of the 3 groups with the 2 groups, the significant efficiency of the 3 groups was significantly higher than that of the 2 groups, which indicates that the breast augmentation cream provided in example 7 can promote the growth of mammary glands more rapidly by adding commiphora mukul resin extract to act synergistically with palmitoyl tripeptide and acetyl hexapeptide.

Finally, it should be noted that: the above embodiments are only used to illustrate the technical solution of the present invention, and not to limit the same; while the invention has been described in detail and with reference to the foregoing embodiments, it will be understood by those skilled in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some or all of the technical features may be equivalently replaced; and the modifications or the substitutions do not make the essence of the corresponding technical solutions depart from the scope of the technical solutions of the embodiments of the present invention.

Claims

1. The breast enlarging cream is characterized by being prepared from the following components in parts by weight: 8 parts of soybean isoflavone extract, 2 parts of cowherb seed extract, 2 parts of kudzu root extract, 8 parts of vitamin E, 2 parts of palmitoyl tripeptide, 2 parts of acetyl hexapeptide, 2 parts of commiphora mukul resin extract, 12 parts of glycerol, 1.2 parts of carbomer, 0.5 part of triethanolamine, 1 part of coconut oil and 0.4 part of tea tree oil.

2. The method for preparing the breast augmentation cream of claim 1, comprising the steps of: mixing soybean isoflavone extract, semen Vaccariae extract, radix Puerariae extract, vitamin E, palmitoyl tripeptide, acetyl hexapeptide, commiphora mukul resin extract, glycerol, carbomer, triethanolamine, coconut oil and tea tree oil, and making into breast enlarging cream.