CN110393789A - One kind is delayed for male, antibacterial, the spray of nourishing - Google Patents

One kind is delayed for male, antibacterial, the spray of nourishing Download PDF

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Publication number
CN110393789A
CN110393789A CN201810375681.8A CN201810375681A CN110393789A CN 110393789 A CN110393789 A CN 110393789A CN 201810375681 A CN201810375681 A CN 201810375681A CN 110393789 A CN110393789 A CN 110393789A
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Prior art keywords
male
antibacterial
nourishing
spray
effect
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CN201810375681.8A
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Chinese (zh)
Inventor
杜阳
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XI'AN WANHE PHARMACEUTICAL CO Ltd
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XI'AN WANHE PHARMACEUTICAL CO Ltd
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Priority to CN201810375681.8A priority Critical patent/CN110393789A/en
Publication of CN110393789A publication Critical patent/CN110393789A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/155Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/29Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
    • A61K36/296Epimedium
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/39Convolvulaceae (Morning-glory family), e.g. bindweed
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/43Cuscutaceae (Dodder family), e.g. Cuscuta epithymum or greater dodder
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/489Sophora, e.g. necklacepod or mamani
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/64Orobanchaceae (Broom-rape family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8962Allium, e.g. garden onion, leek, garlic or chives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/02Peptides of undefined number of amino acids; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/12Aerosols; Foams
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dispersion Chemistry (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Reproductive Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The present invention provides one kind to be delayed for male, it is antibacterial, the spray of nourishing, it is made of the raw material of following weight ratio: biologically active peptide, kuh-seng, borneol, Herba Cistanches, leek seed, Semen Cuscutae, Herba Epimedii, cynomorium songaricum, acetic acid chlorhexidine, remaining is purified water, after product of the invention is sprayed on male external genital organs, it can go deep into skin texture rapidly, destroy the living environment of harmful bacteria, adjust the acid-base balance on male external genital organs surface, it is allowed to come to normal physiological PH value, improve antibacterial ability, and Chinese medicine combination drug effect is mild, it nourishes lubricious, there is fabulous maintenance effect.

Description

One kind is delayed for male, antibacterial, the spray of nourishing
Technical field
The invention belongs to technical field of traditional Chinese medicines, and in particular to one kind is delayed for male, antibacterial, the spray of nourishing.
Background technique
Modern life rhythm is more next fast, and the job and life stress of people is gradually increased, especially for numerous males, daytime It works heavy, stays up late for work at night, to be also swamped with, toiling away excessively causes body to be in sub-health state, Jin Erying Sexual life experience is rung, love life is caused to be discord, the drug of male's delay is mostly Western medicine on the market at present, although Western medicine takes effect Fastly, but thus bring side effect is also very big, and Western medicine cannot treat unmentionable disease from source always, and spray of the present invention is mixed a variety of Chinese medicine essence plays Chinese medicine effect to greatest extent, mentions smart Guyang, and has enriching yin to support kidney function effect, and Chinese medicine is as China's history culture In one of rarity of long standing and well established, Chinese medicine is to meet compatriots to take care of health, and cures being preferably selected for disease, and Chinese medicine system is delayed spray class in the market Drug is actually rare, therefore the present invention extremely accords with the demands of the market.
Well-known reason, the genital structure feature of male determine male external genital organs be easily contaminated and Pathogenic infection, the region are influenced by urine, male's redundant prepuce, and phimosis is easy to make glans penis, and the positions such as coronary sulcus dirt increases, It is infected, such as Prepuce balanitis symptom, serious person even causes the diseases such as sex dysfunction, these illnesss not only annoying Male also will affect love life harmony, in addition, easily to generate in foreskin since male's foreskin smegma is vigorous The white secretion of stench, these white secretion are the good places of bacterial reproduction.Antibacterial class drug currently on the market is more For Western medicine ointment class preparation, Traditional Chinese medicinal spray rarely has, though Western medicine is quick, also there is apparent side effect, and safety coefficient is low, this Invention is Chinese materia medica preparation, the mild Small side effects of the efficacy of a drug, and quick, suppression stable to maintenance male external genital organs topical microbial Bacterium has obvious action.
Summary of the invention
According to above-mentioned elaboration, the purpose of the present invention is to provide a kind of Chinese medicine composition sprays, are delayed for male, suppression Bacterium nourishes.
Technical solution provided by the invention: one kind is delayed for male, and antibacterial, the spray of nourishing is by following weight ratio Raw material be made:
Biologically active peptide 1%~3%, kuh-seng 1%~3%, borneol 1%~3%, Herba Cistanches 3%~5%, semen allii tuberosi 1% ~3%, Semen Cuscutae 5%~10%, Herba Epimedii 8%~15%, cynomorium songaricum 1%~3%, acetic acid chlorhexidine 0.10-0.30%, remaining For purified water,
In above-mentioned technical proposal, biologically active peptide 1%, kuh-seng 1%, borneol 1%, Herba Cistanches 3%, leek seed 1%, Tu Son 5%, Herba Epimedii 8%, cynomorium songaricum 1%, acetic acid chlorhexidine 0.10%, remaining be purified water.
Provided by the invention a kind of for male's delay, antibacterial, the preparation method of the spray of nourishing is: by the parts by weight Raw material: biologically active peptide, kuh-seng, borneol, Herba Cistanches, leek seed, Semen Cuscutae, Herba Epimedii, cynomorium songaricum, acetic acid chlorhexidine, addition are pure Change water and mixes liquid.
The extraction of Chinese medicine uses aqueous solvent extracting mode, the effective component of extraction.
The present invention is based on pathogenesis and treatment principle to male external genital organs disease, and compatibility is reasonable, scientific, through big Amount clinical verification after product of the invention is sprayed on male external genital organs, can go deep into rapidly skin texture, destruction has without any toxicity and side effects The living environment of evil bacterium, adjusts the acid-base balance on male external genital organs surface, is allowed to come to normal physiological PH value, improves anti- Bacterium ability, and Chinese medicine combination drug effect is mild, nourishing is lubricious, there is fabulous maintenance effect.
Specific embodiment
Technical solution of the present invention is clearly and completely described below, it is clear that described embodiment is only this Invention a part of the embodiment, instead of all the embodiments.Based on the embodiments of the present invention, those of ordinary skill in the art exist Every other embodiment obtained under the premise of creative work is not made, shall fall within the protection scope of the present invention.
Compatibility of drugs of the invention is reasonable, and component effect is:
Biologically active peptide adjusts the physiological function of internal cell, activates related enzyme system in vivo, promotes the logical of intermediate supersession film The effect of permeability.
Kuh-seng, bitter is cold in nature, return heart, liver, stomach, large intestine, bladder meridian, has heat-clearing, eliminating dampness, and the effect of desinsection has only negative The benefits of itching.
Borneol, property is arduous, cold in nature, sensible, and scattered silt fire has the effect of inhibiting bacteria and diminishing inflammation.
Herba Cistanches, taste is salty, sweet, warm-natured, returns kidney, large intestine channel, has kidney-replenishing, the effect of benefiting essence-blood.
Leek seed, property is pungent, sweet, warm, returns kidney, Liver Channel, semen allii tuberosi has the effect of warm nourishing liver and kidney, establishing-Yang controlling nocturnal emission with astringent drugs, warm waist and knee, right Impotence, soreness and weakness of waist and knees have remarkable effect.
Semen Cuscutae, property is sweet, warm, and kidney,liver,spleen is returned to pass through, and has the effect of nourishing liver and kidney.
Herba Epimedii, property acrid, sweet, warm.Return liver and kidney channel, there is the effect of kidney-replenishing, to impotence and seminal emission, muscles and bones impotence has significantly Curative effect,
Cynomorium songaricum, property is sweet, warm, there is tonifying yin gas, benefiting essence-blood effect.
Acetic acid chlorhexidine plays bactericidal effect.
According to above-mentioned component and compatibility principle analysis, the present invention, following embodiment is disclosed.
Embodiment:
Take: one kind is delayed for male, and antibacterial, the spray of nourishing is to be made from the following raw materials in parts by weight:
The cistanche extracts that Borneolum Syntheticum extract 10g that borneol effective content is 10%, Herba Cistanches effective content are 10% The Allium tubersum rottl extract that shrubby sophora extract 10g that 30g, matrine effective content are 98%, leek seed effective content are 10% The Shorthorned Epimedium P.E that Semen Cuscutae extract 50g that 10g, Semen Cuscutae effective content are 10%, Herba Epimedii effective content are 10% 80g, the Herba Cynomorii extract 10g that cynomorium songaricum effective content is 10%, acetic acid chlorhexidine 0.02g, biologically active peptide 10g add purified water It to 1000g, stirs evenly, the last weight of mixture is 1000g.
In use, Chinese medicine composition liquid is sprayed to male external genital organs surface by patient.
To show fungistatic effect of the invention, the embodiment of the present invention does bacteriostatic test:
One, equipment
1, test strain: Escherichia coli (8099) are cultivated 9 generations, Candida albicans (ATCC10231), culture 9 generations, golden yellow Color staphylococcus (ATCC6538) cultivated for 9 generations, is provided by Chinese Culture Collection Center.
2, general English agar medium, sabouraud's agar are provided by Beijing road and bridge technology Co., Ltd.
3/0.03mol/L phosphate buffer solution (PBS)
4, carrier: filter paper (2.0cm × 3.0cm), sterile measuring pipette, sterilized petri dishes, sterile test tube, constant incubator Deng
Two, sample is the present embodiment 5g, is put into sterile mortar grinding, crushes, mixes, is put into sterilized petri dishes and is directly pressed down Bacterium test.
Three, method is according to GB15979-200 " Disposable Sanitary Accessory sanitary standard " appendix C 4, " disinfection technology rule Model " 2002 editions 2.1.8 test.
Bacteriostatic test is carrier test, and 20 DEG C ± 1 DEG C of test temperature, test is repeated 3 times.
Four, result
Under conditions of 20 DEG C ± 2 DEG C of test temperature, embodiment is to Escherichia coli, Candida albicans, Staphylococcus aureus Bacterium inhibitory effect.
The embodiment of the present invention is shown in Table 1 to the inhibitory effect inspection of staphylococcus aureus;
The inhibitory effect of 1 staphylococcus aureus of table
The embodiment of the present invention is shown in Table 2 for the inhibitory effect inspection of Candida albicans.
The inhibitory effect of 2 Candida albicans of table
The embodiment of the present invention is shown in Table 3 to the inhibitory effect inspection of Escherichia coli;
The inhibitory effect of 3 Escherichia coli of table
The conclusion tested above, for embodiment to Escherichia coli, Candida albicans, staphylococcus aureus inhibiting rate are reachable 90% or more.
To show clinical application effect of the invention, the present invention is proved through clinical and experimental study: to the composition of embodiment Crowd through age groups carries out test effect, and through testing, this product is for the skin of external genitalia disease such as posthitis, balanitis Disease has good effect, such as there are vulvas to have itch, scorching hot symptom to obtain after using 3-7 days before use by patient Biggish improvement takes this product to be sprayed to uncomfortable position when use after cleaning vulva.It is 1-2 times daily.
The above description is merely a specific embodiment, but scope of protection of the present invention is not limited thereto, any Those familiar with the art in the technical scope disclosed by the present invention, can easily think of the change or the replacement, and should all contain Lid is within protection scope of the present invention.Therefore, the protection scope of the present invention shall be subject to the protection scope of the claims.

Claims (2)

1. one kind is delayed for male, antibacterial, the spray of nourishing, it is characterised in that: be made of the raw material of following weight ratio: raw Object active peptide 1%~3%, kuh-seng 1%~3%, borneol 1%~3%, Herba Cistanches 3%~5%, semen allii tuberosi 1%~3%, Tu Sub 5%~10%, Herba Epimedii 8%~15%, cynomorium songaricum 1%~3%, acetic acid chlorhexidine 0.10-0.30%, remaining is purified water,
Bioactivity by the raw material Herba Cistanches, Semen Cuscutae, Herba Epimedii, cynomorium songaricum, acetic acid chlorhexidine, with equivalent weight Peptide mixing, kuh-seng, borneol, semen allii tuberosi, cynomorium songaricum, be added purified water mix liquid.
2. according to claim 1 a kind of for male's delay, antibacterial, the spray of nourishing, it is characterised in that: be by following The raw material of weight ratio is made: biologically active peptide 1%, kuh-seng 1%, borneol 1%, Herba Cistanches 3%, leek seed 1%, Semen Cuscutae 5%, Herba Epimedii 8%, cynomorium songaricum 1%, acetic acid chlorhexidine 0.10%, remaining be purified water.
CN201810375681.8A 2018-04-25 2018-04-25 One kind is delayed for male, antibacterial, the spray of nourishing Pending CN110393789A (en)

Priority Applications (1)

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101066414A (en) * 2007-06-05 2007-11-07 北京艺信堂医药研究所 Chinese medicine composition for treating sterility of impotence
CN103055109A (en) * 2012-12-18 2013-04-24 苏州天南星生物科技有限公司 Chinese medicinal preparation
CN103960420A (en) * 2014-05-17 2014-08-06 孙钰家 Health-maintaining cynomorium songaricum tea and preparation method thereof
CN105395802A (en) * 2015-12-24 2016-03-16 江西启鹏药业有限公司 External use liquid which is unique in effect and can treat prospermia of men and prolong time of sexual life and making method thereof
CN107281367A (en) * 2017-07-20 2017-10-24 天马(安徽)国药科技股份有限公司 It is a kind of to be directed to male's antibacterial, anti-inflammatory, the pharmaceutical composition of delay

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101066414A (en) * 2007-06-05 2007-11-07 北京艺信堂医药研究所 Chinese medicine composition for treating sterility of impotence
CN103055109A (en) * 2012-12-18 2013-04-24 苏州天南星生物科技有限公司 Chinese medicinal preparation
CN103960420A (en) * 2014-05-17 2014-08-06 孙钰家 Health-maintaining cynomorium songaricum tea and preparation method thereof
CN105395802A (en) * 2015-12-24 2016-03-16 江西启鹏药业有限公司 External use liquid which is unique in effect and can treat prospermia of men and prolong time of sexual life and making method thereof
CN107281367A (en) * 2017-07-20 2017-10-24 天马(安徽)国药科技股份有限公司 It is a kind of to be directed to male's antibacterial, anti-inflammatory, the pharmaceutical composition of delay

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
吴近曾: "中西医结合治疗男性不育症86例分析", 《新中医》 *
李世文,等,主编: "《当代男科妙方 第4版》", 31 January 2016, 人民军医出版社, *
黄震洲: "黄海波教授治疗精液不液化症经验介绍", 《南京中医药大学学报》 *

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