CN110387353B - 一种用于治疗肿瘤的柯萨奇b组病毒 - Google Patents

一种用于治疗肿瘤的柯萨奇b组病毒 Download PDF

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Publication number
CN110387353B
CN110387353B CN201810338046.2A CN201810338046A CN110387353B CN 110387353 B CN110387353 B CN 110387353B CN 201810338046 A CN201810338046 A CN 201810338046A CN 110387353 B CN110387353 B CN 110387353B
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cvb1
sequence
modified
cancer
nucleic acid
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Chinese (zh)
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CN110387353A (zh
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程通
王玮
叶祥忠
付文锟
潘德全
张军
夏宁邵
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Yang Sheng Tang Co Ltd
Xiamen University
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Yang Sheng Tang Co Ltd
Xiamen University
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Priority to AU2019254948A priority patent/AU2019254948B2/en
Priority to PCT/CN2019/082608 priority patent/WO2019201192A1/zh
Priority to CA3097306A priority patent/CA3097306A1/en
Priority to EP19788373.9A priority patent/EP3783100A4/en
Priority to JP2020557325A priority patent/JP7336791B2/ja
Priority to KR1020207033014A priority patent/KR102768669B1/ko
Priority to US17/047,783 priority patent/US20210154249A1/en
Publication of CN110387353A publication Critical patent/CN110387353A/zh
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    • A—HUMAN NECESSITIES
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    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN201810338046.2A 2018-04-16 2018-04-16 一种用于治疗肿瘤的柯萨奇b组病毒 Active CN110387353B (zh)

Priority Applications (8)

Application Number Priority Date Filing Date Title
CN201810338046.2A CN110387353B (zh) 2018-04-16 2018-04-16 一种用于治疗肿瘤的柯萨奇b组病毒
PCT/CN2019/082608 WO2019201192A1 (zh) 2018-04-16 2019-04-15 一种用于治疗肿瘤的柯萨奇b组病毒
CA3097306A CA3097306A1 (en) 2018-04-16 2019-04-15 Coxsackie virus b for treating tumors
EP19788373.9A EP3783100A4 (en) 2018-04-16 2019-04-15 Coxsackie virus b for treating tumors
AU2019254948A AU2019254948B2 (en) 2018-04-16 2019-04-15 Coxsackie virus B for treating tumors
JP2020557325A JP7336791B2 (ja) 2018-04-16 2019-04-15 腫瘍を治療するためのコクサッキーウイルスｂ群
KR1020207033014A KR102768669B1 (ko) 2018-04-16 2019-04-15 종양 치료용 콕삭키바이러스 b
US17/047,783 US20210154249A1 (en) 2018-04-16 2019-04-15 Coxsackie virus b for treating tumors

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201810338046.2A CN110387353B (zh) 2018-04-16 2018-04-16 一种用于治疗肿瘤的柯萨奇b组病毒

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CN110387353A CN110387353A (zh) 2019-10-29
CN110387353B true CN110387353B (zh) 2023-07-18

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US (1) US20210154249A1 (enExample)
EP (1) EP3783100A4 (enExample)
JP (1) JP7336791B2 (enExample)
KR (1) KR102768669B1 (enExample)
CN (1) CN110387353B (enExample)
AU (1) AU2019254948B2 (enExample)
CA (1) CA3097306A1 (enExample)
WO (1) WO2019201192A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022543610A (ja) * 2019-08-05 2022-10-13 ヴァイロジン バイオテック カナダ リミテッド 遺伝子改変エンテロウイルスベクター
CN113549146B (zh) * 2020-04-26 2023-07-14 北京万泰生物药业股份有限公司 针对柯萨奇病毒b1型的单克隆抗体及其用途
CN118086228A (zh) * 2022-11-28 2024-05-28 厦门大学 用于治疗肿瘤的柯萨奇b组1型病毒
CN116769733B (zh) * 2023-08-02 2023-11-03 中国医学科学院医学生物学研究所 一种柯萨奇病毒b组4型毒株及应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA200702269B (en) * 2004-08-20 2008-09-25 Viralytics Ltd Methods and compositions for treatment of hematologic cancers
EP2125032A4 (en) * 2007-02-20 2011-02-23 Mayo Foundation CANCER TREATMENT WITH VIRAL NUCLEIC ACID
US9919047B2 (en) * 2011-01-04 2018-03-20 Sillajen, Inc. Generation of antibodies to tumor antigens and generation of tumor specific complement dependent cytotoxicity by administration of oncolytic vaccinia virus
CA2892183C (en) * 2012-11-21 2019-03-26 Duke University Oncolytic poliovirus for human tumors expressing nectin-like protein 5
WO2014171526A1 (ja) * 2013-04-17 2014-10-23 国立大学法人九州大学 遺伝子改変コクサッキーウイルス
CN103981152B (zh) * 2014-04-16 2015-01-21 武汉博威德生物技术有限公司 一种柯萨奇病毒及其制备抗肿瘤药物之应用
ES2833425T3 (es) * 2014-07-16 2021-06-15 Roussy Inst Gustave Combinación de virus oncolítico con moduladores de punto de control inmunitario
MX428707B (es) * 2016-09-27 2025-11-13 Sator Therapeutics LLC Virus oncoliticos optimizados y usos de los mismos.
CN109568350B (zh) * 2017-09-29 2023-02-03 厦门大学 一种用于治疗肿瘤的柯萨奇病毒

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
Evaluation of IRES-mediated, cell-type-specific cytotoxicity of poliovirus using a colorimetric cell proliferation assay;Xiaoyi Yang et al;《Journal of Virological Methods》;20081108;44-54 *
GenBank：JX976769.1;GenBank：JX976769.1;《NCBI blast》;20130726;1 *
Integrin avb6 Enhances Coxsackievirus B1 Lytic Infection of Human Colon Cancer Cells;Michael V. Agrez et al;《VIROLOGY》;19971231;71-77 *
Oncolytic activity of a coxsackievirus B3 strain in human endometrial cancer cell lines;Yanzhen Lin et al;《Virology Journal》;20180410;1-12 *

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Publication number Publication date
AU2019254948A1 (en) 2020-11-12
KR20210005637A (ko) 2021-01-14
KR102768669B1 (ko) 2025-02-13
WO2019201192A1 (zh) 2019-10-24
JP2021522190A (ja) 2021-08-30
EP3783100A1 (en) 2021-02-24
JP7336791B2 (ja) 2023-09-01
CN110387353A (zh) 2019-10-29
CA3097306A1 (en) 2019-10-24
US20210154249A1 (en) 2021-05-27
EP3783100A4 (en) 2022-02-16
AU2019254948B2 (en) 2025-04-17

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