JP7336791B2 - 腫瘍を治療するためのコクサッキーウイルスｂ群 - Google Patents

腫瘍を治療するためのコクサッキーウイルスｂ群 Download PDF

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JP7336791B2
JP7336791B2 JP2020557325A JP2020557325A JP7336791B2 JP 7336791 B2 JP7336791 B2 JP 7336791B2 JP 2020557325 A JP2020557325 A JP 2020557325A JP 2020557325 A JP2020557325 A JP 2020557325A JP 7336791 B2 JP7336791 B2 JP 7336791B2
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cancer
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JP2021522190A (ja
JP2021522190A5 (enExample
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チェン、トン
ワン、ウェイ
イェ、シャンツォン
フ、ウェンクン
パン、デクァン
チャン、ジュン
シア、ニンシャオ
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シァメン・ユニヴァーシティ
ヤン シェン ターン カンパニー リミテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • C—CHEMISTRY; METALLURGY
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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A61K35/768—Oncolytic viruses not provided for in groups A61K35/761 - A61K35/766
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C12N2310/141—MicroRNAs, miRNAs
    • C—CHEMISTRY; METALLURGY
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    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32311—Enterovirus
    • C12N2770/32321—Viruses as such, e.g. new isolates, mutants or their genomic sequences
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    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32311—Enterovirus
    • C12N2770/32332—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32311—Enterovirus
    • C12N2770/32341—Use of virus, viral particle or viral elements as a vector
    • C12N2770/32343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
    • C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • General Health & Medical Sciences (AREA)
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  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
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  • Microbiology (AREA)
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  • Animal Behavior & Ethology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
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  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2020557325A 2018-04-16 2019-04-15 腫瘍を治療するためのコクサッキーウイルスｂ群 Active JP7336791B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201810338046.2A CN110387353B (zh) 2018-04-16 2018-04-16 一种用于治疗肿瘤的柯萨奇b组病毒
CN201810338046.2 2018-04-16
PCT/CN2019/082608 WO2019201192A1 (zh) 2018-04-16 2019-04-15 一种用于治疗肿瘤的柯萨奇b组病毒

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JP2021522190A JP2021522190A (ja) 2021-08-30
JP2021522190A5 JP2021522190A5 (enExample) 2022-04-19
JP7336791B2 true JP7336791B2 (ja) 2023-09-01

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US (1) US20210154249A1 (enExample)
EP (1) EP3783100A4 (enExample)
JP (1) JP7336791B2 (enExample)
KR (1) KR102768669B1 (enExample)
CN (1) CN110387353B (enExample)
AU (1) AU2019254948B2 (enExample)
CA (1) CA3097306A1 (enExample)
WO (1) WO2019201192A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022543610A (ja) * 2019-08-05 2022-10-13 ヴァイロジン バイオテック カナダ リミテッド 遺伝子改変エンテロウイルスベクター
CN113549146B (zh) * 2020-04-26 2023-07-14 北京万泰生物药业股份有限公司 针对柯萨奇病毒b1型的单克隆抗体及其用途
CN118086228A (zh) * 2022-11-28 2024-05-28 厦门大学 用于治疗肿瘤的柯萨奇b组1型病毒
CN116769733B (zh) * 2023-08-02 2023-11-03 中国医学科学院医学生物学研究所 一种柯萨奇病毒b组4型毒株及应用

Citations (6)

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Publication number Priority date Publication date Assignee Title
CN103429258A (zh) 2011-01-04 2013-12-04 詹纳里克斯公司 通过施用溶瘤痘苗病毒生成针对肿瘤抗原的抗体和生成肿瘤特异性补体依赖性细胞毒性
CN103981152A (zh) 2014-04-16 2014-08-13 武汉博威德生物技术有限公司 一种柯萨奇病毒及其制备抗肿瘤药物之应用
WO2014171526A1 (ja) 2013-04-17 2014-10-23 国立大学法人九州大学 遺伝子改変コクサッキーウイルス
JP2016500108A (ja) 2012-11-21 2016-01-07 デューク ユニバーシティー ヒトの腫瘍のための腫瘍溶解性ポリオウイルス
CN106999577A (zh) 2014-07-16 2017-08-01 特兰斯吉恩股份有限公司 溶瘤病毒和免疫检查点调节因子组合
US20180085411A1 (en) 2016-09-27 2018-03-29 Sator Therapeutics LLC Optimized oncolytic viruses and uses thereof

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ZA200702269B (en) * 2004-08-20 2008-09-25 Viralytics Ltd Methods and compositions for treatment of hematologic cancers
EP2125032A4 (en) * 2007-02-20 2011-02-23 Mayo Foundation CANCER TREATMENT WITH VIRAL NUCLEIC ACID
CN109568350B (zh) * 2017-09-29 2023-02-03 厦门大学 一种用于治疗肿瘤的柯萨奇病毒

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103429258A (zh) 2011-01-04 2013-12-04 詹纳里克斯公司 通过施用溶瘤痘苗病毒生成针对肿瘤抗原的抗体和生成肿瘤特异性补体依赖性细胞毒性
JP2014502970A (ja) 2011-01-04 2014-02-06 ジェンネレックス インコーポレイティッド 腫瘍溶解性ワクシニアウイルスの投与による腫瘍抗原に対する抗体の生成および腫瘍特異的補体依存性細胞傷害の生成
JP2016500108A (ja) 2012-11-21 2016-01-07 デューク ユニバーシティー ヒトの腫瘍のための腫瘍溶解性ポリオウイルス
WO2014171526A1 (ja) 2013-04-17 2014-10-23 国立大学法人九州大学 遺伝子改変コクサッキーウイルス
CN103981152A (zh) 2014-04-16 2014-08-13 武汉博威德生物技术有限公司 一种柯萨奇病毒及其制备抗肿瘤药物之应用
CN106999577A (zh) 2014-07-16 2017-08-01 特兰斯吉恩股份有限公司 溶瘤病毒和免疫检查点调节因子组合
JP2017524693A (ja) 2014-07-16 2017-08-31 トランジェーヌ、ソシエテ、アノニムＴｒａｎｓｇｅｎｅ Ｓ．Ａ． 腫瘍溶解性ウイルスと免疫チェックポイントモジュレーターとの組合せ
US20180085411A1 (en) 2016-09-27 2018-03-29 Sator Therapeutics LLC Optimized oncolytic viruses and uses thereof

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Molecular Therapy，2009年，Vol. 17, No. 3，p. 409-416
Oncoimmunology，2016年，Vol. 5, No. 10，e1220467，doi: 10.1080/2162402X.2016.1220467
Virology，1997年，Vol. 239, No. 10，p. 71-77

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Publication number Publication date
AU2019254948A1 (en) 2020-11-12
KR20210005637A (ko) 2021-01-14
KR102768669B1 (ko) 2025-02-13
CN110387353B (zh) 2023-07-18
WO2019201192A1 (zh) 2019-10-24
JP2021522190A (ja) 2021-08-30
EP3783100A1 (en) 2021-02-24
CN110387353A (zh) 2019-10-29
CA3097306A1 (en) 2019-10-24
US20210154249A1 (en) 2021-05-27
EP3783100A4 (en) 2022-02-16
AU2019254948B2 (en) 2025-04-17

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