CN110354013A - A kind of antibacterial mouthwash of cleaning - Google Patents

A kind of antibacterial mouthwash of cleaning Download PDF

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Publication number
CN110354013A
CN110354013A CN201910606690.8A CN201910606690A CN110354013A CN 110354013 A CN110354013 A CN 110354013A CN 201910606690 A CN201910606690 A CN 201910606690A CN 110354013 A CN110354013 A CN 110354013A
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王振华
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/41—Amines
    • A61K8/416—Quaternary ammonium compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures
    • A61K2800/592—Mixtures of compounds complementing their respective functions
    • A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Emergency Medicine (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention discloses a kind of antibacterial mouthwashes of cleaning, belong to cosmetic technical field.The present invention generates a variety of micro fibers, can play the role of careful cleaning when oral cavity is gargled, not influence enamel, can clear up oral cavity food residual well.Originally to the regulation of pH, the introducing of a small amount of metal ion osmotic pressure also can be changed, prevent bacterium achievees the effect that sterilization from maintaining homeostasis in aqueous systems of gargling.The polymer for making the imitative membrane structure of the functional group containing Phosphorylcholine, can maintain intraoral cleannes well, reduce the possibility of bacteria breed, form long-effective protection to oral cleaning.A variety of micro fibers are provided by fermentation, in conjunction with the active constituent and metal ion of dissolution, strengthens the cleaning to oral cavity and fungistatic effect, reduces the growth of bacterium.It is bad to the inhibition of bacterium and to the elimination effect of oral cavity swill that the present invention solves the problems, such as to commonly use mouthwash at present.

Description

A kind of antibacterial mouthwash of cleaning
Technical field
The invention belongs to cosmetic technical fields, and in particular to a kind of antibacterial mouthwash of cleaning.
Background technique
Since internal environment of oral cavity (humidity, temperature and nutrition condition) is particularly suitable for microbial growth, so oral cavity is There are most positions for microbe number in human body.Studies have shown that: existing in each gram of tartar (tooth rust) of normal healthy people 10000000000 bacteriums, bacterial population is much more compared with the bacterial population of skin surface in oral cavity.Prolific bacterium and virus are in oral cavity The most basic reason of oral inflammation is caused, and brings different degrees of pain and healthhazard.Simultaneously as these The reasons such as the breeding and effect of microorganism and food, tobacco and wine, disease of digestive tract, and cause oral peculiar smell.
Mouth disease is the common frdquently encountered disease as caused by pathogenic bacteria various in oral cavity, directly affects the health of people. People also already prevent the generation of mouth disease by various oral care products.Currently, in detergents and cosmetic oral care Major product can be divided into toothpaste, gargle and flavorants, these products mainly play cleaning tooth, tooth-whitening, removal tooth Spot kills the effects of oral cavity harmful bacteria, pre- anti-caries, fresh breath, while to such as some mouth diseases such as various focusing depths represented Treatment also functions to certain positive effect.Also on having there are also the chewing gum of some other such as foodstuff, edible implication cleaning sheet State more or few effect living.
Gargling is the complementary measure that cleans one's teeth, and has good fungistatic effect, can cooperate the use of toothpaste, further enhance Clean one's teeth effect.Its principle is: mechanically destroying the integrality of bacterial plaque surface biological film by brushing teeth, while reducing in bacterial plaque Bacterial number.Bacteriostatic agent in gargle penetrates the bacterial plaque surface biological film of destroyed, directly performance bactericidal effect, to improve Bacterial plaque is inhibited to form and kill the effect of plaque bacteria.
The history gargled relatively is brushed teeth long.Although the use of toothbrush and dental floss being the effective measures for removing bacterial plaque, bacterial plaque The more difficult education of the method for control is grasped, and dull, time-consuming, especially is difficult to complete to the patient of body and mind deformity, amotivational People is also difficult to be used.Mouthwash may be a kind of preferably instead of method for this groups of people.It was verified that mouthwash uses Come easily, be easily mastered, it is pratical and feasible, be not only suitble to carry out daily oral care at home, but when being suitble to work, going on business make With.Especially pursue the crowd of high-quality life, it is desirable to make breath freshening with various means, mouthwash can reach in a short time The effect.
Now majority is Integrated TCM to prevent and treat mouth disease in gargle in the market, and is wanted based on Western medicine Functional component, though having preferable bacteriostasis, Western medicine side effect is big, is easy to produce drug resistance, and there are mouthfeel is bad and medicine Object adverse reaction, serious person possibly even cause flora imbalance, mucous membrane of mouth strip off and superposition infection；And it is some containing Chinese herbal medicine at The mouth care solution divided then just shows the superiority of oneself in this regard.The present invention is main former using medicinal and edible plant Pure Chinese medicine gargle is made in material, by a variety of active ingredients collective effect, through antibacterial activity in vitro, anti-inflammatory activity research, and as a result table It is bright stronger to the activity of staphylococcus aureus and hemolytic streptococcus, inflammatory edema caused by dimethylbenzene can be mitigated.It is suitable for The mouth diseases such as canker sore, periodontitis, gingivitis, bleeding gums, halitosis, sphagitis, tonsillitis.
Gargle huge number currently on the market, but contain artificial synthesized chemicals mostly, long-time service can lead to Buccal absorption is crossed, human health is influenced.Chinese medicine and other plant are also widely used as gargle additive, pacify to human body and environment Entirely, and to tooth protective effect is had no, and inhibition to bacterium and bad to the elimination effect of oral cavity swill.
Summary of the invention
The technical problems to be solved by the invention: residual to the inhibition of bacterium and to oral cavity food for current common mouthwash The bad problem of the elimination effect of slag provides a kind of antibacterial mouthwash of cleaning.
In order to solve the above technical problems, the present invention is using technical solution as described below:
A kind of antibacterial mouthwash of cleaning, including following component: 5 ~ 8 parts of sour agents, 3 ~ 7 parts of auxiliary materials, 0.3 ~ 0.8 part of jasmine anthosin At oil, 2 ~ 5 parts of alkyl glycosides, 1 ~ 4 part of sodium sorbate, 50 ~ 70 parts of water, 25 ~ 35 parts of composite clean base-materials, 12 ~ 20 parts of macromoleculars Manage agent.
The preparation method of the composite clean base-material, includes the following steps:
(1) 5:3:1 ~ 2:15 in mass ratio takes strawberry, grape, grape pedicel, water mixing to smash homogenate to pieces, obtains slurry, in parts by weight Meter, takes 20 ~ 40 parts of slurries, 5 ~ 8 parts of pretreatment dregs of beans, 0.2 ~ 0.5 part of Na2HPO4, 4 ~ 8 parts of glycerol, 6 ~ 10 parts of yeast extracts, 3 ~ 7 parts Glucose, 1 ~ 3 part of lactobacillus bulgaricus powder, 500 ~ 700 parts of water mixing shake shaker fermentation culture in 28 ~ 33 DEG C, discharge, Sterilizing, must sterilize material, and fermentation material is taken to decolourize, and be concentrated under reduced pressure in 40 ~ 55 DEG C, obtain concentrate feed, and concentrate feed Freezing smashing is taken to be sieved, and receive Collection sieving particle, obtains fermentation process material；
(2) according to parts by weight, take 20 ~ 45 parts of fermentation process material, 2 ~ 5 parts of mixed sizing materials, 1 ~ 4 part of additive, 0.1 ~ 0.5 part of tea more Phenol, 1 ~ 3 part of sodium tripolyphosphate, 50 ~ 70 parts of reagent As take fermentation process material, mixed sizing material, reagent A mixing to stir prior to 55 ~ 75 DEG C It mixes, is cooled to 27 ~ 33 DEG C, additive, sodium tripolyphosphate, tea polyphenols are added and are mixed to get composite clean base-material.
Pretreatment dregs of beans in the step (1): taking dregs of beans boiling water blanching, and microwave treatment pulverizes and sieves, and collects sieving Grain is to get pretreatment dregs of beans.
Reagent A in the step (2): 1:20 ~ 35 take honey, PBS buffer solution mixing to get reagent A in mass ratio.
Mixed sizing material in the step (2): 3 ~ 7:1:1 ~ 2 take guar gum, xanthan gum, Acritamer 940 mixing in mass ratio, Up to mixed sizing material.
Additive in the step (2): 3 ~ 6:1 in mass ratio takes hydroxymethyl cellulose, zinc lactate mixing to get addition Agent.
The preparation of the macromolecular inorganic agent: in a nitrogen atmosphere, in ice-water bath, 5 ~ 8:3:25 ~ 35 are taken in mass ratio Methacrylic acid -2- hydroxyethyl ester, phosphorus oxychloride, chloroform are mixed, and vacuum distillation obtains concentrate, takes concentrate by quality Choline chloride, reagent B mixing is added than 2 ~ 5:3:15, obtains mixed liquor, in 27 ~ 33 DEG C, takes mixed liquor 24 ~ 35:7:5 in mass ratio N-BMA, methanol mixing is added, is warming up to 60 ~ 75 DEG C, the potassium peroxydisulfate of mixed liquor quality 1 ~ 4% is added Mixing is kept the temperature, cooling, obtains reaction material, is taken reaction material 1:5 in mass ratio ~ 8 that n-hexane mixing is added, is centrifuged, dry, obtains drying Material, takes dried object under ammonia atmosphere, plasma treatment, discharges to get macromolecular inorganic agent.
The reagent B: 15 ~ 25:4 in mass ratio takes triethylamine solution, sodium bicarbonate mixing to get reagent B.
The acid agent: 2 ~ 5:1:1 in mass ratio takes gallic acid, sodium citrate, sodium fluoride mixing to get acid effect Agent.
The auxiliary material: 3 ~ 7:1 in mass ratio ~ 3:0.2 takes poly alkyl alcohol ethylene oxide ether, xylitol, polylysine mixing, Up to auxiliary material.
The present invention is compared with other methods, and advantageous effects are:
(1) present invention carries out smashing homogenate to pieces, and carry out mixed fermentation processing with strawberry, grape, grape pedicel etc. for raw material, generates A variety of micro fibers include plant fiber, dietary fiber, bacterial fibers, and are decolourized, to avoid pigment in the residual of oral cavity It stays, careful cleaning can be played the role of when oral cavity is gargled, in addition, strawberry can provide natural bleaching, cleansing, Portugal Grape can provide acid ingredient, can all clean tooth well, enamel is protected not to be destroyed, cleaning oral cavity food residual, and This mouthwash contains the ingredients such as sodium, calcium, phosphorus,
The enough quickly dissolutions of water energy are met, is formed a film in dental surface, is blocked dentinal tubule, be at least not easy that swill occurs again To the regulation of pH, the introducing of a small amount of metal ion osmotic pressure also can be changed, prevent bacterium is from tieing up in residual, aqueous systems of originally gargling Homeostasis is held, achievees the effect that sterilization；
(2) present invention makes the functional group containing Phosphorylcholine with methacrylic acid -2- hydroxyethyl ester, choline chloride etc. for raw material The polymer of imitative membrane structure breaks so that surface polarity hydrophilic radical increases, and carries out plasma treatment under ammonia atmosphere Molecular link is split, amino therein, hydroxyl isoreactivity free radical is further increased, anti-albumen can be formed in oral cavity, dental surface Adsorbed film removes the high protein diet of adherency, and this mouthwash is added to the sour agent with natural bacteriostatic effect, adjusts Whole pH slant acidity, can be while ensureing bactericidal activity, so that intraoral pH is less than adhered to food residual institute Isoelectric point containing protein, so that the protein of adherency is in positive charge, so that repulsion is generated between protein, so that in oral cavity The residual of protein food is reduced, and improves size exclusion effect, can maintain intraoral cleannes well, reduces bacterium The possibility of growth forms long-effective protection to oral cleaning；
(3) present invention provides a variety of micro fibers by fermentation, convenient for the cleaning to oral cavity food residual, and combines the work of dissolution Property ingredient and metal ion, strengthen the cleaning to oral cavity and fungistatic effect, make the imitative cell membrane knot of the functional group containing Phosphorylcholine The polymer of structure forms anti-protein adsorption film, and is convenient for the removing of the swill containing albumen by the adjusting of pH, and reduces thin The growth of bacterium, the present invention are bad to the inhibition of bacterium and to the elimination effect of oral cavity swill for common mouthwash at present Problem, improvement is significant, has a good application prospect.
Specific embodiment
Auxiliary material: 3 ~ 7:1 in mass ratio ~ 3:0.2 take poly alkyl alcohol ethylene oxide ether, xylitol, polylysine mixing to get Auxiliary material.
Sour agent: 2 ~ 5:1:1 in mass ratio takes gallic acid, sodium citrate, sodium fluoride mixing to get sour agent.
Pretreatment dregs of beans: take dregs of beans after 3 ~ 6min of blanching, to move to micro-wave oven in boiling water, with 400W power microwave processing 6 ~ After 10min, pulverizer is moved to, crushed 120 meshes, collects sieving particle to get pretreatment dregs of beans.
Reagent A: the PBS buffer solution that 1:20 ~ 35 take honey in mass ratio, pH is 7.2 ~ 7.7 mixes to get reagent A.
Reagent B: 15 ~ 25:4 in mass ratio takes the triethylamine solution of concentration 0.5mol/L, sodium bicarbonate mixing to get reagent B。
Additive: 3 ~ 6:1 in mass ratio takes hydroxymethyl cellulose, zinc lactate mixing to get additive.
Mixed sizing material: 3 ~ 7:1:1 ~ 2 take guar gum, xanthan gum, Acritamer 940 mixing to get mixed sizing material in mass ratio.
The preparation method of composite clean base-material, includes the following steps:
(1) 5:3:1 ~ 2:15 in mass ratio takes strawberry, grape, grape pedicel, water mixing to smash homogenate to pieces, obtains slurry, in parts by weight Meter, takes 20 ~ 40 parts of slurries, 5 ~ 8 parts of pretreatment dregs of beans, 0.2 ~ 0.5 part of Na2HPO4, 4 ~ 8 parts of glycerol, 6 ~ 10 parts of yeast extracts, 3 ~ 7 parts Glucose, 1 ~ 3 part of lactobacillus bulgaricus powder, 500 ~ 700 parts of water are mixed in fermentor, in 28 ~ 33 DEG C, with 180 ~ 230r/min Concussion shaker fermentation culture 4 ~ 7 days, discharging, in 121 DEG C of 14 ~ 20min of insulated sterilizing, must sterilize material, after taking sterilizing material decoloration, in 40 ~ 55 DEG C are concentrated under reduced pressure into constant weight, obtain concentrate feed, and concentrate feed is taken to crushed 150 meshes in freezing crusher, collect sieving Grain, obtains fermentation process material；
(2) according to parts by weight, take 20 ~ 45 parts of fermentation process material, 2 ~ 5 parts of mixed sizing materials, 1 ~ 4 part of additive, 0.1 ~ 0.5 part of tea more Phenol, 1 ~ 3 part of sodium tripolyphosphate, 50 ~ 70 parts of reagent As take fermentation process material, mixed sizing material, reagent A in reaction kettle prior to 55 ~ 75 DEG C Mixing is cooled to 27 ~ 33 DEG C with 400 ~ 700r/min, 40 ~ 60min of magnetic agitation, and it is more that additive, sodium tripolyphosphate, tea is added 1 ~ 3h is mixed to get composite clean base-material in phenol.
The preparation of macromolecular inorganic agent: in a nitrogen atmosphere, in ice-water bath, 5 ~ 8:3:25 ~ 35 take methyl in mass ratio 2-hydroxyethyl acrylate, phosphorus oxychloride, chloroform mixing are evaporated under reduced pressure with 300 ~ 550r/min, 30 ~ 45min of magnetic agitation, Concentrate is obtained, takes concentrate 2 ~ 5:3:15 in mass ratio that choline chloride, reagent B mixing is added, obtains mixed liquor, in 27 ~ 33 DEG C, take N-BMA is added in mixed liquor 24 ~ 35:7:5 in mass ratio, 30 ~ 55min is mixed in methanol, is warming up to 60 ~ 75 DEG C, the potassium peroxydisulfate mixing of mixed liquor quality 1 ~ 4% is added, keeps the temperature 5 ~ 8h, cooled to room temperature obtains reaction material, takes reaction material N-hexane mixing is added in 1:5 in mass ratio ~ 8, moves to centrifuge with 3000 ~ 5000r/min and is centrifuged 12 ~ 25min, collects centrifugation object In the dry 3 ~ 5h of drying box, obtain dried feed, dried object taken to be laid in plasma treatment instrument, under ammonia atmosphere, with 100W power, Constant air pressure 20Pa, 3 ~ 6min of plasma treatment discharge to get macromolecular inorganic agent.
A kind of antibacterial mouthwash of cleaning, according to parts by weight, including following component: 5 ~ 8 parts of sour agents, 3 ~ 7 parts of auxiliary materials, 0.3 ~ 0.8 part of jasmine essential oil, 2 ~ 5 parts of alkyl glycosides, 1 ~ 4 part of sodium sorbate, 50 ~ 70 parts of water, 25 ~ 35 parts of composite clean bases Material, 12 ~ 20 parts of macromolecular inorganic agents.
Embodiment 1
Auxiliary material: 3:1:0.2 in mass ratio takes poly alkyl alcohol ethylene oxide ether, xylitol, polylysine mixing to get auxiliary material.
Sour agent: 2:1:1 in mass ratio takes gallic acid, sodium citrate, sodium fluoride mixing to get sour agent.
Pretreatment dregs of beans: taking dregs of beans after blanching 3min, to move to micro-wave oven in boiling water, handles 6min with 400W power microwave Afterwards, pulverizer is moved to, crushed 120 meshes, collects sieving particle to get pretreatment dregs of beans.
Reagent A: the PBS buffer solution that 1:20 in mass ratio takes honey, pH is 7.2 mixes to get reagent A.
Reagent B: 15:4 in mass ratio takes the triethylamine solution of concentration 0.5mol/L, sodium bicarbonate mixing to get reagent B.
Additive: 3:1 in mass ratio takes hydroxymethyl cellulose, zinc lactate mixing to get additive.
Mixed sizing material: 3:1:1 in mass ratio takes guar gum, xanthan gum, Acritamer 940 mixing to get mixed sizing material.
The preparation method of composite clean base-material, includes the following steps:
(1) 5:3:1:15 in mass ratio takes strawberry, grape, grape pedicel, water mixing to smash homogenate to pieces, obtains slurry, according to parts by weight, Take 20 parts of slurries, 5 parts of pretreatment dregs of beans, 0.2 part of Na2HPO4, 4 parts of glycerol, 6 parts of yeast extracts, 3 parts of glucose, 1 part of Bulgaria Lactobacillus powder, 500 parts of water are mixed in fermentor, in 28 DEG C, with 180r/min concussion shaker fermentation culture 4 days, discharging, in 121 DEG C insulated sterilizing 14min, must sterilize material, after taking sterilizing material decoloration, be concentrated under reduced pressure into constant weight in 40 DEG C, obtain concentrate feed, take concentration Expect to crushed 150 meshes in freezing crusher, collects sieving particle, obtain fermentation process material；
(2) according to parts by weight, 20 parts of fermentation process material, 2 parts of mixed sizing materials, 1 part of additive, 0.1 part of tea polyphenols, 1 part of trimerization are taken Sodium phosphate, 50 parts of reagent As take fermentation process material, mixed sizing material, reagent A to mix in reaction kettle, prior to 55 DEG C with 400r/min magnetic Power stirs 40min, is cooled to 27 DEG C, additive, sodium tripolyphosphate, tea polyphenols is added, 1h is mixed to get composite clean base Material.
The preparation of macromolecular inorganic agent: in a nitrogen atmosphere, in ice-water bath, 5:3:25 takes metering system in mass ratio Acid -2- hydroxyethyl ester, phosphorus oxychloride, chloroform mixing, with 300r/min magnetic agitation 30min, vacuum distillation obtains concentrate, takes Choline chloride, reagent B mixing is added in concentrate 2:3:15 in mass ratio, obtains mixed liquor, in 27 DEG C, takes mixed liquor in mass ratio N-BMA is added in 24:7:5,30min is mixed in methanol, is warming up to 60 DEG C, and the mistake of mixed liquor quality 1% is added Potassium sulfate mixing, keeps the temperature 5h, and cooled to room temperature obtains reaction material, takes reaction material 1:5 in mass ratio that n-hexane mixing is added, It moves to centrifuge and 12min is centrifuged with 3000r/min, collect centrifugation object in the dry 3h of drying box, obtain dried feed, dried object is taken to tile In plasma treatment instrument, under ammonia atmosphere, with 100W power, constant air pressure 20Pa, plasma treatment 3min, discharging to get Macromolecular inorganic agent.
A kind of antibacterial mouthwash of cleaning, according to parts by weight, including following component: 5 parts of sour agents, 3 parts of auxiliary materials, 0.3 Part jasmine essential oil, 2 parts of alkyl glycosides, 1 part of sodium sorbate, 50 parts of water, 25 parts of composite clean base-materials, 12 parts of macromoleculars processing Agent.
Embodiment 2
Auxiliary material: 5:2:0.2 in mass ratio takes poly alkyl alcohol ethylene oxide ether, xylitol, polylysine mixing to get auxiliary material.
Sour agent: 4:1:1 in mass ratio takes gallic acid, sodium citrate, sodium fluoride mixing to get sour agent.
Pretreatment dregs of beans: taking dregs of beans after blanching 5min, to move to micro-wave oven in boiling water, handles 8min with 400W power microwave Afterwards, pulverizer is moved to, crushed 120 meshes, collects sieving particle to get pretreatment dregs of beans.
Reagent A: the PBS buffer solution that 1:27 in mass ratio takes honey, pH is 7.4 mixes to get reagent A.
Reagent B: 20:4 in mass ratio takes the triethylamine solution of concentration 0.5mol/L, sodium bicarbonate mixing to get reagent B.
Additive: 5:1 in mass ratio takes hydroxymethyl cellulose, zinc lactate mixing to get additive.
Mixed sizing material: 5:1:1.5 in mass ratio takes guar gum, xanthan gum, Acritamer 940 mixing to get mixed sizing material.
The preparation method of composite clean base-material, includes the following steps:
(1) 5:3:1.5:15 in mass ratio takes strawberry, grape, grape pedicel, water mixing to smash homogenate to pieces, obtains slurry, in parts by weight Meter, takes 30 parts of slurries, 7 parts of pretreatment dregs of beans, 0.4 part of Na2HPO4, 6 parts of glycerol, 8 parts of yeast extracts, 5 parts of glucose, 2 parts of Bao Jiali Sub- lactobacillus powder, 600 parts of water are mixed in fermentor, in 30 DEG C, with 205r/min concussion shaker fermentation culture 6 days, are discharged, in 121 DEG C of insulated sterilizing 17min, must sterilize material, after taking sterilizing material decoloration, be concentrated under reduced pressure into constant weight in 47 DEG C, obtain concentrate feed, take dense Contracting material crushed 150 meshes in freezing crusher, collects sieving particle, obtains fermentation process material；
(2) according to parts by weight, 35 parts of fermentation process material, 4 parts of mixed sizing materials, 3 parts of additives, 0.3 part of tea polyphenols, 2 parts of trimerizations are taken Sodium phosphate, 60 parts of reagent As take fermentation process material, mixed sizing material, reagent A to mix in reaction kettle, prior to 65 DEG C with 550r/min magnetic Power stirs 50min, is cooled to 30 DEG C, additive, sodium tripolyphosphate, tea polyphenols is added, 2h is mixed to get composite clean base Material.
The preparation of macromolecular inorganic agent: in a nitrogen atmosphere, in ice-water bath, 7:3:30 takes metering system in mass ratio Acid -2- hydroxyethyl ester, phosphorus oxychloride, chloroform mixing, with 425r/min magnetic agitation 37min, vacuum distillation obtains concentrate, takes Choline chloride, reagent B mixing is added in concentrate 4:3:15 in mass ratio, obtains mixed liquor, in 30 DEG C, takes mixed liquor in mass ratio N-BMA is added in 29:7:5,42min is mixed in methanol, is warming up to 68 DEG C, and the mistake of mixed liquor quality 3% is added Potassium sulfate mixing, keeps the temperature 7h, and cooled to room temperature obtains reaction material, takes reaction material 1:6 in mass ratio that n-hexane mixing is added, It moves to centrifuge and 18min is centrifuged with 4000r/min, collect centrifugation object in the dry 4h of drying box, obtain dried feed, dried object is taken to tile In plasma treatment instrument, under ammonia atmosphere, with 100W power, constant air pressure 20Pa, plasma treatment 5min, discharging to get Macromolecular inorganic agent.
A kind of antibacterial mouthwash of cleaning, according to parts by weight, including following component: 6 parts of sour agents, 5 parts of auxiliary materials, 0.5 Part jasmine essential oil, 4 parts of alkyl glycosides, 2 parts of sodium sorbates, 60 parts of water, 30 parts of composite clean base-materials, 16 parts of macromoleculars processing Agent.
Embodiment 3
Auxiliary material: 7:3:0.2 in mass ratio takes poly alkyl alcohol ethylene oxide ether, xylitol, polylysine mixing to get auxiliary material.
Sour agent: 5:1:1 in mass ratio takes gallic acid, sodium citrate, sodium fluoride mixing to get sour agent.
Pretreatment dregs of beans: taking dregs of beans after blanching 6min, to move to micro-wave oven in boiling water, is handled with 400W power microwave After 10min, pulverizer is moved to, crushed 120 meshes, collects sieving particle to get pretreatment dregs of beans.
Reagent A: the PBS buffer solution that 1:35 in mass ratio takes honey, pH is 7.7 mixes to get reagent A.
Reagent B: 25:4 in mass ratio takes the triethylamine solution of concentration 0.5mol/L, sodium bicarbonate mixing to get reagent B.
Additive: 6:1 in mass ratio takes hydroxymethyl cellulose, zinc lactate mixing to get additive.
Mixed sizing material: 7:1:2 in mass ratio takes guar gum, xanthan gum, Acritamer 940 mixing to get mixed sizing material.
The preparation method of composite clean base-material, includes the following steps:
(1) 5:3:2:15 in mass ratio takes strawberry, grape, grape pedicel, water mixing to smash homogenate to pieces, obtains slurry, according to parts by weight, Take 40 parts of slurries, 8 parts of pretreatment dregs of beans, 0.5 part of Na2HPO4, 8 parts of glycerol, 10 parts of yeast extracts, 7 parts of glucose, 3 parts of Bulgaria Lactobacillus powder, 700 parts of water are mixed in fermentor, in 33 DEG C, with 230r/min concussion shaker fermentation culture 7 days, discharging, in 121 DEG C insulated sterilizing 20min, must sterilize material, after taking sterilizing material decoloration, be concentrated under reduced pressure into constant weight in 55 DEG C, obtain concentrate feed, take concentration Expect to crushed 150 meshes in freezing crusher, collects sieving particle, obtain fermentation process material；
(2) according to parts by weight, 45 parts of fermentation process material, 5 parts of mixed sizing materials, 4 parts of additives, 0.5 part of tea polyphenols, 3 parts of trimerizations are taken Sodium phosphate, 70 parts of reagent As take fermentation process material, mixed sizing material, reagent A to mix in reaction kettle, prior to 75 DEG C with 700r/min magnetic Power stirs 60min, is cooled to 33 DEG C, additive, sodium tripolyphosphate, tea polyphenols is added, 3h is mixed to get composite clean base Material.
The preparation of macromolecular inorganic agent: in a nitrogen atmosphere, in ice-water bath, 8:3:35 takes metering system in mass ratio Acid -2- hydroxyethyl ester, phosphorus oxychloride, chloroform mixing, with 550r/min magnetic agitation 45min, vacuum distillation obtains concentrate, takes Choline chloride, reagent B mixing is added in concentrate 5:3:15 in mass ratio, obtains mixed liquor, in 33 DEG C, takes mixed liquor in mass ratio N-BMA is added in 35:7:5,55min is mixed in methanol, is warming up to 75 DEG C, and the mistake of mixed liquor quality 4% is added Potassium sulfate mixing, keeps the temperature 8h, and cooled to room temperature obtains reaction material, takes reaction material 1:8 in mass ratio that n-hexane mixing is added, It moves to centrifuge and 25min is centrifuged with 5000r/min, collect centrifugation object in the dry 5h of drying box, obtain dried feed, dried object is taken to tile In plasma treatment instrument, under ammonia atmosphere, with 100W power, constant air pressure 20Pa, plasma treatment 6min, discharging to get Macromolecular inorganic agent.
A kind of antibacterial mouthwash of cleaning, according to parts by weight, including following component: 8 parts of sour agents, 7 parts of auxiliary materials, 0.8 Part jasmine essential oil, 5 parts of alkyl glycosides, 4 parts of sodium sorbates, 70 parts of water, 35 parts of composite clean base-materials, 20 parts of macromoleculars processing Agent.
Comparative example 1: it is essentially identical with the preparation method of embodiment 1, it has only the difference is that lacking composite clean base-material.Comparison Example 2: it is essentially identical with the preparation method of embodiment 1, it has only the difference is that lacking macromolecular inorganic agent.
Comparative example 3: the mouthwash of Shanghai City company production.
Embodiment is tested with the antibacterial mouthwash of cleaning obtained by comparative example according to GB/T 35919-2018, is tested The results are shown in Table 1:
Table 1:
Test item Embodiment 1 Embodiment 2 Embodiment 3 Comparative example 1 Comparative example 2 Comparative example 3
Bacteriostasis rate/% 98.2 95.1 92.8 90.4 88.6 82.7
To swill clearance rate/% 97.5 95.8 94.3 92.6 89.7 81.3
Toxicity It is nontoxic It is nontoxic It is nontoxic It is nontoxic It is nontoxic It is nontoxic
Sensibility Without allergic phenomena Without allergic phenomena Without allergic phenomena Without allergic phenomena Without allergic phenomena There is allergic phenomena in groups of people
In summary, the resulting antibacterial mouthwash fungistatic effect of cleaning of the present invention is preferable and nontoxic nonirritant.Compared to commercially available Product effect is more preferable, is worth promoting.
The foregoing is merely preferred modes of the invention, are not intended to limit the invention, all in spirit and original of the invention Within then, any modification, equivalent replacement, improvement and so on be should all be included in the protection scope of the present invention.

Claims (10)

1. a kind of antibacterial mouthwash of cleaning, according to parts by weight, including following component: 5 ~ 8 parts of sour agents, 3 ~ 7 parts of auxiliary materials, 0.3 ~ 0.8 part of jasmine essential oil, 2 ~ 5 parts of alkyl glycosides, 1 ~ 4 part of sodium sorbate, 50 ~ 70 parts of water, which is characterized in that further include: 25 ~ 35 parts of composite clean base-materials, 12 ~ 20 parts of macromolecular inorganic agents.
2. a kind of antibacterial mouthwash of cleaning according to claim 1, which is characterized in that the preparation side of the composite clean base-material Method includes the following steps:
(1) 5:3:1 ~ 2:15 in mass ratio takes strawberry, grape, grape pedicel, water mixing to smash homogenate to pieces, obtains slurry, in parts by weight Meter, takes 20 ~ 40 parts of slurries, 5 ~ 8 parts of pretreatment dregs of beans, 0.2 ~ 0.5 part of Na2HPO4, 4 ~ 8 parts of glycerol, 6 ~ 10 parts of yeast extracts, 3 ~ 7 parts Glucose, 1 ~ 3 part of lactobacillus bulgaricus powder, 500 ~ 700 parts of water mixing shake shaker fermentation culture in 28 ~ 33 DEG C, discharge, Sterilizing, must sterilize material, and fermentation material is taken to decolourize, and be concentrated under reduced pressure in 40 ~ 55 DEG C, obtain concentrate feed, and concentrate feed Freezing smashing is taken to be sieved, and receive Collection sieving particle, obtains fermentation process material；
(2) according to parts by weight, take 20 ~ 45 parts of fermentation process material, 2 ~ 5 parts of mixed sizing materials, 1 ~ 4 part of additive, 0.1 ~ 0.5 part of tea more Phenol, 1 ~ 3 part of sodium tripolyphosphate, 50 ~ 70 parts of reagent As take fermentation process material, mixed sizing material, reagent A mixing to stir prior to 55 ~ 75 DEG C It mixes, is cooled to 27 ~ 33 DEG C, additive, sodium tripolyphosphate, tea polyphenols are added and are mixed to get composite clean base-material.
3. a kind of antibacterial mouthwash of cleaning according to claim 2, which is characterized in that the pretreatment beans in the step (1) The dregs of rice: taking dregs of beans boiling water blanching, and microwave treatment pulverizes and sieves, and collects sieving particle to get pretreatment dregs of beans.
4. a kind of antibacterial mouthwash of cleaning according to claim 2, which is characterized in that the reagent A in the step (2): press Mass ratio 1:20 ~ 35 take honey, PBS buffer solution mixing to get reagent A.
5. a kind of antibacterial mouthwash of cleaning according to claim 2, which is characterized in that the mixed sizing material in the step (2): press Mass ratio 3 ~ 7:1:1 ~ 2 take guar gum, xanthan gum, Acritamer 940 mixing to get mixed sizing material.
6. a kind of antibacterial mouthwash of cleaning according to claim 2, which is characterized in that the additive in the step (2): press 3 ~ 6:1 of mass ratio takes hydroxymethyl cellulose, zinc lactate mixing to get additive.
7. a kind of antibacterial mouthwash of cleaning according to claim 1, which is characterized in that the preparation of the macromolecular inorganic agent: In a nitrogen atmosphere, in ice-water bath, in mass ratio 5 ~ 8:3:25 ~ 35 take methacrylic acid -2- hydroxyethyl ester, phosphorus oxychloride, Chloroform is mixed, and vacuum distillation obtains concentrate, takes concentrate 2 ~ 5:3:15 in mass ratio that choline chloride, reagent B is added mixed It closes, obtains mixed liquor, in 27 ~ 33 DEG C, take mixed liquor 24 ~ 35:7:5 in mass ratio that n-BMA, methanol mixing is added Stirring is warming up to 60 ~ 75 DEG C, and the potassium peroxydisulfate mixing of mixed liquor quality 1 ~ 4% is added, keeps the temperature, cooling, obtains reaction material, negates and answer Expect that n-hexane mixing is added in 1:5 in mass ratio ~ 8, is centrifuged, it is dry, dried feed is obtained, takes dried object under ammonia atmosphere, plasma Processing discharges to get macromolecular inorganic agent.
8. a kind of antibacterial mouthwash of cleaning according to claim 7, which is characterized in that the reagent B: in mass ratio 15 ~ 25: 4 take triethylamine solution, sodium bicarbonate mixing to get reagent B.
9. a kind of antibacterial mouthwash of cleaning according to claim 1, which is characterized in that the acid agent: in mass ratio 2 ~ 5:1:1 takes gallic acid, sodium citrate, sodium fluoride mixing to get sour agent.
10. a kind of antibacterial mouthwash of cleaning according to claim 1, which is characterized in that the auxiliary material: 3 ~ 7:1 in mass ratio ~ 3:0.2 takes poly alkyl alcohol ethylene oxide ether, xylitol, polylysine mixing to get auxiliary material.
CN201910606690.8A 2019-07-06 2019-07-06 A kind of antibacterial mouthwash of cleaning Withdrawn CN110354013A (en)

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Application publication date: 20191022