CN110337434B - 制备2-氰基咪唑化合物的方法 - Google Patents

制备2-氰基咪唑化合物的方法 Download PDF

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Publication number
CN110337434B
CN110337434B CN201880012532.3A CN201880012532A CN110337434B CN 110337434 B CN110337434 B CN 110337434B CN 201880012532 A CN201880012532 A CN 201880012532A CN 110337434 B CN110337434 B CN 110337434B
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sodium
group
potassium
reducing agent
bisulfite
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Chinese (zh)
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CN110337434A (zh
Inventor
梅卡·博帕尔
苏拉·贾加迪什
比朱库马尔·戈皮纳坦·皮莱
迈克尔·瓜巴尔尼克
多伦·梅森
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Adama Makhteshim Ltd
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Makhteshim Chemical Works Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/80—Two oxygen atoms, e.g. hydantoin with hetero atoms or acyl radicals directly attached to ring nitrogen atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN201880012532.3A 2017-02-23 2018-02-23 制备2-氰基咪唑化合物的方法 Active CN110337434B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN201731006545 2017-02-23
IN201731006545 2017-02-23
PCT/IL2018/050211 WO2018154582A1 (en) 2017-02-23 2018-02-23 Process for the preparation of 2-cyanoimidazole compounds

Publications (2)

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CN110337434A CN110337434A (zh) 2019-10-15
CN110337434B true CN110337434B (zh) 2022-11-22

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US (1) US10968182B2 (enExample)
EP (1) EP3583094B1 (enExample)
JP (1) JP7142639B2 (enExample)
CN (1) CN110337434B (enExample)
AR (1) AR110997A1 (enExample)
BR (1) BR112019017556B1 (enExample)
ES (1) ES2890553T3 (enExample)
IL (1) IL268835B (enExample)
PL (1) PL3583094T3 (enExample)
PT (1) PT3583094T (enExample)
WO (1) WO2018154582A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL3583094T3 (pl) 2017-02-23 2022-01-03 Adama Makhteshim Ltd. Sposób wytwarzania związków 2-cyjanoimidazolowych
AU2021282645A1 (en) * 2020-06-03 2023-01-19 Ishihara Sangyo Kaisha, Ltd. Antimicrobial agent for nonhuman animal
CN115745893A (zh) * 2022-11-16 2023-03-07 西安近代化学研究所 一种合成2-氰基-5-芳基-1h-咪唑类化合物的方法
WO2025068800A1 (en) * 2023-09-29 2025-04-03 Cropnosys (India) Private Limited A process for the preparation of 4-chloro-5-(4-methylphenyl)-1h-imidazole-2-carbonitrile
WO2025068799A1 (en) * 2023-09-29 2025-04-03 Cropnosys (India) Private Limited A process for the preparation of 4-chloro-5-(4-methylphenyl)-1h-imidazole-2-carbonitrile
CN117800920A (zh) * 2023-12-05 2024-04-02 西安近代化学研究所 一种2-氰基-5-（对甲基苯基）咪唑的合成方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102424671A (zh) * 2011-11-04 2012-04-25 西安近代化学研究所 4-氯-2-氰基-1-二甲基氨基磺酰基-5-(4-甲基苯基)咪唑的合成方法
CN103936678A (zh) * 2014-04-23 2014-07-23 西安近代化学研究所 一种4-氯-2-氰基-n,n-二甲基-5-(4-甲基苯基)-1h-咪唑-1-磺酰胺的合成方法
CN104292166A (zh) * 2014-10-14 2015-01-21 西安近代化学研究所 4-氯-2-氰基-n,n-二甲基-5-对甲苯基咪唑-1-磺酰胺合成方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4605521A (en) 1985-03-29 1986-08-12 Eastman Kodak Company Process for the preparation of organic nitriles from organic carboxylic acid primary amides
JP2879164B2 (ja) 1990-06-28 1999-04-05 石原産業株式会社 置換２―シアノイミダゾール系化合物の製造方法
EP0765872B1 (en) 1994-09-08 1999-12-01 Ishihara Sangyo Kaisha Ltd. Processes for producing 1-substituted 2-cyanoimidazole compounds
WO2016024224A1 (en) 2014-08-11 2016-02-18 Sun Pharmaceutical Industries Limited A process for the preparation of 4-fluoro-2-methylbenzonitrile
CN105130904B (zh) * 2015-08-24 2017-10-13 如东众意化工有限公司 一种2‑氰基‑4‑氯‑5‑（4‑甲基苯基）咪唑的合成方法
PL3583094T3 (pl) 2017-02-23 2022-01-03 Adama Makhteshim Ltd. Sposób wytwarzania związków 2-cyjanoimidazolowych

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102424671A (zh) * 2011-11-04 2012-04-25 西安近代化学研究所 4-氯-2-氰基-1-二甲基氨基磺酰基-5-(4-甲基苯基)咪唑的合成方法
CN103936678A (zh) * 2014-04-23 2014-07-23 西安近代化学研究所 一种4-氯-2-氰基-n,n-二甲基-5-(4-甲基苯基)-1h-咪唑-1-磺酰胺的合成方法
CN104292166A (zh) * 2014-10-14 2015-01-21 西安近代化学研究所 4-氯-2-氰基-n,n-二甲基-5-对甲苯基咪唑-1-磺酰胺合成方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PYRROLO[3,2-d]PYRIMIDINES. IV. SYNTHESIS AND ANTIBACTERIAL AND ANTITUMOR ACTIVITY OF 2,4,7-SUBSTITUTED PYRROLO[3,2-d]PYRIMIDINES;O. S. Sizova等;《PHARMACEUTICAL CHEMISTRY JOURNAL》;19821231;第16卷(第11期);834-838 *

Also Published As

Publication number Publication date
IL268835A (en) 2019-10-31
PT3583094T (pt) 2021-09-21
JP2020508324A (ja) 2020-03-19
CN110337434A (zh) 2019-10-15
BR112019017556B1 (pt) 2023-02-07
US10968182B2 (en) 2021-04-06
IL268835B (en) 2021-10-31
EP3583094B1 (en) 2021-06-23
PL3583094T3 (pl) 2022-01-03
US20200071278A1 (en) 2020-03-05
AR110997A1 (es) 2019-05-22
WO2018154582A9 (en) 2018-11-01
ES2890553T3 (es) 2022-01-20
BR112019017556A2 (pt) 2020-04-07
JP7142639B2 (ja) 2022-09-27
WO2018154582A1 (en) 2018-08-30
EP3583094A1 (en) 2019-12-25

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