CN110269830A - A kind of Bletilla glucomannan repair latex and its preparation and application - Google Patents
A kind of Bletilla glucomannan repair latex and its preparation and application Download PDFInfo
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- CN110269830A CN110269830A CN201910673357.9A CN201910673357A CN110269830A CN 110269830 A CN110269830 A CN 110269830A CN 201910673357 A CN201910673357 A CN 201910673357A CN 110269830 A CN110269830 A CN 110269830A
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- bletilla
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
Abstract
The invention discloses a kind of Bletilla glucomannan repair latex and its preparation and application, belong to cosmetic technical field, its key points of the technical solution are that a kind of Bletilla glucomannan repair latex, based on parts by weight, including following component: 75-85 parts of water, 3-5 parts of butanediol, 1-3 parts of bletilla striata extract, 4-6 parts of stabilizer, 0.4-0.6 parts of allantoin, 0.8-1 parts of preservative, 0.4-0.6 parts of angelica extract, 0.4-0.6 parts of shrubby sophora extract, 2-4 parts of niacinamide, 0.4-0.6 parts of arbutin, 0.4-0.6 parts of glabridin, 0.2-0.4 parts of chamomile extracting solution and 0.3-0.5 parts of plants essential oil.Bletilla glucomannan repair latex prepared by the present invention have the advantages that desalinate scar, alleviate itch, anti-inflammatory analgetic, mood of releiving.
Description
Technical field
The present invention relates to cosmetic technical fields, more specifically, it is related to a kind of Bletilla glucomannan repair latex and its preparation
And application method.
Background technique
In recent years, with the raising that people live, more and more people start to pay attention to the skin nursing of itself；In various skins
In skin problem, influence of the skin scar to people is particularly important；Scar be the factors such as physics, biology, chemistry detrimental effect in
Human skin soft tissue leads to the serious damage of skin soft tissue and completely voluntarily normal cannot repair, turns to be replaced by fibr tissue
Generation repairs the appearance that influences left influences the local symptom of function again；It can be classified as according to the histology of scar Hypertrophic
Scar, keloid, superficial scars, atrophic scar, contracture scars, depressed scar and operative scar.Scar
Generation can cause great somatopsychic disturbance to patient, therefore people are largely grinding to dispelling or desalinate to have put on scar
Hair.
In the prior art, the patent application document that application publication number is CN104997697A discloses a kind of scar lotion of dispelling
Preparation method, the preparation method include the following steps: step 1: oil is mutually prepared: taking 5-10 parts of dimethicone, glycerol 5-10
75-80 DEG C is heated to after part and albolene 50-60 parts of stirring；Step 2: it thick lotion preparation: mutually vacuumizing oily, stirring
Under the conditions of sodium carboxymethylcellulose 5-10 part, 5-10 part of triethanolamine, 5-10 parts of ethyl hydroxy benzoate acid, singly tristearin glyceride 5- is added
10 parts, it is heated to 75-80 DEG C；Step 3: liquid feeding: thick lotion is cooled to 60-70 DEG C, and aloe vera highlights 1-2 parts, lavender is added
1-2 parts of essential oil and 1-2 parts of centrifugation homogeneous of DPS active factors.
For skin of face, other than the wound scar caused by because of accident, substantial portion of scar is because of people
Dispel scar proliferation caused by mole, the various operations such as wash eyebrow, plastic operation, and this kind of scar clinical manifestation is skin damage position
Occur scar scleroma gradually hyperplasia, thicken, the edge of scar is irregular, and kermesinus, itch or tingling sensation is presented in skin, needs
Longer time is restored；And in summer, since temperature is higher, skin tension increases, so that the red and swollen phenomenon of scar scar at this time
It is even more serious, the problem of being easy to produce infection, itch, so that the recovery time of scar is longer, drastically influence the normal of people
Work and life.
Summary of the invention
One of the objects of the present invention is to provide a kind of Bletilla glucomannan repair latexes, have desalination scar, alleviate and itch, disappear
The advantages of inflammation analgesic, mood of releiving.
Above-mentioned technical purpose of the invention has the technical scheme that
A kind of Bletilla glucomannan repair latex, based on parts by weight, including following component:
75-85 parts of water, 3-5 parts of butanediol, 1-3 parts of bletilla striata extract, 4-6 parts of stabilizer, 0.4-0.6 parts of allantoin, preservative
0.8-1 parts, 0.4-0.6 parts of angelica extract, 0.4-0.6 parts of shrubby sophora extract, 2-4 parts of niacinamide, 0.4-0.6 parts of arbutin,
0.4-0.6 parts of glabridin, 0.2-0.4 parts of chamomile extracting solution and 0.3-0.5 parts of plants essential oil.
By using above-mentioned technical proposal, bletilla striata extract, which has, releives with detumescence and promoting granulation, reparation, promotes wound healing
Effect, angelica extract, which has, accelerates sanguimotor effect, and shrubby sophora extract, which has, to be promoted cell growth and repair, alleviate skin
The effect of skin itch has with the composition A of bletilla striata extract, angelica extract and shrubby sophora extract compounding and wound is promoted to be cured
It closes, desalination scar, the effect for alleviating itch；Niacinamide has the function of that skin whitening, moisturizing, arbutin can inhibit with glabridin
The activity of internal tyrosinase prevents the generation of melanin and the effect of antibacterial anti-inflammatory, sweet with niacinamide, arbutin and light
The composition B that grass compounds surely has the function of antibacterial anti-inflammatory, can prevent the infection inflammation of scar, wound, promote the new of cell
It is raw, desalinate scar color, alleviates the red and swollen phenomenon of scar；By composition A, composition B and there is antibacterial anti-inflammatory, anti-allergic effects
Chamomile extracting solution and with the effect of releiving plants essential oil compounding when, lotion can be alleviated to the irritation of skin, made
It is suitable for easy allergic human population and uses.
Further, the stabilizer is hydroxypropyl-β-cyclodextrin.
By using above-mentioned technical proposal, hydroxypropyl-β-cyclodextrin can be with volatile component in Bletilla glucomannan repair latex
Volatilization, oxidation, increase the stability of effective component, reduce stimulation of the organic molecule in raw material to skin, enhancing effectively at
The stability divided.
Further, the preservative is mixed by the parahydroxyacet-ophenone and hexylene glycol that weight ratio is 1:1.
By using above-mentioned technical proposal, preservative of the parahydroxyacet-ophenone as system, when it is cooperated with hexylene glycol,
It is highly-safe, it is small to the irritation of skin, it can effectively extend the storage life of Bletilla glucomannan repair latex.
Further, flores aurantii essential oil, Lavender and sandalwood essential oil that the plants essential oil is 2:2:1 by weight ratio
It mixes.
By using above-mentioned technical proposal, flores aurantii essential oil, sandalwood essential oil and Lavender can activate skin when compounding
Skin is newborn, desalinates epidermis scar, acne print；When plants essential oil is compounded with chamomile extracting solution, there is antibacterial anti-inflammatory and antiallergy
Effect, be suitble to use with the crowd of skin sensitivity, but also as aromatic, distribute pleasant smell, mood of releiving, alleviate it is tight
The mood opened, so that alleviating scar gives people's bring pain sensation.
Further, the Bletilla glucomannan repair latex further includes Cortex Moutan extract, Radix Arnebiae extract and menthol.
By using above-mentioned technical proposal, the paeonol in Cortex Moutan extract has the work of antipruritic, antibacterial anti-inflammatory
With；Radix Arnebiae extract has the function of antibacterial anti-inflammatory, analgesia cool blood, is added to Cortex Moutan extract, Radix Arnebiae extract and thin
The Bletilla glucomannan repair latex of lotus brain have to skin releive, analgesic effect, skin temperature can be reduced, when alleviation scar hyperplasia
Scratchiness can prevent scar inflammation from infecting, the sense of discomfort of reduction of patient in hot weather.
Further, the additive amount of the Cortex Moutan extract is the 10% of bletilla striata extract, the Radix Arnebiae extract
Additive amount is the 10% of bletilla striata extract, and the additive amount of the menthol is the 10% of bletilla striata extract.
The second object of the present invention is to provide a kind of preparation method of Bletilla glucomannan repair latex.
Above-mentioned technical purpose of the invention has the technical scheme that
A kind of preparation method of Bletilla glucomannan repair latex, includes the following steps:
By using above-mentioned technical proposal, 75-85 parts of water intaking, 3-5 parts of butanediol, 1-3 parts of bletilla striata extract, 4-6 parts of stabilizer,
0.4-0.6 parts of allantoin and 0.8-1 parts of preservative after stirring and dissolving, are heated to 75-85 DEG C, after keeping the temperature 30-40min；
It is cooled to 40-50 DEG C, then adds 0.4-0.6 parts of angelica extract, 0.4-0.6 parts of shrubby sophora extract, niacinamide 2-4
Part, 0.4-0.6 parts of arbutin, 0.4-0.6 parts of glabridin, 0.2-0.4 parts of chamomile extracting solution and plants essential oil 0.3-0.5
Part, after stirring 30-40min, obtain Bletilla glucomannan repair latex.
The third object of the present invention is to provide a kind of application method of Bletilla glucomannan repair latex.
Above-mentioned technical purpose of the invention has the technical scheme that
A kind of application method of Bletilla glucomannan repair latex, includes the following steps:
1-2mL Bletilla glucomannan repair latex is taken, is applied to it on skin scar, 2-4min is massaged, skin is made to fully absorb the bletilla striata
Glue repair latex；Then 2-3mL Bletilla glucomannan repair latex is taken again, it is coated on skin scar, its film-forming is made, and is stopped
After 10-20min, film is removed, is massaged into absorption for lotion is remained on skin.
By using above-mentioned technical proposal, Bletilla glucomannan repair latex is applied on skin scar, not only may be used by massage
To improve absorption of the scarred skin to effective component in lotion, and it is also beneficial to promote Skin Cell again under massage stimulation
It is raw, improve the effect of desalination scar；After massage, Bletilla glucomannan repair latex is coated on skin scar, after moisture evaporation,
Repair latex film-forming, the film formed at this time can play the role of starvation, allow effective component in lotion by
It gradually penetrates into skin, and can prevent it from aoxidizing；When removing film, skin, massage residual cream can be stimulated again
Absorption of the skin to lotion can be improved when liquid again, to improve the effect of desalination scar.
In conclusion the present invention has the advantages that compared with the prior art
1. bletilla striata extract plays the role of wound healing of releiving, promote with detumescence and promoting granulation, reparation, angelica extract, which has, to be accelerated
Sanguimotor effect, shrubby sophora extract has the function of promoting cell growth and repairs, alleviates pruitus, is extracted with the bletilla striata
The composition A of object, angelica extract and shrubby sophora extract compounding, which has, to be promoted wound healing, desalination scar, alleviates itch
Effect；Niacinamide has the function of that skin whitening, moisturizing, arbutin and glabridin can inhibit the activity of internal tyrosinase, prevent
The generation of melanin and the effect of antibacterial anti-inflammatory have anti-with the composition B of niacinamide, arbutin and glabridin compounding
The effect of bacterium anti-inflammatory can prevent the infection inflammation of scar, wound, promote the new life of cell, desalinate scar color, alleviate scar
Red and swollen phenomenon；By composition A, composition B with the chamomile extracting solution with antibacterial anti-inflammatory, anti-allergic effects and with easypro
When the plants essential oil compounding of slow effect, lotion can be alleviated to the irritation of skin, easy allergic human population is made it suitable for and use；
2. flores aurantii essential oil, sandalwood essential oil and Lavender can desalinate epidermis scar, acne when compounding with activating skin new life
Print；When plants essential oil is compounded with chamomile extracting solution, there is antibacterial anti-inflammatory and antianaphylactic effect, be suitble to and skin sensitivity
Crowd uses, and but also as aromatic, distributes pleasant smell, mood of releiving, the mood of keeping tensions down, thus alleviate scar to
People's bring pain sensation；
3. the paeonol in Cortex Moutan extract has the function of antipruritic, antibacterial anti-inflammatory；Radix Arnebiae extract disappears with antibacterial
Scorching, analgesia cool blood effect, is added to the Bletilla glucomannan repair latex of Cortex Moutan extract, Radix Arnebiae extract and menthol to skin
Skin have releive, analgesic effect, can reduce skin temperature, alleviate scratchiness when scar hyperplasia, can in the weather of sweltering heat
To prevent scar inflammation from infecting, the sense of discomfort of reduction of patient；
4. Bletilla glucomannan repair latex is applied on skin scar, scarred skin not only can be improved to having in lotion by massage
The absorption of ingredient is imitated, and is also beneficial to promote the regeneration of Skin Cell under massage stimulation, improves the effect of desalination scar；It presses
After rubbing, Bletilla glucomannan repair latex is coated on skin scar, after moisture evaporation, repair latex film-forming, shape at this time
At film can play the role of starvation, the effective component in lotion is gradually penetrated into skin, and can be to prevent
Only it is aoxidized；When removing film, skin can be stimulated again, and massage can improve skin to cream when remaining lotion again
The absorption of liquid, to improve the effect of desalination scar.
Specific embodiment
Invention is further described in detail below.
One, embodiment
Butanediol in following embodiment provides for Daisel chemical industry Co., Ltd；Bletilla striata extract is Xi'an Guan Mao biology
The specification that Science and Technology Ltd. provides is the bletilla striata extract of 10:1；Hydroxypropyl-β-cyclodextrin is Shandong Binzhou intelligence source biology section
Skill Co., Ltd provides；Allantoin provides for the biochemical Co., Ltd of Ningbo Xiang mind；Parahydroxyacet-ophenone is that fragrant (Shanghai) of moral has
Limit company provides；Ethylene glycol provides for fragrant (Shanghai) Co., Ltd. of moral；Angelica extract is that the gloomy not natural product in Shaanxi is limited
The specification that company provides is the angelica extract of 10:1；Shrubby sophora extract is the rule that Guan Mao Biotechnology Co., Ltd in Xi'an provides
Lattice are the shrubby sophora extract of 10:1；Niacinamide is the niacinamide that Dutch DSM N. V. provides；Arbutin is Xi'an Tian Feng biotechnology
The article No. that limited liability company provides is the arbutin of NF068；Glabridin provides for Xi'an Guan Mao Biotechnology Co., Ltd
Content be 40% glabridin；Chamomile extracting solution provides for Xi'an Guan Mao Biotechnology Co., Ltd；Flores aurantii essential oil is
The article No. that Jiangxi Po Lam natural perfume material Co., Ltd provides is the flores aurantii essential oil of BL-24；Lavender is that Jiangxi Po Lam is natural
The article No. that fragrance Co., Ltd provides is the Lavender of BL-62；Sandalwood essential oil is Jiangxi Po Lam natural perfume material Co., Ltd
The article No. of offer is the sandalwood essential oil of BL-115；Cortex Moutan extract is selected from the rule that Olympic Competition Biotechnology Co., Ltd in Xi'an provides
Lattice are the Cortex Moutan extract of 10:1；Radix Arnebiae extract is the purple that the specification that Xi'an Guan Mao Biotechnology Co., Ltd mentions is 10:1
Careless extract；Menthol is the menthol that the article No. that Henan source Changxing Biotechnology Co., Ltd provides is 20080007-100.
Embodiment 1: a kind of Bletilla glucomannan repair latex is prepared with the following method:
Fetch water 75kg, butanediol 3kg, bletilla striata extract 1kg, stabilizer 4kg, allantoin 0.4kg and preservative 0.8kg, stirs
After mixing dissolution, 75 DEG C are heated to, after keeping the temperature 30min；Be cooled to 40 DEG C, then add glabridin 0.4kg, when
Return extract 0.4kg, shrubby sophora extract 0.4kg, niacinamide 2kg, arbutin 0.4kg, light fruit glabridin 0.1kg, chamomile
Extracting solution 0.2kg and plants essential oil 0.3kg obtains Bletilla glucomannan repair latex after stirring 30min.
Embodiment 2: a kind of Bletilla glucomannan repair latex is prepared with the following method:
Fetch water 80kg, butanediol 4kg, bletilla striata extract 2kg, stabilizer 8kg, allantoin 0.5kg and preservative 0.9kg, stirs
After mixing dissolution, 80 DEG C are heated to, after keeping the temperature 35min；Be cooled to 45 DEG C, then add glabridin 0.5kg, when
Return extract 0.5kg, shrubby sophora extract 0.5kg, niacinamide 3kg, arbutin 0.5kg, light fruit glabridin 0.15kg, chamomile
Extracting solution 0.3kg and plants essential oil 0.4kg obtains Bletilla glucomannan repair latex after stirring 35min.
Embodiment 3: a kind of Bletilla glucomannan repair latex is prepared with the following method:
Fetch water 85kg, butanediol 5kg, bletilla striata extract 3kg, stabilizer 6kg, allantoin 0.6kg and preservative 1kg, stirring
After dissolution, 85 DEG C are heated to, after keeping the temperature 40min；50 DEG C are cooled to, glabridin 0.6kg, Radix Angelicae Sinensis are then added
Extract 0.6kg, shrubby sophora extract 0.6kg, niacinamide 4kg, arbutin 0.6kg, light fruit glabridin 0.2kg, chamomile mention
Liquid 0.4kg and plants essential oil 0.5kg is taken, after stirring 40min, obtains Bletilla glucomannan repair latex.
Embodiment 4: a kind of Bletilla glucomannan repair latex is prepared with the following method:
Fetch water 75kg, butanediol 3kg, bletilla striata extract 1kg, stabilizer 4kg, allantoin 0.4kg and preservative 0.8kg, stirs
After mixing dissolution, 75 DEG C are heated to, after keeping the temperature 30min；Be cooled to 40 DEG C, then add glabridin 0.4kg, when
Return extract 0.4kg, shrubby sophora extract 0.4kg, niacinamide 2kg, arbutin 0.4kg, light fruit glabridin 0.1kg, chamomile
Extracting solution 0.2kg, Cortex Moutan extract 0.1kg, Radix Arnebiae extract 0.1kg, Mentholum extract 0.1kg and plants essential oil
0.3kg obtains Bletilla glucomannan repair latex after stirring 30min.
1 embodiment 1-4 raw material dosage table of table
Two, comparative example
Comparative example 1: this comparative example difference from example 1 is that, be not added in raw material glabridin, angelica extract with
And shrubby sophora extract.
Comparative example 2: this comparative example difference from example 1 is that, be not added in raw material niacinamide, arbutin and
Light fruit glabridin.
Comparative example 3: this comparative example difference from example 1 is that, be not added in raw material flores aurantii essential oil, lavender essence
Oil, sandalwood essential oil and chamomile extracting solution.
Three, application examples
2mL Bletilla glucomannan repair latex is taken, is applied to it on skin scar, 4min is massaged, so that skin is fully absorbed Bletilla glucomannan and repair
Double emulsion；Then 3mL Bletilla glucomannan repair latex is taken again, it is coated on skin scar, makes its film-forming, stops 20min
Afterwards, film is removed, is massaged into absorption for lotion is remained on skin.
Four, performance test
1. animal toxicity is tested
(1) acute oral poison is tested: taking 50 healthy rats, weight is 200 ± 20g, is randomly divided into 5 groups, every group female
Male fifty-fifty, wherein four groups are experimental group, as experimental group 1, experimental group 2, experimental group 3, experimental group 4, another group is control group；Make
The rat of experimental group 1,2,3,4 takes orally the Bletilla glucomannan repair latex of the embodiment 1,2,3,4 of 5000mg/kg body weight dose respectively,
The physiological saline of the Oral Administration in Rats same dose of control group observes and records the state of mind of rat (such as whether occurring trembling, taking out
Jerk, salivate, diarrhea, it is drowsiness and stupor etc. symptoms)；Feeding for 24 hours after, to rat carry out anatomical examination, to its internal organs into
Row pathologic inspection；Test result is the state of mind of experimental group rat and without exception, and lesion does not occur for internal organs inspection；Implement
The LD of the Bletilla glucomannan repair latex of example 1-450Oral toxicity is classified as practical nontoxic.
(2) acute percutaneous poison is tested: taking 50 healthy rats, weight is 200 ± 20g, is randomly divided into 5 groups, often
Group half male and half female, wherein four groups are experimental group, as experimental group 1, experimental group 2, experimental group 3, experimental group 4, another group is control
Group；The back of rat is lost hair or feathers, the Bletilla glucomannan repair latex of 2000mg/kg is then smeared on its skin that loses hair or feathers, is smeared
Area is 30cm2, the Bletilla glucomannan repair latex of embodiment 1,2,3,4 is respectively adopted in experimental group 1,2,3,4, daily to smear twice；
The rat of control group smears the physiological saline of same dose twice daily；Observe rat the state of mind, after two weeks to rat into
Row weighing, then dissects it, its each internal organs (heart, liver, spleen, lung, stomach, kidney) and medication skin is taken to do pathologic inspection,
Table 2
For experimental group compared with the rat of control group, spirit, diet and active state be not bright it can be seen from 2 data of table
Significant difference is different, and for administration skin without significant change, internal organs without lesion, body weight growth rate illustrates prepared by embodiment 1-4 also without significant difference
Bletilla glucomannan repair latex the growth of rat is had no significant effect.
2. acne print is tested: the selection face volunteer dark or red and swollen because of acne print caused by acne, pigmentation, face yellow
700, volunteer's age is 16-35 years old, is randomly divided into 7 groups, the side of embodiment 1-4 and comparative example 1-3 is respectively adopted
Method prepares bletilla striata latex solution makes volunteer be applied to affected part every night according to the method for application examples, continues 28 days, every 7 days
The number for recording the disappearance of a symptom accounts for the ratio of this group of total number of persons, and test result is shown in table 3.
Table 3
| Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Comparative example 1 | Comparative example 2 | Comparative example 3 | |
| 7 days | 9 | 8 | 8 | 8 | 5 | 4 | 6 |
| 14 days | 46 | 45 | 46 | 46 | 38 | 36 | 39 |
| 21 days | 89 | 90 | 90 | 91 | 75 | 74 | 75 |
| 28 days | 97 | 97 | 98 | 98 | 88 | 90 | 92 |
It can be seen from 3 data of table Bletilla glucomannan repair latex prepared by the present invention for face because acne acne print, pigmentation,
The face of the dark or red and swollen volunteer of face yellow has good repairing effect, and when using 21 days, facial symptom disappears substantially,
When using 28 days, the cure rate of facial symptom can achieve 97%.
Glabridin, angelica extract and shrubby sophora extract are not added in raw material in comparative example 1；The original of comparative example 2
Niacinamide, arbutin and light fruit glabridin are not added in material；Flores aurantii essential oil, lavender are not added in the raw material of comparative example 3
Essential oil, sandalwood essential oil and chamomile extracting solution；Compared to embodiment 1, the Bletilla glucomannan repair latex of comparative example 1-3 has face
There is repairing effect, but its repairing effect is still worse than the repairing effect of embodiment 1, illustrates to pass through when the raw material compounding of the application multiple
The synergistic effect of factor, to acne print caused by face acnes, pigmentation, face yellow be dark or red and swollen good curative effect.
3. scar is tested: selection because mole of dispelling, wash eyebrow, plastic operation leads to volunteer 362 of scar, generation scar
Time is within one month, wherein the volunteer for generating scar because washing eyebrow is because the volunteer that mole of dispelling generates scar is 105
93, because the volunteer that plastic operation generates scar is 164；Testing time is June to August part, using making in embodiment 4
Standby bletilla striata latex solution makes volunteer be applied to affected part every night according to the method for application examples, continues 90 days, and test is tied
Fruit is shown in table 4
Table 4
| It dispels mole | Wash eyebrow | Plastic operation | |
| Desalinate number, people using the 30th day scar | 82 | 68 | 87 |
| Desalinate number, people using the 60th day scar | 95 | 87 | 105 |
| Desalinate number, people using the 90th day scar | 102 | 90 | 155 |
It can be seen from 4 data of table for mole of dispelling, wash scar caused by eyebrow, using the number that after 30 days, scar is obviously desalinated
Accounting is respectively 78%, 73%, and after using 90 days, the number accounting that scar is obviously desalinated can reach 97%, for shaping
Scar caused by performing the operation, after using 90 days, the number accounting that scar is obviously desalinated is 94.5%, illustrates that the following are upper by the present invention
State the typical case in volunteer:
High mountain, it is female 23 years old, postoperative there are scar and scar because face is with the biggish black mole of area, therefore the mole operation that dispel
Position presents red；The Bletilla glucomannan repair latex prepared using embodiment 4, skin color when using the 30th day, at scar
Become smaller with the color difference of other skins, scar is obviously desalinated.
Zhao, female, 34 years old, because wash eyebrow operation, it is postoperative there are scar and scar position present it is red；Using embodiment
The Bletilla glucomannan repair latex of 4 preparations, when using the 30th day, scar is obviously desalinated.
Lee, female are 28 years old, postoperative there are scar and with itching and have a swelling pain because carrying out eyelid-slicing operation
Situation, mood more anxiety and tense；The Bletilla glucomannan repair latex prepared using embodiment 4, when in use, scarred skin feel clear
Cool, pain mitigates, and mood is obtained loosening and be releived, and when using the 7th day, is itched, swelling, pain phenomenon are substantially reduced, is made
When with the 30th day, itch, swelling, pain phenomenon disappear substantially, scar is obviously desalinated.
This specific embodiment is only explanation of the invention, is not limitation of the present invention, those skilled in the art
Member can according to need the modification that not creative contribution is made to the present embodiment after reading this specification, but as long as at this
All by the protection of Patent Law in the scope of the claims of invention.
Claims (8)
1. a kind of Bletilla glucomannan repair latex, it is characterised in that: based on parts by weight, including following component:
75-85 parts of water, 3-5 parts of butanediol, 1-3 parts of bletilla striata extract, 4-6 parts of stabilizer, 0.4-0.6 parts of allantoin, preservative
0.8-1 parts, 0.4-0.6 parts of angelica extract, 0.4-0.6 parts of shrubby sophora extract, 2-4 parts of niacinamide, 0.4-0.6 parts of arbutin,
0.4-0.6 parts of glabridin, 0.2-0.4 parts of chamomile extracting solution and 0.3-0.5 parts of plants essential oil.
2. a kind of Bletilla glucomannan repair latex according to claim 1, it is characterised in that: the stabilizer is hydroxy propyl-Beta-
Cyclodextrin.
3. a kind of Bletilla glucomannan repair latex according to claim 1, it is characterised in that: the preservative is 1 by weight ratio:
1 parahydroxyacet-ophenone and hexylene glycol mixes.
4. a kind of Bletilla glucomannan repair latex according to claim 1, it is characterised in that: the plants essential oil is by weight ratio
Flores aurantii essential oil, Lavender and the sandalwood essential oil of 2:2:1 mixes.
5. a kind of Bletilla glucomannan repair latex according to claim 1, it is characterised in that: the Bletilla glucomannan repair latex also wraps
Include Cortex Moutan extract, Radix Arnebiae extract and menthol.
6. a kind of Bletilla glucomannan repair latex according to claim 5, it is characterised in that: the addition of the Cortex Moutan extract
Amount is the 10% of bletilla striata extract, and the additive amount of the Radix Arnebiae extract is the 10% of bletilla striata extract, the addition of the menthol
Amount is the 10% of bletilla striata extract.
7. a kind of preparation method of Bletilla glucomannan repair latex, characterized by the following steps:
Water intaking 75-85 part, 3-5 parts of butanediol, 1-3 parts of bletilla striata extract, 4-6 parts of stabilizer, 0.4-0.6 parts of allantoin and prevent
Rotten agent 0.8-1 parts, after stirring and dissolving, it is heated to 75-85 DEG C, after keeping the temperature 30-40min；It is cooled to 40-50 DEG C, so
After add 0.4-0.6 parts of angelica extract, 0.4-0.6 parts of shrubby sophora extract, 2-4 parts of niacinamide, 0.4-0.6 parts of arbutin,
0.4-0.6 parts of glabridin, 0.2-0.4 parts of chamomile extracting solution and 0.3-0.5 parts of plants essential oil, after stirring 30-40min,
Obtain Bletilla glucomannan repair latex.
8. a kind of application method of Bletilla glucomannan repair latex, characterized by the following steps: take 1-2mL Bletilla glucomannan reparation
Lotion is applied to it on skin scar, massages 2-4min, skin is made to fully absorb Bletilla glucomannan repair latex；Then 2- is taken again
It is coated on skin scar by 3mL Bletilla glucomannan repair latex, makes its film-forming, and after stopping 10-20min, film is removed,
Absorption is massaged by lotion is remained on skin.
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