CN110214139B - 用于生产三唑并吡啶化合物的方法 - Google Patents

用于生产三唑并吡啶化合物的方法 Download PDF

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Publication number
CN110214139B
CN110214139B CN201780072928.2A CN201780072928A CN110214139B CN 110214139 B CN110214139 B CN 110214139B CN 201780072928 A CN201780072928 A CN 201780072928A CN 110214139 B CN110214139 B CN 110214139B
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compound
salt
acid
reaction
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CN110214139A (zh
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下间文人
山口峻
佐川胜一
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Japan Tobacco Inc
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Japan Tobacco Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN201780072928.2A 2016-11-25 2017-11-24 用于生产三唑并吡啶化合物的方法 Active CN110214139B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2016-228897 2016-11-25
JP2016228897 2016-11-25
PCT/JP2017/042239 WO2018097254A1 (ja) 2016-11-25 2017-11-24 トリアゾロピリジン化合物の製造方法

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CN110214139A CN110214139A (zh) 2019-09-06
CN110214139B true CN110214139B (zh) 2022-08-23

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US (1) US11434238B2 (enExample)
EP (1) EP3546459A4 (enExample)
JP (2) JP6600103B2 (enExample)
KR (1) KR102523786B1 (enExample)
CN (1) CN110214139B (enExample)
AU (1) AU2017364725B2 (enExample)
CA (1) CA3044654A1 (enExample)
IL (1) IL266858B (enExample)
MX (1) MX2019006083A (enExample)
RU (1) RU2752384C2 (enExample)
WO (1) WO2018097254A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2017364725B2 (en) * 2016-11-25 2021-04-01 Japan Tobacco Inc. Method for producing triazolopyridine compound
CN113387948B (zh) * 2021-02-06 2022-06-10 成都诺和晟泰生物科技有限公司 一种稠环杂芳基衍生物及其药物组合物和治疗方法及用途
CN114773333A (zh) * 2021-12-25 2022-07-22 上海泰坦科技股份有限公司 一种卤代三唑并吡啶的合成方法
CN117486878A (zh) * 2023-10-27 2024-02-02 扬州市普林斯医药科技有限公司 一种恩那司他的制备方法
CN119039291A (zh) * 2024-09-09 2024-11-29 南京药坦生物科技有限公司 一种恩那度司他中间体及其制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102471337A (zh) * 2009-07-17 2012-05-23 日本烟草产业株式会社 三唑并吡啶化合物及其作为脯氨酰基羟化酶抑制剂和红细胞生成素产生诱导剂的作用
EP3305293A1 (en) * 2015-05-28 2018-04-11 Japan Tobacco Inc. Method for treating or preventing diabetic nephropathy

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3374350B1 (en) * 2015-11-09 2022-01-05 Forge Therapeutics, Inc. Hydroxypyridinone and hydroxypyrimidinone based compounds for treating bacterial infections
AU2017364725B2 (en) * 2016-11-25 2021-04-01 Japan Tobacco Inc. Method for producing triazolopyridine compound

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102471337A (zh) * 2009-07-17 2012-05-23 日本烟草产业株式会社 三唑并吡啶化合物及其作为脯氨酰基羟化酶抑制剂和红细胞生成素产生诱导剂的作用
EP3305293A1 (en) * 2015-05-28 2018-04-11 Japan Tobacco Inc. Method for treating or preventing diabetic nephropathy

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
《A general and efficient route to 6-methyl-pyrazin-2-yl-amines: Alkylation of 2,6-dichloropyrazine via malonate derivatives》;Colbon, Paul J. J.;《JOURNAL OF HETEROCYCLIC CHEMISTRY 》;第1451-1456;20081231;第45卷(第5期);参见第1453页，方案5； *
《An efficient synthesis of 2-alkylpyridines using an alkylation/double decarboxylation strategy》;Craig Donald;《Tetrahedron Letters》;20120510;第53卷(第30期);参见第3854页方案2，第3855页方案3；表1-2 *

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Publication number Publication date
EP3546459A4 (en) 2020-05-20
RU2019119584A (ru) 2020-12-25
US11434238B2 (en) 2022-09-06
RU2752384C2 (ru) 2021-07-26
IL266858A (en) 2019-08-29
RU2019119584A3 (enExample) 2021-03-25
US20200339563A1 (en) 2020-10-29
JPWO2018097254A1 (ja) 2019-10-17
KR20190085004A (ko) 2019-07-17
JP2020073474A (ja) 2020-05-14
WO2018097254A1 (ja) 2018-05-31
CN110214139A (zh) 2019-09-06
KR102523786B1 (ko) 2023-04-20
IL266858B (en) 2021-10-31
AU2017364725B2 (en) 2021-04-01
MX2019006083A (es) 2019-07-10
EP3546459A1 (en) 2019-10-02
AU2017364725A1 (en) 2019-06-13
JP6600103B2 (ja) 2019-10-30
CA3044654A1 (en) 2018-05-31
BR112019010017A2 (pt) 2019-08-20

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PB01 Publication
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SE01 Entry into force of request for substantive examination
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Application publication date: 20190906

Assignee: SHENZHEN SALUBRIS PHARMACEUTICALS Co.,Ltd.

Assignor: JAPAN TOBACCO Inc.

Contract record no.: X2022990000256

Denomination of invention: Method for producing triazolopyridine compounds

License type: Exclusive License

Record date: 20220610

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