RU2752384C2 - Способ получения триазолопиридинового соединения - Google Patents

Способ получения триазолопиридинового соединения Download PDF

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Publication number
RU2752384C2
RU2752384C2 RU2019119584A RU2019119584A RU2752384C2 RU 2752384 C2 RU2752384 C2 RU 2752384C2 RU 2019119584 A RU2019119584 A RU 2019119584A RU 2019119584 A RU2019119584 A RU 2019119584A RU 2752384 C2 RU2752384 C2 RU 2752384C2
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Russia
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compound
salt
reaction
acid
mixture
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RU2019119584A
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English (en)
Russian (ru)
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RU2019119584A3 (enExample
RU2019119584A (ru
Inventor
Фумито СИМОМА
Такаси ЯМАГУТИ
Соити САГАВА
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Джапан Тобакко Инк.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
RU2019119584A 2016-11-25 2017-11-24 Способ получения триазолопиридинового соединения RU2752384C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2016228897 2016-11-25
JP2016-228897 2016-11-25
PCT/JP2017/042239 WO2018097254A1 (ja) 2016-11-25 2017-11-24 トリアゾロピリジン化合物の製造方法

Publications (3)

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RU2019119584A RU2019119584A (ru) 2020-12-25
RU2019119584A3 RU2019119584A3 (enExample) 2021-03-25
RU2752384C2 true RU2752384C2 (ru) 2021-07-26

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RU2019119584A RU2752384C2 (ru) 2016-11-25 2017-11-24 Способ получения триазолопиридинового соединения

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US (1) US11434238B2 (enExample)
EP (1) EP3546459A4 (enExample)
JP (2) JP6600103B2 (enExample)
KR (1) KR102523786B1 (enExample)
CN (1) CN110214139B (enExample)
AU (1) AU2017364725B2 (enExample)
CA (1) CA3044654A1 (enExample)
IL (1) IL266858B (enExample)
MX (1) MX2019006083A (enExample)
RU (1) RU2752384C2 (enExample)
WO (1) WO2018097254A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018097254A1 (ja) * 2016-11-25 2018-05-31 日本たばこ産業株式会社 トリアゾロピリジン化合物の製造方法
CN113387948B (zh) * 2021-02-06 2022-06-10 成都诺和晟泰生物科技有限公司 一种稠环杂芳基衍生物及其药物组合物和治疗方法及用途
CN114773333A (zh) * 2021-12-25 2022-07-22 上海泰坦科技股份有限公司 一种卤代三唑并吡啶的合成方法
CN117486878A (zh) * 2023-10-27 2024-02-02 扬州市普林斯医药科技有限公司 一种恩那司他的制备方法
CN119039291A (zh) * 2024-09-09 2024-11-29 南京药坦生物科技有限公司 一种恩那度司他中间体及其制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2538963C2 (ru) * 2009-07-17 2015-01-10 Джапан Тобакко Инк. Триазолопиридиновое соединение и его действие в качестве ингибитора пролилгидроксилазы и индуктора выработки эритропоэтина

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JP6814134B2 (ja) 2015-05-28 2021-01-13 日本たばこ産業株式会社 糖尿病性腎症を治療又は予防する方法
EP3374350B1 (en) * 2015-11-09 2022-01-05 Forge Therapeutics, Inc. Hydroxypyridinone and hydroxypyrimidinone based compounds for treating bacterial infections
WO2018097254A1 (ja) * 2016-11-25 2018-05-31 日本たばこ産業株式会社 トリアゾロピリジン化合物の製造方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2538963C2 (ru) * 2009-07-17 2015-01-10 Джапан Тобакко Инк. Триазолопиридиновое соединение и его действие в качестве ингибитора пролилгидроксилазы и индуктора выработки эритропоэтина

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Colbon, P. J. J. и др.: "A general and efficient route to 6-methyl-pyrazin-2-yl-amines: Alkylation of 2,6-dichloropyrazineviamalonate derivatives", Journal of Heterocyclic Chemistry, 45(5), 2008, с.1451-1456, doi:10.1002/jhet.5570450531.. *
Donald, C. и др. "An efficient synthesis of 2-alkylpyridines using an alkylation/double decarboxylation strategy", Tetrahedron Letters, 53(30), 2012, с.3853-3856, doi:10.1016/j.tetlet.2012.05.049. *
Donald, C. и др. "An efficient synthesis of 2-alkylpyridines using an alkylation/double decarboxylation strategy", Tetrahedron Letters, 53(30), 2012, с.3853-3856, doi:10.1016/j.tetlet.2012.05.049. Colbon, P. J. J. и др.: "A general and efficient route to 6-methyl-pyrazin-2-yl-amines: Alkylation of 2,6-dichloropyrazineviamalonate derivatives", Journal of Heterocyclic Chemistry, 45(5), 2008, с.1451-1456, doi:10.1002/jhet.5570450531.. *

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Publication number Publication date
BR112019010017A2 (pt) 2019-08-20
JP6600103B2 (ja) 2019-10-30
AU2017364725B2 (en) 2021-04-01
US11434238B2 (en) 2022-09-06
CN110214139A (zh) 2019-09-06
MX2019006083A (es) 2019-07-10
IL266858A (en) 2019-08-29
CA3044654A1 (en) 2018-05-31
KR20190085004A (ko) 2019-07-17
RU2019119584A3 (enExample) 2021-03-25
EP3546459A4 (en) 2020-05-20
AU2017364725A1 (en) 2019-06-13
CN110214139B (zh) 2022-08-23
RU2019119584A (ru) 2020-12-25
EP3546459A1 (en) 2019-10-02
US20200339563A1 (en) 2020-10-29
IL266858B (en) 2021-10-31
WO2018097254A1 (ja) 2018-05-31
KR102523786B1 (ko) 2023-04-20
JPWO2018097254A1 (ja) 2019-10-17
JP2020073474A (ja) 2020-05-14

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