CN110187089B - 快速测量小容量样本中有形血液成分的沉降率 - Google Patents

快速测量小容量样本中有形血液成分的沉降率 Download PDF

Info

Publication number
CN110187089B
CN110187089B CN201910463083.0A CN201910463083A CN110187089B CN 110187089 B CN110187089 B CN 110187089B CN 201910463083 A CN201910463083 A CN 201910463083A CN 110187089 B CN110187089 B CN 110187089B
Authority
CN
China
Prior art keywords
hematocrit
blood
interface
centrifugation
sedimentation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201910463083.0A
Other languages
English (en)
Chinese (zh)
Other versions
CN110187089A (zh
Inventor
M·戴耶尔
S·阿内卡尔
E·A·霍姆斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Theranos Inc
Original Assignee
Theranos Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Theranos Inc filed Critical Theranos Inc
Publication of CN110187089A publication Critical patent/CN110187089A/zh
Application granted granted Critical
Publication of CN110187089B publication Critical patent/CN110187089B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/04—Investigating sedimentation of particle suspensions
    • G01N15/042—Investigating sedimentation of particle suspensions by centrifuging and investigating centrifugates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/04—Investigating sedimentation of particle suspensions
    • G01N15/05—Investigating sedimentation of particle suspensions in blood
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D21/00—Separation of suspended solid particles from liquids by sedimentation
    • B01D21/30—Control equipment
    • B01D21/32—Density control of clear liquid or sediment, e.g. optical control ; Control of physical properties
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/491—Blood by separating the blood components
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V10/00—Arrangements for image or video recognition or understanding
    • G06V10/10—Image acquisition
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
    • G01N2015/011—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells with lysing, e.g. of erythrocytes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
    • G01N2015/012—Red blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/04—Investigating sedimentation of particle suspensions
    • G01N15/042—Investigating sedimentation of particle suspensions by centrifuging and investigating centrifugates
    • G01N2015/045—Investigating sedimentation of particle suspensions by centrifuging and investigating centrifugates by optical analysis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/04—Investigating sedimentation of particle suspensions
    • G01N15/05—Investigating sedimentation of particle suspensions in blood
    • G01N2015/055—Investigating sedimentation of particle suspensions in blood for hematocrite determination

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Ecology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Multimedia (AREA)
  • Theoretical Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Centrifugal Separators (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
CN201910463083.0A 2012-07-18 2013-07-18 快速测量小容量样本中有形血液成分的沉降率 Expired - Fee Related CN110187089B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261673037P 2012-07-18 2012-07-18
US61/673,037 2012-07-18
CN201380048272.2A CN104641230B (zh) 2012-07-18 2013-07-18 快速测量小容量样本中有形血液成分的沉降率

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201380048272.2A Division CN104641230B (zh) 2012-07-18 2013-07-18 快速测量小容量样本中有形血液成分的沉降率

Publications (2)

Publication Number Publication Date
CN110187089A CN110187089A (zh) 2019-08-30
CN110187089B true CN110187089B (zh) 2021-10-29

Family

ID=49945429

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201910463083.0A Expired - Fee Related CN110187089B (zh) 2012-07-18 2013-07-18 快速测量小容量样本中有形血液成分的沉降率
CN201380048272.2A Expired - Fee Related CN104641230B (zh) 2012-07-18 2013-07-18 快速测量小容量样本中有形血液成分的沉降率

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201380048272.2A Expired - Fee Related CN104641230B (zh) 2012-07-18 2013-07-18 快速测量小容量样本中有形血液成分的沉降率

Country Status (13)

Country Link
US (6) US9347867B2 (enExample)
EP (1) EP2875351B1 (enExample)
JP (4) JP6336697B2 (enExample)
KR (1) KR20150036494A (enExample)
CN (2) CN110187089B (enExample)
AU (1) AU2013292378A1 (enExample)
BR (1) BR112015001239A2 (enExample)
CA (1) CA2878872A1 (enExample)
IL (1) IL236767A (enExample)
IN (1) IN2014DN11202A (enExample)
MX (1) MX372784B (enExample)
SG (2) SG10201605479QA (enExample)
WO (1) WO2014015177A1 (enExample)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101252259B1 (ko) * 2011-12-12 2013-04-08 포항공과대학교 산학협력단 디스크형 미세 유체 시스템 및 혈액 상태 확인 방법
SG10201605479QA (en) 2012-07-18 2016-08-30 Theranos Inc Rapid measurement of formed blood component sedimentation rate from small sample volumes
US8984932B2 (en) 2012-07-18 2015-03-24 Theranos, Inc. Rapid measurement of formed blood component sedimentation rate from small sample volumes
CA2939595A1 (en) 2014-02-25 2015-09-03 Theranos, Inc. Systems, devices, and methods for sample integrity verification
US10591409B2 (en) 2014-02-25 2020-03-17 Theranos Ip Company, Llc Systems, devices, and methods for sample integrity verification
JP6360696B2 (ja) * 2014-03-18 2018-07-18 日本光電工業株式会社 血液検査装置および血液検査方法
JP6681384B2 (ja) * 2014-07-30 2020-04-15 エフ ホフマン−ラ ロッシュ アクチェン ゲゼルシャフト 粒子を処理するための自動化システム
CN104458519B (zh) * 2014-12-08 2017-01-18 重庆南方数控设备有限责任公司 获取血沉数据的精确检测方法
US10634660B2 (en) * 2015-03-31 2020-04-28 Sony Corporation Electrical characteristic measurement device, electrical characteristic measurement method, and blood condition analysis system
JP6327751B2 (ja) * 2015-10-06 2018-05-23 株式会社セルピック 自動血液分離装置
ES2946184T3 (es) * 2015-12-08 2023-07-13 Biomatrica Inc Reducción de la velocidad de eritrosedimentación
WO2020170772A1 (ja) * 2019-02-21 2020-08-27 株式会社シンキー 遠心機において使用される検出器及び検出システム
SE545603C2 (en) * 2019-08-22 2023-11-07 Grimaldi Dev Ab Separating particles through centrifugal sedimentation
WO2021097610A1 (zh) * 2019-11-18 2021-05-27 深圳迈瑞生物医疗电子股份有限公司 样本分析仪及样本分析方法
CN112033868B (zh) * 2020-09-01 2025-01-17 湖南伊鸿健康科技有限公司 一种加速细胞沉淀的方法、金属板及显微镜
CN111912753A (zh) * 2020-09-01 2020-11-10 湖南伊鸿健康科技有限公司 一种加速细胞沉淀的方法及装置
CN112034192B (zh) * 2020-09-07 2021-04-13 北京大学第三医院（北京大学第三临床医学院） 一种血沉校正方法
CN112766148A (zh) * 2021-01-18 2021-05-07 河南大学 一种受人类扰动冲积地层沉积韵律的识别方法及系统
TWI774220B (zh) * 2021-01-29 2022-08-11 國泰醫療財團法人國泰綜合醫院 紅血球沈降速率量測方法、血液檢測載體與量測套組
IT202100028064A1 (it) * 2021-11-04 2023-05-04 Arcangelo Ventura Dispositivo per la misura automatica della velocita' di sedimentazione e del volume del fango.
WO2023217732A1 (en) * 2022-05-10 2023-11-16 Radiometer Medical Aps Determining an amount of analyte in plasma based on a measurement of an amount of analyte in a whole-blood sample
CN118050290A (zh) 2022-11-16 2024-05-17 深圳迈瑞生物医疗电子股份有限公司 血沉检测装置以及血沉检测方法
KR102791324B1 (ko) * 2023-03-22 2025-04-08 부산대학교 산학협력단 딥러닝을 이용한 적혈구 침강 속도 진단 시간 단축 방법 및 이를 위한 시스템
WO2025144706A1 (en) * 2023-12-28 2025-07-03 Idexx Laboratories, Inc. Determination of components in samples
CN119985470B (zh) * 2025-01-14 2025-09-19 中国人民解放军总医院第八医学中心 基于图像检测的血液分离血浆样本的层析效果评估方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1063515A2 (en) * 1999-06-25 2000-12-27 Wardlaw, Stephen Clark Rapid method for determining the erythrocyte sedimentation rate in a sample of anticoagulated whole blood
EP1063513A2 (en) * 1999-06-22 2000-12-27 Wardlaw, Stephen Clark Method and apparatus for timing intermittant illumination of a sample tube positioned on a centrifuge platen and for calibrating a sample tube imaging system
CN1791800A (zh) * 2003-03-21 2006-06-21 赫默维神有限责任公司 红细胞沉降率(esr)试验测量仪的整体设计和方法
CN101228426A (zh) * 2005-07-13 2008-07-23 阿里法克斯国际股份公司 用于分析与血液密度相关的诸如红细胞沉降率和/或红血球聚集率的血液参数的仪器校准方法
CN201773058U (zh) * 2010-01-08 2011-03-23 郭瑞林 一种带负压气囊血沉管

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL92884C (enExample) * 1953-07-09
US3288019A (en) * 1962-05-08 1966-11-29 Charles M Blumenfeld Photographic type sedimentation recorder
US3848796A (en) * 1971-02-08 1974-11-19 Coulter Electronics A centrifuge apparatus for sedimentation study
US4010893A (en) 1975-06-20 1977-03-08 Becton, Dickinson And Company Triac centrifuge
US4197735A (en) 1978-11-06 1980-04-15 Chase Instruments Corporation Blood sedimentation rate test means
US4558947A (en) 1983-11-07 1985-12-17 Wardlaw Stephen C Method and apparatus for measuring blood constituent counts
US4745279A (en) 1986-01-02 1988-05-17 American Hospital Supply Corporation Hematocrit measuring apparatus
US4848900A (en) 1987-06-22 1989-07-18 Kuo Cheng Deng Computerized automatic monitoring and recording system of erythrocyte sedimentation process
JPH0275959A (ja) * 1988-09-12 1990-03-15 Nittec Co Ltd 自動分折装置
US5003488A (en) * 1989-03-10 1991-03-26 Gespac, Inc. Automatic fluid sedimentation rate measurement apparatus and method
CA2011100C (en) 1989-05-24 1996-06-11 Stephen C. Wardlaw Centrifuged material layer measurements taken in an evacuated tube
US5578269A (en) 1993-06-11 1996-11-26 Ortho Diagnostic Systems Inc. Automated blood analysis system with an integral centrifuge
US5594164A (en) * 1994-07-12 1997-01-14 Bull; Brian S. Method and apparatus for rapid determination of blood sedimentation rate
US6506606B1 (en) * 1995-06-06 2003-01-14 Brigham And Women's Hospital Method and apparatus for determining erythrocyte sedimentation rate and hematocrit
CN2259629Y (zh) * 1995-12-26 1997-08-13 张崇俊 微血量血沉仪
US5914272A (en) * 1996-06-19 1999-06-22 Becton Dickinson And Company Test method for determining the erythrocyte sedimentation rate and a surfactant for use therein
CA2230222A1 (en) * 1997-03-10 1998-09-10 Stephen C. Wardlaw Method and assembly for rapid measurement of cell layers
US20010044584A1 (en) 1997-08-28 2001-11-22 Kensey Kenneth R. In vivo delivery methods and compositions
GB9804560D0 (en) * 1998-03-05 1998-04-29 Zynocyte Ltd Method of measuring erthrocyte sedimentation rate (esr),plasma viscosity and plasma fibrinogen of a blood sample
US6517475B1 (en) 1998-09-25 2003-02-11 Baldwin Filters, Inc. Centrifugal filter for removing soot from engine oil
JP2000329779A (ja) * 1999-05-19 2000-11-30 Sefa Technology Kk 沈降速度測定方法およびその装置
US20030205538A1 (en) 2002-05-03 2003-11-06 Randel Dorian Methods and apparatus for isolating platelets from blood
US7207939B2 (en) 2002-10-03 2007-04-24 Coulter International Corp. Apparatus and method for analyzing a liquid in a capillary tube of a hematology instrument
US7422905B2 (en) * 2004-02-27 2008-09-09 Medtronic, Inc. Blood coagulation test cartridge, system, and method
CN1256587C (zh) 2004-05-31 2006-05-17 苏州市第二人民医院 血液流变全血质控物及其制备方法
WO2008021626A2 (en) * 2006-08-17 2008-02-21 Caridianbct, Inc. Blood processing apparatus with robust automated process control
JP2008231095A (ja) * 2007-02-16 2008-10-02 Harvest Technologies Corp 沈降速度を調整する方法
WO2009126800A1 (en) 2008-04-09 2009-10-15 Abbott Point Of Care, Inc. Method for measuring the area of a sample disposed within an analysis chamber
AU2010308329B2 (en) 2009-10-19 2016-10-13 Labrador Diagnostics Llc Integrated health data capture and analysis system
US20110226045A1 (en) 2009-11-25 2011-09-22 Mcquillan Adrian Charles Liquid analysis system
US20110295365A1 (en) * 2010-05-28 2011-12-01 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Anti-viral compositions and methods for administration
CN103002932B (zh) 2010-07-15 2015-04-22 泰尔茂比司特公司 在用于生物流体的离心装置中优化旋转时间的方法
CN103477197B (zh) 2011-01-21 2016-08-17 提拉诺斯公司 样品使用最大化的系统和方法
US8475739B2 (en) 2011-09-25 2013-07-02 Theranos, Inc. Systems and methods for fluid handling
SG10201605479QA (en) 2012-07-18 2016-08-30 Theranos Inc Rapid measurement of formed blood component sedimentation rate from small sample volumes
US8984932B2 (en) 2012-07-18 2015-03-24 Theranos, Inc. Rapid measurement of formed blood component sedimentation rate from small sample volumes

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1063513A2 (en) * 1999-06-22 2000-12-27 Wardlaw, Stephen Clark Method and apparatus for timing intermittant illumination of a sample tube positioned on a centrifuge platen and for calibrating a sample tube imaging system
EP1063515A2 (en) * 1999-06-25 2000-12-27 Wardlaw, Stephen Clark Rapid method for determining the erythrocyte sedimentation rate in a sample of anticoagulated whole blood
CN1791800A (zh) * 2003-03-21 2006-06-21 赫默维神有限责任公司 红细胞沉降率(esr)试验测量仪的整体设计和方法
CN101228426A (zh) * 2005-07-13 2008-07-23 阿里法克斯国际股份公司 用于分析与血液密度相关的诸如红细胞沉降率和/或红血球聚集率的血液参数的仪器校准方法
CN201773058U (zh) * 2010-01-08 2011-03-23 郭瑞林 一种带负压气囊血沉管

Also Published As

Publication number Publication date
IN2014DN11202A (enExample) 2015-10-02
EP2875351A4 (en) 2016-06-15
US9347867B2 (en) 2016-05-24
JP2022009402A (ja) 2022-01-14
MX2015000807A (es) 2015-05-07
US20190170630A1 (en) 2019-06-06
JP2020012852A (ja) 2020-01-23
JP6336697B2 (ja) 2018-06-06
US20140020457A1 (en) 2014-01-23
CN104641230A (zh) 2015-05-20
US20150198515A1 (en) 2015-07-16
CN110187089A (zh) 2019-08-30
US20160341650A1 (en) 2016-11-24
US20210140866A1 (en) 2021-05-13
CA2878872A1 (en) 2014-01-23
EP2875351B1 (en) 2022-11-09
WO2014015177A1 (en) 2014-01-23
IL236767A (en) 2017-06-29
MX372784B (es) 2020-07-01
CN104641230B (zh) 2019-06-28
US10018549B2 (en) 2018-07-10
JP2015528910A (ja) 2015-10-01
SG11201500349YA (en) 2015-02-27
US11320355B2 (en) 2022-05-03
SG10201605479QA (en) 2016-08-30
HK1210833A1 (en) 2016-05-06
US10788409B2 (en) 2020-09-29
BR112015001239A2 (pt) 2017-07-04
KR20150036494A (ko) 2015-04-07
US20190226967A1 (en) 2019-07-25
US10222310B2 (en) 2019-03-05
AU2013292378A1 (en) 2015-01-29
JP2018021936A (ja) 2018-02-08
EP2875351A1 (en) 2015-05-27

Similar Documents

Publication Publication Date Title
CN104641230B (zh) 快速测量小容量样本中有形血液成分的沉降率
CN106170696B (zh) 来自小样品体积的成形血液组分沉降速率的快速测量
US10012638B2 (en) Rapid measurement of formed blood component sedimentation rate from small sample volumes
Hendrix et al. Extracellular vesicle analysis
WO2022009104A2 (en) Focusing a microscope using fluorescent images
US20200173980A1 (en) Method of determining quality of cell separation, particle detection method, and particle separation apparatus
JP2020134341A (ja) 測定成否判定方法および試料測定装置
HK1231958A1 (en) Rapid measurement of formed blood component sedimentation rate from small sample volumes
HK1210833B (en) Rapid measurement of formed blood component sedimentation rate from small sample volumes
HK1231958B (en) Rapid measurement of formed blood component sedimentation rate from small sample volumes
JP2006047064A (ja) 粒子径分布測定方法および粒子径分布測定装置
JP2705147B2 (ja) 細胞分析装置

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20211029