IN2014DN11202A - - Google Patents

Info

Publication number
IN2014DN11202A
IN2014DN11202A IN11202DEN2014A IN2014DN11202A IN 2014DN11202 A IN2014DN11202 A IN 2014DN11202A IN 11202DEN2014 A IN11202DEN2014 A IN 11202DEN2014A IN 2014DN11202 A IN2014DN11202 A IN 2014DN11202A
Authority
IN
India
Prior art keywords
sedimentation rate
hematocrit
sedimentation
rate
methods
Prior art date
Application number
Inventor
Mark Dayel
Samartha Anekal
Elizabeth A Holmes
Original Assignee
Theranos Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Theranos Inc filed Critical Theranos Inc
Publication of IN2014DN11202A publication Critical patent/IN2014DN11202A/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/04—Investigating sedimentation of particle suspensions
    • G01N15/042—Investigating sedimentation of particle suspensions by centrifuging and investigating centrifugates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D21/00—Separation of suspended solid particles from liquids by sedimentation
    • B01D21/30—Control equipment
    • B01D21/32—Density control of clear liquid or sediment, e.g. optical control ; Control of physical properties
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/04—Investigating sedimentation of particle suspensions
    • G01N15/05—Investigating sedimentation of particle suspensions in blood
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/491—Blood by separating the blood components
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V10/00—Arrangements for image or video recognition or understanding
    • G06V10/10—Image acquisition
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
    • G01N2015/011—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells with lysing, e.g. of erythrocytes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
    • G01N2015/012—Red blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/04—Investigating sedimentation of particle suspensions
    • G01N15/042—Investigating sedimentation of particle suspensions by centrifuging and investigating centrifugates
    • G01N2015/045—Investigating sedimentation of particle suspensions by centrifuging and investigating centrifugates by optical analysis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/04—Investigating sedimentation of particle suspensions
    • G01N15/05—Investigating sedimentation of particle suspensions in blood
    • G01N2015/055—Investigating sedimentation of particle suspensions in blood for hematocrite determination

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Ecology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Multimedia (AREA)
  • Theoretical Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Centrifugal Separators (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

Devices and methods are described for measuring formed blood component sedimentation rate. Some of the methods may use (1) centrifugal techniques for separating red blood cells from plasma and (2) video and/or still imaging capability. Both may be used alone or in combination to accelerate formed blood component sedimentation and to measure its rate. In one example the method may advantageously enable rapid measurement of sedimentation rate using small blood sample volumes. Automated image analysis can be used to determine both sedimentation rate and hematocrit. Automated techniques may be used to compensate for effects of hematocrit on uncorrected sedimentation rate data.
IN11202DEN2014 2012-07-18 2013-07-18 IN2014DN11202A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261673037P 2012-07-18 2012-07-18
PCT/US2013/051143 WO2014015177A1 (en) 2012-07-18 2013-07-18 Rapid measurement of formed blood component sedimentation rate from small sample volumes

Publications (1)

Publication Number Publication Date
IN2014DN11202A true IN2014DN11202A (en) 2015-10-02

Family

ID=49945429

Family Applications (1)

Application Number Title Priority Date Filing Date
IN11202DEN2014 IN2014DN11202A (en) 2012-07-18 2013-07-18

Country Status (13)

Country Link
US (6) US9347867B2 (en)
EP (1) EP2875351B1 (en)
JP (4) JP6336697B2 (en)
KR (1) KR20150036494A (en)
CN (2) CN110187089B (en)
AU (1) AU2013292378A1 (en)
BR (1) BR112015001239A2 (en)
CA (1) CA2878872A1 (en)
IL (1) IL236767A (en)
IN (1) IN2014DN11202A (en)
MX (1) MX372784B (en)
SG (2) SG11201500349YA (en)
WO (1) WO2014015177A1 (en)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101252259B1 (en) * 2011-12-12 2013-04-08 포항공과대학교 산학협력단 Microfluidic disc system and method for identifying state of blood
CN110187089B (en) 2012-07-18 2021-10-29 赛拉诺斯知识产权有限责任公司 Rapid measurement of sedimentation rate of tangible blood components in small volume samples
US8984932B2 (en) 2012-07-18 2015-03-24 Theranos, Inc. Rapid measurement of formed blood component sedimentation rate from small sample volumes
CN106233308B (en) 2014-02-25 2019-12-13 赛拉诺斯知识产权有限责任公司 Systems, devices and methods for sample integrity verification
US10591409B2 (en) 2014-02-25 2020-03-17 Theranos Ip Company, Llc Systems, devices, and methods for sample integrity verification
JP6360696B2 (en) * 2014-03-18 2018-07-18 日本光電工業株式会社 Blood test apparatus and blood test method
EP3174970A1 (en) * 2014-07-30 2017-06-07 F. Hoffmann-La Roche AG Automated system for processing particles
CN104458519B (en) * 2014-12-08 2017-01-18 重庆南方数控设备有限责任公司 Precise detecting method for obtaining erythrocyte sedimentation data
CN107407650B (en) * 2015-03-31 2020-09-11 索尼公司 Electrical characteristic measuring device, electrical characteristic measuring method, blood condition analyzing system, and electrical characteristic measuring program for computerized method
JP6327751B2 (en) * 2015-10-06 2018-05-23 株式会社セルピック Automatic blood separator
KR102589056B1 (en) * 2015-12-08 2023-10-12 바이오매트리카 인코포레이티드 decreased erythrocyte sedimentation rate
JP6858947B2 (en) * 2019-02-21 2021-04-14 株式会社シンキー Detectors and detection systems used in centrifuges
SE545603C2 (en) * 2019-08-22 2023-11-07 Grimaldi Dev Ab Separating particles through centrifugal sedimentation
CN111712703B (en) * 2019-11-18 2024-04-12 深圳迈瑞生物医疗电子股份有限公司 Sample analyzer and sample analysis method
CN111912753A (en) * 2020-09-01 2020-11-10 湖南伊鸿健康科技有限公司 Method and device for accelerating cell precipitation
CN112033868B (en) * 2020-09-01 2025-01-17 湖南伊鸿健康科技有限公司 Method for accelerating cell precipitation, metal plate and microscope
CN112034192B (en) * 2020-09-07 2021-04-13 北京大学第三医院（北京大学第三临床医学院） A kind of erythrocyte sedimentation rate correction method
CN112766148A (en) * 2021-01-18 2021-05-07 河南大学 Method and system for identifying stratum deposition rhythm disturbed and alluvial by human
TWI774220B (en) * 2021-01-29 2022-08-11 國泰醫療財團法人國泰綜合醫院 Erythrocyte sedimentation rate measurement method, blood detection carrier and measurement kit
IT202100028064A1 (en) * 2021-11-04 2023-05-04 Arcangelo Ventura DEVICE FOR THE AUTOMATIC MEASUREMENT OF THE SEDIMENTATION SPEED AND VOLUME OF THE SLUDGE.
US20250341531A1 (en) * 2022-05-10 2025-11-06 Radiometer Medical Aps Determining an amount of analyte in plasma based on a measurement of an amount of analyte in a whole-blood sample
KR102791324B1 (en) * 2023-03-22 2025-04-08 부산대학교 산학협력단 Method for shortening the measurement time of erythrocyte sedimentation rate using deep learning and system therefor
WO2025144706A1 (en) * 2023-12-28 2025-07-03 Idexx Laboratories, Inc. Determination of components in samples
CN119985470B (en) * 2025-01-14 2025-09-19 中国人民解放军总医院第八医学中心 Image detection-based method for evaluating the chromatographic effect of blood-separated plasma samples

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL92884C (en) * 1953-07-09
US3288019A (en) * 1962-05-08 1966-11-29 Charles M Blumenfeld Photographic type sedimentation recorder
US3848796A (en) * 1971-02-08 1974-11-19 Coulter Electronics A centrifuge apparatus for sedimentation study
US4010893A (en) 1975-06-20 1977-03-08 Becton, Dickinson And Company Triac centrifuge
US4197735A (en) 1978-11-06 1980-04-15 Chase Instruments Corporation Blood sedimentation rate test means
US4558947A (en) 1983-11-07 1985-12-17 Wardlaw Stephen C Method and apparatus for measuring blood constituent counts
US4745279A (en) 1986-01-02 1988-05-17 American Hospital Supply Corporation Hematocrit measuring apparatus
US4848900A (en) 1987-06-22 1989-07-18 Kuo Cheng Deng Computerized automatic monitoring and recording system of erythrocyte sedimentation process
JPH0275959A (en) * 1988-09-12 1990-03-15 Nittec Co Ltd Automatic analysis apparatus
US5003488A (en) * 1989-03-10 1991-03-26 Gespac, Inc. Automatic fluid sedimentation rate measurement apparatus and method
CA2011100C (en) * 1989-05-24 1996-06-11 Stephen C. Wardlaw Centrifuged material layer measurements taken in an evacuated tube
US5578269A (en) 1993-06-11 1996-11-26 Ortho Diagnostic Systems Inc. Automated blood analysis system with an integral centrifuge
US5594164A (en) * 1994-07-12 1997-01-14 Bull; Brian S. Method and apparatus for rapid determination of blood sedimentation rate
US6506606B1 (en) 1995-06-06 2003-01-14 Brigham And Women's Hospital Method and apparatus for determining erythrocyte sedimentation rate and hematocrit
CN2259629Y (en) * 1995-12-26 1997-08-13 张崇俊 Micro blood volume sedimentometer
US5914272A (en) * 1996-06-19 1999-06-22 Becton Dickinson And Company Test method for determining the erythrocyte sedimentation rate and a surfactant for use therein
CA2230222A1 (en) * 1997-03-10 1998-09-10 Stephen C. Wardlaw Method and assembly for rapid measurement of cell layers
US20010044584A1 (en) 1997-08-28 2001-11-22 Kensey Kenneth R. In vivo delivery methods and compositions
GB9804560D0 (en) * 1998-03-05 1998-04-29 Zynocyte Ltd Method of measuring erthrocyte sedimentation rate (esr),plasma viscosity and plasma fibrinogen of a blood sample
US6517475B1 (en) 1998-09-25 2003-02-11 Baldwin Filters, Inc. Centrifugal filter for removing soot from engine oil
JP2000329779A (en) * 1999-05-19 2000-11-30 Sefa Technology Kk Sedimentation speed measuring method and its device
US6388740B1 (en) * 1999-06-22 2002-05-14 Robert A. Levine Method and apparatus for timing intermittent illumination of a sample tube positioned on a centrifuge platen and for calibrating a sample tube imaging system
US6204066B1 (en) * 1999-06-25 2001-03-20 Robert A. Levine Rapid method for determining the erythrocyte sedimentation rate in a sample of anticoagulated whole blood
US20030205538A1 (en) 2002-05-03 2003-11-06 Randel Dorian Methods and apparatus for isolating platelets from blood
US7207939B2 (en) 2002-10-03 2007-04-24 Coulter International Corp. Apparatus and method for analyzing a liquid in a capillary tube of a hematology instrument
US6974701B2 (en) * 2003-03-21 2005-12-13 Hemovations, Llc Erythrocyte sedimentation rate (ESR) test measurement instrument of unitary design and method of using the same
US7422905B2 (en) * 2004-02-27 2008-09-09 Medtronic, Inc. Blood coagulation test cartridge, system, and method
CN1256587C (en) 2004-05-31 2006-05-17 苏州市第二人民医院 All blood quality controlling arlicles for blood rheology and their preparation
ITUD20050118A1 (en) * 2005-07-13 2007-01-14 Sire Analytical Systems Srl PROCEDURE FOR THE CALIBRATION OF MACHINES FOR THE ANALYSIS OF BLOOD PARAMETERS CONNECTED TO THE BLOOD DENSITY, SUCH AS THE ERITROSEDIMENTATION AND / OR AGGREGATION SPEED OF THE RED GLOBULES
CN101501472A (en) * 2006-08-17 2009-08-05 科安比司特公司 Blood processing equipment with robust automatic process control
CA2621436A1 (en) 2007-02-16 2008-08-16 Sherwin Kevy Method for adjusting sedimentation rates
ES2597927T3 (en) 2008-04-09 2017-01-24 Abbott Point Of Care, Inc. Procedure to measure the area of a sample arranged inside an analysis chamber
CN105808956A (en) 2009-10-19 2016-07-27 提拉诺斯公司 Integrated health data capture and analysis system
US20110226045A1 (en) 2009-11-25 2011-09-22 Mcquillan Adrian Charles Liquid analysis system
CN201773058U (en) * 2010-01-08 2011-03-23 郭瑞林 Blood sedimentation tube with negative-pressure air bag
US20110290821A1 (en) * 2010-05-28 2011-12-01 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Anti-viral compositions and methods for administration
WO2012009177A1 (en) 2010-07-15 2012-01-19 Caridianbct, Inc. Method for optimizing spin time in a centrifuge apparatus for biologic fluids
CN106323875B (en) 2011-01-21 2019-07-09 西拉诺斯知识产权有限责任公司 Sample uses maximized system and method
US8475739B2 (en) 2011-09-25 2013-07-02 Theranos, Inc. Systems and methods for fluid handling
US8984932B2 (en) 2012-07-18 2015-03-24 Theranos, Inc. Rapid measurement of formed blood component sedimentation rate from small sample volumes
CN110187089B (en) 2012-07-18 2021-10-29 赛拉诺斯知识产权有限责任公司 Rapid measurement of sedimentation rate of tangible blood components in small volume samples

Also Published As

Publication number Publication date
EP2875351B1 (en) 2022-11-09
HK1210833A1 (en) 2016-05-06
US20160341650A1 (en) 2016-11-24
JP2020012852A (en) 2020-01-23
US20190170630A1 (en) 2019-06-06
IL236767A (en) 2017-06-29
MX2015000807A (en) 2015-05-07
US20150198515A1 (en) 2015-07-16
WO2014015177A1 (en) 2014-01-23
BR112015001239A2 (en) 2017-07-04
JP2022009402A (en) 2022-01-14
SG10201605479QA (en) 2016-08-30
CN110187089B (en) 2021-10-29
US11320355B2 (en) 2022-05-03
EP2875351A1 (en) 2015-05-27
CN104641230A (en) 2015-05-20
SG11201500349YA (en) 2015-02-27
US20190226967A1 (en) 2019-07-25
KR20150036494A (en) 2015-04-07
JP6336697B2 (en) 2018-06-06
CA2878872A1 (en) 2014-01-23
MX372784B (en) 2020-07-01
CN104641230B (en) 2019-06-28
AU2013292378A1 (en) 2015-01-29
US9347867B2 (en) 2016-05-24
JP2018021936A (en) 2018-02-08
US10788409B2 (en) 2020-09-29
JP2015528910A (en) 2015-10-01
US10222310B2 (en) 2019-03-05
US20140020457A1 (en) 2014-01-23
US20210140866A1 (en) 2021-05-13
EP2875351A4 (en) 2016-06-15
US10018549B2 (en) 2018-07-10
CN110187089A (en) 2019-08-30

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