JPH0275959A - Automatic analysis apparatus - Google Patents
Automatic analysis apparatusInfo
- Publication number
- JPH0275959A JPH0275959A JP22652688A JP22652688A JPH0275959A JP H0275959 A JPH0275959 A JP H0275959A JP 22652688 A JP22652688 A JP 22652688A JP 22652688 A JP22652688 A JP 22652688A JP H0275959 A JPH0275959 A JP H0275959A
- Authority
- JP
- Japan
- Prior art keywords
- blood
- collection tube
- blood collection
- reagent
- rotor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000004458 analytical method Methods 0.000 title abstract description 23
- 210000004369 blood Anatomy 0.000 claims abstract description 109
- 239000008280 blood Substances 0.000 claims abstract description 109
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 46
- 210000002966 serum Anatomy 0.000 claims abstract description 16
- 210000000601 blood cell Anatomy 0.000 claims abstract description 7
- 238000004040 coloring Methods 0.000 claims description 2
- 238000004820 blood count Methods 0.000 abstract description 17
- 230000001900 immune effect Effects 0.000 abstract description 13
- 230000007246 mechanism Effects 0.000 abstract description 13
- 238000007689 inspection Methods 0.000 abstract description 2
- 238000006243 chemical reaction Methods 0.000 description 18
- 238000005259 measurement Methods 0.000 description 14
- 238000012360 testing method Methods 0.000 description 10
- 238000004140 cleaning Methods 0.000 description 7
- 238000005119 centrifugation Methods 0.000 description 6
- 230000003287 optical effect Effects 0.000 description 6
- 238000009534 blood test Methods 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 238000000034 method Methods 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 230000032258 transport Effects 0.000 description 3
- 239000003146 anticoagulant agent Substances 0.000 description 2
- 229940127219 anticoagulant drug Drugs 0.000 description 2
- 210000003743 erythrocyte Anatomy 0.000 description 2
- 210000000265 leukocyte Anatomy 0.000 description 2
- 238000007789 sealing Methods 0.000 description 2
- 241000270295 Serpentes Species 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000001174 ascending effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Abstract
Description
【発明の詳細な説明】
〔産業上の利用分野〕
この発明は、一つの！ｔｃＲで生化学的・免疫学的分析
と血球の計数を行うことができる自動分析装置に関する
。[Detailed description of the invention] [Industrial application field] This invention is one! This invention relates to an automatic analyzer that can perform biochemical/immunological analysis and blood cell counting using tcR.
周知のように、血液検査には１，１！々の検査があり、
その中でも各種の生化学的・免疫学的血液検査及び赤血
球や白血球等の血球数を計数する検査は１人体情報を正
確に知る上て不可欠な検査として重要である。As we all know, blood tests are 1,1! There are various inspections,
Among these, various biochemical and immunological blood tests and tests that count the number of blood cells such as red blood cells and white blood cells are important as tests that are essential for accurately obtaining information about the human body.
しかしながら、従来より提案されている種々の血液目動
分析？を置は、全血を対象とする血球計数検査と、血清
を対象とする生化学的・免疫学的分析検査と、に大別さ
れ、夫々別個の専用機器として製造販売されているのが
現状である。However, the various blood movement analyzes that have been proposed so far? Currently, these tests are broadly divided into blood cell counting tests that target whole blood, and biochemical and immunological analysis tests that target serum, and each is manufactured and sold as a separate specialized device. It is.
これは、全血を対象とする血球計数検査において採取さ
れた血液中に添加される抗凝固剤が、生化学的・免疫学
的分析検査に悪影響を及ぼすため、夫々別の機種として
製造販売されている最大の理由である。This is because the anticoagulant added to the blood collected during a blood cell count test for whole blood has an adverse effect on biochemical and immunological analysis tests, so they are manufactured and sold as separate models. This is the biggest reason.
しかしながら、上記のように、遣球計数検査と生化学的
・免疫学的分析検査とを、夫々別個の専用機種で行なう
場合には、少なくとも２台の上記検査装置を必要とする
ことから、検査数がそれほど多くない病く医）院てあっ
ても、生化学的・免疫学的分析を行なう自動分析装置と
、血球計数装置とを各々別個に備えておかなければなら
ず、設備費用が嵩むとともに、血清の分注作業と生化学
的・免疫学的分析作業及び血球計数作業とを、夫々別個
に行なわなければならないため、タイムロスか大きく、
しかも、これらの作業か非常に煩雑である、という問題
を有していた。However, as mentioned above, when performing the ball count test and the biochemical/immunological analysis test using separate dedicated models, at least two of the above testing devices are required. Even if there are only a small number of medical clinics, it is necessary to have separate automatic analyzers for biochemical and immunological analyzes and hematology counters, which increases equipment costs. At the same time, the serum dispensing work, biochemical/immunological analysis work, and blood cell counting work must be performed separately, resulting in a large time loss.
Moreover, there is a problem in that these operations are extremely complicated.
この発明は、かかる現状に鑑み創案されたものであって
、その目的とするところは、前記血球計数作業と生化学
的・免疫学的分析作業とを一台の装置で行うことができ
、以って、この種の血液検査を大幅に簡易化・迅速化す
ることができると共に、設備コストも大幅に低減させる
ことができる自動分析装置を提供しようとするものであ
る。The present invention was devised in view of the current situation, and its purpose is to be able to perform the blood cell counting operation and the biochemical/immunological analysis operation with a single device, and to: Therefore, it is an object of the present invention to provide an automatic analyzer that can greatly simplify and speed up this type of blood test, and can also significantly reduce equipment costs.
（課題を解決するための構成）
上記目的を達成するため、この発明に係る自動分析装置
あつては、採血管を保持する採血管保持体と、この採血
管保持体に保持された採血管を所定位置まで移送する手
段と、この採血管から血液を吸引して血球を計数する手
段と、上記採血管保持体を高速回転させる手段と、この
高速回転により遠心分離された血清を吸引する手段と、
この血清と試薬との呈色状態を光学的に測定する手段と
、を有して構成したことを特徴とするものである。(Configuration for Solving the Problems) In order to achieve the above object, the automatic analyzer according to the present invention includes a blood collection tube holder that holds blood collection tubes, and a blood collection tube held in this blood collection tube holder. means for transporting the blood to a predetermined position; means for aspirating blood from the blood collection tube to count blood cells; means for rotating the blood collection tube holder at high speed; and means for aspirating serum centrifuged by the high speed rotation. ,
The present invention is characterized by comprising a means for optically measuring the coloring state of the serum and the reagent.
それ故、この発明に係る自動分析装置にあっては、採血
後の血液は、そのまま採血管保持体によって全血吸引位
置まで移送された後、血球計数ラインへと吸引され、ま
た、この全血吸引位置における吸引作業が終了した採血
管は、高速回転する採血管保持体によって遠心分離処理
され、この遠心分離が終了した採血管保持体内の血清は
、サンプル吸引位置において生化学的・免疫学的分析ラ
インへと分注されるように構成したことを特徴とするも
のである。Therefore, in the automatic analyzer according to the present invention, the blood after blood collection is directly transferred to the whole blood suction position by the blood collection tube holder, and then sucked into the blood cell counting line. After the suction operation at the suction position has been completed, the blood collection tube is centrifuged by the blood collection tube holder that rotates at high speed. It is characterized in that it is configured to be dispensed into an analysis line.
以下、添付図面に示す一実施例に基づき、この発明の詳
細な説明する。Hereinafter, the present invention will be described in detail based on an embodiment shown in the accompanying drawings.
第１図に示すように、この実施例に係る自動分析装置ｌ
は、採取された血液が全血状態で収容される採血管２と
、この採血管２が複数本保持される採血管保持体３と、
この採血管保持体３のレール４，４に沿って上記採血管
２を所定位置まで移送する駆動装置（図示せず）と、こ
の採血管２から血液を吸引して血球を計数する血球計数
機構部５と、血球計数用の血液か採取された後の採血管
２をロータ６に移しかえるロボット７と、上記ロータ６
を高速回転させて採血１！？２内の血液を遠心分離する
遠心分ＪＩＩｌａ！構（′ｃＡホせず）と、上記ロータ
６を高速回転させて得られた血清を吸引するピペット装
置８と。As shown in FIG. 1, the automatic analyzer l according to this embodiment
A blood collection tube 2 that stores collected blood in a whole blood state, a blood collection tube holder 3 that holds a plurality of blood collection tubes 2,
A drive device (not shown) that transports the blood collection tube 2 to a predetermined position along the rails 4, 4 of the blood collection tube holder 3, and a blood cell counting mechanism that sucks blood from the blood collection tube 2 and counts blood cells. 5, a robot 7 that transfers the blood collection tube 2 from which blood has been collected for blood cell counting to the rotor 6, and the rotor 6.
Rotate at high speed and collect blood 1! ? Centrifugal minute JIIla to centrifuge the blood in 2! and a pipette device 8 for aspirating the serum obtained by rotating the rotor 6 at high speed.
この血清に試薬を加えてその呈色状態に光学的に比色測
定して生化学的・免疫学的分析を行なう分析部９と、こ
れら各機構を連係して駆動制御する制御ｌ装’ａ＜図示
せず）と、から構成されている。An analysis section 9 adds reagents to the serum and performs biochemical and immunological analysis by optically colorimetrically measuring the colored state, and a control section 9 that links and controls these mechanisms. <not shown).
採血管２は、従来の遠心分離器に使用される遠心管と同
様に構成されており、そのＥ端開口部には、密封栓２ａ
が嵌装される。尚、この発明にあっては、血球計数のた
めの血液吸引と生化学的・免疫学的分析のための血清吸
引との時間間隔か短いため、採取された血液中にはｒ抗
凝固剤１か添加されない。The blood collection tube 2 is configured similarly to a centrifugal tube used in a conventional centrifuge, and has a sealing stopper 2a at its E-end opening.
is fitted. In this invention, since the time interval between blood aspiration for blood cell counting and serum aspiration for biochemical/immunological analysis is short, the collected blood contains r anticoagulant 1. or not added.
採血管保持体３は、例えば、スネークチェーン等のよう
な２木のレール４，４によって形成されており、前記採
血管２が丘記レール４゜４間に吊り下げ保持され、かつ
、上記レール４．４に沿って移動可能に保持されている
。勿論、このレール４．４間に吊り下げ保持された採血
管２は、アーム等の公知の移送手段によって全血吸引位
置ａまで移送される。The blood collection tube holder 3 is formed of two wooden rails 4, 4, such as snake chains, and the blood collection tube 2 is suspended and held between the rails 4. 4.4. Of course, the blood collection tube 2 suspended between the rails 4, 4 is transferred to the whole blood suction position a by a known transfer means such as an arm.
このようにして採血管２が全血吸引位１１ａに到達する
と、血球計数機構部５の血液吸引ピペット（図示せず）
が上記密封栓を貫通して採血管２内に差し込まれ、該採
血管２内から所要量の血液を吸引する。When the blood collection tube 2 reaches the whole blood suction position 11a in this way, the blood suction pipette (not shown) of the blood cell counting mechanism section 5
is inserted into the blood collection tube 2 through the sealing stopper, and a required amount of blood is aspirated from the blood collection tube 2.
Ｌ記血球計数機構部５は、上記のようにして吸引された
血液の赤血球数や白血球数などの血球数等を調べ、この
データをプリンター１０で打ち出す、尚、上記血液吸引
ピペット及び血球計数機構部５の構成は、公知のものと
同様であるため、その詳細な説明をここでは省略する。The blood cell counting mechanism section 5 checks the number of red blood cells, white blood cells, etc. of the blood aspirated as described above, and prints out this data on the printer 10. The configuration of the unit 5 is the same as a known one, so a detailed explanation thereof will be omitted here.
一方、全血か採取された採血管２は、次に前記全血吸引
位２！ａから採血管ピックアップ位置すへと移送され、
同位置すに到達した採血管２は、前記ロボット７を把持
した後、前記ロータ６に移しかえられる。On the other hand, the blood collection tube 2 from which whole blood has been collected is placed next at the whole blood suction position 2! The blood collection tube is transferred from a to the blood collection tube pickup position,
The blood collection tube 2 that has reached the same position grips the robot 7 and is then transferred to the rotor 6.
このロボット７は、採血管２を上記採血管ピックアップ
位５１ｂにおいて把持した後、この採血管２を把持した
まま上昇して該採痺管２を、Ｉ：、記し−ル４，４間か
ら離脱させ、この後、旋回して採血管セット位置Ｃにお
いて下降し、該採血ｖ−２が上記ロータ６の保持孔１ｋ
に挿入保持された後、上記把持状態を解除し１次に、再
び上昇時旋回−下降−把持の各動作を繰り返すことで、
採血管２を順次ロータ６にセットするように構成されて
おり、その詳細な構成・作用は公知のクランプロボット
と同様である。After gripping the blood collection tube 2 at the blood collection tube pickup position 51b, the robot 7 ascends while gripping the blood collection tube 2 and removes the blood collection tube 2 from between the marks 4 and 4. After that, it turns and descends to the blood collection tube set position C, and the blood sample v-2 is inserted into the holding hole 1k of the rotor 6.
After being inserted and held, the above-mentioned gripping state is released, and the first movement is repeated again: turning when ascending, descending, and grasping.
It is configured to sequentially set the blood collection tubes 2 on the rotor 6, and its detailed configuration and operation are similar to those of known clamp robots.
前記遠心分離作業は、採血管２内の血液を血清と血ペイ
に分離させ、かつ、従来のオートサンプラーとしてのａ
壱を有するものである。The centrifugation work separates the blood in the blood collection tube 2 into serum and blood, and also separates the blood in the blood collection tube 2 into serum and blood.
It has one.
このロータ６は、基本的には公知の遠心分離器と同様に
構成され駆動されるもので、該ロータ６の周方向には、
所定間隔毎に採血ｖ２を保持するための保持孔１１（図
示の実施例では６個）が開設されている。This rotor 6 is basically configured and driven in the same manner as a known centrifugal separator, and in the circumferential direction of the rotor 6,
Holding holes 11 (six holes in the illustrated embodiment) are opened at predetermined intervals for holding blood sample v2.
尚、上記ロータ６は１図示しないモータによって高速遠
心分離回転を行ない、かつ、遠心分離作業の採血管２を
、順次サンプル吸引位置ｄまで間欠回転移送するように
駆０制御される。The rotor 6 is controlled by a motor (not shown) to perform high-speed centrifugal rotation and to intermittently rotate and transfer the blood collection tubes 2 to be centrifuged to the sample suction position d.
勿論、図示はしないか、ロータ６の北方には、カバ一体
か配設されており、遠心分離作業中は、自然開閉ができ
ないように構成されていると共に、該カバ一体が開いた
場合には、遠心分離作業か中正されるように構成されて
いる。Of course, although it is not shown in the drawings, there is a cover installed north of the rotor 6, which is configured so that it cannot be opened and closed naturally during centrifugation work, and when the cover is opened. , configured to be corrected during centrifugation operations.
このように構成されたロータ６に、前記血液の入った採
血管２を、バランスを保ちながら順次セットし、保持孔
１１の全てに採血管２がセットされた後、上記カバ一体
を閉じる。The blood collection tubes 2 containing blood are sequentially set in the rotor 6 configured as described above while maintaining balance, and after the blood collection tubes 2 are set in all of the holding holes 11, the cover is closed.
このカム一体が閉じられると、ロータ６が回転して一定
時間遠心分離作業を行ない、この遠心分離作業か終了し
ロータ６か完全に停止した後、該ロータ６はサンプル移
送作業を行なう。When the cam unit is closed, the rotor 6 rotates to perform centrifugation for a certain period of time, and after the centrifugation is completed and the rotor 6 comes to a complete stop, the rotor 6 performs the sample transfer operation.
このサンプル移送作業は、採血管２を順次サンプル吸引
位置ｄまで間欠移送することで行なわれる。This sample transfer operation is performed by sequentially and intermittently transferring the blood collection tubes 2 to the sample suction position d.
とベット装置８は、サンプル吸引位置ｄに到達した採血
管２内から所要量の血清を吸引し、これを反応容器１２
へと分注するもので、その構成・作用は公知のピペット
装置と同様であるため、その詳細な説明をここでは省略
する。The bed device 8 aspirates the required amount of serum from the blood collection tube 2 that has reached the sample suction position d, and transfers it to the reaction container 12.
Since its structure and operation are similar to those of known pipette devices, a detailed explanation thereof will be omitted here.
分析部９は、Ｊ：、記反応容器１２を所定のタイミング
で試料（血清）分注位ｉｆ、第１試薬分注位置ｇ、ｐｌ
ＩＩ２試薬分注・撹拌位置ｈ、光学側定位７ｉｌ及び洗
浄位置ｊ１乃至ｊ、まで移送する反応容器移送装置（図
示せず）と、上記反応容器１２内に測定項目に対応する
第１試薬を分注する第１試薬用ピペツト１３と、ｉ７Ｊ
記反応容器１２内に測定項目に対応する第２試薬を分注
する第２試薬用ピペツト１４と、この第２試薬ピペツト
１４と連動する攪拌装置（図示せず）と、光学測定装置
１５と、洗浄装Ｍ１６と、ｉＪ記第１及び第２試薬か収
容された試薬ボトル１７を第１試薬吸引位ｌｋ或は第２
試薬吸引位置ｍへと移送する試薬装置１８と、から構成
されている。The analysis section 9 sets the reaction container 12 at a predetermined timing to a sample (serum) dispensing position if, a first reagent dispensing position g, and a first reagent dispensing position g, pl.
II2 A reaction container transfer device (not shown) for transferring the reagent to the reagent dispensing/stirring position h, the optical side orientation position 7il, and the cleaning positions j1 to j, and a first reagent corresponding to the measurement item in the reaction container 12. The first reagent pipette 13 and i7J
A second reagent pipette 14 for dispensing a second reagent corresponding to the measurement item into the reaction container 12, a stirring device (not shown) interlocked with the second reagent pipette 14, and an optical measuring device 15. The cleaning device M16 and the reagent bottle 17 containing the first and second reagents listed in iJ are moved to the first reagent suction position lk or the second reagent.
The reagent device 18 is configured to transport the reagent to the reagent suction position m.
反応容器移送装置は、複数個（３６個）の反応容器１２
を略３７°Ｃに加温しつつ順次所要の位置まで１ピツチ
ずつ間欠移送するもので１間欠移送される方向（第１図
時計方向）とは逆の方向（第１図反時計方向）へ１反応
容器分少ない数（３５容器分）だけステップ回転し、詰
果的に反応容器１２を第１図時計方向へと１容器ずつ間
欠移送するように構成されている。この反応容器の移送
手段は、公知のパルスモータか用いられる。The reaction container transfer device has a plurality of (36) reaction containers 12.
While heating the material to approximately 37°C, it intermittently transfers it one pitch at a time to the required position, and the direction in which it is intermittently transferred (clockwise in Figure 1) is opposite to the direction (counterclockwise in Figure 1). It is configured to rotate stepwise by one reaction container (35 containers) and to intermittently transfer the reaction containers 12 one container at a time clockwise in FIG. 1. A known pulse motor is used as a means for transferring the reaction container.
試薬装置１８は、測定項目に対応する試薬が収容されて
なる第１試薬が収容された室１７ａ及び第２試薬が収容
された室１７ｂを有する前記試薬ボトル１７と、この試
薬ボトル１７かａａされたテーブル２０を回動制御して
°測定項目に対応する試薬を第１試薬吸引位置ｋ又は第
２試薬吸引位ｆｉ１ｍまで移送するボトル移送装′ｔ１
（図示せず）と、第１試薬吸引位置にで室１７ａ内から
測定項目に対応する第１試薬を所要ｆｆｉ吸引する前記
第１試薬用ピペツト１３と、第２試薬吸引位１ｉｆｆ
ｍ ”ｅ室１７ｂ内から測定項目に対応する第２試薬を
所要量吸引する前記第２試薬用ピペツト１４と、から構
成されている。尚、上記試薬ボトル１７は、予め定めら
れた位置にセットされ、これらの位置は各々制御装置Ｃ
ＰＵにメモリーされている。また、この試薬ボトル１７
は、例えば１２容器が１セツトとして構成されており、
測定項目が異なる場合には、他のセットとワンタッチで
交換てきるように構成されている。The reagent device 18 includes the reagent bottle 17, which has a chamber 17a containing a first reagent and a chamber 17b containing a second reagent, each containing a reagent corresponding to a measurement item; Bottle transfer device 't1 which controls the rotation of the table 20 and transfers the reagent corresponding to the measurement item to the first reagent suction position k or the second reagent suction position fi1m.
(not shown), the first reagent pipette 13 at a first reagent suction position to aspirate the first reagent corresponding to the measurement item from within the chamber 17a as required ffi, and a second reagent suction position 1iff.
and the second reagent pipette 14 that aspirates the required amount of the second reagent corresponding to the measurement item from inside the chamber 17b.The reagent bottle 17 is set at a predetermined position. and these positions are each controlled by the controller C.
Memory is stored in the PU. In addition, this reagent bottle 17
For example, 12 containers are configured as one set,
If the measurement items are different, the set is configured so that it can be exchanged with another set with a single touch.
このようにして測定項目に対応する試薬ボトル１７か所
定の試薬吸引位置に、ｍに到来すると、夫々ｆｊＳ１及
び第２試薬用ピペツト１３゜１４を介して反応容器１２
内に対応する試薬か所要驕毎に夫々分注される。In this way, when the reagent bottle 17 corresponding to the measurement item reaches the predetermined reagent suction position m, it is transferred to the reaction container 12 via fjS1 and the second reagent pipette 13, 14, respectively.
The corresponding reagents are dispensed according to the required amount.
この第１及び第２試薬用ピペツト１３及び１４は、公知
のピペット装置の構成と同様に構成されているので、そ
の詳細な説明をここては省略する。Since the first and second reagent pipettes 13 and 14 are constructed in the same manner as a known pipette device, a detailed explanation thereof will be omitted here.
撹拌装置は１図示はしていないが、上記：５２試薬井Ｉ
どベット１４に固定されており、この試薬用ピペット１
４の回動に伴って移送され、第２試薬が分注された直後
に反応容器１２内の試料を気泡攪拌し、その後、第２試
薬川ピペツト１４のピペット洗節位ｉｎて同ピペット１
４と共に洗浄される。Although the stirring device is not shown, the above: 52 reagent well I
This reagent pipette 1 is fixed to the pipette 14.
Immediately after the second reagent is dispensed, the sample in the reaction vessel 12 is bubble-stirred, and then the second reagent pipette 14 is transferred to the pipette cleaning position of the second reagent pipette 14.
Washed together with 4.
検出部もしくは観測点を形成する光学測定袋２２１５は
、回折格子方式に構成されており、光Ｉ（２１と、この
光源２１から照射された測定光をローランド円上に配列
された複数個の受光素子２２と、測定項目に対応する受
光素子２２で受光された光量を電圧変換してその分析値
を処理する制御装置ＣＰＵと、該データを記憶する記憶
部（図示せず）と、から構成されている。The optical measurement bag 2215, which forms a detection part or an observation point, is configured using a diffraction grating method, and receives the light I (21) and the measurement light irradiated from this light source 21 through a plurality of light receiving units arranged on a Rowland circle. It is composed of an element 22, a control device CPU that converts the amount of light received by the light receiving element 22 corresponding to the measurement item into a voltage and processes the analysis value, and a storage unit (not shown) that stores the data. ing.
勿論、光学測定装置１５をフィルターによる波長変換方
式に変更して適用してもよい。Of course, the optical measuring device 15 may be changed to a wavelength conversion method using a filter.
それ故、この光学測定？ｔＭ７は１反応容器１２の洗浄
位置ｊ＋から測定終了位ｍｑまでの反応容器１２の全て
（図示の実施例では３５容器分）を２０秒毎に連続測定
し、各反応容器１２の反応タイムコースな得ることがで
きる。Hence this optical measurement? tM7 continuously measures all the reaction vessels 12 (35 vessels in the illustrated example) from the cleaning position j+ of one reaction vessel 12 to the measurement end position mq every 20 seconds, and calculates the reaction time course of each reaction vessel 12. Obtainable.
以とのようにして得られた分析値は、制Ｗ部制御装＠Ｃ
ＰＵでデータ処理されてプリンター１０でプリントアウ
トされる。The analysis values obtained in the following manner are
The data is processed by the PU and printed out by the printer 10.
洗浄装置１６は、光学測定作業か終了した反応容器１２
の内部を再使用に供するため洗浄するもので、公知の液
吸上げ機構と洗浄水供給機構とから構成されている。The cleaning device 16 cleans the reaction vessel 12 after optical measurement work has been completed.
The inside of the machine is cleaned for reuse, and it is composed of a known liquid suction mechanism and a cleaning water supply mechanism.
このようにして洗浄作業か終了した反応容器１２は、こ
の後に再びサンプル分注位ａｌｆへと移送される。After the cleaning operation has been completed in this manner, the reaction vessel 12 is transferred to the sample dispensing position alf again.
また、前記ロータ６に保持された採血管２の前記サンプ
ル吸引位ｉｄにおけるサンプリンク作業か終了した採血
管２は、この後、再び前記採血管セット位δＣまで順次
移送され、同位置Ｃにおいて前記ロボット７により再び
採血管保持体３に移しかえられ、その後７人手により採
血管保持体３から取り除かれる。Further, the blood collection tubes 2 held by the rotor 6 that have completed the sample linking operation at the sample suction position id are then sequentially transferred again to the blood collection tube set position δC, and at the same position C, The robot 7 transfers it to the blood collection tube holder 3 again, and then it is removed from the blood collection tube holder 3 by seven people.
尚、この発明にあっては１分析８ｓ９の構成を図示のよ
うに構成した場合を例にとり説明したか、この発明にあ
っては、これに限定されるものではなく、公知の各種方
式からなる日動分析装置に適用することができる。Although the present invention has been explained by taking as an example the case where the configuration of 1 analysis 8s9 is configured as shown in the figure, the present invention is not limited to this, and may be implemented using various known systems. It can be applied to Nichido analyzers.
また１図示の実施例では、ロータ６を１台配設して構成
した場合を例にとり説明したか、この発明にあってはこ
れに限定されるものではなく１例えば、採血管保持体３
を廃１ヒし、ロータ６をレールに沿って血球計数機構部
５から分析部９間を往復層動’ｆＪｆ能に形成し、或は
、２台以上のロータを−の支持台に配設し、この支持台
を軸を中心に回転移送して前記採血管セット位Ｚｔｃか
らサンプル吸引位置ｄを経て再び採血管セット位置Ｃま
で移送するように構成することもできる。In addition, in the embodiment shown in FIG. 1, the case where one rotor 6 is disposed is explained as an example, but the present invention is not limited to this.
The rotor 6 is formed in a reciprocating laminar motion between the blood cell counting mechanism section 5 and the analysis section 9 along the rail, or two or more rotors are arranged on a support stand. However, it is also possible to configure the support stand to be rotated about an axis and transported from the blood collection tube setting position Ztc, through the sample suction position d, and again to the blood collection tube setting position C.
（発明の効果）
この発明は、以上説明したように、採血後の血液をその
まま採血管保持体によって全血吸引位置まで移送した後
、血球計数ラインに供給し、また、この全血吸引位置に
おける吸引作業が終了した採血管は、高速回転する採血
管保持体によって遠心分離処理した後、この遠心分離か
終了した採血管保持体内の血清を、サンプル吸引位置に
３いて生化学的・免疫学的分析ラインへと分注するよう
に構成したので、前記血球計数作業と生化学的・免疫学
的分析作業とを一台の装置で行うことかでき、以って、
この種の血液検査を大幅に簡易化・迅速化することがで
きると共に、設備コストも大幅に低減させることかでき
る等、幾多の優れた効果を奏する。(Effects of the Invention) As explained above, the present invention transports blood after blood collection as it is to the whole blood suction position using the blood collection tube holder, and then supplies it to the blood cell counting line. After the suction operation has been completed, the blood collection tube is centrifuged using a blood collection tube holder that rotates at high speed, and the serum inside the blood collection tube holder that has been centrifuged is transferred to the sample suction position for biochemical and immunological analysis. Since it is configured to dispense into the analysis line, the blood cell counting operation and the biochemical/immunological analysis operation can be performed with one device, and thus,
This type of blood test can be greatly simplified and speeded up, and equipment costs can be significantly reduced, among other excellent effects.
第１図は、この発明の一実施例に係る自動分析装置の全
体構成を概略的に示す平面説明図、第２図は遠心分離後
の採血管を示す断面図である。
（符合の説明〕
ｌ・・・自動分析装置 ２・、・採血管３・・・採
血管保持体 ５・・・血球計数機構部６・・・ロー
タ ７・・・ロボット９・・・分析部FIG. 1 is an explanatory plan view schematically showing the overall configuration of an automatic analyzer according to an embodiment of the present invention, and FIG. 2 is a sectional view showing a blood collection tube after centrifugation. (Explanation of symbols) l... Automatic analyzer 2... Blood collection tube 3... Blood collection tube holder 5... Blood cell counting mechanism section 6... Rotor 7... Robot 9... Analysis section
Claims (1)
保持された採血管を所定位置まで移送する手段と、この
採血管から血液を吸引して血球を計数する手段と、上記
採血管保持体を高速回転させる手段と、この高速回転に
より遠心分離された血清を吸引する手段と、この血清と
試薬との呈色状態を光学的に測定する手段と、を備えて
なる自動分析装置。A blood collection tube holder for holding a blood collection tube, a means for transporting the blood collection tube held by the blood collection tube holder to a predetermined position, a means for aspirating blood from the blood collection tube and counting blood cells, and the blood collection tube. An automatic analyzer comprising means for rotating a holder at high speed, means for aspirating serum centrifuged by this high speed rotation, and means for optically measuring the coloring state of this serum and a reagent.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP22652688A JPH0275959A (en) | 1988-09-12 | 1988-09-12 | Automatic analysis apparatus |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP22652688A JPH0275959A (en) | 1988-09-12 | 1988-09-12 | Automatic analysis apparatus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH0275959A true JPH0275959A (en) | 1990-03-15 |
Family
ID=16846511
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP22652688A Pending JPH0275959A (en) | 1988-09-12 | 1988-09-12 | Automatic analysis apparatus |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH0275959A (en) |
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-
1988
- 1988-09-12 JP JP22652688A patent/JPH0275959A/en active Pending
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