CN110151640A - A kind of sodium hyaluronate composition and its nanometer formulation based on beautifying use - Google Patents
A kind of sodium hyaluronate composition and its nanometer formulation based on beautifying use Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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- A61K8/678—Tocopherol, i.e. vitamin E
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- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
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- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A61Q19/00—Preparations for care of the skin
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/007—Preparations for dry skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/413—Nanosized, i.e. having sizes below 100 nm
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Abstract
The invention discloses a kind of sodium hyaluronate composition and its nanometer formulations, wherein the sodium hyaluronate composition is made of sodium hyaluronate, polyethylene glycol-400, oleanolic acid, European Lee's berry extract, olive oil, coconut oil, shea butter, vitamin E, saualane, Tween 80, glycerol, glycerin monostearate, 2,6- di-tert-butyl-4-methy phenol and deionized water.The sodium hyaluronate composition is in nano-emulsion form, has effects that excellent skin moisturizing, moisturizing.
Description
Technical field
The present invention relates to cosmetic technical fields, and in particular to a kind of sodium hyaluronate composition based on beautifying use and its receives
Metric system agent.
Background technique
Skin is as the maximum organ of human body and the natural barrier for resisting external environment influence, in the biological function of human normal
It is played an important role in the performance of energy.Since air pollution, climate change, mechanical damage, chemical contact, microorganism connect
The effect of the external factor such as touching, ultraviolet light irradiation and human body itself are with continuous increase at age and the phenomenon that aging, people
Skin barrier be highly susceptible to damage, occur dry skin, crackle, elasticity reduction the problems such as.These skins are for wide
It is that one very intractable but urgent problem to be solved for big people seeking beauty.
Therefore, for a long time, this field researcher constantly seeks that the cosmetics system of skin can be effectively improved
The raw material of agent.Sodium hyaluronate (Hyaluronan), also known as uronic acid, hyaluronic acid are by two dissacharide units D-Glucose aldehydic acid
And the large-scale polysaccharide of N-acetyl-glucosamine composition, wherein by β -1 between D-Glucose aldehydic acid and N-acetyl-glucosamine, 3- is with sugar
Key is connected, and is connected between dissacharide units by β-Isosorbide-5-Nitrae-glycosidic inkage.Sodium hyaluronate is universally present in skin corium and knot hoof tissue
In, its hyalomitome molecule can carry 500 times or more of moisture, have powerful water suction and moisture-keeping functions, make skin moisturizing,
Fine and smooth, tender, high resilience.Thus, sodium hyaluronate is widely used in cosmetics as moisturizer.
But since the molecular weight of sodium hyaluronate is larger, the existing cosmetic formulations based on sodium hyaluronate, which often exist, to be absorbed
The low problem of effect enables the sodium hyaluronate of only sub-fraction to penetrate into skin the effect of playing moisturizing, moisturizing, and
And acting duration is of short duration.Therefore, the shortcomings that how overcoming sodium hyaluronate enables to be effective as moisturizer by widely
It applies in cosmetics, becomes the problem of those skilled in the art aim to solve the problem that.
Summary of the invention
The technical problem to be solved by the present invention is to overcome the deficiencies of the prior art and provide a kind of glass based on beautifying use
Uric acid composition and preparation method thereof.The sodium hyaluronate composition is by sodium hyaluronate, polyethylene glycol-400, oleanolic acid, European Lee
Berry extract, olive oil, coconut oil, shea butter, vitamin E, saualane, Tween 80, glycerol, glycerin monostearate, 2,
6- di-tert-butyl-4-methy phenol and deionized water are made, and are in nano-emulsion form, the function with excellent skin moisturizing, moisturizing
Effect.
Technical concept of the invention is as follows:
1, using three kinds of work being made of sodium hyaluronate, oleanolic acid and European Lee (PRUNUS DOMESTICA) berry extract
The compounded formula of property ingredient, further increases moisturizing effect of sodium hyaluronate.
2, nano-emulsion preparation is made in the active constituent, changes the thermodynamic phase of conventional emulsion, Neng Gouchang
Phase keeps stablizing, while improving the bioaffinity of active constituent, enable active constituent more skin permeation to
Play the skin care activity of moisturizing, moisturizing.
By the above technical concept, the present inventor successfully solves to apply sodium hyaluronate as moisturizing active constituent and make up
Technical problem in product preparation.
For this purpose, the present invention provides a kind of sodium hyaluronate composition, it is characterised in that it is to be made of raw material from the following weight
Nano-emulsion: 10-20 parts of sodium hyaluronate, 5-9 parts of polyethylene glycol-400,3-7 parts of oleanolic acid, European 1-5 parts of Lee's berry extract,
20-25 portions of olive oil, 10-15 parts of shea butter, 0.5-0.9 parts of vitamin E, 5-10 parts of saualane, is spat 10-15 parts of coconut oil
Warm 80 15-20 parts, 10-15 parts of glycerol, 20-25 parts of glycerin monostearate, 2,6 di tert butyl 4 methyl phenol 0.4-0.8
Part and deionized water 90-100 parts, preparation method are as follows:
1) by oleanolic acid, European Lee's berry extract, olive oil, coconut oil, shea butter, vitamin at 35-45 DEG C
E, saualane, glycerin monostearate, 2,6- di-tert-butyl-4-methy phenol are sufficiently mixed, and form oily phase；
2) sodium hyaluronate, polyethylene glycol-400, Tween 80, glycerol and deionized water are sufficiently mixed at 35-45 DEG C, are formed
Water phase；
3) it is vigorously stirred the lower oil for obtaining step 1) at 20-30 DEG C to be added in the water phase that step 2) obtains, is placed in
With 40-50Hz higher-order of oscillation mixing 15-25min in supersonic generator, the sodium hyaluronate composition of the nano-emulsion form is obtained.
In one embodiment, the sodium hyaluronate composition is the nano-emulsion be made of raw material from the following weight: glass
10 parts of uric acid, 5 parts of polyethylene glycol-400,3 parts of oleanolic acid, European 1 part of Lee's berry extract, 20 parts of olive oil, coconut oil 10
Part, 10 parts of shea butter, 0.5 part of vitamin E, 5 parts of saualane, 15 parts of Tween 80,10 parts of glycerol, glycerin monostearate 20
Part, 0.4 part of 2,6 di tert butyl 4 methyl phenol and 90 parts of deionized water.
In another embodiment, the sodium hyaluronate composition is by being the nanometer be made of raw material from the following weight
Cream: 15 parts of sodium hyaluronate, 7 parts of polyethylene glycol-400,5 parts of oleanolic acid, European 3 parts of Lee's berry extract, 23 parts of olive oil, coconut
Oily 13 parts, 13 parts of shea butter, 0.7 part of vitamin E, 7 parts of saualane, 17 parts of Tween 80,13 parts of glycerol, glycerol monostearate
23 parts of ester, 0.6 part of 2,6 di tert butyl 4 methyl phenol and 95 parts of deionized water.
In another embodiment again, the sodium hyaluronate composition is the nanometer be made of raw material from the following weight
Cream: 20 parts of sodium hyaluronate, 9 parts of polyethylene glycol-400,7 parts of oleanolic acid, European 5 parts of Lee's berry extract, 25 parts of olive oil, coconut
15 parts of oil, 15 parts of shea butter, 0.9 part of vitamin E, 10 parts of saualane, 20 parts of Tween 80,15 parts of glycerol, monostearate are sweet
25 parts of grease, 0.8 part of 2,6 di tert butyl 4 methyl phenol and 100 parts of deionized water.
In one embodiment, the sodium hyaluronate is in the molecular weight with 100,0000-180,0000 dalton
Molecule sodium hyaluronate.
In one embodiment, European Lee's berry extract is prepared according to following methods: being taken the fruit of European Lee, is gone
Core, pulp are squeezed into pulp with juice extractor, and 70v/v% ethyl alcohol is added according to the ratio that 1g pulp corresponds to 5ml 70v/v% ethyl alcohol,
It impregnates 2-3 days at room temperature, filtering, then revolving obtains European Lee's berry extract to doing under 45 DEG C of bath temperatures.
In one embodiment, sodium hyaluronate composition of the present invention is used to prepare the present invention also provides a kind of
Method, described method includes following steps:
1) by oleanolic acid, European Lee's berry extract, olive oil, coconut oil, shea butter, vitamin at 35-45 DEG C
E, saualane, glycerin monostearate, 2,6- di-tert-butyl-4-methy phenol are sufficiently mixed, and form oily phase；
2) sodium hyaluronate, polyethylene glycol-400, Tween 80, glycerol and deionized water are sufficiently mixed at 35-45 DEG C, are formed
Water phase；
3) it is vigorously stirred the lower oil for obtaining step 1) at 20-30 DEG C to be added in the water phase that step 2) obtains, is placed in
With 40-50Hz higher-order of oscillation mixing 15-25min in supersonic generator, the sodium hyaluronate composition of the nano-emulsion form is obtained.
Beneficial effects of the present invention are as follows:
1, novel nano emulsion formulation of the invention changes the thermodynamic phase of conventional emulsion, can keep for a long time steady
It is fixed.
2, the bioaffinity of novel nano emulsion formulation of the invention increases, and active constituent is more seeped
Transdermal is to play the skin care activity of moisturizing, moisturizing.
3, the compounded formula for three kinds of active constituents being made of sodium hyaluronate, oleanolic acid and European Lee's berry extract, into one
Step increases moisturizing effect of sodium hyaluronate, can significantly improve the situation of dry skin water shortage, thus can be used for various types of
The daily nursing of skin.
For the spirit and main idea that the present invention is furture elucidated, below in conjunction with specific embodiment to of the invention preferred
Embodiment and its effect are described.It however, it should be understood that the description of these preferred embodiments is only intended to further illustrate
Illustrate the features and advantages of the present invention, and any restrictions are constituted to claim of the invention absolutely not.
Specific embodiment
Embodiment 1
Weigh middle molecule sodium hyaluronate 10g, polyethylene glycol-400 5g, oleanolic acid 3g, European Lee's berry extract 1g, olive
Oily 20g, coconut oil 10g, shea butter 10g, vitamin E 0.5g, saualane 5g, Tween 80 15g, glycerol 10g, monostearate
Glyceride 20g, 2,6- di-tert-butyl-4-methy phenol 0.4g and deionized water 90g, prepare in accordance with the following methods: 1) at 40 DEG C
It is lower that oleanolic acid, European Lee's berry extract, olive oil, coconut oil, shea butter, vitamin E, saualane, monostearate is sweet
Grease, 2,6- di-tert-butyl-4-methy phenol are sufficiently mixed, and form oily phase；2) by sodium hyaluronate, polyethylene glycol-at 40 DEG C
400, Tween 80, glycerol and deionized water are sufficiently mixed, and form water phase；3) the lower oil for obtaining step 1) is vigorously stirred at 25 DEG C
It is added in the water phase that step 2) obtains, is placed in supersonic generator with 45Hz higher-order of oscillation mixing 20min, is implemented
Sodium hyaluronate composition described in example 1.
Embodiment 2
Weigh middle molecule sodium hyaluronate 15g, polyethylene glycol-400 7g, oleanolic acid 5g, European Lee's berry extract 3g, olive
Oily 23g, coconut oil 13g, shea butter 13g, vitamin E 0.7g, saualane 7g, Tween 80 17g, glycerol 13g, monostearate
Glyceride 23g, 2,6- di-tert-butyl-4-methy phenol 0.6g and deionized water 95g, prepare in accordance with the following methods: 1) at 40 DEG C
It is lower that oleanolic acid, European Lee's berry extract, olive oil, coconut oil, shea butter, vitamin E, saualane, monostearate is sweet
Grease, 2,6- di-tert-butyl-4-methy phenol are sufficiently mixed, and form oily phase；2) by sodium hyaluronate, polyethylene glycol-at 40 DEG C
400, Tween 80, glycerol and deionized water are sufficiently mixed, and form water phase；3) the lower oil for obtaining step 1) is vigorously stirred at 25 DEG C
It is added in the water phase that step 2) obtains, is placed in supersonic generator with 45Hz higher-order of oscillation mixing 20min, is implemented
Sodium hyaluronate composition described in example 2.
Embodiment 3
Weigh middle molecule sodium hyaluronate 20g, polyethylene glycol-400 9g, oleanolic acid 7g, European Lee's berry extract 5g, olive
Oily 25g, coconut oil 15g, shea butter 15g, vitamin E 0.9g, saualane 10g, Tween 80 20g, glycerol 15g, single tristearin
Acid glyceride 25g, 2,6- di-tert-butyl-4-methy phenol 0.8g and deionized water 100g, prepare: in accordance with the following methods 1) 40
By oleanolic acid, European Lee's berry extract, olive oil, coconut oil, shea butter, vitamin E, saualane, monostearate at DEG C
Glyceride, 2,6- di-tert-butyl-4-methy phenol are sufficiently mixed, and form oily phase；2) by sodium hyaluronate, polyethylene glycol-at 40 DEG C
400, Tween 80, glycerol and deionized water are sufficiently mixed, and form water phase；3) the lower oil for obtaining step 1) is vigorously stirred at 25 DEG C
It is added in the water phase that step 2) obtains, is placed in supersonic generator with 45Hz higher-order of oscillation mixing 20min, is implemented
Sodium hyaluronate composition described in example 3.
Comparative example 1
Middle molecule sodium hyaluronate 15g is weighed, is uniformly mixed with deionized water 95g, the combination of sodium hyaluronate described in comparative example 1 is obtained
Object.
Comparative example 2
Weigh middle molecule sodium hyaluronate 15g, polyethylene glycol-400 7g, olive oil 23g, coconut oil 13g, shea butter 13g,
Vitamin E 0.7g, saualane 7g, Tween 80 17g, glycerol 13g, glycerin monostearate 23g, 2,6- di-t-butyl -4- first
Base phenol 0.6g and deionized water 95g, prepares in accordance with the following methods: 1) at 40 DEG C by olive oil, coconut oil, shea butter,
Vitamin E, saualane, glycerin monostearate, 2,6- di-tert-butyl-4-methy phenol are sufficiently mixed, and form oily phase；2) 40
Sodium hyaluronate, polyethylene glycol-400, Tween 80, glycerol and deionized water are sufficiently mixed at DEG C, form water phase；3) acutely at 25 DEG C
The oil for obtaining step 1) under stirring is added in the water phase that step 2) obtains, and is placed in supersonic generator with 45Hz high frequency
Oscillation mixing 20min, obtains sodium hyaluronate composition described in comparative example 2.
Comparative example 3
Weigh middle molecule sodium hyaluronate 15g, polyethylene glycol-400 7g, oleanolic acid 5g, olive oil 23g, coconut oil 13g, cream
The wooden fruit oil 13g, vitamin E 0.7g, saualane 7g, Tween 80 17g, glycerol 13g, bis- uncle of glycerin monostearate 23g, 2,6-
Butyl -4- methylphenol 0.6g and deionized water 95g, prepare in accordance with the following methods: 1) by oleanolic acid, olive at 40 DEG C
Oil, coconut oil, shea butter, vitamin E, saualane, glycerin monostearate, 2,6 di tert butyl 4 methyl phenol are abundant
Mixing forms oily phase；2) sodium hyaluronate, polyethylene glycol-400, Tween 80, glycerol and deionized water are sufficiently mixed at 40 DEG C,
Form water phase；3) it is vigorously stirred the lower oil for obtaining step 1) at 25 DEG C to be added in the water phase that step 2) obtains, is placed in super
With 45Hz higher-order of oscillation mixing 20min in sonic generator, sodium hyaluronate composition described in comparative example 3 is obtained.
Comparative example 4
Weigh middle molecule sodium hyaluronate 15g, polyethylene glycol-400 7g, European Lee's berry extract 3g, olive oil 23g, coconut oil
13g, shea butter 13g, vitamin E 0.7g, saualane 7g, Tween 80 17g, glycerol 13g, glycerin monostearate 23g, 2,
6- di-tert-butyl-4-methy phenol 0.6g and deionized water 95g, prepares in accordance with the following methods: 1) by European Lee fruit at 40 DEG C
Extract, olive oil, coconut oil, shea butter, vitamin E, saualane, glycerin monostearate, 2,6- di-t-butyl -4- first
Base phenol is sufficiently mixed, and forms oily phase；2) by sodium hyaluronate, polyethylene glycol-400, Tween 80, glycerol and deionized water at 40 DEG C
It is sufficiently mixed, forms water phase；3) it is vigorously stirred the lower oil for obtaining step 1) at 25 DEG C and is added to the water phase that step 2) obtains
In, it is placed in supersonic generator with 45Hz higher-order of oscillation mixing 20min, obtains sodium hyaluronate composition described in comparative example 4.
Experimental example
The purpose of this experimental example be investigate the sodium hyaluronate composition being prepared according to the method for the present invention whether have it is excellent
Different moistening effect.
1, Subjects
The women's health subject that " dry skin " type is identified as to 80 is recruited in this experiment altogether, and the age is in 32-40
Between year.Before carrying out this experiment, the subject is required to be forbidden to use any in addition to carrying out daily skin cleaning
It is other claim with moisturizing, moisture-keeping functions skin care item up to 10 days time.
2, experimental method
Using double-blind study, 80 subjects are randomly divided into 8 groups, every group of 10 people.1st group is blank control group, no
Apply any cosmetics.2nd, 3,4,5 group is experimental comparison group, applies the glass urine of comparative example 1,2,3,4 according to the present invention respectively
Acid composition.5th, 6,7 group is experimental group, applies the sodium hyaluronate group that embodiment according to the present invention 1,2,3 is prepared respectively
Close object.
Specific method of administration are as follows: after daily morning and evening cleaning skin, by about 5-8mL test sample be applied to skin of face (including
Forehead and two cheeks), and lightly pat and it is promoted to be absorbed into skin.Continuous application 30 days.
3, evaluation method
After experiment, the subject is required in inspection chamber using commercially available moisture of skin analyzerThe measurement of CM 825 is in the skin moisture content variation before experiment starts and after experiment.
4, experimental result
1 skin moisture content test result of table
| Group | Use preceding water content % | Use rear water content % |
| Blank control group | 8.57 | 8.41 |
| 1 group of comparative example | 8.45 | 10.21 |
| 2 groups of comparative example | 8.36 | 12.65 |
| 3 groups of comparative example | 8.41 | 13.87 |
| 4 groups of comparative example | 8.56 | 14.15 |
| Example 1 group | 8.51 | 18.91 |
| 2 groups of embodiment | 8.42 | 19.53 |
| 3 groups of embodiment | 8.53 | 21.15 |
The above numerical value is the average value of the water content result of each experimental group.(Student's t is examined using Student t
Test the statistical conspicuousness of the difference between each group result) is investigated, as the result is shown each embodiment group and blank control group
It compares p value < 0.05 with comparative example group, instruction difference has statistical significance.
5, it discusses
Result above demonstrates function of the sodium hyaluronate aqueous solution for the skin of subject with certain moisturizing, moisturizing
Effect, but it is limited to the larger molecular weight of sodium hyaluronate and shorter acting duration, effect are not obvious.It is prepared when by sodium hyaluronate
At nano-emulsion form sodium hyaluronate composition when, there is a tentering in the effect of moisturizing, moisturizing for the skin of subject
The promotion of degree.When further adding oleanolic acid or European Lee's berry extract into sodium hyaluronate composition, can further mention
The effect of rising moisturizing, the moisturizing of sodium hyaluronate composition.Present inventors have surprisingly found that when will be by a certain amount of sodium hyaluronate, Qi Dun
It, can be significant when the compounded formula of three kinds of active constituents of tartaric acid and European Lee's berry extract composition is applied in nano-emulsion preparation
The effect of promoting moisturizing, the moisturizing of sodium hyaluronate composition.This illustrates that there is sodium hyaluronate composition of the invention excellent skin to mend
Water, moisturizing effect, thus can be used for various skin types, especially live in hot area and with dry skin situation
The daily skin nursing of subject.
The above is only a preferred embodiment of the present invention.It should be pointed out that for the ordinary skill people of the art
For member, under the premise of not departing from spirit and principles of the present invention, several improvement, modification and equivalent replacement can also be made
Deng, these improve, modification and equivalent replacement after technical solution also should be regarded as falling within the scope and spirit of the invention.
Claims (7)
1. a kind of sodium hyaluronate composition, it is characterised in that it is the nano-emulsion be made of raw material from the following weight: sodium hyaluronate 10-
20 parts, 5-9 parts of polyethylene glycol-400,3-7 parts of oleanolic acid, European 1-5 parts of Lee's berry extract, 20-25 parts of olive oil, coconut
10-15 parts oily, 10-15 parts of shea butter, 0.5-0.9 parts of vitamin E, 5-10 parts of saualane, 15-20 parts of Tween 80, glycerol
10-15 parts, 20-25 parts of glycerin monostearate, 0.4-0.8 parts of 2,6 di tert butyl 4 methyl phenol and deionized water 90-
100 parts, preparation method are as follows:
1) by oleanolic acid, European Lee's berry extract, olive oil, coconut oil, shea butter, vitamin E, angle at 35-45 DEG C
Shark alkane, glycerin monostearate, 2,6- di-tert-butyl-4-methy phenol are sufficiently mixed, and form oily phase；
2) sodium hyaluronate, polyethylene glycol-400, Tween 80, glycerol and deionized water are sufficiently mixed at 35-45 DEG C, form water
Phase；
3) it is vigorously stirred the lower oil for obtaining step 1) at 20-30 DEG C to be added in the water phase that step 2) obtains, is placed in ultrasound
With 40-50Hz higher-order of oscillation mixing 15-25min in wave producer, the sodium hyaluronate composition of the nano-emulsion form is obtained.
2. sodium hyaluronate composition according to claim 1 is the nano-emulsion be made of raw material from the following weight: glass urine
10 parts of acid, 5 parts of polyethylene glycol-400,3 parts of oleanolic acid, European 1 part of Lee's berry extract, 20 parts of olive oil, 10 parts of coconut oil,
10 parts of shea butter, 0.5 part of vitamin E, 5 parts of saualane, 15 parts of Tween 80,10 parts of glycerol, glycerin monostearate 20
Part, 0.4 part of 2,6 di tert butyl 4 methyl phenol and 90 parts of deionized water.
3. sodium hyaluronate composition according to claim 1 is the nano-emulsion be made of raw material from the following weight: glass urine
15 parts of acid, 7 parts of polyethylene glycol-400,5 parts of oleanolic acid, European 3 parts of Lee's berry extract, 23 parts of olive oil, 13 parts of coconut oil,
13 parts of shea butter, 0.7 part of vitamin E, 7 parts of saualane, 17 parts of Tween 80,13 parts of glycerol, glycerin monostearate 23
Part, 0.6 part of 2,6 di tert butyl 4 methyl phenol and 95 parts of deionized water.
4. sodium hyaluronate composition according to claim 1 is the nano-emulsion be made of raw material from the following weight: glass urine
20 parts of acid, 9 parts of polyethylene glycol-400,7 parts of oleanolic acid, European 5 parts of Lee's berry extract, 25 parts of olive oil, 15 parts of coconut oil,
15 parts of shea butter, 0.9 part of vitamin E, 10 parts of saualane, 20 parts of Tween 80,15 parts of glycerol, glycerin monostearate 25
Part, 0.8 part of 2,6 di tert butyl 4 methyl phenol and 100 parts of deionized water.
5. sodium hyaluronate composition according to claim 1-4, wherein the sodium hyaluronate is that have 100,0000-
The middle molecule sodium hyaluronate of the molecular weight of 180,0000 dalton.
6. sodium hyaluronate composition according to claim 1-4, wherein Europe Lee's berry extract is according to following
Method preparation: taking the fruit of European Lee, is enucleated, and pulp is squeezed into pulp with juice extractor, corresponds to 5 ml 70v/v% according to 1g pulp
70v/v% ethyl alcohol is added in the ratio of ethyl alcohol, impregnates 2-3 days at room temperature, filtering, then under 45 DEG C of bath temperatures revolving to doing,
Obtain European Lee's berry extract.
7. a kind of method for being used to prepare sodium hyaluronate composition according to claim 1-4, the method includes
Following steps:
1) by oleanolic acid, European Lee's berry extract, olive oil, coconut oil, shea butter, vitamin E, angle at 35-45 DEG C
Shark alkane, glycerin monostearate, 2,6- di-tert-butyl-4-methy phenol are sufficiently mixed, and form oily phase；
2) sodium hyaluronate, polyethylene glycol-400, Tween 80, glycerol and deionized water are sufficiently mixed at 35-45 DEG C, form water
Phase；
3) it is vigorously stirred the lower oil for obtaining step 1) at 20-30 DEG C to be added in the water phase that step 2) obtains, is placed in ultrasound
With 40-50Hz higher-order of oscillation mixing 15-25min in wave producer, the sodium hyaluronate composition of the nano-emulsion form is obtained.
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| CN110664733A (en) * | 2019-10-09 | 2020-01-10 | 华欧研创生物科技(深圳)有限公司 | Hyaluronic acid nanoemulsion gel for nursing female vagina |
| CN114099552A (en) * | 2021-12-09 | 2022-03-01 | 武汉自然萃创新科技有限公司 | Preparation method of hyaluronic acid honey dew |
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| JP2006124322A (en) * | 2004-10-28 | 2006-05-18 | Takasago Internatl Corp | Hyaluronidase inhibitor, skin care composition for external use containing the hyaluronidase inhibitor, and oral composition containing the same |
| CN107582438A (en) * | 2017-10-24 | 2018-01-16 | 深圳市仙迪化妆品有限公司 | A kind of skin moisturizing cosmetics composition and its preparation technology containing shea butter |
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| JP2006124322A (en) * | 2004-10-28 | 2006-05-18 | Takasago Internatl Corp | Hyaluronidase inhibitor, skin care composition for external use containing the hyaluronidase inhibitor, and oral composition containing the same |
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| CN110664733A (en) * | 2019-10-09 | 2020-01-10 | 华欧研创生物科技(深圳)有限公司 | Hyaluronic acid nanoemulsion gel for nursing female vagina |
| CN114099552A (en) * | 2021-12-09 | 2022-03-01 | 武汉自然萃创新科技有限公司 | Preparation method of hyaluronic acid honey dew |
| CN114099552B (en) * | 2021-12-09 | 2023-09-01 | 武汉自然萃创新科技有限公司 | Preparation method of hyaluronic acid honeydew |
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