CN109464295A - A kind of skin care compositions and methods of the fucose containing low molecular weight - Google Patents
A kind of skin care compositions and methods of the fucose containing low molecular weight Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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Abstract
The invention discloses a kind of skin care compositions and methods of fucose containing low molecular weight.The skin care compositions and methods include the deionized water of 0.01%~20.0% fucose, 2.0%~10.0% surfactant, 0.2%~1.0% stabilizer, 10.0%~30.0% emollient, 0.6%~2.0% preservative, 0.1%~1.0% essence and surplus.The fucose, it is characterized in that average molecular weight is 1000Da or less.Low molecule fucose remains the original bioactivity of polysaccharide, has good moisturizing, oxidation resistance, and good penetrability, can pass through keratoderma, act on corium confluent monolayer cells, stimulate the regeneration of skin.Skin care compositions and methods of the invention can effectively improve the activity of dermis of skin cell, promote the expression of cell collagen albumen, mitigate cutis laxa, dim senile symptom.
Description
Technical field
The present invention relates to a kind of skin care compositions and methods containing oligosaccharides, more particularly to a kind of fucose containing low molecular weight
Skin care compositions and methods, belong to personal-care supplies technical field.
Background technique
With advancing age and the exacerbation of problem of environmental pollution, human skin cell's vigor gradually weaken, glue in cell
The decomposition rate of former albumen is greater than generating rate, therefore skin starts wrinkle occur and tarnish, and the symptom of aging is presented, therefore
The process of the highly desirable nursing materials energy delay skin aging for being reduced wrinkle of skin, promoting skin gloss of consumer.
Polysaccharide from marine organisms has a variety of physiological active functions, is the hot spot of current Natural products research exploitation,
The wherein polyoses extract from seaweed or sea cucumber --- fucoidin, have been shown to have anticoagulation, antitumor, antithrombotic,
The multiple functions such as antiviral, anti-oxidant and enhancing human body immune function, but fucoidin molecular weight is excessive, is unfavorable for human body suction
It receives and utilizes, especially as cosmetic material in use, excessive molecular weight makes active constituent only reside within keratoderma,
And the living cells that cannot be introduced into skin corium plays a role, it is therefore desirable to which fucoidin is hydrolyzed into suitable molecular weight, Cai Nenggeng
Its effect is played well.
There is anti-oxidant, active cell vigor characteristic using fucose, exploitation has effects that the makeup of skin nursing
Product are able to satisfy demand of the current consumer to delay skin aging symptom, have a vast market foreground.
Summary of the invention
The object of the present invention is to provide a kind of skin care compositions and methods of fucose containing low molecular weight, the composition can promote
Into the generation of Skin Cell collagen, has and reduce wrinkle of skin, promote skin gloss, the effect of delay skin aging.
To achieve the above object, the present invention provides a kind of skin care compositions and methods of fucose containing low molecular weight, by weight
It measures percentage to calculate, is to be made of the following components:
0.01%~10.0% fucose, 2.0%~10.0% surfactant, 0.2%~1.0% stabilization
Agent, 10.0%~30.0% emollient, 0.6%~2.0% preservative, 0.1%~1.0% essence and surplus go from
Sub- water.
Furthermore, the skin care compositions and methods of present invention fucose containing low molecular weight, count by weight percentage,
It is to be made of the following components:
0.1%~10.0% fucose, 5.0%~8.0% surfactant, 0.5%~1.0% stabilization
Agent, 20.0%~30.0% emollient, 0.6%~1.0% preservative, 0.1%~0.5% essence and surplus go from
Sub- water.
Skin care compositions and methods of the invention, the fucose are the average molecular weight that fucoidin passes through that hydrolysis obtains
Oligosaccharides less than 1000Da, preparation process are as follows:
1) initial hydrolysis of fucosan: fucosan is dissolved in dilute acid soln, in boiling water bath, hydrolyzes 3-10h, then
Neutrality is adjusted with lye, obtains fucosan just hydrolyzate；
2) enzymatic hydrolysis of fucosan: at 30~35 DEG C, water at the beginning of fucosan is added in suitable fucoidan
Liquid is solved, 1-5h is hydrolyzed, obtains fucose hydrolyzate；
3) dialysis separation: it is less than the fucose of 1000Da with dialysis UF membrane fucose hydrolyzate middle-molecular-weihydroxyethyl；
4) dry: dialyzate being spray-dried, fucose powder is obtained.
Skin care compositions and methods of the invention, the additive amount of the fucose are 0.1%~10.0%.
Skin care compositions and methods of the invention, the fucoidin are also known as fucosan, fucoidin sulfuric ester, Mo Jiao
Polysaccharides, fucoidan, fucoidin can derive from sea cucumber, seaweed.
Skin care compositions and methods of the invention, the molecular weight preferred scope of the fucose are 500~1000Da.
Skin care compositions and methods of the invention, the surfactant are high-carbon fatty alcohol polyoxyethylene ether class, ethyoxyl
Change methyl esters glucoside stearic acid esters, polyoxyethylene sorbitan monostearate class, fatty acid glycerine esters, lecithin
One or more of combination.
Skin care compositions and methods of the invention, the stabilizer are xanthan gum, in cellulose, acrylic acid (ester) analog copolymer
A combination of one or more.
Skin care compositions and methods of the invention, the emollient are White Mineral Oil, vaseline, lanolin, jojoba oil, almond
The combination of one or more of oil, diglycerol, glycerol, D-sorbite, propylene glycol, silicone oil, ethoxy urea.
Skin care compositions and methods of the invention, the preservative are Sensiva SC50, Phenoxyethanol, acyl in DMDM second
The group of one or more of urea, benzoic acid (sodium), parabens, polyalcohol, iodopropynyl butyl formate
It closes.
The skin care compositions and methods of present invention fucose containing low molecular weight can be made into toner, facial treatment essence liquid, lotion
Or the various dosage forms such as cream.
The skin care compositions and methods of present invention fucose containing low molecular weight can be prepared by technique below:
1) A phase: low weight molecular fucoidan of the invention is dissolved in deionized water, is warming up to 85 DEG C, spare；
2) B phase: being warming up to 85 DEG C for the stirring of surfactant, stabilizer, emollient and deionization, spare；
3) solution of A phase is added in B phase, insulated and stirred 30 minutes, homogeneous 3 minutes；
4) be cooled to 45 DEG C, preservative be added, continue stirring 30 minutes to get.
The skin care compositions and methods of present invention fucose containing low molecular weight have the following technical effect that
1) the present inventor has largely studied the effect of skin fucoidin, fucose, as a result
Display fucoidin, fucose can promote the generation of cell collagen albumen；
2) relative to fucoidin, fucose is applied in cosmetic material, can be by keratoderma, into corium
In layer, dermal cell is acted on, thus can more effectively promote the generation of Skin Cell collagen, has and reduces skin wrinkle
Line promotes skin gloss, the effect of delay skin aging.
Detailed description of the invention
The anti-oxidant experimental result picture of fucose is shown in Fig. 1.
Fig. 2 is shown fucose and promotes fibroblastic collagen synthesis effect picture.
Specific embodiment
Below by specific preferred embodiment combination attached drawing, the present invention is described in further detail, but reality of the invention
It is without being limited thereto to apply mode.
Sour initial hydrolysis, enzyme of the fucose through fucoidin in the present invention degrade, dialysis separation, are spray-dried and obtain
, the fucoidin that the present invention uses is also known as fucosan, fucoidin sulfuric ester, fucoidin, sulfated fucan
Ester, fucoidin derive from sea cucumber, seaweed.
Fucose of the invention is shown in specific preparation process is as follows:
1) initial hydrolysis of fucosan: 20g fucosan is dissolved in the dilute acid soln of 250ml, in boiling water bath, hydrolysis
Then 4-8h adjusts neutrality with lye, obtain fucosan just hydrolyzate 270g；
2) enzymatic hydrolysis of fucosan: at 30~35 DEG C, by 4 × 105Fucosan is added in the fucosan sulfatase of U
First hydrolyzate hydrolyzes 3h, obtains fucose hydrolyzate；
3) dialysis separation: it is less than the fucose of 1000Da with dialysis UF membrane fucose hydrolyzate middle-molecular-weihydroxyethyl；
4) dry: dialyzate being spray-dried, low molecular weight fucose powder 14.2g is obtained.
Unless stated otherwise, all percentages of the invention are all calculated with the mass percentage of composition, all proportions
It is mass percent.
Various test apparatuses and reagent are commercial goods, are that can buy to obtain by commercial sources.
Embodiment 1
A kind of facial treatment essence liquid of the fucose containing low molecular weight, each raw material and weight percent are as follows:
Preparation process is as follows:
1, xanthan gum is dissolved in the mixed liquor of diglycerol, propylene glycol, glycerol, stirring is warming up to 80-85 DEG C, insulated and stirred
20-30min；Appropriate amount of deionized water is added, continues to be uniformly mixed；
2, it is cooled to 40-45 DEG C, investment lecithin, fucose, Phenoxyethanol, Sensiva SC50, essence and residue
Deionized water, stir 30-50min.
Embodiment 2
A kind of facial treatment milk of the fucose containing low molecular weight, each raw material and weight percent are as follows:
Preparation process is as follows:
1) water phase configure: disperse hydroxyethyl cellulose in glycerol, add diglycerol, fucose, EDTA-2Na,
Deionized water, stirring are warming up to 80-85 DEG C, insulated and stirred 20-30min；
2) oily phase configuration: by tween, glycerin monostearate, lanolin, Miglyol 812N, White Mineral Oil, silicone oil,
Acrylic acid (ester) analog copolymer, methylparaben, propylben stirring are warming up to 80-85 DEG C, insulated and stirred 20-30min；
3) at 80-85 DEG C, stirring and emulsifying 10-15min during the oil phase is added to the aqueous phase, then homogeneous 4-6min；
4) slow cooling is to 45 DEG C hereinafter, addition essence, continues to stir 30-40min.
Embodiment 3
A kind of cream of the fucose containing low molecular weight, each raw material and weight percent are as follows:
Preparation process is as follows:
1) water phase configures: dispersing xanthan gum in glycerol, adds ethoxy urea, fucose, EDTA-2Na, goes
Ionized water, stirring are warming up to 80-85 DEG C, insulated and stirred 20-30min；
2) oily phase configuration: by tween, glycerin monostearate, lanolin, Miglyol 812N, White Mineral Oil, silicone oil,
The stirring of acrylic acid (ester) analog copolymer is warming up to 80-85 DEG C, insulated and stirred 20-30min；
3) at 80-85 DEG C, stirring and emulsifying 10-15min during the oil phase is added to the aqueous phase, then homogeneous 4-6min；
4) slow cooling is to 45 DEG C hereinafter, addition pentanediol, Phenoxyethanol, essence, continue to stir 30-40min.
The following are the contents of effect experimental examples.
Effect experimental examples 1
1, anti-oxidant experiment
Its inoxidizability ability is measured using ORAC method.When being detected in microplate reader, the time interval of detection is set
For 1min, 90min is detected altogether.
Testing result discovery, the fucose prepared by the method for the invention, inoxidizability are significantly higher than fucoidin,
This is because the oligosaccharides of small molecule has more reducing ends to be exposed, therefore under same concentrations, the inoxidizability of fucose
It can greatly promote (see attached drawing 1), this also complies with thinking of the invention.
Effect experimental examples 2
2, fucose promotes fibroblastic collagen synthesis effect
By the normal skin fibroblast in logarithmic growth phase with 5 × 104The density in/hole is inoculated in 24 orifice plates, for 24 hours
After cell is adherent, supernatant is sucked out, changes to plasma-free DMEM medium, continue culture makes cell synchronization for 24 hours.
Then, the control group serum and processing group for being separately added into different volumes contain Sample serum, and (note: sample is respectively TGF-
β (15ng/mL), 1 facial treatment essence liquid of embodiment, the facial treatment essence liquid (blank group) not containing low weight molecular fucoidan of the present invention).
37 DEG C, 5%CO2Incubator culture 72h.It is handled by the detecting step of cell culture supernatant Hyp testing cassete, with light splitting
Photometer surveys each pipe absorbance (A) value at 560nm wavelength.
Hyp mass concentration (mg/L)=(measurement pipe A- blank tube A)/(standard pipe A- blank tube A) × standard pipe concentration
(5mg/L) × extension rate.
Experimental result is shown in attached drawings 2.From Figure 2 it can be seen that with blank group comparison it can be found that the facial treatment essence liquid pair of embodiment 1
The expression of Collagen of Fibroblasts albumen has apparent facilitation, and the enhancing rate of TGF-β (15ng/mL) is 36%, and is implemented
The enhancing rate of the facial treatment essence liquid of example 1 is 47%, shows the facial treatment essence liquor ratio TGF-β (15ng/mL) of embodiment 1 at fiber
The facilitation of the expression of the collagen of cell is stronger, to effectively prove that the present invention has the skin care function for mitigating cutis laxa
Effect.
Effect experimental examples 3
3, normal individual trial is tested
Collection aspiration subject 60, the age 40-55 years old, men and women was fifty-fifty, without any skin disease or skin allergy history；It surveys
Start within examination first 2 days and test process must not be using any cosmetics outside test sample；After subject's warm water cleaning face, one
Side face uses the facial treatment milk (experimental group) of embodiment 2, and another side face uses the control lotion without fucose of the present invention (empty
White control group), it is once in the morning and once at night, continuous 4 weeks on probation.
Evaluation criterion:
Subject makes evaluation to autologous skin change:
Effect is obvious: being significantly reduced or is disappeared using rear wrinkle of skin, skin shine significantly improves；
It is effective: to be reduced using rear wrinkle of skin, all promotions of skin shine；
Effect is unobvious: having no reduction using rear wrinkle of skin, skin shine has no change；
1 normal individual trial result of table
| Group | Total number of persons | Effect is obvious | It is effective | Effect is unobvious | Total effective rate (%) |
| Experimental group | 30 | 15 | 13 | 2 | 93.3 |
| Blank control group | 30 | 3 | 8 | 19 | 36.7 |
Can be obtained by the test result of table 1: 93.3% subject is after using the facial treatment milk containing fucose, skin
The index of skin is significantly improved, and comparison is free of the facial treatment milk of fucose, and significant difference illustrates containing rock of the present invention
The facial treatment milk of algae oligosaccharides can improve the facial wrinkles of user really, promote skin shine, reduce skin ageing symptoms, make
Skin seems younger, vibrant.
The above described is only a preferred embodiment of the present invention, be not intended to limit the present invention in any form, therefore
Without departing from the technical solutions of the present invention, to the above embodiments according to the technical essence of the invention any simply to repair
Change, equivalent variations and modification, all of which are still within the scope of the technical scheme of the invention.
Claims (10)
1. a kind of skin care compositions and methods of fucose containing low molecular weight, which is characterized in that count by weight percentage, be by
Following components is made:
0.01%~20.0% fucose, 2.0%~10.0% surfactant, 0.2%~1.0% stabilizer,
10.0%~30.0% emollient, 0.6%~2.0% preservative, 0.1%~1.0% essence and surplus deionization
Water.
2. the skin care compositions and methods of the fucose according to claim 1 containing low molecular weight, it is characterised in that:, by weight
It measures percentage to calculate, is to be made of the following components:
0.1%~10.0% fucose, 5.0%~8.0% surfactant, 0.5%~1.0% stabilizer,
20.0%~30.0% emollient, 0.6%~1.0% preservative, 0.1%~0.5% essence and surplus deionization
Water.
3. the skin care compositions and methods of the fucose according to claim 1 containing low molecular weight, it is characterised in that:
The fucose is the oligosaccharides that fucoidin is less than 1000Da by the average molecular weight that hydrolysis obtains, preparation process
It is as follows:
1) initial hydrolysis of fucosan: fucosan is dissolved in dilute acid soln, in boiling water bath, is hydrolyzed 3-10h, is then used alkali
Liquid adjusts neutrality, obtains fucosan just hydrolyzate；
2) enzymatic hydrolysis of fucosan: at 30~35 DEG C, hydrolyzate at the beginning of fucosan is added in suitable fucoidan,
1-5h is hydrolyzed, fucose hydrolyzate is obtained；
3) dialysis separation: it is less than the fucose of 1000Da with dialysis UF membrane fucose hydrolyzate middle-molecular-weihydroxyethyl；
4) dry: dialyzate being spray-dried, fucose powder is obtained.
4. the skin care compositions and methods of the fucose according to claim 3 containing low molecular weight, it is characterised in that: the rock
Polysaccharides be any one of fucosan, fucoidin sulfuric ester, fucoidin, fucoidan, fucoidin,
Sea cucumber, seaweed can be derived from.
5. the skin care compositions and methods of the fucose according to claim 1 containing low molecular weight, it is characterised in that: the rock
The molecular weight preferred scope of algae oligosaccharides is 500~1000Da.
6. the skin care compositions and methods of the fucose according to claim 1 containing low molecular weight, it is characterised in that: the table
Face activating agent is high-carbon fatty alcohol polyoxyethylene ether class, ethoxylation methyl esters glucoside stearic acid esters, polyoxyethylene
The combination of one or more of sugar alcohol acid anhydride monostearate esters, fatty acid glycerine esters, lecithin；
The stabilizer is the combination of one or more of xanthan gum, cellulose, acrylic acid (ester) analog copolymer；
The emollient is White Mineral Oil, vaseline, lanolin, jojoba oil, apricot kernel oil, diglycerol, glycerol, D-sorbite, third
The combination of one or more of glycol, silicone oil, ethoxy urea；
The preservative is Sensiva SC50, Phenoxyethanol, DMDM hydantoin, benzoic acid (sodium), parabens, polynary
The combination of one or more of alcohol, iodopropynyl butyl formate.
7. the skin care compositions and methods of the fucose according to claim 1 containing low molecular weight, it is characterised in that: the skin
Skin care composition can be toner, facial treatment essence liquid, lotion or cream.
8. the skin care compositions and methods of the fucose according to claim 7 containing low molecular weight, it is characterised in that: the shield
Skin Essence is prepared by following technique:
1) xanthan gum is dissolved in the mixed liquor of diglycerol, propylene glycol, glycerol, stirring is warming up to 80-85 DEG C, insulated and stirred 20-
30min；Appropriate amount of deionized water is added, continues to be uniformly mixed；
2) it is cooled to 40-45 DEG C, investment lecithin, fucose, Phenoxyethanol, Sensiva SC50, essence and remaining goes
Ionized water, stir 30-50min to get.
9. the skin care compositions and methods of the fucose according to claim 7 containing low molecular weight, it is characterised in that: the shield
Skin lotion is prepared by following technique:
1) water phase configure: disperse hydroxyethyl cellulose in glycerol, add diglycerol, fucose, EDTA-2Na, go from
Sub- water, stirring are warming up to 80-85 DEG C, insulated and stirred 20-30min；
2) oily phase configuration: by tween, glycerin monostearate, lanolin, Miglyol 812N, White Mineral Oil, silicone oil, propylene
Sour (ester) analog copolymer, methylparaben, propylben stirring are warming up to 80-85 DEG C, insulated and stirred 20-30min；
3) at 80-85 DEG C, stirring and emulsifying 10-15min during the oil phase is added to the aqueous phase, then homogeneous 4-6min；
4) slow cooling is to 45 DEG C hereinafter, addition essence, continues to stir 30-40min.
10. the skin care compositions and methods of the fucose according to claim 7 containing low molecular weight, it is characterised in that: described
Cream is prepared by following technique:
1) water phase configures: dispersing xanthan gum in glycerol, adds ethoxy urea, fucose, EDTA-2Na, deionization
Water, stirring are warming up to 80-85 DEG C, insulated and stirred 20-30min；
2) oily phase configuration: by tween, glycerin monostearate, lanolin, Miglyol 812N, White Mineral Oil, silicone oil, propylene
Sour (ester) analog copolymer stirring is warming up to 80-85 DEG C, insulated and stirred 20-30min；
3) at 80-85 DEG C, stirring and emulsifying 10-15min during the oil phase is added to the aqueous phase, then homogeneous 4-6min；
4) slow cooling is to 45 DEG C hereinafter, addition pentanediol, Phenoxyethanol, essence, continue to stir 30-40min.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109970823A (en) * | 2019-05-07 | 2019-07-05 | 青岛农业大学 | A kind of fucose and its preparation method and application |
| CN110526949A (en) * | 2019-09-17 | 2019-12-03 | 烟台新时代健康产业日化有限公司 | A kind of preparation method of the fine and soft anti-oxidant oligosaccharides in sea |
| CN111096922A (en) * | 2020-02-26 | 2020-05-05 | 钟达金 | Moisturizing and antioxidant essence and preparation method thereof |
| CN111529543A (en) * | 2019-12-31 | 2020-08-14 | 蓝脑科技(厦门)有限公司 | Anti-acne fucoxanthin-agar oligosaccharide composition, preparation method and application thereof |
| CN111990403A (en) * | 2020-09-08 | 2020-11-27 | 北京雷力海洋生物新产业股份有限公司 | Brown algae double-oligoglycoprotein composition, preparation method and application thereof |
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| CN111096922B (en) * | 2020-02-26 | 2020-10-30 | 佛山天韵化妆品科技有限公司 | Moisturizing and antioxidant essence and preparation method thereof |
| CN111990403A (en) * | 2020-09-08 | 2020-11-27 | 北京雷力海洋生物新产业股份有限公司 | Brown algae double-oligoglycoprotein composition, preparation method and application thereof |
| CN111990403B (en) * | 2020-09-08 | 2022-03-25 | 北京雷力海洋生物新产业股份有限公司 | Brown algae double-oligoglycoprotein composition, preparation method and application thereof |
| CN113143794A (en) * | 2021-03-03 | 2021-07-23 | 青岛明月藻酸盐组织工程材料有限公司 | Bionic petal with multiple effects and preparation method thereof |
| CN117624406A (en) * | 2023-12-13 | 2024-03-01 | 山东尔雅基因科技有限公司 | Preparation method of modified polysaccharide and application of modified polysaccharide in skin care ointment |
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