CN110139871A - 用于治疗中风和相关凝血障碍的凝血酶抑制剂 - Google Patents

用于治疗中风和相关凝血障碍的凝血酶抑制剂 Download PDF

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Publication number
CN110139871A
CN110139871A CN201780078158.2A CN201780078158A CN110139871A CN 110139871 A CN110139871 A CN 110139871A CN 201780078158 A CN201780078158 A CN 201780078158A CN 110139871 A CN110139871 A CN 110139871A
Authority
CN
China
Prior art keywords
thrombin
peptide
seq
inhibitor
exosite
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201780078158.2A
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English (en)
Chinese (zh)
Inventor
R·J·佩恩
S·P·杰克逊
佩雷拉 P·J·巴博萨
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
The University of Sydney
Original Assignee
The University of Sydney
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2016905231A external-priority patent/AU2016905231A0/en
Application filed by The University of Sydney filed Critical The University of Sydney
Publication of CN110139871A publication Critical patent/CN110139871A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicinal Preparation (AREA)
CN201780078158.2A 2016-12-16 2017-12-15 用于治疗中风和相关凝血障碍的凝血酶抑制剂 Pending CN110139871A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AU2016905231 2016-12-16
AU2016905231A AU2016905231A0 (en) 2016-12-16 Thrombin inhibitors for treatment of stroke and related coagulative disorders
PCT/AU2017/051405 WO2018107247A1 (en) 2016-12-16 2017-12-15 Thrombin inhibitors for treatment of stroke and related coagulative disorders

Publications (1)

Publication Number Publication Date
CN110139871A true CN110139871A (zh) 2019-08-16

Family

ID=62557849

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201780078158.2A Pending CN110139871A (zh) 2016-12-16 2017-12-15 用于治疗中风和相关凝血障碍的凝血酶抑制剂

Country Status (8)

Country Link
US (1) US11091535B2 (cg-RX-API-DMAC7.html)
EP (1) EP3555116A4 (cg-RX-API-DMAC7.html)
JP (2) JP2020501561A (cg-RX-API-DMAC7.html)
CN (1) CN110139871A (cg-RX-API-DMAC7.html)
AU (1) AU2017376839B2 (cg-RX-API-DMAC7.html)
CA (1) CA3047159A1 (cg-RX-API-DMAC7.html)
NZ (1) NZ754781A (cg-RX-API-DMAC7.html)
WO (1) WO2018107247A1 (cg-RX-API-DMAC7.html)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110590911A (zh) * 2019-09-30 2019-12-20 华南理工大学 一种含酪氨酸硫酸化修饰的多肽合成方法及其应用
CN114887123A (zh) * 2022-04-18 2022-08-12 南通大学 水蛭素接枝纳米纤维血管支架材料、制备方法与应用
CN119462906A (zh) * 2024-11-11 2025-02-18 武汉元启合生科技有限公司 一种酪氨酸硫酸化的重组水蛭素、制备方法及其用途

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20230416341A1 (en) * 2020-06-19 2023-12-28 The University Of Sydney Improved thrombin inhibitors for treatment of thromboembolic conditions

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001000667A2 (en) * 1999-06-29 2001-01-04 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anti-thrombin peptide from anopheles albimanus salivary gland
CN101029079A (zh) * 2006-07-31 2007-09-05 浙江中医药大学 硫酸化丝素蛋白的制备方法及其在抗凝血药物上的应用
CN102026652A (zh) * 2007-06-18 2011-04-20 自然环境研究会 凝血酶抑制剂
CN102574909A (zh) * 2009-05-05 2012-07-11 自然环境研究会 修饰丝氨酸蛋白酶抑制剂的方法

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DE4323754C1 (de) * 1993-07-15 1994-12-01 Gruenenthal Gmbh Bifunktionelle Urokinasevarianten mit verbesserten fibrinolytischen Eigenschaften und thrombinhemmender Wirkung
US6759384B1 (en) * 1994-04-26 2004-07-06 Aventis Pharmaceuticals Inc. Factor Xa inhibitors
EP1240194A2 (en) 1999-11-24 2002-09-18 Sugen, Inc. Novel human protein kinases and protein kinase-like enzymes
EP1425296B1 (de) * 2001-09-10 2011-04-13 Novel Science International GmbH Organische verbindungen mit biologischer wirkung als thrombinhemmer und ihre verwendung
JP3648548B2 (ja) * 2001-10-15 2005-05-18 国立大学法人三重大学 血液凝固阻害活性を有するハマダラカ由来のＡｓ−１蛋白質
DE10301255A1 (de) * 2003-01-15 2004-07-29 Cpi Creative Pharma International Gmbh Organische Verbindungen mit biologischer Wirkung als Thrombinhemmer und ihre Verwendung
EP1856147A4 (en) 2005-02-15 2008-07-02 Apollo Life Sciences Ltd MOLECULE AND CHIMESE MOLECULES THEREOF
US20070298034A9 (en) * 2005-12-09 2007-12-27 Angela Widom Sulfotyrosine specific antibodies and uses therefor
WO2012024543A1 (en) 2010-08-18 2012-02-23 Caris Life Sciences Luxembourg Holdings Circulating biomarkers for disease
US9777123B2 (en) * 2013-05-30 2017-10-03 Virginia Commonwealth University Sulfated beta-O4 low molecular weight lignins
DK3004134T3 (da) 2013-06-04 2019-05-13 Univ Sydney Peptid-ligering
US11279771B2 (en) 2014-09-17 2022-03-22 Novo Nordisk A/S Antibodies capable of binding two epitopes on tissue factor pathway inhibitor (1-161)
US20230416341A1 (en) * 2020-06-19 2023-12-28 The University Of Sydney Improved thrombin inhibitors for treatment of thromboembolic conditions

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001000667A2 (en) * 1999-06-29 2001-01-04 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anti-thrombin peptide from anopheles albimanus salivary gland
CN101029079A (zh) * 2006-07-31 2007-09-05 浙江中医药大学 硫酸化丝素蛋白的制备方法及其在抗凝血药物上的应用
CN102026652A (zh) * 2007-06-18 2011-04-20 自然环境研究会 凝血酶抑制剂
CN102574909A (zh) * 2009-05-05 2012-07-11 自然环境研究会 修饰丝氨酸蛋白酶抑制剂的方法

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ANA C. FIGUEIREDO等: "The Tick-Derived Anticoagulant Madanin Is Processed by Thrombin and Factor Xa", PLOS ONE, vol. 8, no. 8, pages 1 - 11 *
ANA C. FIGUEIREDO等: "Unique thrombin inhibition mechanism by anophelin,an anticoagulant from the malaria vector", 《PNAS》 *
ANA C. FIGUEIREDO等: "Unique thrombin inhibition mechanism by anophelin,an anticoagulant from the malaria vector", 《PNAS》, 5 December 2012 (2012-12-05), pages 3649 *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110590911A (zh) * 2019-09-30 2019-12-20 华南理工大学 一种含酪氨酸硫酸化修饰的多肽合成方法及其应用
CN110590911B (zh) * 2019-09-30 2021-10-22 华南理工大学 一种含酪氨酸硫酸化修饰的多肽合成方法及其应用
CN114887123A (zh) * 2022-04-18 2022-08-12 南通大学 水蛭素接枝纳米纤维血管支架材料、制备方法与应用
CN114887123B (zh) * 2022-04-18 2023-07-04 南通大学 水蛭素接枝纳米纤维血管支架材料、制备方法与应用
CN119462906A (zh) * 2024-11-11 2025-02-18 武汉元启合生科技有限公司 一种酪氨酸硫酸化的重组水蛭素、制备方法及其用途
CN119462906B (zh) * 2024-11-11 2026-06-05 北京元启合生科技有限公司 一种酪氨酸硫酸化的重组水蛭素、制备方法及其用途

Also Published As

Publication number Publication date
EP3555116A1 (en) 2019-10-23
US20190367583A1 (en) 2019-12-05
NZ754781A (en) 2021-12-24
JP2022130527A (ja) 2022-09-06
AU2017376839A1 (en) 2019-07-11
CA3047159A1 (en) 2018-06-21
AU2017376839B2 (en) 2021-01-14
JP2020501561A (ja) 2020-01-23
WO2018107247A1 (en) 2018-06-21
EP3555116A4 (en) 2020-07-22
US11091535B2 (en) 2021-08-17

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Application publication date: 20190816