CA3047159A1 - Thrombin inhibitors for treatment of stroke and related coagulative disorders - Google Patents

Thrombin inhibitors for treatment of stroke and related coagulative disorders Download PDF

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Publication number
CA3047159A1
CA3047159A1 CA3047159A CA3047159A CA3047159A1 CA 3047159 A1 CA3047159 A1 CA 3047159A1 CA 3047159 A CA3047159 A CA 3047159A CA 3047159 A CA3047159 A CA 3047159A CA 3047159 A1 CA3047159 A1 CA 3047159A1
Authority
CA
Canada
Prior art keywords
thrombin
peptide
seq
inhibitor
exosite
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3047159A
Other languages
English (en)
French (fr)
Inventor
Richard J. Payne
Shaun Phillip Jackson
Pedro Jose BARBOSA PEREIRA
Original Assignee
The University of Sydney
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2016905231A external-priority patent/AU2016905231A0/en
Application filed by The University of Sydney filed Critical The University of Sydney
Publication of CA3047159A1 publication Critical patent/CA3047159A1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicinal Preparation (AREA)
CA3047159A 2016-12-16 2017-12-15 Thrombin inhibitors for treatment of stroke and related coagulative disorders Pending CA3047159A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AU2016905231 2016-12-16
AU2016905231A AU2016905231A0 (en) 2016-12-16 Thrombin inhibitors for treatment of stroke and related coagulative disorders
PCT/AU2017/051405 WO2018107247A1 (en) 2016-12-16 2017-12-15 Thrombin inhibitors for treatment of stroke and related coagulative disorders

Publications (1)

Publication Number Publication Date
CA3047159A1 true CA3047159A1 (en) 2018-06-21

Family

ID=62557849

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3047159A Pending CA3047159A1 (en) 2016-12-16 2017-12-15 Thrombin inhibitors for treatment of stroke and related coagulative disorders

Country Status (8)

Country Link
US (1) US11091535B2 (cg-RX-API-DMAC7.html)
EP (1) EP3555116A4 (cg-RX-API-DMAC7.html)
JP (2) JP2020501561A (cg-RX-API-DMAC7.html)
CN (1) CN110139871A (cg-RX-API-DMAC7.html)
AU (1) AU2017376839B2 (cg-RX-API-DMAC7.html)
CA (1) CA3047159A1 (cg-RX-API-DMAC7.html)
NZ (1) NZ754781A (cg-RX-API-DMAC7.html)
WO (1) WO2018107247A1 (cg-RX-API-DMAC7.html)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110590911B (zh) * 2019-09-30 2021-10-22 华南理工大学 一种含酪氨酸硫酸化修饰的多肽合成方法及其应用
US20230416341A1 (en) * 2020-06-19 2023-12-28 The University Of Sydney Improved thrombin inhibitors for treatment of thromboembolic conditions
CN114887123B (zh) * 2022-04-18 2023-07-04 南通大学 水蛭素接枝纳米纤维血管支架材料、制备方法与应用
CN119462906B (zh) * 2024-11-11 2026-06-05 北京元启合生科技有限公司 一种酪氨酸硫酸化的重组水蛭素、制备方法及其用途

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4323754C1 (de) * 1993-07-15 1994-12-01 Gruenenthal Gmbh Bifunktionelle Urokinasevarianten mit verbesserten fibrinolytischen Eigenschaften und thrombinhemmender Wirkung
US6759384B1 (en) * 1994-04-26 2004-07-06 Aventis Pharmaceuticals Inc. Factor Xa inhibitors
AU5903000A (en) * 1999-06-29 2001-01-31 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Novel anti-thrombin peptide
EP1240194A2 (en) 1999-11-24 2002-09-18 Sugen, Inc. Novel human protein kinases and protein kinase-like enzymes
EP1425296B1 (de) * 2001-09-10 2011-04-13 Novel Science International GmbH Organische verbindungen mit biologischer wirkung als thrombinhemmer und ihre verwendung
JP3648548B2 (ja) * 2001-10-15 2005-05-18 国立大学法人三重大学 血液凝固阻害活性を有するハマダラカ由来のＡｓ−１蛋白質
DE10301255A1 (de) * 2003-01-15 2004-07-29 Cpi Creative Pharma International Gmbh Organische Verbindungen mit biologischer Wirkung als Thrombinhemmer und ihre Verwendung
EP1856147A4 (en) 2005-02-15 2008-07-02 Apollo Life Sciences Ltd MOLECULE AND CHIMESE MOLECULES THEREOF
US20070298034A9 (en) * 2005-12-09 2007-12-27 Angela Widom Sulfotyrosine specific antibodies and uses therefor
CN100595208C (zh) * 2006-07-31 2010-03-24 浙江中医药大学 硫酸化丝素蛋白的制备方法及其在抗凝血药物上的应用
GB0711779D0 (en) * 2007-06-18 2007-07-25 Univ Singapore Thrombin inhibitor
GB0907698D0 (en) * 2009-05-05 2009-06-10 Univ Singapore Method of modifying serine protease inhibitors
WO2012024543A1 (en) 2010-08-18 2012-02-23 Caris Life Sciences Luxembourg Holdings Circulating biomarkers for disease
US9777123B2 (en) * 2013-05-30 2017-10-03 Virginia Commonwealth University Sulfated beta-O4 low molecular weight lignins
DK3004134T3 (da) 2013-06-04 2019-05-13 Univ Sydney Peptid-ligering
US11279771B2 (en) 2014-09-17 2022-03-22 Novo Nordisk A/S Antibodies capable of binding two epitopes on tissue factor pathway inhibitor (1-161)
US20230416341A1 (en) * 2020-06-19 2023-12-28 The University Of Sydney Improved thrombin inhibitors for treatment of thromboembolic conditions

Also Published As

Publication number Publication date
EP3555116A1 (en) 2019-10-23
US20190367583A1 (en) 2019-12-05
NZ754781A (en) 2021-12-24
JP2022130527A (ja) 2022-09-06
CN110139871A (zh) 2019-08-16
AU2017376839A1 (en) 2019-07-11
AU2017376839B2 (en) 2021-01-14
JP2020501561A (ja) 2020-01-23
WO2018107247A1 (en) 2018-06-21
EP3555116A4 (en) 2020-07-22
US11091535B2 (en) 2021-08-17

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