CN110139668A - 一种预防和治疗肝纤维化的方法 - Google Patents

一种预防和治疗肝纤维化的方法 Download PDF

Info

Publication number
CN110139668A
CN110139668A CN201780078166.7A CN201780078166A CN110139668A CN 110139668 A CN110139668 A CN 110139668A CN 201780078166 A CN201780078166 A CN 201780078166A CN 110139668 A CN110139668 A CN 110139668A
Authority
CN
China
Prior art keywords
plasminogen
subject
drug
fibrosis
prevention
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201780078166.7A
Other languages
English (en)
Chinese (zh)
Inventor
李季男
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tailunji International Co ltd
Original Assignee
Tailunji International Co ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tailunji International Co ltd filed Critical Tailunji International Co ltd
Publication of CN110139668A publication Critical patent/CN110139668A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/484—Plasmin (3.4.21.7)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN201780078166.7A 2016-12-15 2017-06-19 一种预防和治疗肝纤维化的方法 Pending CN110139668A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2016110174 2016-12-15
CNPCT/CN2016/110174 2016-12-15
PCT/CN2017/089056 WO2018107696A1 (zh) 2016-12-15 2017-06-19 一种预防和治疗肝纤维化的方法

Publications (1)

Publication Number Publication Date
CN110139668A true CN110139668A (zh) 2019-08-16

Family

ID=62557850

Family Applications (4)

Application Number Title Priority Date Filing Date
CN201780078166.7A Pending CN110139668A (zh) 2016-12-15 2017-06-19 一种预防和治疗肝纤维化的方法
CN201780078169.0A Pending CN110191718A (zh) 2016-12-15 2017-06-19 一种预防和治疗组织器官纤维化的方法
CN201780078132.8A Pending CN110121358A (zh) 2016-12-15 2017-06-19 一种预防和治疗肺纤维化的方法
CN201780078123.9A Pending CN110114080A (zh) 2016-12-15 2017-06-19 一种预防和治疗皮肤纤维化的方法

Family Applications After (3)

Application Number Title Priority Date Filing Date
CN201780078169.0A Pending CN110191718A (zh) 2016-12-15 2017-06-19 一种预防和治疗组织器官纤维化的方法
CN201780078132.8A Pending CN110121358A (zh) 2016-12-15 2017-06-19 一种预防和治疗肺纤维化的方法
CN201780078123.9A Pending CN110114080A (zh) 2016-12-15 2017-06-19 一种预防和治疗皮肤纤维化的方法

Country Status (7)

Country Link
US (4) US20190314466A1 (https=)
EP (4) EP3556380A4 (https=)
JP (4) JP7213552B2 (https=)
CN (4) CN110139668A (https=)
CA (3) CA3047174A1 (https=)
TW (6) TWI670075B (https=)
WO (5) WO2018107696A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7213552B2 (ja) * 2016-12-15 2023-01-27 タレンゲン インターナショナル リミテッド 肝の繊維化を予防及び治療するための方法
CA3067890A1 (en) 2017-06-19 2018-12-27 Talengen International Limited Method for regulating and controling glp-1/glp-1r and drug
TWI868051B (zh) * 2017-06-23 2025-01-01 美商波麥堤克生物治療股份有限公司 與pai-1過表現相關之病狀的纖維蛋白溶酶原治療
US20230081922A1 (en) * 2020-02-11 2023-03-16 Talengen International Limited Method and drug for treating viral pneumonia
TWI910217B (zh) * 2020-08-20 2026-01-01 大陸商深圳瑞健生命科學研究院有限公司 一種治療腫瘤的方法和藥物
CN114984032B (zh) * 2022-06-27 2023-07-07 四川大学 Dna四面体框架核酸-绿原酸复合物及其在制备治疗肝纤维化的药物中的用途

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101628113A (zh) * 2009-08-18 2010-01-20 南京农业大学 蚯蚓纤溶酶抗肝纤维化的应用
WO2012093132A1 (en) * 2011-01-05 2012-07-12 Thrombogenics Nv Plasminogen and plasmin variants

Family Cites Families (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
IE52535B1 (en) 1981-02-16 1987-12-09 Ici Plc Continuous release pharmaceutical compositions
US4645668A (en) 1983-08-04 1987-02-24 Biospecifics, Nv Method for the prevention and treatment of scars with enzymes
GB8721951D0 (en) * 1987-09-18 1987-10-28 Thrombosis Research Trust Organic compounds
ES2434840T3 (es) 1995-07-27 2013-12-17 Genentech, Inc. Formulación de proteína liofilizada isotónica estable
US6057122A (en) 1996-05-03 2000-05-02 Abbott Laboratories Antiangiogenic peptides polynucleotides encoding same and methods for inhibiting angiogenesis
JP2002510209A (ja) 1997-06-26 2002-04-02 カロリンスカ イノベイションズ アクチボラゲット インビボで血管形成を調節することができるプラスミノーゲンのクリングルドメイン１−５
WO2000010506A2 (en) 1998-08-20 2000-03-02 University Of Vermont And State Agriculture College Angiogenesis inhibitors and uses thereof
US7763580B2 (en) 1999-01-05 2010-07-27 University Of Utah Research Foundation Methods for treating conditions associated with the accumulation of excess extracellular matrix
AU2002239414A1 (en) 2000-11-02 2002-05-27 Bristol-Myers Squibb Company Modified plasminogen related peptide fragments and their use as angiogenesis inhibitors
MXPA00011713A (es) * 2000-11-28 2002-05-31 Tgt Lab S A De C V Vectores recombinantes virales y no virales conteniendo el gen humano del activador de plasminogeno derivado de urocinasa y su utilidad en el tratamiento de diversos tipos de fibrosis hepatica, renal, pulmonar, pancreatica, cardiaca y cicatrices hipe
US7067492B2 (en) 2001-09-06 2006-06-27 Omnio Ab Method of promoting healing of a tympanic membrane perforation
US20050124036A1 (en) 2002-02-06 2005-06-09 Rudy Susilo Method for producing recombinant proteins in micro-organisms
MXPA04007585A (es) * 2002-02-06 2005-09-20 N Zyme Biotec Gmbh Metodo para la produccion de proteinas recombinantes en microorganismos.
JP2006507297A (ja) 2002-05-13 2006-03-02 チルドレンズ・ホスピタル・ロサンジェルス ケロイドおよび他の皮膚または内部創傷または病変における異常瘢痕形成の処置および予防
CA2509170A1 (en) 2002-12-10 2004-06-24 Wyeth Substituted 3-alkyl and 3-arylalkyl 1h-indol-1-yl acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1)
US20050250694A1 (en) * 2003-10-10 2005-11-10 Ma Jian-Xing Compounds useful in inhibiting vascular leakage, inflammation and fibrosis and methods of making and using same
AU2005277137A1 (en) 2004-08-23 2006-03-02 Wyeth Pyrrolo-naphthyl acids as PAI-1 inhibitors
US8318661B2 (en) 2006-08-28 2012-11-27 Omnio Healer Ab Candidates against infection
US20100080773A1 (en) 2008-09-26 2010-04-01 Sdg, Inc. Orally Bioavailable Lipid-Based Constructs
JP5539896B2 (ja) 2007-11-29 2014-07-02 グリフオルス・セラピユーテイクス・インコーポレーテツド 組換え的に改変されたプラスミン
WO2009111625A2 (en) * 2008-03-05 2009-09-11 Board Of Regents, The University Of Texas System Peptide inhibition of lung epithelial apoptosis and pulmonary fibrosis
KR20120050442A (ko) * 2009-07-10 2012-05-18 쓰롬보제닉스 엔.브이. 플라스미노겐 및 플라스민의 변이체
CA2779905A1 (en) 2009-11-07 2011-05-12 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
EP2566514A4 (en) 2010-05-03 2013-11-27 Abbvie Inc METHODS OF INHIBITING FIBROSIS WITH ANTI-PAI-1 ANTIBODIES
CN102121023B (zh) 2010-12-22 2012-07-04 中山大学 突变型人纤溶酶原kringle5及其制备方法及应用
CN102154253A (zh) 2011-01-06 2011-08-17 郑州大学 具有抑制血小板凝集功能的微小纤溶酶原突变体及其制备方法和用途
WO2013134781A1 (en) 2012-03-09 2013-09-12 Vascular Biosciences Orally active, cell-penetrating homing peptide and methods of using same
KR101467109B1 (ko) 2013-07-10 2014-12-01 영남대학교 산학협력단 Ｂｉｘ02189 화합물을 유효성분으로 포함하는 폐섬유증 예방 또는 치료용 조성물
HK1221725A1 (zh) * 2013-08-13 2017-06-09 Sanofi 纤溶酶原激活剂抑制剂-1(pai-1)的抗体及其用途
CN104371019B (zh) 2013-08-13 2019-09-10 鸿运华宁（杭州）生物医药有限公司 一种能与glp-1r特异性结合的抗体及其与glp-1的融合蛋白质
TW201722994A (zh) 2013-08-13 2017-07-01 賽諾菲公司 胞漿素原活化素抑制劑-１（ｐａｉ-１）之抗體及其用途
US20160199466A1 (en) 2013-08-20 2016-07-14 Trustees Of Dartmouth College Methods For Treating Tissue Fibrosis
PL3109320T3 (pl) 2014-02-21 2019-08-30 Astellas Pharma Inc. Nowe przeciwciało anty-ludzki PAI-1
PY1577621A (es) 2014-12-19 2017-10-02 Prometic Biotherapeutics Inc Composicion farmaceutica que comprende plasminogeno y uso para el mismo
TWI801331B (zh) 2015-11-03 2023-05-11 美商波麥堤克生物治療股份有限公司 纖維蛋白溶酶原缺乏症之纖維蛋白溶酶原替代療法
CN106890320A (zh) 2015-12-18 2017-06-27 深圳瑞健生命科学研究院有限公司 一种用于预防或治疗急性及慢性血栓的方法
DK3391902T5 (da) 2015-12-18 2024-09-23 Talengen Int Ltd Plasminogen til anvendelse i behandlingen af diabetisk angiokardiopati
ES2982294T3 (es) 2015-12-18 2024-10-15 Talengen Int Ltd Plasminógeno para su uso en el tratamiento o prevención de lesiones nerviosas por diabetes mellitus
CN106890324A (zh) 2015-12-18 2017-06-27 深圳瑞健生命科学研究院有限公司 一种预防和治疗糖尿病肾病的方法
JP6793748B2 (ja) 2015-12-18 2020-12-02 タレンゲン インターナショナル リミテッドＴａｌｅｎｇｅｎ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｌｉｍｉｔｅｄ 放射性および化学的損傷を予防及び治療するための方法
ES2968254T3 (es) 2015-12-18 2024-05-08 Talengen Int Ltd Plasminógeno para su uso en la prevención o el tratamiento de la trombosis aguda y la trombosis crónica
CN106890318A (zh) 2015-12-18 2017-06-27 深圳瑞健生命科学研究院有限公司 一种预防和治疗糖尿病性心脏病的新方法
JP7242057B2 (ja) * 2016-12-15 2023-03-20 タレンゲン インターナショナル リミテッド 薬物性腎損傷を予防及び治療するための方法
JP7168990B2 (ja) 2016-12-15 2022-11-10 タレンゲン インターナショナル リミテッド 肥満症を予防および治療するための方法および薬物
WO2018107686A1 (zh) * 2016-12-15 2018-06-21 深圳瑞健生命科学研究院有限公司 一种治疗动脉粥样硬化及其并发症的方法
JP7213552B2 (ja) 2016-12-15 2023-01-27 タレンゲン インターナショナル リミテッド 肝の繊維化を予防及び治療するための方法
TWI677348B (zh) * 2016-12-15 2019-11-21 大陸商深圳瑞健生命科學研究院有限公司 一種改善心臟病變的方法
CN110198732A (zh) 2016-12-15 2019-09-03 泰伦基国际有限公司 一种促进胰岛素受体底物-2表达的方法
CA3067890A1 (en) * 2017-06-19 2018-12-27 Talengen International Limited Method for regulating and controling glp-1/glp-1r and drug

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101628113A (zh) * 2009-08-18 2010-01-20 南京农业大学 蚯蚓纤溶酶抗肝纤维化的应用
WO2012093132A1 (en) * 2011-01-05 2012-07-12 Thrombogenics Nv Plasminogen and plasmin variants
CN103384722A (zh) * 2011-01-05 2013-11-06 斯路姆基因公司 纤溶酶原和纤溶酶变体

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BEIER,J.I.等: "Alcoholic liver disease and the potential role of plasminogen activator inhibitor-1 and fibrin metabolism", 《EXPERIMENTAL BIOLOGY AND MEDICINE》 *
J.MATHYS VOGTEN等: "Angiostatin inhibits experimental liver fibrosis in mice", 《INTERNATIONAL JOURNAL OF COLORECTAL DISEASE》 *
JOHN F. POHL等: "Plasminogen Deficiency Leads to Impaired Lobular Reorganization and Matrix Accumulation after Chronic Liver Injury", 《AMERICAN JOURNAL OF PATHOLOGY》 *

Also Published As

Publication number Publication date
EP3556395A4 (en) 2020-07-22
TWI752044B (zh) 2022-01-11
JP7313058B2 (ja) 2023-07-24
JP7213552B2 (ja) 2023-01-27
EP3556380A4 (en) 2020-05-13
WO2018107697A1 (zh) 2018-06-21
EP3556382A4 (en) 2020-12-09
CA3046671A1 (en) 2018-06-21
WO2018107693A1 (zh) 2018-06-21
CA3046671C (en) 2023-08-08
CN110114080A (zh) 2019-08-09
JP7213553B2 (ja) 2023-01-27
JP2020502133A (ja) 2020-01-23
CN110121358A (zh) 2019-08-13
US11154595B2 (en) 2021-10-26
CN110191718A (zh) 2019-08-30
CA3046666A1 (en) 2018-06-21
EP3556382A1 (en) 2019-10-23
TWI734798B (zh) 2021-08-01
CA3046669A1 (en) 2018-06-21
EP3556395A1 (en) 2019-10-23
US20190314467A1 (en) 2019-10-17
TWI670075B (zh) 2019-09-01
WO2018107694A1 (zh) 2018-06-21
US20190314466A1 (en) 2019-10-17
EP3556389A1 (en) 2019-10-23
JP2020511413A (ja) 2020-04-16
TW201822783A (zh) 2018-07-01
TW202123955A (zh) 2021-07-01
EP3556380A1 (en) 2019-10-23
TW201822795A (zh) 2018-07-01
CA3047174A1 (en) 2018-06-21
JP2020512288A (ja) 2020-04-23
EP3556389A4 (en) 2020-07-15
US11219669B2 (en) 2022-01-11
WO2018107698A1 (zh) 2018-06-21
WO2018107696A1 (zh) 2018-06-21
TWI657823B (zh) 2019-05-01
US20190365872A1 (en) 2019-12-05
TW201822790A (zh) 2018-07-01
JP2020502132A (ja) 2020-01-23
US11071772B2 (en) 2021-07-27
TW201822789A (zh) 2018-07-01
US20190314468A1 (en) 2019-10-17
TW201822796A (zh) 2018-07-01

Similar Documents

Publication Publication Date Title
CN110139668A (zh) 一种预防和治疗肝纤维化的方法
JP6919087B2 (ja) アバロパラチドの製剤、その経皮パッチ、およびその使用
Mathaes et al. Subcutaneous injection volume of biopharmaceuticals—pushing the boundaries
Squadrito et al. Pharmacological activity and clinical use of PDRN
JP2024083587A (ja) 異常な新生血管形成を伴う眼疾患を処置するためにニンテダニブを使用する組成物および方法
US20220040225A1 (en) Method of administration and treatment
Chung et al. The effects of polydeoxyribonucleotide on the survival of random pattern skin flaps in rats
US9044436B2 (en) Compositions and methods for the treatment of angiogenesis-related eye diseases
Wickramasinghe et al. Treatment of neoplastic skin lesions with intralesional interferon
JP2015187125A5 (https=)
RU2016122957A (ru) Способы применения интерлейкина-10 для лечения заболеваний и расстройств
Colangelo et al. Polydeoxyribonucleotide regulation of inflammation
US11298423B2 (en) Protection and delivery of multiple therapeutic proteins
Panigrahi et al. Brain tumor and Gliadel wafer treatment
US20190328824A1 (en) Hydrogel composition and associated method of use
RU2007101492A (ru) Способ и композиция для лечения ожирения, инсулинзависимых заболеваний и гиперхолестеринемии
JP2016537380A5 (https=)
JP2022535127A5 (https=)
US20140328826A1 (en) Product and method for treating keloid scars, hypertrophic scars and burn scars with contracture
JP2020510628A5 (https=)
US20190209512A1 (en) Treatment for Ischemic Stroke
CA3133084A1 (en) Formulation including a combination of .beta.-endorphin and adrenocorticotropic hormone
JP2022153587A (ja) チロシン誘導体及びそれらを含む組成物
KR20100031123A (ko) Ｖｅｇｆ 억제제 및 이리노테칸을 함유하는 항종양 조합물
US20220202890A1 (en) Formulation containing cornus wilsoniana extract and use thereof

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination