CN110072566A - 骨与软组织同步再生诱导剂及其制备方法和用途 - Google Patents

骨与软组织同步再生诱导剂及其制备方法和用途 Download PDF

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CN110072566A
CN110072566A CN201780060982.5A CN201780060982A CN110072566A CN 110072566 A CN110072566 A CN 110072566A CN 201780060982 A CN201780060982 A CN 201780060982A CN 110072566 A CN110072566 A CN 110072566A
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bmp
bone
regeneration
inducer
toe
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刘英芹
孙广臣
孙欣
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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    • A61L27/3633—Extracellular matrix [ECM]
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    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
    • A61L27/3645—Connective tissue
    • A61L27/365—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A61L27/3691—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by physical conditions of the treatment, e.g. applying a compressive force to the composition, pressure cycles, ultrasonic/sonication or microwave treatment, lyophilisation
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    • A61P19/00—Drugs for skeletal disorders
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Abstract

诱导剂属于再生医学领域的原位再生诱导，诱导剂包含细胞外基质和/或骨形态发生蛋白，可于伤残的残余组织处同步诱导骨及肌肉、血管、皮肤等包绕骨的软组织的再生。再生组织量的多少与植入诱导剂的剂量相关。

Description

PCT国内申请，说明书已公开。

Claims (15)

  1. PCT国内申请，权利要求书已公开。
CN201780060982.5A 2016-10-09 2017-09-19 骨与软组织同步再生诱导剂及其制备方法和用途 Pending CN110072566A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201610878374.2A CN107913436A (zh) 2016-10-09 2016-10-09 作用于伤残组织原位的骨与软组织同步再生诱导剂
CN2016108783742 2016-10-09
PCT/CN2017/102270 WO2018064930A1 (zh) 2016-10-09 2017-09-19 骨与软组织同步再生诱导剂及其制备方法和用途

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CN110072566A true CN110072566A (zh) 2019-07-30

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CN201610878374.2A Pending CN107913436A (zh) 2016-10-09 2016-10-09 作用于伤残组织原位的骨与软组织同步再生诱导剂
CN201780060982.5A Pending CN110072566A (zh) 2016-10-09 2017-09-19 骨与软组织同步再生诱导剂及其制备方法和用途

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US (1) US11547780B2 (zh)
EP (1) EP3524281A4 (zh)
JP (1) JP6936324B2 (zh)
CN (2) CN107913436A (zh)
WO (1) WO2018064930A1 (zh)
ZA (1) ZA201902097B (zh)

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JP2019531170A (ja) 2019-10-31
JP6936324B2 (ja) 2021-09-15
EP3524281A1 (en) 2019-08-14
CN107913436A (zh) 2018-04-17
US11547780B2 (en) 2023-01-10
EP3524281A4 (en) 2020-06-03
WO2018064930A1 (zh) 2018-04-12
ZA201902097B (en) 2019-11-27
US20190224381A1 (en) 2019-07-25

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