CN110052301A - A kind of movement microlayer model continuous separation method for cutting lithium niobate sandwich chip based on y - Google Patents
A kind of movement microlayer model continuous separation method for cutting lithium niobate sandwich chip based on y Download PDFInfo
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- CN110052301A CN110052301A CN201910427611.7A CN201910427611A CN110052301A CN 110052301 A CN110052301 A CN 110052301A CN 201910427611 A CN201910427611 A CN 201910427611A CN 110052301 A CN110052301 A CN 110052301A
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- microlayer model
- continuous separation
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- lithium niobate
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/34—Purifying; Cleaning
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0887—Laminated structure
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0454—Moving fluids with specific forces or mechanical means specific forces radiation pressure, optical tweezers
Abstract
The invention discloses a kind of movement microlayer model continuous separation methods that lithium niobate sandwich chip is cut based on y, this method cuts sandwich that lithium niobate crystal chip forms as core using y, the electric field of the superposition formed using laser interrupted illuminating realizes the continuous separation of microlayer model in interlayer, it solves the problems, such as that microlayer model is not easy to continue separation by polarization, and the separation to different size microlayer models may be implemented by laser power size and interrupted illuminating distance.The technology can be applied to the transport and separation of trace reagent, have great importance to the development in the fields such as biologic medical, pharmacodiagnosis, environmental monitoring and molecular biology.
Description
Technical field
The present invention relates to a kind of microlayer models to manipulate technology, specifically a kind of fortune that lithium niobate sandwich chip is cut based on y
Dynamic microlayer model continuous separation method
Background technique
With the rapid development of micro-fluidic chip, microlayer model manipulates the research hotspot for having become the field.Microlayer model behaviour
Control technology is mainly used in the analysis and detection of micro-example during biology, chemistry, pharmacy etc., it relates generally to trace reagent
Acquisition, mix and transport.It leads biologic medical, pharmacodiagnosis, food hygiene, environmental monitoring and molecular biology etc.
The development in domain has very important significance.
Esseling in 2015 et al. (Optofluidic droplet router [J] .Laser and Photonics
Reviews, 2015,9 (1): 98-104) report it is a kind of realize that dielectric drop transports and isolated method using dielectrophoretic force,
Referred to as microlayer model router.The router mainly utilizes mask plate to realize to the spatial modulation of laser, cuts niobium by induced with laser c
Sour lithium generates manipulation of the photovoltage electric field realization to microlayer model.They propose to be steered drop and matchmaker by comparing in article
The size of the dielectric constant of Jie can determine the direction of dielectrophoretic force.When the dielectric constant for being steered drop is greater than surrounding medium
When dielectric constant, light position is directed toward in the direction for being steered drop by dielectrophoretic force, drop can be attracted along light position at this time
It is mobile；And be steered drop dielectric constant be less than surrounding medium dielectric constant when, be steered drop by dielectrophoretic force
With direction of illumination on the contrary, illumination bar paten is as virtual barrier, prevention drop is moved to light position direction in direction.And
And in an experiment they by using two bar shaped illumination patterns as virtual attraction optical path, being successfully realized point of microlayer model
It splits.
Gazzetto M in 2016 et al. (Numerical and Experimental Study of
Optoelectronic Trapping on Iron-Doped Lithium Niobate Substrate [J] .Crystals,
2016,6 (10): it 123.) cuts to be successfully realized on lithium columbate crystal in y by dielectrophoretic force and catch to being dispersed in water droplet in the oil
It obtains.Polymethyl methacrylate (PMMA) particle is distributed in oil film by they, and by its uniform drop coating to lithium columbate crystal,
After the laser irradiation 30s of 532nm, the capture to particle can be observed on the top of laser-irradiated domain and bottom.It is logical
Identical experimental procedure is crossed, the particle of leaching in aqueous solution is but not observed the presence of dielectrophoretic force, i.e., to the suction of particle
Draw or rejection.Exist however, they by the way that the water droplet of 2~10um to be distributed in oil, observed positive dielectrophoretic force,
Realize the attraction to water droplet.
Chu Y in 2016 et al. (Remote Manipulation of a Microdroplet in Water by
Near-Infrared Laser, 8,1273-1279,2015) it is realized using near-infrared laser and nano particle in water is encapsulated
CHCl3The remote control of microlayer model, under the effect of the laser, drop can rise, and shuttle, move horizontally, or even be suspended in water
In.Although this method can be such that microlayer model moves back and forth along any one-dimensional path, the packaging technology of nano particle is complicated, can
Microlayer model can be polluted, laser can make drop internal environment disturbance to the long-time irradiation of drop, and the method is only
It can apply to the microlayer model being packaged in water environment, greatly limit its application range.
Summary of the invention
The present invention provides a kind of simple, easy movement microlayer model continuous separation method, can realize during transportation
The continuous separation of microlayer model is not influenced by drop is polarized, whole process in real time may be used without carrying out any pre-processing to drop
Control.
A kind of movement microlayer model continuous separation method, it is characterised in that: lithium niobate folder is cut with the y of c-axis direction reverse configuration
Layer fabric chip drives in microlayer model motion process as substrate in laser, realizes that microlayer model exists using the interrupted illuminating of laser
Along the continuous separation in c-axis direction in motion process.
A kind of movement microlayer model continuous separation method, it is characterised in that: utilize lithium niobate chip before and after laser interrupted illuminating
The superposition xenogenesis electric field of formation realizes the separation of drop to the dielectrophoretic force that drop generates.
A kind of movement microlayer model continuous separation method, it is characterised in that: pass through control laser power size and interrupted illuminating
The continuous separation to different size microlayer models may be implemented in distance.
Compared with the prior art, the advantages of the present invention are as follows: the continuous separation of microlayer model can be realized during transportation,
Solve the problems, such as that microlayer model is not readily separated through polarization；It may be implemented by laser power size and interrupted illuminating distance to difference
The separation of size microlayer model.
Detailed description of the invention
Fig. 1 is that the present invention is based on y to cut used by the movement microlayer model continuous separation method of lithium niobate sandwich chip
Apparatus structure schematic diagram.
Fig. 2 is the lithium niobate that the movement microlayer model continuous separation method of lithium niobate sandwich chip is cut the present invention is based on y
The schematic diagram of sandwich chip.
Fig. 3 is that the present invention is based on the principles of the y movement microlayer model continuous separation method for cutting lithium niobate sandwich chip to show
It is intended to.
Fig. 4 is a kind of reality that the movement microlayer model continuous separation method of lithium niobate sandwich chip is cut the present invention is based on y
Apply the continuous separation process figure of movement drop of example (embodiment 1).
Fig. 5 is a kind of reality that the movement microlayer model continuous separation method of lithium niobate sandwich chip is cut the present invention is based on y
Apply the continuous separation process figure of movement drop of example (embodiment 2).
Fig. 6 is a kind of reality that the movement microlayer model continuous separation method of lithium niobate sandwich chip is cut the present invention is based on y
Apply the continuous separation process figure of movement drop of example (embodiment 3).
Specific embodiment
Below with reference to embodiment and attached drawing, the present invention will be further described
The invention discloses a kind of movement drop continuous separation method, realize that device required for this method includes: laser
Device 1, electronic shutter 2, diaphragm 3, laser mirror 6, object lens 7, lithium niobate sandwich chip 8, transparent objective table 9 shape in order
Optical path is separated at movement microlayer model；Background light source 10, transparent objective table 9, lithium niobate sandwich chip 8, object lens 7, laser are anti-
It penetrates mirror 6, optical filter 5, CCD camera 4 and forms observation optical path in real time in order；Servo motor 11, transparent objective table 9 are formed in order
Mobile device.All optical devices and electronic device pass through rigid connecting rod and are fixed on optical experiment bench, guarantee all
Element coaxially collimates.
The invention discloses a kind of movement drop continuous separation method, the operating procedures of this method are as follows: by liquid to be manipulated
Body 12 imports in lithium niobate sandwich chip (cutting lithium niobate crystal chip i.e. 8-1,8-2 by two y to form), and by niobic acid lithium intercalation
Fabric chip 8 is placed on transparent objective table 9, and the position of transparent objective table 9 is controlled by adjusting servo motor 11, is made to be manipulated
Liquid 12 is located at 7 near focal point of object lens, captures clearly image using CCD camera 4；Open laser 1, adjust laser power to
Size appropriate is adjusted the position of interlayer chip by servo motor 11, liquid to be manipulated is allowed to be located at 13 irradiation of laser, is opened
Electronic shutter 2 is moved with laser along c-axis direction by the mobile interlayer chip of servo motor by drop simultaneously, by closing one
Section time electronic shutter realizes the effect of laser interrupted illuminating, keeps the motion state of interlayer chip not during interrupted illuminating
Become, by the reasonable cooperation of laser power and interrupted illuminating distance, realizes the continuous separation of movement microlayer model.
The laser 1, it is desirable that its laser irradiation issued can effectively inspire current-carrying in lithium niobate crystal on piece
Son, the space electric field of formation can reach the magnitude of manipulation dielectric drop, therefore its wavelength should should be situated between 350~550nm, power
In 3~110mW；Xenon lamp, halogen lamp or high power white LED lamp can be used in background light source 10；7 enlargement ratio of object lens between 4~
25 times.
The working principle of the present invention program: laser irradiation y cuts lithium niobate crystal chip surface, and the light that can generate displacement, which swashs, to be carried
It flows sub (electronics), light swashs carrier and moves along the c-axis positive direction of lithium niobate crystal chip, cuts lithium niobate crystal on piece in the y of laser irradiation
It will form that (c-axis forward direction is negative charge accumulating area, and c-axis negative sense is positive accumulation along two positive and negative charge regions of c-axis distribution
Region), the electric field that positive and negative charge is formed generates dielectrophoretic force to microlayer model, when laser cuts lithium niobate crystal chip along c-axis side relative to y
To the overlapping (positive and negative charge, which exists, to be neutralized) that when movement, will lead to charge area, when laser interrupted illuminating, before interrupted illuminating
Positive charge region is Chong Die with the negative electrical charge region after interrupted illuminating, forms the positive and negative charge area that two distances are greater than laser radius
Domain, and the charge among two regions becomes smaller due to neutralizing even close to zero, and such distribution of charges generates microlayer model
Dielectrophoretic force it is highly beneficial to the separation of drop, be able to achieve microlayer model and separate during the motion.
The specific embodiment that the present invention realizes the movement continuous separation scheme of drop is given below, specific embodiment is only used in detail
It describes the bright present invention in detail, is not intended to limit the protection scope of the claim of this application.
Embodiment 1
Using 405nm laser, laser power 3.8mW, background light source selects halogen lamp, and focusing objective len amplification factor is
16 times, liquid to be manipulated is imported into lithium niobate sandwich chip, chip position is adjusted by servo motor, it is to be manipulated
Microlayer model having a size of 60 μm, open electronic shutter, control drop closes electronic shutter, in electronic shutter with laser motion
The motion state of down periods chip is constant, and the chip displacement of interrupted illuminating is 20 μm, is again turned on shutter and realizes microlayer model
Continuous separation.
Embodiment 2
Using 405nm laser, laser power 4.3mW, background light source selects halogen lamp, and focusing objective len amplification factor is
16 times, liquid to be manipulated is imported into lithium niobate sandwich chip, chip position is adjusted by servo motor, it is to be manipulated
Microlayer model having a size of 80 μm, open electronic shutter, control drop closes electronic shutter, in electronic shutter with laser motion
The motion state of down periods chip is constant, and the chip displacement of interrupted illuminating is 35 μm, is again turned on shutter and realizes microlayer model
Continuous separation.
Embodiment 3
Using 405nm laser, laser power 8mW, background light source selects halogen lamp, and focusing objective len amplification factor is 16
Times, liquid to be manipulated is imported into lithium niobate sandwich chip, chip position is adjusted by servo motor, it is to be manipulated
Microlayer model opens electronic shutter having a size of 100 μm, and control drop closes electronic shutter, in the pass of electronic shutter with laser motion
The motion state of chip is constant during closing, and the chip displacement of interrupted illuminating is 60 μm, is again turned on the company that shutter realizes microlayer model
Continuous separation.
Specific example described above has been further detailed description, Ying Li to technical solution of the present invention, implementing method
Solution, above example are not solely used for the present invention, all equal modifications carried out within the spirit and principles in the present invention, etc.
Effect replacement, improvement etc. should be within protection scope of the present invention.
Claims (3)
1. a kind of movement microlayer model continuous separation method, it is characterised in that: cut niobic acid lithium intercalation with the y of c-axis direction reverse configuration
Fabric chip drives in microlayer model motion process as substrate in laser, realizes that microlayer model is being transported using the interrupted illuminating of laser
Along the continuous separation in c-axis direction during dynamic.
2. a kind of movement microlayer model continuous separation method according to claim 1, it is characterised in that: shone using laser interruption
The superposition xenogenesis electric field for penetrating the formation of front and back lithium niobate chip realizes the separation of drop to the dielectrophoretic force that drop generates.
3. a kind of movement microlayer model continuous separation method according to claim 1, by control laser power size and
The continuous separation to different size microlayer models may be implemented in disconnected irradiation distance.
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| CN201910427611.7A CN110052301B (en) | 2019-05-20 | 2019-05-20 | Motion micro-droplet continuous separation method based on y-cut lithium niobate sandwich structure chip |
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Cited By (3)
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| CN110560189A (en) * | 2019-10-21 | 2019-12-13 | 河北工业大学 | Hydrated liquid drop separation method and device based on y-cut lithium niobate chip |
| CN114225977A (en) * | 2021-11-25 | 2022-03-25 | 西安电子科技大学 | Multi-core multi-component micro-droplet processing system |
| CN114425462A (en) * | 2020-10-29 | 2022-05-03 | 京东方科技集团股份有限公司 | Micro-fluidic chip and preparation method thereof |
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