CN105413767B - A kind of microlayer model based on lithium niobate crystal chip sandwich controllable separator and method in real time - Google Patents
A kind of microlayer model based on lithium niobate crystal chip sandwich controllable separator and method in real time Download PDFInfo
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- B01L3/502753—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
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Abstract
The invention discloses a kind of device and method of microlayer model controllable separation in real time, the device includes laser 1, CCD camera 2, band resistance optical filter 3, semi-transparent semi-reflecting lens 4, object lens 5, lithium niobate crystal chip sandwich 6, background light source 7.The laser that laser is sent, which is reflected into object lens via semi-transparent semi-reflecting lens and focused on microlayer model to be separated in lithium niobate crystal chip sandwich, forms separation light path, while microlayer model irradiates via background light source and is imaged on CCD camera formation real-time monitored light path by object lens.The present invention irradiates the microlayer model realization separation made among interlayer by focusing on laser, and the position not only separated, ratio is controllable but also can accomplish real-time monitored, additionally can regulate and control separation accuracy by adjusting interlayer spacing.Separation of the technology available for micro medicament and fluid sample during biology, chemistry, medical analysis, the development to fields such as biologic medical, pharmacodiagnosis, environmental monitorings all have very important significance.
Description
Technical field
The present invention relates to a kind of microlayer model to manipulate technology, specifically a kind of device that can realize microlayer model controllable separation in real time
And method.
Background technology
Microlayer model manipulation technology is generally used for biology, chemistry, micro medicament and fluid sample during medical analysis
Separate and transport, can be applied to the basic operation units such as integrated culture, reaction, separation, detection and set in the micro-fluidic chip of one
Meter and exploitation, the development to fields such as biologic medical, pharmacodiagnosis, food hygiene, environmental monitoring and molecular biology all have
There is very important meaning.
The separation (or division) of microlayer model refers to the local effect by power of the larger microlayer model of volume and divided from original drop
From the process for forming smaller droplet.Document (Electrowetting-based actuation of droplets for
Integrated microfluidics, Lab on a chip, 2,96-101 (2002)) utilize the side of dielectric wetting (EWOD)
Method realizes the separation of microlayer model, and original drop, simultaneously by the active force of two lateral electrodes, is divided into two in bipolar EWOD chips
Individual droplet.The method needs to prepare electrode in chip base, and its structure is special and can not adjust, therefore this method chip knot
Structure complexity, drop separation can not be realized controllable in real time.In addition, this method can only right >=700nL drop separate, and separate
Obtained minimum droplet size, i.e. separation accuracy are about 300nL, can not adapt to wanting for following micro-fluidic chip Highgrade integration
Ask.
Univ Munich Germany C.Strobl and Z.Guttenberg (Nano-and pico-dispensing in 2004
Of fluids on planar substrates using SAW, IEEE Transactions on Ultrasonics
Ferroelectrics and Frequency Control, 51,1432-1436 (2004)) et al. in piezoelectric substrate material table
Face makes one layer by the alternate checkerboard film formed of hydrophobic group and hydrophilic group, recycles surface acoustic wave to drive drop on film
Slowly motion, makes water droplet leave microlayer model on hydrophilic group, it is achieved thereby that drop separation.Right >=50nL the drops of the method energy enter
Row separation, separation accuracy is about 50pL, and lifting is notable.The shortcomings that the method, is：Need to prepare the interdigital electricity needed for surface wave
Pole simultaneously carries out specially treated to surface, and chip structure is more complicated, and its separation accuracy can not regulate and control, and still can not realize reality
When controllable microlayer model separation, in addition, although this method separation accuracy is increased dramatically in theory, but its is isolated micro-
Drop is directly exposed in air, be very easy to volatilization, therefore isolated microlayer model under full accuracy can not preserve and
Subsequent operation is carried out, without practical significance.
Recently, M.Esseling et al. (Optofluidic droplet router.Laser and Photonics
Reviews, 9,98-104 (2015)), substrate is done with lithium niobate crystal chip, using produced by the material Preset grating space-charge accumulation
Dielectrophoretic force, realize the separation of microlayer model.This method does not need electrode structure, is obtained using the distribution of space charge of lithium niobate
Dummy electrodes, chip structure has been obtained certain simplification, and the method can realize pair >=1.2nl drop divides
From separation accuracy is about 0.6nL.The shortcomings that this method, is mainly reflected in：The formation of dummy electrodes needs laser and spatial light to adjust
The mask illumination system of device composition processed pre-processes to lithium niobate base bottom, therefore this method cost is higher, and its separation accuracy is still
It can not regulate and control, and the real-time controllable separation to microlayer model can not be realized.
The content of the invention
The separation method reported has that acp chip is complicated, cost is higher, separation accuracy is low and non-adjustable at present
It is whole, can not controllable separation in real time the shortcomings of.In view of the above-mentioned problems, the present invention provides, one kind is simple, easy, separation accuracy is high and can
The microlayer model separation method of real-time monitoring.
A kind of device of microlayer model controllable separation in real time, it is characterised in that：By laser 1, semi-transparent semi-reflecting lens 4, object lens 5,
Lithium niobate crystal chip sandwich 6 sequentially forms separation light path, by background light source 7, lithium niobate crystal chip sandwich 6, object lens 5,
Semi-transparent semi-reflecting lens 4, optical filter 3, CCD camera 2 sequentially form real-time monitored light path, pass through two light paths for partially overlapping and realize
Microlayer model is separated and carried out while observation, i.e. separation in real time.
A kind of device for realizing the controllable separation of microlayer model, it is characterised in that：The Sanming City formed using two lithium niobate crystal chips
Control the core apparatus that sandwich separates as microlayer model.Two lithium niobate crystal chips are separately fixed at by the forms of+Z in face of-Z faces
On four axles combination fine motion translation stage, the clearance distance of the parallel crystal face of sandwich can adjust, while sandwich also can be in two dimension
Mass motion in plane.
A kind of method for realizing microlayer model separation, it is characterised in that：Made by focusing on laser irradiation among interlayer
Microlayer model realizes separation, and its position separated can be controlled by the relative position of sandwich and focal beam spot.
A kind of method for realizing microlayer model separation, it is characterised in that：Made by focusing on laser irradiation among interlayer
Microlayer model realizes separation, and its volume separated can be controlled by focusing on luminous power.
A kind of method for realizing microlayer model separation, it is characterised in that：Microlayer model separation essence is adjusted by adjusting interlayer spacing
Degree.
A kind of method for realizing microlayer model separation, it is characterised in that：Can be with Synchronous by background light source and CCD camera
The activity of microlayer model, its separation process can real-time monitored, that is, realize in real time separation.
Compared with prior art, it is an advantage of the current invention that being gathered based on lithium niobate crystal chip sandwich and object lens laser
Burnt system, apparatus structure are relatively easy；Secondly this method can right >=0.1nL microlayer model separate, separation accuracy is about
20pL, separating property are substantially improved；Other this method can be realized to micro- by regulating and controlling laser power and laser spot position
The real-time controllable separation of drop.
Brief description of the drawings
Fig. 1 is that the device of the microlayer model based on lithium niobate crystal chip sandwich of the invention controllable separation scheme in real time is integrally tied
Structure schematic diagram.
Fig. 2 is that the microlayer model based on lithium niobate crystal chip sandwich of the invention is pressed from both sides in controllable separation scheme equipment therefor in real time
The concrete structure schematic diagram of layer device.
Fig. 3 is a kind of embodiment of the microlayer model based on niobic acid lithium piece sandwich of the invention controllable separation scheme in real time
The separation process figure of (example 1).
Fig. 4 is a kind of embodiment of the microlayer model based on niobic acid lithium piece sandwich of the invention controllable separation scheme in real time
The separation process figure of (example 2).
Fig. 5 is a kind of embodiment of the microlayer model based on niobic acid lithium piece sandwich of the invention controllable separation scheme in real time
The separation process figure of (example 3).
Fig. 6 is a kind of embodiment of the microlayer model based on niobic acid lithium piece sandwich of the invention controllable separation scheme in real time
The separation process figure of (example 4).
Fig. 7 is a kind of embodiment of the microlayer model based on niobic acid lithium piece sandwich of the invention controllable separation scheme in real time
The separation process figure of (example 5).
Fig. 8 is a kind of embodiment of the microlayer model based on niobic acid lithium piece sandwich of the invention controllable separation scheme in real time
The separation process figure of (example 6).
Fig. 9 is a kind of embodiment of the microlayer model based on niobic acid lithium piece sandwich of the invention controllable separation scheme in real time
The separation process figure of (example 7).
Embodiment
With reference to embodiment and accompanying drawing, the present invention will be further described.
The invention discloses a kind of device and method of microlayer model controllable separation in real time, the device includes laser 1, CCD
Camera 2, band resistance optical filter 3, semi-transparent semi-reflecting lens 4, object lens 5, lithium niobate crystal chip sandwich 6, background light source 7.Wherein laser
1st, semi-transparent semi-reflecting lens 4, object lens 5, lithium niobate crystal chip sandwich 6 form separation light path in order；Background light source 7, lithium niobate crystal
Piece sandwich 6, object lens 5, semi-transparent semi-reflecting lens 4, optical filter 3, CCD camera 2 form real-time monitored light path in order.Utilize two
The core apparatus that the sandwich sandwich 6 that lithium niobate crystal chip is formed separates as microlayer model.Two lithium niobate crystal chips 6-1 and 6-
6 are separately fixed on four axles combination fine motion translation stage (6-2,6-3,6-4,6-5) by+Z in face of the form in-Z faces, and sandwich is put down
The clearance distance of row crystal face can adjust, while sandwich also can the mass motion on two dimensional surface.
The invention discloses a kind of device and method of microlayer model controllable separation in real time, the operating procedure of this method is：It is logical
Cross the spacing of two lithium niobate crystal chips 6-1 and 6-6 in fine motion translation stage 6-2 regulation interlayers mechanism 6；Microlayer model to be separated is led
Enter lithium niobate crystal chip sandwich 6；Made by the axle fine motion translation stage (6-3,6-4,6-5) of comprehensive adjustment three in sandwich 6
Microlayer model to be separated is located at the near focal point of object lens, and is confirmed using the CCD clear microlayer model images captured；Open laser
Device, and laser power is suitably adjusted, by the mobile interlayer drop of the axle fine motion translation stage (6-4,6-5) of comprehensive adjustment two, make focusing
Hot spot gets to position to be separated on microlayer model, completes the adjustable microlayer model separation of volume.
Described laser 1, the laser requirement sent, which is radiated in niobic acid lithium piece, can effectively inspire carrier, so
Its wavelength should be between 400~700nm, and its laser power should be between 0.1~10mW.Background light source can be used xenon lamp, Halogen lamp LED or
High power white LED.Focusing objective len enlargement ratio is between 4~100 times.Two lithium niobate crystal chips 6-1 and 6-6 in sandwich 6
Spacing should be between 10~30 μm.The volume of microlayer model to be separated should be not less than 0.1nL.
Summary simultaneously considers the cost of element and the effect of separation, and the preferred scope of each parameter is：Laser wavelength
Should be between 400~550nm, its laser power should select Halogen lamp LED or white light LEDs, focusing objective len between 1~10mW, background light source
Enlargement ratio is between 20~50 times.
All optical elements and electronic device in light path are each attached on gun iron link frame 8, ensure that the correct of light
Propagation and measurement accuracy.
The operation principle of the present invention program：Laser irradiation lithium niobate crystal chip surface, the light that can produce displacement swash current-carrying
Sub (electronics), moves because light swashs positive direction of the carrier along niobic acid lithium piece+Z axis, makes its+Z face negatively charged ,-Z faces positively charged.
Sandwich in this programme is to be combined by two niobic acid lithium pieces by+Z in face of-Z faces are parallel, therefore when laser irradiation interlayer
During structure, the inner surface of sandwich can produce xenogenesis electric charge at hot spot, form dielectrophoretic force, capture is at spot center
The partially liq of microlayer model, and microlayer model remainder is discharged by tangential dielectrophoretic force, so as to realize microlayer model
It is automatically separated.Because the dielectrophoretic force for being used to capture liquid at spot center is proportional to focusing light intensity, therefore microlayer model separates
Volume can be controlled by focusing on luminous power.
The specific embodiment that the present invention realizes microlayer model controllable separation scheme in real time is given below, specific embodiment is only used for
Describe the present invention in detail, be not intended to limit the application scope of the claims.
Example 1
Using 405nm lasers, laser power 7.2mW, background light source selects Halogen lamp LED, and focusing objective len multiplication factor is
25 times, the microlayer model that volume to be separated is 2.205nL is imported in lithium niobate crystal chip sandwich, and adjust interlayer spacing and be
25 μm, interlayer drop is moved by comprehensive adjustment fine motion translation stage, focal beam spot is got to microlayer model edge, it is isolated
Small drop volume be 207pL.
Example 2
Using 405nm lasers, laser power 8.1mW, background light source selects white light LEDs, focusing objective len multiplication factor
For 25 times, the microlayer model that volume to be separated is 0.283nL is imported in lithium niobate crystal chip sandwich, and adjust interlayer spacing
For 13 μm, interlayer drop is moved by comprehensive adjustment fine motion translation stage, focal beam spot is got to microlayer model centre, separates
The small drop volume arrived is 129pL.
Example 3
Using 405nm lasers, laser power 4.8mW, background light source selects white light LEDs, focusing objective len multiplication factor
For 25 times, the microlayer model that volume to be separated is 0.277nL is imported in lithium niobate crystal chip sandwich, and adjust interlayer spacing
For 13 μm, interlayer drop is moved by comprehensive adjustment fine motion translation stage, focal beam spot is got to microlayer model centre, separates
The small drop volume arrived is 43pL.
Example 4
Using 532nm lasers, laser power 7.3mW, background light source selects Halogen lamp LED, and focusing objective len multiplication factor is
25 times, the microlayer model that volume to be separated is 0.237nL is imported in lithium niobate crystal chip sandwich, and adjust interlayer spacing and be
10 μm, interlayer drop is moved by comprehensive adjustment fine motion translation stage, focal beam spot is got to microlayer model centre, it is isolated
Small drop volume be 26pL.
Example 5
Using 488nm lasers, laser power 1.9mW, background light source selects Halogen lamp LED, and focusing objective len multiplication factor is
25 times, the microlayer model that volume to be separated is 0.710nL is imported in lithium niobate crystal chip sandwich, and adjust interlayer spacing and be
13 μm, interlayer drop is moved by comprehensive adjustment fine motion translation stage, focal beam spot is got to microlayer model centre, it is isolated
Small drop volume be 263pL.
Example 6
Using 532nm lasers, laser power 2.3mW, background light source selects Halogen lamp LED, and focusing objective len multiplication factor is
50 times, the microlayer model that volume to be separated is 0.372nL is imported in lithium niobate crystal chip sandwich, and adjust interlayer spacing and be
15 μm, interlayer drop is moved by comprehensive adjustment fine motion translation stage, focal beam spot is got to microlayer model centre, it is isolated
Small drop volume be 27pL.
Example 7
Using 488nm lasers, laser power 3,1mW, background light source selects white light LEDs, focusing objective len multiplication factor
For 50 times, the microlayer model that volume to be separated is 1.070nL is imported in lithium niobate crystal chip sandwich, and adjust interlayer spacing
For 28 μm, interlayer drop is moved by comprehensive adjustment fine motion translation stage, focal beam spot is got to microlayer model edge, separates
The small drop volume arrived is 443pL.
Instantiation described above has done to technical scheme and implementing method and further described in detail, Ying Li
Solution, above example are not solely used for the present invention, every equal modification carried out within the spirit and principles in the present invention, etc.
Effect replacement, improvement etc. should be within protection scope of the present invention.
Claims (6)
- A kind of 1. microlayer model based on lithium niobate crystal chip sandwich controllable separator in real time, it is characterised in that：By laser (1), semi-transparent semi-reflecting lens (4), object lens (5), lithium niobate crystal chip sandwich (6) sequentially form separation light path, by background light source (7), lithium niobate crystal chip sandwich (6), object lens (5), semi-transparent semi-reflecting lens (4), optical filter (3), the order shape of CCD camera (2) Into real-time monitored light path, carry out, i.e., divide in real time while realizing microlayer model separation and observation by two light paths to partially overlap From.
- 2. a kind of microlayer model based on lithium niobate crystal chip sandwich according to claim 1 controllable separator in real time, It is characterized in that：Lithium niobate crystal chip sandwich is that the sandwich sandwich formed by the use of two lithium niobate crystal chips is used as micro- liquid The core apparatus of separation is dripped, two lithium niobate crystal chips are separately fixed at four axles combination fine motion translation stage by the forms of+Z in face of-Z faces On, the clearance distance of the parallel crystal face of lithium niobate crystal chip sandwich is controllable, while lithium niobate crystal chip sandwich also can be two Mass motion on dimensional plane.
- A kind of 3. microlayer model based on lithium niobate crystal chip sandwich controllable separation method in real time, it is characterised in that：Using right It is required that on the basis of 1 described device, divide the microlayer model realization among lithium niobate crystal chip interlayer by focusing on laser irradiation From its position separated can be controlled by the relative position of lithium niobate crystal chip sandwich and focal beam spot.
- 4. a kind of microlayer model based on lithium niobate crystal chip sandwich according to claim 3 controllable separation method in real time, It is characterized in that：The microlayer model among lithium niobate crystal chip interlayer is set to realize separation by focusing on laser irradiation, what it was separated Volume can be controlled by focusing on luminous power.
- 5. a kind of microlayer model based on lithium niobate crystal chip sandwich according to claim 3 controllable separation method in real time, It is characterized in that：Microlayer model separation accuracy is adjusted by changing lithium niobate crystal chip interlayer spacing.
- 6. a kind of microlayer model based on lithium niobate crystal chip sandwich according to claim 3 controllable separation method in real time, It is characterized in that：It can be seen in real time with the activity of Synchronous microlayer model, its separation process by background light source and CCD camera Survey, that is, realize separation in real time.
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| CN105921355B (en) * | 2016-05-24 | 2019-09-10 | 河北工业大学 | A kind of fine liquid drop spray device and method controllable in real time based on lithium columbate crystal |
| CN106093443B (en) * | 2016-05-31 | 2019-05-21 | 河北工业大学 | It is a kind of that lithium niobate chip microlayer model transportation method controllable in real time is cut based on C |
| CN106311368B (en) * | 2016-07-29 | 2018-06-15 | 大连理工大学 | A kind of lossless release unit of drop for microsyringe |
| CN107121318B (en) * | 2017-04-27 | 2020-07-07 | 河北工业大学 | Real-time controllable micro-droplet arraying device and method based on lithium niobate sandwich structure chip |
| CN108031499B (en) * | 2017-12-07 | 2020-10-02 | 河北工业大学 | Light-induced micro-droplet continuous generation and transfer method |
| CN107930711B (en) * | 2017-12-07 | 2020-10-02 | 河北工业大学 | Light-triggered micro-droplet directional transportation method based on Y-cut lithium niobate chip |
| CN108872084B (en) * | 2018-04-24 | 2022-05-17 | 河北工业大学 | All-optical micro-droplet separation method based on asymmetric lithium niobate interlayer structure |
| CN109127180A (en) * | 2018-09-10 | 2019-01-04 | 河北工业大学 | A kind of device and method for cutting lithium niobate crystal chip controllable aerosol jet in real time based on C |
| CN110092347A (en) * | 2019-04-26 | 2019-08-06 | 河北工业大学 | A kind of device and method that micro-nano electrode is prepared based on lithium niobate light manipulation microlayer model |
| CN110052301B (en) * | 2019-05-20 | 2022-03-15 | 河北工业大学 | Motion micro-droplet continuous separation method based on y-cut lithium niobate sandwich structure chip |
| CN110560189B (en) * | 2019-10-21 | 2022-02-01 | 河北工业大学 | Hydrated liquid drop separation method and device based on y-cut lithium niobate chip |
| CN111974470A (en) * | 2020-06-09 | 2020-11-24 | 天津城建大学 | Device and method for realizing micro-droplet transportation on heterogeneous substrate |
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| US7772523B2 (en) * | 2004-07-30 | 2010-08-10 | Semiconductor Energy Laboratory Co., Ltd | Laser irradiation apparatus and laser irradiation method |
| US7745788B2 (en) * | 2005-09-23 | 2010-06-29 | Massachusetts Institute Of Technology | Optical trapping with a semiconductor |
| CN100487171C (en) * | 2007-05-21 | 2009-05-13 | 河北工业大学 | Double-doped lithium niobate crystsal and method for making same |
| CN101601987B (en) * | 2009-06-30 | 2012-05-09 | 宁波大学 | Device and method for realizing transportation of digital micro-fluid between microfluidic chips |
| GB0914762D0 (en) * | 2009-08-24 | 2009-09-30 | Univ Glasgow | Fluidics apparatus and fluidics substrate |
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