CN109966434A - 一种中药组合物、中药复方制剂及其制备方法和应用 - Google Patents
一种中药组合物、中药复方制剂及其制备方法和应用 Download PDFInfo
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- 230000001131 transforming effect Effects 0.000 description 1
- WKOLLVMJNQIZCI-UHFFFAOYSA-N vanillic acid Chemical compound COC1=CC(C(O)=O)=CC=C1O WKOLLVMJNQIZCI-UHFFFAOYSA-N 0.000 description 1
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- 231100000611 venom Toxicity 0.000 description 1
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- 239000000341 volatile oil Substances 0.000 description 1
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Abstract
Description
组别 | 24小时 | 48小时 | 72小时 |
空白组 | 1.56±0.44 | 3.20±1.01 | 4.05±0.52 |
西多福韦 | 32.24±2.08 | 48.58±3.50 | 58.09±3.21 |
实施例1 | 42.74±1.48 | 55.83±2.47 | 74.89±2.63 |
实施例2 | 41.45±1.94 | 54.73±2.91 | 74.75±2.62 |
实施例3 | 43.82±2.78 | 57.46±2.18 | 77.35±3.11 |
实施例4 | 41.32±2.03 | 57.74±2.95 | 76.48±2.27 |
实施例5 | 39.55±2.17 | 56.08±3.24 | 75.84±2.58 |
实施例6 | 42.17±2.66 | 58.24±1.97 | 78.01±3.06 |
实施例7 | 43.58±3.04 | 60.62±2.65 | 80.33±3.14 |
组别 | 病例数 | 显效 | 有效 | 无效 | 有效率/% |
空白组 | 50 | 0 | 0 | 50 | 0 |
阳性药组 | 50 | 6 | 30 | 14 | 72 |
实施例5 | 50 | 34 | 9 | 7 | 86 |
实施例6 | 50 | 39 | 6 | 5 | 90 |
实施例7 | 50 | 38 | 8 | 4 | 92 |
Claims (15)
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CN2018107659037 | 2018-07-12 |
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US (1) | US20210008145A1 (zh) |
EP (1) | EP3821902B1 (zh) |
JP (1) | JP7196192B2 (zh) |
CN (1) | CN109966434B (zh) |
WO (1) | WO2020010919A1 (zh) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112618674A (zh) * | 2020-12-31 | 2021-04-09 | 江苏正阳药业有限公司 | 一种辅助卵巢癌治疗的中药组合物、制剂及制备方法 |
CN113384548A (zh) * | 2020-12-31 | 2021-09-14 | 江苏正阳药业有限公司 | 一种具有抗hpv病毒感染的阴道泡腾片及其制备方法 |
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CN113144115A (zh) * | 2021-06-03 | 2021-07-23 | 上海市第七人民医院(上海中医药大学附属第七人民医院) | 一种治疗寻常疣的中药组合物及其应用 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1215557A (zh) * | 1997-10-27 | 1999-05-05 | 崔凤玉 | 性病浸洗消毒液 |
CN1628771A (zh) * | 2004-08-26 | 2005-06-22 | 唐秋海 | 治疗妇科疾病的洗剂及其制备方法 |
CN101342137A (zh) * | 2008-08-15 | 2009-01-14 | 黄洪弼 | 多功能女阴护理液及其制备方法 |
CN103933429A (zh) * | 2014-05-08 | 2014-07-23 | 孙云 | 治疗阴道炎的中药组合物 |
CN108853404A (zh) * | 2018-07-24 | 2018-11-23 | 近晟(上海)医药科技有限公司 | 一种治疗皮肤及黏膜疾病的中药复方制剂及其制备方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102743662B (zh) * | 2012-07-18 | 2015-03-11 | 广西中医药大学 | 治疗妇科炎症的壮药制剂及其制备方法 |
CN102908559A (zh) * | 2012-09-26 | 2013-02-06 | 韩临晓 | 一种治疗人乳头状瘤病毒感染的外用中药药剂 |
CN103520592B (zh) * | 2013-09-24 | 2016-06-15 | 张丽香 | 治疗妇科慢性盆腔痛的中药汤剂 |
CN104524465A (zh) * | 2014-12-30 | 2015-04-22 | 苏少中 | 一种治疗霉菌性阴道炎的中药清洗液及其制备方法 |
CN107929619A (zh) * | 2017-12-29 | 2018-04-20 | 广西万德药业有限公司 | 用于妇科炎症的洗剂及其制备方法 |
CN108066672A (zh) * | 2017-12-29 | 2018-05-25 | 广西万德药业有限公司 | 用于妇科炎症的乳剂及其制备方法 |
-
2019
- 2019-05-16 CN CN201910411430.5A patent/CN109966434B/zh active Active
- 2019-05-16 JP JP2020552700A patent/JP7196192B2/ja active Active
- 2019-05-16 EP EP19834655.3A patent/EP3821902B1/en active Active
- 2019-05-16 WO PCT/CN2019/087286 patent/WO2020010919A1/zh unknown
-
2020
- 2020-09-29 US US17/037,617 patent/US20210008145A1/en not_active Abandoned
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1215557A (zh) * | 1997-10-27 | 1999-05-05 | 崔凤玉 | 性病浸洗消毒液 |
CN1628771A (zh) * | 2004-08-26 | 2005-06-22 | 唐秋海 | 治疗妇科疾病的洗剂及其制备方法 |
CN101342137A (zh) * | 2008-08-15 | 2009-01-14 | 黄洪弼 | 多功能女阴护理液及其制备方法 |
CN103933429A (zh) * | 2014-05-08 | 2014-07-23 | 孙云 | 治疗阴道炎的中药组合物 |
CN108853404A (zh) * | 2018-07-24 | 2018-11-23 | 近晟(上海)医药科技有限公司 | 一种治疗皮肤及黏膜疾病的中药复方制剂及其制备方法 |
Non-Patent Citations (2)
Title |
---|
张秀杰 等: "中西医联合治疗细菌性阴道炎疗效分析", 《中国医药科学》 * |
无: "火炭母草的适用症状及使用方法", 《河南狮傲康实业有限公司网站》 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112618674A (zh) * | 2020-12-31 | 2021-04-09 | 江苏正阳药业有限公司 | 一种辅助卵巢癌治疗的中药组合物、制剂及制备方法 |
CN113384548A (zh) * | 2020-12-31 | 2021-09-14 | 江苏正阳药业有限公司 | 一种具有抗hpv病毒感染的阴道泡腾片及其制备方法 |
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EP3821902B1 (en) | 2023-02-22 |
JP7196192B2 (ja) | 2022-12-26 |
US20210008145A1 (en) | 2021-01-14 |
WO2020010919A1 (zh) | 2020-01-16 |
EP3821902A1 (en) | 2021-05-19 |
JP2021516696A (ja) | 2021-07-08 |
EP3821902A4 (en) | 2021-08-25 |
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