CN108066672A - 用于妇科炎症的乳剂及其制备方法 - Google Patents
用于妇科炎症的乳剂及其制备方法 Download PDFInfo
- Publication number
- CN108066672A CN108066672A CN201711488097.5A CN201711488097A CN108066672A CN 108066672 A CN108066672 A CN 108066672A CN 201711488097 A CN201711488097 A CN 201711488097A CN 108066672 A CN108066672 A CN 108066672A
- Authority
- CN
- China
- Prior art keywords
- parts
- emulsion
- preparation
- gynaecological imflammation
- borneol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000839 emulsion Substances 0.000 title claims abstract description 39
- 238000002360 preparation method Methods 0.000 title claims abstract description 31
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims abstract description 30
- 240000003109 Persicaria chinensis Species 0.000 claims abstract description 23
- 235000008495 Chrysanthemum leucanthemum Nutrition 0.000 claims abstract description 17
- 244000001632 Acorus gramineus Species 0.000 claims abstract description 16
- 244000035851 Chrysanthemum leucanthemum Species 0.000 claims abstract description 16
- 239000003814 drug Substances 0.000 claims abstract description 16
- 235000013073 Acorus gramineus Nutrition 0.000 claims abstract description 15
- 241000605422 Asparagus asparagoides Species 0.000 claims abstract description 15
- 241000209035 Ilex Species 0.000 claims abstract description 15
- 235000003332 Ilex aquifolium Nutrition 0.000 claims abstract description 15
- 235000002296 Ilex sandwicensis Nutrition 0.000 claims abstract description 15
- 235000002294 Ilex volkensiana Nutrition 0.000 claims abstract description 15
- 229910052742 iron Inorganic materials 0.000 claims abstract description 15
- 229940079593 drug Drugs 0.000 claims abstract description 12
- 238000002156 mixing Methods 0.000 claims abstract description 10
- 239000002994 raw material Substances 0.000 claims abstract description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 44
- 239000006071 cream Substances 0.000 claims description 26
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims description 25
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 claims description 25
- 229940116229 borneol Drugs 0.000 claims description 25
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 claims description 25
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 claims description 25
- 229960002152 chlorhexidine acetate Drugs 0.000 claims description 24
- MCSINKKTEDDPNK-UHFFFAOYSA-N propyl propionate Chemical compound CCCOC(=O)CC MCSINKKTEDDPNK-UHFFFAOYSA-N 0.000 claims description 24
- 235000019441 ethanol Nutrition 0.000 claims description 23
- 238000003756 stirring Methods 0.000 claims description 18
- 239000000706 filtrate Substances 0.000 claims description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 14
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 12
- 229920000053 polysorbate 80 Polymers 0.000 claims description 12
- 238000001914 filtration Methods 0.000 claims description 11
- 229940126678 chinese medicines Drugs 0.000 claims description 7
- 238000011049 filling Methods 0.000 claims description 7
- 238000002386 leaching Methods 0.000 claims description 7
- 238000004064 recycling Methods 0.000 claims description 7
- 239000006228 supernatant Substances 0.000 claims description 7
- 201000010099 disease Diseases 0.000 claims description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 6
- 230000001954 sterilising effect Effects 0.000 claims description 6
- 239000004744 fabric Substances 0.000 claims description 5
- 238000004321 preservation Methods 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 3
- 239000012141 concentrate Substances 0.000 claims description 2
- 238000001556 precipitation Methods 0.000 claims description 2
- 241000894006 Bacteria Species 0.000 claims 1
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 claims 1
- 244000301850 Cupressus sempervirens Species 0.000 claims 1
- 239000003610 charcoal Substances 0.000 claims 1
- 229960003260 chlorhexidine Drugs 0.000 claims 1
- 235000021419 vinegar Nutrition 0.000 claims 1
- 239000000052 vinegar Substances 0.000 claims 1
- 208000002193 Pain Diseases 0.000 abstract description 10
- 230000008961 swelling Effects 0.000 abstract description 6
- 230000000694 effects Effects 0.000 abstract description 5
- 238000005516 engineering process Methods 0.000 abstract description 5
- 208000017520 skin disease Diseases 0.000 abstract description 5
- 230000001139 anti-pruritic effect Effects 0.000 abstract description 3
- 239000003908 antipruritic agent Substances 0.000 abstract description 3
- 231100000252 nontoxic Toxicity 0.000 abstract description 3
- 230000003000 nontoxic effect Effects 0.000 abstract description 3
- 230000001804 emulsifying effect Effects 0.000 abstract description 2
- 238000004945 emulsification Methods 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 description 9
- 239000000047 product Substances 0.000 description 8
- 208000003251 Pruritus Diseases 0.000 description 7
- 239000000796 flavoring agent Substances 0.000 description 7
- 235000019634 flavors Nutrition 0.000 description 7
- 230000006870 function Effects 0.000 description 7
- 210000004185 liver Anatomy 0.000 description 6
- 230000010415 tropism Effects 0.000 description 6
- 201000004624 Dermatitis Diseases 0.000 description 5
- 208000010668 atopic eczema Diseases 0.000 description 5
- 239000012530 fluid Substances 0.000 description 5
- 210000001215 vagina Anatomy 0.000 description 5
- 240000005001 Paeonia suffruticosa Species 0.000 description 4
- 206010037660 Pyrexia Diseases 0.000 description 4
- 208000006374 Uterine Cervicitis Diseases 0.000 description 4
- 206010046914 Vaginal infection Diseases 0.000 description 4
- 201000008100 Vaginitis Diseases 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 206010008323 cervicitis Diseases 0.000 description 4
- 208000001848 dysentery Diseases 0.000 description 4
- 201000005630 leukorrhea Diseases 0.000 description 4
- 230000027758 ovulation cycle Effects 0.000 description 4
- 206010046901 vaginal discharge Diseases 0.000 description 4
- 210000003905 vulva Anatomy 0.000 description 4
- 208000006820 Arthralgia Diseases 0.000 description 3
- 206010007247 Carbuncle Diseases 0.000 description 3
- 206010061218 Inflammation Diseases 0.000 description 3
- 235000003889 Paeonia suffruticosa Nutrition 0.000 description 3
- 238000003745 diagnosis Methods 0.000 description 3
- 230000004054 inflammatory process Effects 0.000 description 3
- 208000014674 injury Diseases 0.000 description 3
- 238000007689 inspection Methods 0.000 description 3
- 210000004072 lung Anatomy 0.000 description 3
- 230000001737 promoting effect Effects 0.000 description 3
- 206010067484 Adverse reaction Diseases 0.000 description 2
- 206010010071 Coma Diseases 0.000 description 2
- 206010012735 Diarrhoea Diseases 0.000 description 2
- 206010023126 Jaundice Diseases 0.000 description 2
- 206010061926 Purulence Diseases 0.000 description 2
- 208000009205 Tinnitus Diseases 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 230000006838 adverse reaction Effects 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 241000411851 herbal medicine Species 0.000 description 2
- 230000007803 itching Effects 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 201000007227 lymph node tuberculosis Diseases 0.000 description 2
- 201000002266 mite infestation Diseases 0.000 description 2
- 230000000306 recurrent effect Effects 0.000 description 2
- 231100000886 tinnitus Toxicity 0.000 description 2
- 230000008736 traumatic injury Effects 0.000 description 2
- 206010000087 Abdominal pain upper Diseases 0.000 description 1
- 241000544682 Acorus tatarinowii Species 0.000 description 1
- 240000000113 Baeckea frutescens Species 0.000 description 1
- 235000004335 Baeckea frutescens Nutrition 0.000 description 1
- 241000131317 Capitulum Species 0.000 description 1
- 240000005250 Chrysanthemum indicum Species 0.000 description 1
- 244000192528 Chrysanthemum parthenium Species 0.000 description 1
- 235000000604 Chrysanthemum parthenium Nutrition 0.000 description 1
- 208000034656 Contusions Diseases 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 206010011878 Deafness Diseases 0.000 description 1
- 208000005171 Dysmenorrhea Diseases 0.000 description 1
- 206010013935 Dysmenorrhoea Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 201000000297 Erysipelas Diseases 0.000 description 1
- 208000005577 Gastroenteritis Diseases 0.000 description 1
- 206010018612 Gonorrhoea Diseases 0.000 description 1
- 208000034507 Haematemesis Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 241000519740 Ilex rotunda Species 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 208000008763 Mercury poisoning Diseases 0.000 description 1
- 206010027439 Metal poisoning Diseases 0.000 description 1
- 208000000112 Myalgia Diseases 0.000 description 1
- 241000475481 Nebula Species 0.000 description 1
- 206010068319 Oropharyngeal pain Diseases 0.000 description 1
- 201000005702 Pertussis Diseases 0.000 description 1
- 206010034829 Pharyngeal oedema Diseases 0.000 description 1
- 241000972673 Phellodendron amurense Species 0.000 description 1
- 241001079007 Phellodendron chinense Species 0.000 description 1
- 206010035664 Pneumonia Diseases 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 241000219000 Populus Species 0.000 description 1
- 241000218201 Ranunculaceae Species 0.000 description 1
- 241001404789 Smilax glabra Species 0.000 description 1
- 244000299492 Thespesia populnea Species 0.000 description 1
- 235000009430 Thespesia populnea Nutrition 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 241001251949 Xanthium sibiricum Species 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 208000019790 abdominal distention Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 206010000269 abscess Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 208000002399 aphthous stomatitis Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 208000034526 bruise Diseases 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 230000019771 cognition Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000001784 detoxification Methods 0.000 description 1
- 206010013023 diphtheria Diseases 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 208000001780 epistaxis Diseases 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 210000003414 extremity Anatomy 0.000 description 1
- 230000004438 eyesight Effects 0.000 description 1
- 235000008384 feverfew Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 208000001786 gonorrhea Diseases 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 201000001881 impotence Diseases 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- 210000000867 larynx Anatomy 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 230000003211 malignant effect Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000027939 micturition Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 206010029410 night sweats Diseases 0.000 description 1
- 230000036565 night sweats Effects 0.000 description 1
- 231100000862 numbness Toxicity 0.000 description 1
- 230000001151 other effect Effects 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- -1 r Species 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 235000019615 sensations Nutrition 0.000 description 1
- 210000004999 sex organ Anatomy 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 238000010025 steaming Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000004575 stone Substances 0.000 description 1
- 208000006379 syphilis Diseases 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 208000023409 throat pain Diseases 0.000 description 1
- 201000004647 tinea pedis Diseases 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 208000025301 tympanitis Diseases 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- 230000036642 wellbeing Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/90—Smilacaceae (Catbrier family), e.g. greenbrier or sarsaparilla
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/287—Chrysanthemum, e.g. daisy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/756—Phellodendron, e.g. corktree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- General Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
本发明公开了用于妇科炎症的乳剂及其制备方法,原料由以下重量份的中药组分组成:火炭母20‑50份、土茯苓10‑30份、石菖蒲10‑20份、救必应10‑30份、牡丹皮10‑30份、野菊花10‑20份、黄柏10‑20份。本发明乳剂经过提取、浓缩、乳化、均质等步骤制备而成,采用均质乳化技术,大大提高药物的溶解性以及分散均匀性,避免药物成分混合不均匀而影响疗效,具有清热解毒,消肿止痛,杀虫止痒之功,使用方便、安全、无毒、无副作用,对皮肤疾病及妇科炎症有良好的疗效。
Description
技术领域
本发明属于药品领域,涉及一种用于妇科炎症的乳剂及其制备方法。
背景技术
妇科炎症是女性的常见疾病,主要是指女性生殖器官的炎症,具体包括女性外阴炎、阴道炎、宫颈炎、盆腔炎,常见症状主要是外阴及阴道瘙痒,有的局部发生糜烂,伴灼痛、尿痛、尿频、阴道分泌物增多、红肿等。由于许多女性对妇科疾病缺乏应有的认知及自我身体保护意识,加上各种不良生活习性等,导致一些女科疾病缠身,经久不愈或反反复复,给正常的生活、工作带来极大的不便,甚至影响家庭的幸福生活。本发明对妇科炎症具有专属针对性,能有效减少患者痛苦,提高生活质量。目前尚未见有本发明火炭母,野菊花、石菖蒲、土茯苓、救必应、牡丹皮、黄柏组合物的报道。
(1)火炭母,本品为蓼科植物火炭母Polygonum chinense Linn.的干燥全草。【性味】辛;苦;性凉;【功能主治】清热利湿;凉血解毒;平肝明目;活血舒筋。主痢疾;泄泻;咽喉肿痛;白喉;肺热咳嗽;百日咳;肝炎;带下;癌肿;中耳炎;湿疹;眩晕耳鸣;角膜云翳;跌打损伤。
(2)野菊花,本品为菊科植物野菊Chrysanthemum indicum L.的干燥头状花序。【性味】苦辛,凉。【归经】:归肺、肝。【功能主治】疏风清热,消肿解毒。治风热感冒,肺炎、白喉,胃肠炎:高血压,疔,痈,口疮,丹毒,湿疹,天泡疮。
(3)石菖蒲,本品为天南星科植物石菖蒲Acorus tatarinowii Schott的干燥根茎。【性味】味辛;苦;性微温。【归经】心;肝;脾经。【功能主治】化痰开窍;化湿行气;祛风利痹;消肿止痛。主热病神昏;痰厥;健忘;耳鸣;耳聋;脘腹胀痛;噤口痢;风湿痹痛;跌打损伤;痈疽疥癣。
(4)土茯苓,为百合科植物光叶菝葜Smilax glabra Roxb.的干燥根茎。【性味】甘、淡,平。【归经】归肝、胃经。【功能主治】除湿,解毒,通利关节。用于湿热淋浊,带下,痈肿,瘰疬,疥癣,梅毒及汞中毒所致的肢体拘挛,筋骨疼痛。
(5)救必应,为冬青科植物铁冬青Ilex rotunda Thunb.的干燥树皮。【性味】苦;寒。【归经】肺;肝;大肠经。【功能主治】清热解毒;利湿;止痛。主感冒发热;咽喉肿痛;胃痛;署湿泄泻;黄疸;痢疾;跌打损伤;风湿痹痛;湿疹;疮疖。
(6)牡丹皮,本品为毛茛科植物牡丹Paeonia suffruticosa Andr.的干燥根皮。【性味】苦、辛,微寒。【归经】归心、肝、肾经。【功能主治】清热凉血,活血化瘀。用于温毒发斑,吐血衄血,夜热早凉,无汗骨蒸,经闭痛经,痈肿疮毒,跌扑伤痛。
(7)黄柏,本品为芸香科植物黄皮树Phellodendron chinense Schneid.或黄檗Phellodendron amurense Rupr.的干燥树皮。【性味】苦,寒。【归经】归肾、膀胱经。【功能主治】清热燥湿,泻火除蒸,解毒疗疮。用于湿热泻痢,黄疸,带下,热淋,脚气,痿{辟},骨蒸劳热,盗汗,遗精,疮疡肿毒,湿疹瘙痒。
以上背景技术内容的公开仅用于辅助理解本发明的发明构思及技术方案,其并不必然属于本专利申请的现有技术,在没有明确的证据表明上述内容在本专利申请的申请日已经公开的情况下,上述背景技术不应当用于评价本申请的新颖性和创造性。
发明内容
本发明的目的是提供一种用于妇科炎症的乳剂,该乳剂能防治皮肤病及治疗妇科疾病等功效。本发明人通过中医理论的指导,与现代中药先进制剂技术相结合,通过挖掘民间用药进行合理配制,制成一种用于妇科炎症的乳剂,具有清热解毒、消肿止痛、杀虫止痒之功效,能有效防治皮肤病及治疗妇科炎症等疾病,有效减轻患者痛苦,达到提高生活质量的目的。
本发明所采用的技术方案如下:
用于妇科炎症的乳剂,原料由以下重量份的中药组分组成:火炭母20-50份、土茯苓10-30份、石菖蒲10-20份、救必应10-30份、牡丹皮10-30份、野菊花10-20份、黄柏10-20份、冰片1-3份、吐温-80 15-25份、醋酸氯己定1-3份;
其制备方法为:称取火炭母、土茯苓、石菖蒲、救必应、牡丹皮、野菊花、黄柏,加水煎煮2-3次,每次1-3h,过滤,合并滤液;滤液浓缩,加入乙醇,静置,滤取上清液回收乙醇,得清膏;取醋酸氯己定、冰片加乙醇使溶解;另取吐温-80加热至40℃-60℃,加入制得的清膏,搅拌均匀后加入醋酸氯己定、冰片混合液,40℃-60℃下均质搅拌,过滤,灭菌,灌装,即得所述乳剂。
以上所述用于妇科炎症的乳剂,原料优选由以下重量份的中药组分组成:火炭母40份、土茯苓15份、石菖蒲15份、救必应20份、牡丹皮20份、野菊花15份、黄柏18份、冰片2份、吐温-80 20份、醋酸氯己定2份。
以上所述用于妇科炎症的乳剂的制备方法,包括以下步骤:
S1:按以下重量份称取组分:火炭母20-50份、土茯苓10-30份、石菖蒲10-20份、救必应10-30份、牡丹皮10-30份、野菊花10-20份、黄柏10-20份、冰片1-3份、吐温-80 15-25份、醋酸氯己定1-3份;
S2:取步骤S1称量好的火炭母等七味中药材加6-10倍量水,煎煮2-3次,每次1-3h,过滤,合并滤液;
S3:将步骤S2的滤液浓缩至相对密度在60-70℃为1.05-1.10的清膏,加入与清膏等量的95%乙醇,静置,滤取上清液回收乙醇并浓缩至相对密度在60-70℃为1.15-1.20的清膏;
S4:取醋酸氯己定、冰片加95%乙醇使溶解,备用;另取吐温-80加热至40℃-60℃,保温情况下加入步骤S3制得的清膏,搅拌均匀后加入以上醋酸氯己定、冰片混合液,40℃-60℃下均质搅拌20-40min,最后加水至配制量,继续均质搅拌20-30min,取出,用滤布过滤,灭菌,灌装,即得所述乳剂。
以上所述用于妇科炎症的乳剂的制备方法,所述原料优选由以下重量份的中药组分组成:火炭母40份、土茯苓15份、石菖蒲15份、救必应20份、牡丹皮20份、野菊花15份、黄柏18份、冰片2份、吐温-80 20份、醋酸氯己定2份。
以上所述用于妇科炎症的乳剂的制备方法,所述步骤S3火炭母等七味中药材优选加8倍量水,煎煮3次,每次2h。
以上所述用于妇科炎症的乳剂的制备方法,所述步骤S3清膏醇沉静置时间优选为12-24h。
以上所述用于妇科炎症的乳剂的制备方法,所述步骤S4均质搅拌时间优选均为30min。
以上所述用于妇科炎症的乳剂的制备方法,所述步骤S4均质搅拌速度为20000-30000rpm。
以上权利要求1所述的用于妇科炎症的乳剂,所述乳剂在制备治疗皮肤病、妇科炎症药物中的应用。
本发明的有益效果是:
(1)组分均为无毒“中草药”品种,使用安全。
(2)组方严谨,药力具有针对性,具有清热解毒、消肿止痛、杀虫止痒之功,对湿疹等皮肤疾病及妇科炎症等有良好的疗效。
(3)本发明制剂制备方法简单,采用均质乳化技术,大大提高药物的溶解性以及分散均匀性,避免药物成分混合不均匀而影响疗效、增加毒性,可明显提高药物稳定性和有效性,使用方便、安全、无毒、无副作用。
具体实施方式
下面结合具体实施例对本发明作进一步描述,但不限制本发明的保护范围和应用范围:
一、乳剂的制备
实施例1
用于妇科炎症的乳剂的制备方法,包括以下步骤:
S1:按以下重量称取组分:火炭母20kg、土茯苓10kg、石菖蒲10kg、救必应10kg、牡丹皮10kg、野菊花10kg、黄柏10kg、冰片1kg、吐温-80 15kg、醋酸氯己定1kg;
S2:取步骤S1称量好的火炭母等七味中药材加6倍量水,煎煮2次,每次1h,过滤,合并滤液;
S3:将步骤S2的滤液浓缩至相对密度在60℃为1.05的清膏,加入与清膏等量的95%乙醇,静置12h,滤取上清液回收乙醇并浓缩至相对密度在60℃为1.15的清膏;
S4:取醋酸氯己定、冰片加95%乙醇使溶解,备用;另取吐温-80加热至40℃,保温情况下加入步骤S3制得的清膏,搅拌均匀后加入以上醋酸氯己定、冰片混合液,40℃下均质搅拌20min,均质搅拌速度为20000rpm,最后加水至配制量,继续均质搅拌20min,均质搅拌速度为20000rpm,取出,用100目滤布过滤,灭菌,灌装,即得所述乳剂。
实施例2
用于妇科炎症的乳剂的制备方法,包括以下步骤:
S1:按以下重量称取组分:火炭母50kg、土茯苓30kg、石菖蒲20kg、救必应30kg、牡丹皮30kg、野菊花20kg、黄柏20kg、冰片3kg、吐温-80 25kg、醋酸氯己定3kg;
S2:取步骤S1称量好的火炭母等七味中药材加10倍量水,煎煮3次,每次3h,过滤,合并滤液;
S3:将步骤S2的滤液浓缩至相对密度在70℃为1.10的清膏,加入与清膏等量的95%乙醇,静置24h,滤取上清液回收乙醇并浓缩至相对密度在70℃为1.20的清膏;
S4:取醋酸氯己定、冰片加95%乙醇使溶解,备用;另取吐温-80加热至60℃,保温情况下加入步骤S3制得的清膏,搅拌均匀后加入以上醋酸氯己定、冰片混合液,60℃下均质搅拌40min,均质搅拌速度为30000rpm;最后加水至配制量,继续均质搅拌25min,均质搅拌速度为30000rpm,取出,用100目滤布过滤,灭菌,灌装,即得所述乳剂。
实施例3
用于妇科炎症的乳剂的制备方法,包括以下步骤:
S1:按以下重量称取组分:火炭母40kg、土茯苓15kg、石菖蒲15kg、救必应20kg、牡丹皮20kg、野菊花15kg、黄柏18kg、冰片2kg、吐温-80 20kg、醋酸氯己定2kg;
S2:取步骤S1称量好的火炭母等七味中药材加8倍量水,煎煮3次,每次2h,过滤,合并滤液;
S3:将步骤S2的滤液浓缩至相对密度在65℃为1.10的清膏,加入与清膏等量的95%乙醇,静置20h,滤取上清液回收乙醇并浓缩至相对密度在65℃为1.20的清膏;
S4:取醋酸氯己定、冰片加95%乙醇使溶解,备用;另取吐温-80加热至50℃,保温情况下加入步骤S3制得的清膏,搅拌均匀后加入以上醋酸氯己定、冰片混合液,50℃下均质搅拌30min,均质搅拌速度为25000rpm;最后加水至配制量,继续均质搅拌30min,均质搅拌速度为25000rpm,取出,用100目滤布过滤,灭菌,灌装,即得所述乳剂。
二、临床应用
1.病例选择
选择患有妇科炎症(宫颈炎、阴道炎)的患者。
2疗效判定
(1)痊愈:无阴道、外阴痒痛症状,阴道分泌物检查无异常,停药3个月经周期没有复发;
(2)显效:阴道、外阴痒痛症状改善,阴道分泌物检查无异常;
(3)有效:阴道分泌物检查无异常,但其他症状存在,或其他症状减轻、消失,但阴道分泌物检查异常;
(4)无效:症状及检查结果均无变化。
3.给药方法
将符合上述病例选择标准患者68例(平均年龄35岁)按就诊顺序随机分成4个组,每组17人。
实施例组:取本发明实施例1、2、3样品,外用晚上睡觉前灌于阴道,一日1次,疗程:用药3周。
对照组:取市售复方岗松乳剂,外用晚上睡觉前灌于阴道,一日1次,疗程:用药3周。
4.试验结果
结果详见表1。
在以上试验过程中,本发明3个实施例以及对照组无一例患者出现不良反应。以上结果表明,本发明实施例1、2、3对妇科炎症的治疗总有效率达88%以上,均高于对照组,而且在治疗过程中未出现任何不良反应,说明本发明的制剂可有效治疗妇科炎症,使用安全有效。以下为几个典型的例子:
典型例子1:张某,33岁,白带多且呈脓样,偶见带血性,伴有腰酸、下腹坠胀痛等不适等症状,反复发作,持续12个月,最近还感觉外阴瘙痒且伴有灼热感,经医院诊断为慢性宫颈炎、阴道炎。使用本发明实施例1的产品21天后,不适症状基本消失,阴道分泌物检查恢复正常,停药4个月经周期没有复发。
典型例子2:杨某,女,25岁,白带多,其形状多为稀薄浆液状,外阴瘙痒并有灼痛感,反复发作,持续时间3个月,经医院诊断为阴道炎。使用本发明实施例2的产品21天后,白带正常,外阴瘙痒现象消失,灼痛感消失,停药3个月经周期没有复发。
典型例子3:潘某,女,38岁,白带多,有时脓样,偶可带血性,常伴有腰酸、下腹痛及坠胀不适等症状,经医院诊断为宫颈炎。使用本发明实施例3的产品21天后,白带正常,腰酸、下腹痛、坠胀等症状消失,停药3个月经周期没有复发。
以上内容是结合具体的/优选的实施方式对本发明所作的进一步详细说明,不能认定本发明的具体实施只局限于这些说明。对于本发明所属技术领域的普通技术人员来说,在不脱离本发明构思的前提下,其还可以对这些已描述的实施例做出若干替代或变型,而这些替代或变型方式都应当视为属于本发明的保护范围。
Claims (9)
1.用于妇科炎症的乳剂,其特征在于,原料由以下重量份的中药组分组成:火炭母20-50份、土茯苓10-30份、石菖蒲10-20份、救必应10-30份、牡丹皮10-30份、野菊花10-20份、黄柏10-20份、冰片1-3份、吐温-80 15-25份、醋酸氯己定1-3份;
其制备方法为:称取火炭母、土茯苓、石菖蒲、救必应、牡丹皮、野菊花、黄柏,加水煎煮2-3次,每次1-3h,过滤,合并滤液;滤液浓缩,加入乙醇,静置,滤取上清液回收乙醇,得清膏;取醋酸氯己定、冰片加乙醇使溶解;另取吐温-80加热至40℃-60℃,加入制得的清膏,搅拌均匀后加入醋酸氯己定、冰片混合液,40℃-60℃下均质搅拌,过滤,灭菌,灌装,即得所述乳剂。
2.根据权利要求1所述用于妇科炎症的乳剂,其特征在于,原料由以下重量份的中药组分组成:火炭母40份、土茯苓15份、石菖蒲15份、救必应20份、牡丹皮20份、野菊花15份、黄柏18份、冰片2份、吐温-80 20份、醋酸氯己定2份。
3.如权利要求1所述用于妇科炎症的乳剂的制备方法,其特征在于,包括以下步骤:
S1:按以下重量份称取组分:火炭母20-50份、土茯苓10-30份、石菖蒲10-20份、救必应10-30份、牡丹皮10-30份、野菊花10-20份、黄柏10-20份、冰片1-3份、吐温-80 15-25份、醋酸氯己定1-3份;
S2:取步骤S1称量好的火炭母等七味中药材加6-10倍量水,煎煮2-3次,每次1-3h,过滤,合并滤液;
S3:将步骤S2的滤液浓缩至相对密度在60-70℃为1.05-1.10的清膏,加入与清膏等量的95%乙醇,静置,滤取上清液回收乙醇并浓缩至相对密度在60-70℃为1.15-1.20的清膏;
S4:取醋酸氯己定、冰片加95%乙醇使溶解,备用;另取吐温-80加热至40℃-60℃,保温情况下加入步骤S3制得的清膏,搅拌均匀后加入以上醋酸氯己定、冰片混合液,40℃-60℃下均质搅拌20-40min,最后加水至配制量,继续均质搅拌20-30min,取出,用滤布过滤,灭菌,灌装,即得所述乳剂。
4.根据权利要求3所述用于妇科炎症的乳剂的制备方法,其特征在于,所述原料由以下重量份的中药组分组成:火炭母40份、土茯苓15份、石菖蒲15份、救必应20份、牡丹皮20份、野菊花15份、黄柏18份、冰片2份、吐温-80 20份、醋酸氯己定2份。
5.根据权利要求3所述用于妇科炎症的乳剂的制备方法,其特征在于,所述步骤S3火炭母等七味中药材加8倍量水,煎煮3次,每次2h。
6.根据权利要求3所述用于妇科炎症的乳剂的制备方法,其特征在于,所述步骤S3清膏醇沉静置时间为12-24h。
7.根据权利要求3所述用于妇科炎症的乳剂的制备方法,其特征在于,所述步骤S4均质搅拌时间均为30min。
8.根据权利要求3所述用于妇科炎症的乳剂的制备方法,其特征在于,所述步骤S4均质搅拌速度为20000-30000rpm。
9.根据权利要求1所述的用于妇科炎症的乳剂,其特征在于,所述乳剂在制备治疗皮肤病、妇科炎症药物中的应用。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201711488097.5A CN108066672A (zh) | 2017-12-29 | 2017-12-29 | 用于妇科炎症的乳剂及其制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201711488097.5A CN108066672A (zh) | 2017-12-29 | 2017-12-29 | 用于妇科炎症的乳剂及其制备方法 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN108066672A true CN108066672A (zh) | 2018-05-25 |
Family
ID=62156174
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201711488097.5A Pending CN108066672A (zh) | 2017-12-29 | 2017-12-29 | 用于妇科炎症的乳剂及其制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN108066672A (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3821902A4 (en) * | 2018-07-12 | 2021-08-25 | Jiangsu Zhengyang Pharmaceutical Co., Ltd. | TRADITIONAL CHINESE MEDICINAL COMPOSITION, TRADITIONAL CHINESE MEDICINAL PREPARATION, AND THE PROCESS FOR THEIR MANUFACTURE AND USE |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101816741A (zh) * | 2010-05-10 | 2010-09-01 | 贵州金桥药业有限公司 | 妇女洁阴用品及其制备方法 |
CN107158125A (zh) * | 2017-05-25 | 2017-09-15 | 广西大海阳光药业有限公司 | 一种用于妇科炎症、湿痒的制剂及其制备方法 |
-
2017
- 2017-12-29 CN CN201711488097.5A patent/CN108066672A/zh active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101816741A (zh) * | 2010-05-10 | 2010-09-01 | 贵州金桥药业有限公司 | 妇女洁阴用品及其制备方法 |
CN107158125A (zh) * | 2017-05-25 | 2017-09-15 | 广西大海阳光药业有限公司 | 一种用于妇科炎症、湿痒的制剂及其制备方法 |
Non-Patent Citations (1)
Title |
---|
吕祖传: "火炭母洗剂治疗霉菌性阴道炎32例", 《广西中医药》 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3821902A4 (en) * | 2018-07-12 | 2021-08-25 | Jiangsu Zhengyang Pharmaceutical Co., Ltd. | TRADITIONAL CHINESE MEDICINAL COMPOSITION, TRADITIONAL CHINESE MEDICINAL PREPARATION, AND THE PROCESS FOR THEIR MANUFACTURE AND USE |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN104524287A (zh) | 一种治疗过敏性紫癜的中药组合物及其制备方法 | |
CN105943963A (zh) | 一种治疗猪肺炎的药物 | |
CN108066672A (zh) | 用于妇科炎症的乳剂及其制备方法 | |
CN106138785A (zh) | 一种治疗神经衰弱的中药组合物及其制备方法 | |
CN107929619A (zh) | 用于妇科炎症的洗剂及其制备方法 | |
CN104888044A (zh) | 一种治疗肺癌的中药药酒及其制备方法 | |
CN108079230A (zh) | 含火炭母的中药组合物及其制备方法 | |
CN104825892B (zh) | 一种治疗排卵期出血的中药制剂及其制备方法 | |
CN103610934A (zh) | 一种治疗咽炎的中药 | |
CN107854662A (zh) | 一种治疗肝硬化腹水的中药制剂及其制备方法 | |
CN102772723A (zh) | 一种治疗肺结核的中药配方 | |
CN105031516A (zh) | 一种用于治疗丹毒的中药膏 | |
CN106620140A (zh) | 一种治疗水牛腐蹄病的中药组合物 | |
CN105535322A (zh) | 一种可有效治疗外感病的内服药物及其制备方法 | |
CN104721786A (zh) | 一种治疗妊娠肝内胆汁淤积症的中药制剂及其制备方法 | |
CN104758842A (zh) | 一种治疗急性阑尾炎的中药制剂 | |
CN109700966A (zh) | 一种治疗乙肝的药物、制备方法及其应用 | |
CN108210829A (zh) | 一种治疗肝郁气滞型月经不调的中药组合物 | |
CN108524651A (zh) | 一种治疗气管炎的中药配方 | |
CN108030843A (zh) | 一种治疗肺气肿的中药 | |
CN108553624A (zh) | 一种用于治疗更年期综合症的膏药及其制备方法 | |
CN108969577A (zh) | 一种作用于神厥穴治疗炎症的组合药物、药物贴膜及其制备方法和应用 | |
CN107823589A (zh) | 一种治疗支气管哮喘的汤剂药物及制备方法 | |
CN108704109A (zh) | 一种治疗痤疮的中药组合物及其制作方法 | |
CN107998209A (zh) | 一种治疗慢性肾病的中药制剂及其制备方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
RJ01 | Rejection of invention patent application after publication | ||
RJ01 | Rejection of invention patent application after publication |
Application publication date: 20180525 |