CN108079230A - 含火炭母的中药组合物及其制备方法 - Google Patents
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Abstract
本发明公开了一种含火炭母的中药组合物及其制备方法，原料由以下重量份的中药组分组成：火炭母20‑50份、土茯苓10‑30份、石菖蒲10‑20份、救必应10‑30份、牡丹皮10‑30份、野菊花10‑20份、黄柏10‑20份。本发明组方严谨，具有清热解毒，消肿止痛，杀虫止痒之功，对皮肤疾病及妇科炎症有良好的疗效。
Description
技术领域
本发明属于药品领域，涉及一种含火炭母的能够起到防治皮肤病及治疗妇科炎症的中药组合物及其制备方法。
背景技术
妇科炎症是女性的常见疾病，主要是指女性生殖器官的炎症，具体包括女性外阴炎、阴道炎、宫颈炎、盆腔炎，常见症状主要是外阴及阴道瘙痒，有的局部发生糜烂，伴灼痛、尿痛、尿频、阴道分泌物增多、红肿等。由于许多女性对妇科疾病缺乏应有的认知及自我身体保护意识，加上各种不良生活习性等，导致一些女科疾病缠身，经久不愈或反反复复，给正常的生活、工作带来极大的不便，甚至影响家庭的幸福生活。本发明对妇科炎症具有专属针对性，能有效减少患者痛苦，提高生活质量。目前尚未见有本发明火炭母，野菊花、石菖蒲、土茯苓、救必应、牡丹皮、黄柏组合物的报道。
(1)火炭母，本品为蓼科植物火炭母Polygonum chinense Linn.的干燥全草。【性味】辛；苦；性凉；【功能主治】清热利湿；凉血解毒；平肝明目；活血舒筋。主痢疾；泄泻；咽喉肿痛；白喉；肺热咳嗽；百日咳；肝炎；带下；癌肿；中耳炎；湿疹；眩晕耳鸣；角膜云翳；跌打损伤。
(2)野菊花，本品为菊科植物野菊Chrysanthemum indicum L.的干燥头状花序。【性味】苦辛，凉。【归经】：归肺、肝。【功能主治】疏风清热，消肿解毒。治风热感冒，肺炎、白喉，胃肠炎：高血压，疔，痈，口疮，丹毒，湿疹，天泡疮。
(3)石菖蒲，本品为天南星科植物石菖蒲Acorus tatarinowii Schott的干燥根茎。【性味】味辛；苦；性微温。【归经】心；肝；脾经。【功能主治】化痰开窍；化湿行气；祛风利痹；消肿止痛。主热病神昏；痰厥；健忘；耳鸣；耳聋；脘腹胀痛；噤口痢；风湿痹痛；跌打损伤；痈疽疥癣。
(4)土茯苓，为百合科植物光叶菝葜Smilax glabra Roxb.的干燥根茎。【性味】甘、淡，平。【归经】归肝、胃经。【功能主治】除湿，解毒，通利关节。用于湿热淋浊，带下，痈肿，瘰疬，疥癣，梅毒及汞中毒所致的肢体拘挛，筋骨疼痛。
(5)救必应，为冬青科植物铁冬青Ilex rotunda Thunb.的干燥树皮。【性味】苦；寒。【归经】肺；肝；大肠经。【功能主治】清热解毒；利湿；止痛。主感冒发热；咽喉肿痛；胃痛；署湿泄泻；黄疸；痢疾；跌打损伤；风湿痹痛；湿疹；疮疖。
(6)牡丹皮，本品为毛茛科植物牡丹Paeonia suffruticosa Andr.的干燥根皮。【性味】苦、辛，微寒。【归经】归心、肝、肾经。【功能主治】清热凉血，活血化瘀。用于温毒发斑，吐血衄血，夜热早凉，无汗骨蒸，经闭痛经，痈肿疮毒，跌扑伤痛。
(7)黄柏，本品为芸香科植物黄皮树Phellodendron chinense Schneid.或黄檗Phellodendron amurense Rupr.的干燥树皮。【性味】苦，寒。【归经】归肾、膀胱经。【功能主治】清热燥湿，泻火除蒸，解毒疗疮。用于湿热泻痢，黄疸，带下，热淋，脚气，痿{辟}，骨蒸劳热，盗汗，遗精，疮疡肿毒，湿疹瘙痒。
以上背景技术内容的公开仅用于辅助理解本发明的发明构思及技术方案，其并不必然属于本专利申请的现有技术，在没有明确的证据表明上述内容在本专利申请的申请日已经公开的情况下，上述背景技术不应当用于评价本申请的新颖性和创造性。
发明内容
本发明的目的是提供一种含火炭母的中药组合物，该组合物能防治皮肤病及治疗妇科疾病等功效。本发明人通过中医理论的指导，与现代中药先进制剂技术相结合，通过挖掘民间用药进行合理配制，制成一种含火炭母的中药组合物，此中药组合物具有清热解毒、消肿止痛、杀虫止痒之功效，能有效起到洁肤、防治皮肤病及治疗妇科炎症等疾病，有效减轻患者痛苦，达到提高生活质量的目的。
本发明所采用的技术方案如下：
一种含火炭母的中药组合物，该组合物原料由以下重量份的中药组分组成：火炭母20-50份、土茯苓10-30份、石菖蒲10-20份、救必应10-30份、牡丹皮10-30份、野菊花10-20份、黄柏10-20份。
以上所述含火炭母的中药组合物，在所述中药组合物中，还优选加入所述中药组合物总重量百分比为0.1-0.3％的冰片、0.2-0.5％的E-聚赖氨酸。
以上所述的含火炭母的中药组合物，原料优选由以下重量份的中药组分组成：火炭母40份、土茯苓15份、石菖蒲15份、救必应20份、牡丹皮20份、野菊花15份、黄柏18份。
以上所述的含火炭母的中药组合物，在所述中药组合物中，还优选加入所述中药组合物总重量百分比为0.2％的冰片、0.2-0.3％的E-聚赖氨酸。
以上所述的含火炭母的中药组合物，可制备成药学领域的任何制剂，优选制备成外用制剂，进一步优选制备成洗剂。
提取是制剂的关键步骤。中药有效成分的提取是一个复杂的过程，当中药样品加入溶剂后，溶剂通过浸泡扩散作用，将中药所含的化学成分逐渐溶解，使其扩散到溶剂中，直到细胞内外溶液中被溶解的化学成分的浓度达到平衡。因此，在提取过程中，中药的粉碎度、提取温度、时间、次数、溶剂等，都是影响提取的因素，选用合理的条件，才能提高有效成分的提取率，达到不同的使用效果。
一种以上所述的含火炭母的中药组合物制备成洗剂的制备方法，其特征在于，包括以下步骤：
S1：按重量份称取：取火炭母20-50份、土茯苓10-30份、石菖蒲10-20份、救必应10-30份、牡丹皮10-30份、野菊花10-20份、黄柏10-20份，净选，干燥；
S2：称取步骤S1所述药材总重量百分比为0.1-0.3％的冰片、步骤S1所述药材总重量百分比为0.2-0.5％的E-聚赖氨酸；
S3：将称量好的野菊花、石菖蒲，加6倍量水蒸馏提取挥发油3小时，收取蒸馏液、药液备用、药渣并入S4步骤；
S4：取火炭母、土茯苓、救必应、牡丹皮、黄柏及野菊花及步骤S3所述的野菊花、石菖蒲药渣，加水8-15倍煎煮1-3次，每次0.5-3小时，滤过，合并滤液，再加入步骤S3所述的药液，浓缩至稠膏，即得；
S5：在步骤S4所述的稠膏中，加入步骤S3所述的蒸馏液，搅匀，放置过夜，滤过，滤液加入冰片、E-聚赖氨酸，搅匀，即得。
以上所述稠膏为60℃时相对密度优选为1.25-1.35。
以上所述步骤S4优选加水10倍煎煮。
以上所述含火炭母的中药组合物，所述中药组合物在制备治疗皮肤病、妇科炎症药物中的应用。
本发明的有益效果是：
(1)组分均为无毒“中草药”品种，使用安全。
(2)组方严谨，药力具有针对性，具有清热解毒、消肿止痛、杀虫止痒之功，对湿疹等皮肤疾病及妇科炎症等有良好的疗效。
具体实施方式
下面结合具体实施例对本发明作进一步描述，但不限制本发明的保护范围和应用范围：
一、洗液的制备
1.试验设计：
本发明用4个实施例分别制备成洗液，具体参数详见表1。
表1洗液实施例制备参数表
2.操作步骤：
S1：按重量份称取：取火炭母20-50份、土茯苓10-30份、石菖蒲10-20份、救必应10-30份、牡丹皮10-30份、野菊花10-20份、黄柏10-20份，净选，干燥；
S2：称取步骤S1所述药材总重量百分比为0.1-0.3％的冰片、步骤S1所述药材总重量百分比为0.2-0.5％的E-聚赖氨酸；
S3：将称量好的野菊花、石菖蒲，加6倍量水蒸馏提取挥发油3小时，收取蒸馏液、药液备用、药渣并入S4步骤；
S4：取火炭母、土茯苓、救必应、牡丹皮、黄柏及野菊花及步骤S3所述的野菊花、石菖蒲药渣，加水8-15倍煎煮1-3次，每次0.5-3小时，滤过，合并滤液，再加入步骤S3所述的药液，浓缩至稠膏，即得；
S5：在步骤S4所述的稠膏中，加入步骤S3所述的蒸馏液，搅匀，放置过夜，滤过，滤液加入冰片、E-聚赖氨酸，搅匀，即得。
二、临床应用
本发明含火炭母的中药组合物，曾用于治疗和观察68例病人或志愿者。将上述制备好的4种实施例样品，分别用于下列3种不同类型的病人或志愿者。
A:阴道炎(阴道分泌物增多，豆腐渣样或凝乳，有异味；外阴瘙痒、灼痛为主要症状)，共27例，平均年龄30.2岁。
B:外阴炎(外阴皮肤瘙痒、疼痛、烧灼感，排尿或性交时加重主要症状)，共26例，平均年龄31.8岁)。
C:湿疹(以皮肤表面呈密集的粟粒大小的丘疹、丘疱疹或小水疱、基底潮红、瘙痒剧烈为主要症状，共15例，平均年龄30.8岁)。
每一种实施例样品用于上述三种类型的病例不少于5例。结果：A组：痊愈20例，改善6例，无效1例，总有效率96.3％；B组：痊愈15，改善11例，有效率100％；C组：痊愈9，改善4，无效2例，总有效率86.7％。结果表明：采用本发明中药组合物制备的洗剂，使用安全、有效，对阴道炎、宫颈炎、盆腔炎有良好的疗效，达到解决患者痛苦的目的、有效提高生活的质量。以下为几个典型病例：
病例1：张××，女，26岁，医院诊断为阴道炎。使用本发明含火炭母的中药组合物制成的洗剂(实施例1)，每日2次，用本品稀释30倍量，坐浴及冲洗阴道，连用5日，阴道炎的各种症状消除，痊愈。
病例2：李××，女，37岁，经医院诊断为外阴炎。使用用本发明含火炭母的中药组合物制成的洗剂(实施例2)，每日2次，用本品稀释30倍量，坐浴及冲洗阴道，连用7日，外阴炎的各种症状消除，痊愈。
病例3：刘××，男，30岁，经医院诊断为皮肤湿疹。使用用本发明含火炭母的中药组合物制成的洗剂(实施例3)，每日2次，用本品稀释30倍量，每次泡洗20分钟，连用7日，皮肤湿疹的各种症状消除，痊愈。
以上内容是结合具体的/优选的实施方式对本发明所作的进一步详细说明，不能认定本发明的具体实施只局限于这些说明。对于本发明所属技术领域的普通技术人员来说，在不脱离本发明构思的前提下，其还可以对这些已描述的实施例做出若干替代或变型，而这些替代或变型方式都应当视为属于本发明的保护范围。
Claims (10)
1.一种含火炭母的中药组合物，其特征在于，原料由以下重量份的中药组分组成：火炭母20-50份、土茯苓10-30份、石菖蒲10-20份、救必应10-30份、牡丹皮10-30份、野菊花10-20份、黄柏10-20份。
2.根据权利要求1所述含火炭母的中药组合物，其特征在于，在所述中药组合物中，还加入所述中药组合物总重量百分比为0.1-0.3％的冰片、0.2-0.5％的E-聚赖氨酸。
3.根据权利要求1所述的含火炭母的中药组合物，其特征在于，原料由以下重量份的中药组分组成：火炭母40份、土茯苓15份、石菖蒲15份、救必应20份、牡丹皮20份、野菊花15份、黄柏18份。
4.根据权利要求2所述的含火炭母的中药组合物，其特征在于，在所述中药组合物中，还加入所述中药组合物总重量百分比为0.2％的冰片、0.2-0.3％的E-聚赖氨酸。
5.根据权利要求1或2所述的含火炭母的中药组合物，其特征在于，所述组合物制备成外用制剂。
6.根据权利要求1或2所述的含火炭母的中药组合物，其特征在于，所述组合物制备成洗剂。
7.一种如权利要求2所述的含火炭母的中药组合物制备成洗剂的制备方法，其特征在于，包括以下步骤：
S1：按重量份称取：取火炭母20-50份、土茯苓10-30份、石菖蒲10-20份、救必应10-30份、牡丹皮10-30份、野菊花10-20份、黄柏10-20份，净选，干燥；
S2：称取步骤S1所述药材总重量百分比为0.1-0.3％的冰片、步骤S1所述药材总重量百分比为0.2-0.5％的E-聚赖氨酸；
S3：将称量好的野菊花、石菖蒲，加6倍量水蒸馏提取挥发油3小时，收取蒸馏液、药液备用、药渣并入S4步骤；
S4：取火炭母、土茯苓、救必应、牡丹皮、黄柏及野菊花及步骤S3所述的野菊花、石菖蒲药渣，加水8-15倍煎煮1-3次，每次0.5-3小时，滤过，合并滤液，再加入步骤S3所述的药液，浓缩至稠膏，即得；
S5：在步骤S4所述的稠膏中，加入步骤S3所述的蒸馏液，搅匀，放置过夜，滤过，滤液加入冰片、E-聚赖氨酸，搅匀，即得。
8.根据权利要求1所述的含火炭母的中药组合物制备成洗剂的制备方法，其特征在于，所述稠膏为60℃时相对密度为1.25-1.35。
9.根据权利要求1所述的含火炭母的中药组合物制备成洗剂的制备方法，其特征在于，所述步骤S4加水10倍煎煮。
10.根据权利要求1或2所述的含火炭母的中药组合物，其特征在于，所述组合物在制备治疗皮肤病、妇科炎症药物中的应用。
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