CN107854662A - 一种治疗肝硬化腹水的中药制剂及其制备方法 - Google Patents
一种治疗肝硬化腹水的中药制剂及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种治疗肝硬化腹水的中药制剂及其制备方法,由以下重量份的原料组成:薏苡仁10‑15份、麻黄3‑6份、青皮10‑20份、陈皮15‑20份、茵陈20‑30份、郁金10‑15份、厚朴15‑25份、大腹皮10‑15份、鳖甲10‑25份、穿山甲15‑30份、半边莲10‑15份、丹参10‑20份、三棱10‑15份、莪术10‑15份、黄芪10‑15份、白芍10‑15份、猪苓10‑18份和甘草6‑9份;本发明以水渗透湿、健脾止泻的薏苡仁为主药,以发汗解表、宣肺平喘、利水消肿的麻黄和疏肝破气、消积化滞的青皮为臣药,对虚实气化不行、气机钦疏、血行不畅的肝硬化腹水效果显著,且无耐药性,价格低廉。
Description
技术领域
本发明涉及中药技术领域,尤其是涉及一种治疗肝硬化腹水的中药制剂及其制备方法。
背景技术
肝硬化腹水是指由于肝脏疾病导致肝脏反复炎症,纤维化及肝硬化形成后由于多种病理因素,如门脉高压、低蛋白血症、水钠潴留等引起腹腔内积液的临床症状。肝硬化腹水不是一个单独的疾病,而是许多肝脏疾病终末期(失代偿期)的共同临床表现。现阶段西医主要采用的治疗办法为:1、可用头孢噻肟3.0g静脉滴注,每日2次;也可用左氧氟沙星静脉滴注,或氨苄青霉素配合丁胺卡那治疗。此方法费用比较高,而且往往治疗效果不是太明显。2、作腹腔灌洗疗法,操作的同时作二处腹腔穿刺,一处引出腹水,另一处灌入林格氏液,放出腹水3000mI后灌入平衡液2000ml,并立即腹腔注入抗生素。此方法在治疗过程中患者比较痛苦,而且向体内注入抗生素,对身体也有一定影响。
发明内容
有鉴于此,本发明的目的是针对现有技术的不足,提供一种治疗肝硬化腹水的中药制剂及其制备方法,对辨证为虚实气化不行、气机钦疏、血行不畅的肝硬化腹水效果显著,疗效好,见效快,无耐药性,无任何副作用,治疗过程中无痛苦,并且价格低廉。
为达到上述目的,本发明采用以下技术方案:
一种治疗肝硬化腹水的中药制剂,由以下重量份的原料组成:薏苡仁10-15份、麻黄3-6份、青皮10-20份、陈皮15-20份、茵陈20-30份、郁金10-15份、厚朴15-25份、大腹皮10-15份、鳖甲10-25份、穿山甲15-30份、半边莲10-15份、丹参10-20份、三棱10-15份、莪术10-15份、黄芪10-15份、白芍10-15份、猪苓10-18份和甘草6-9份。
进一步的,一种治疗肝硬化腹水的中药制剂,由以下重量份的原料组成:薏苡仁13-15份、麻黄4-6份、青皮10-18份、陈皮15-19份、茵陈20-25份、郁金13-15份、厚朴18-22份、大腹皮11-13份、鳖甲17-23份、穿山甲15-23份、半边莲12-13份、丹参15-17份、三棱12-13份、莪术10-12份、黄芪10-12份、白芍13-15份、猪苓10-15份和甘草6-9份。
进一步的,一种治疗肝硬化腹水的中药制剂,由以下重量份的原料组成:薏苡仁12份、麻黄3份、青皮20份、陈皮19份、茵陈28份、郁金11份、厚朴15份、大腹皮15份、鳖甲12份、穿山甲23份、半边莲10份、丹参12份、三棱15份、莪术13份、黄芪13份、白芍12份、猪苓15份和甘草8份。
本发明还提供了一种治疗肝硬化腹水的中药制剂胶囊的制备方法,包括以下步骤:
1)按照所述的治疗肝硬化腹水的中药制剂的原料配比称取薏苡仁、麻黄、青皮、陈皮、茵陈、郁金、厚朴、大腹皮、鳖甲、穿山甲、半边莲、丹参、三棱、莪术、黄芪、白芍、猪苓和甘草,整理除杂后干燥;
2)将步骤1)干燥后的药材混合均匀后研磨成粉,过筛后在紫外杀菌灯灯光下灭菌2.5小时;
3)将步骤2)灭菌后的中药粉装入空胶囊中制成中药胶囊。
进一步的,该制备方法步骤2)所述的过筛的筛网目数为300-500目。
本发明还提供了一种治疗肝硬化腹水的中药制剂汤剂的制备方法,包括以下步骤:
1)按照所述的治疗肝硬化腹水的中药制剂的原料配比称取薏苡仁、麻黄、青皮、陈皮、茵陈、郁金、厚朴、大腹皮、鳖甲、穿山甲、半边莲、丹参、三棱、莪术、黄芪、白芍、猪苓和甘草,整理除杂后放入砂锅浸泡半小时;
2)将步骤1)中盛装中药药材和水的砂锅用武火煮沸,转用文火慢煮半小时,关火自然冷却至60-70℃,经滤网布过滤后得到一次药液;
3)将经过步骤2)处理后剩余的中药药渣中加水,武火煮沸后转用文火慢煮15分钟,关火自然冷却至60-70℃,经滤网布过滤后得到二次药液;
4)将步骤2)和步骤3)中得到的一次药液和二次药液混合,并搅拌均匀,自然冷却至室温后封装,得中药药液制剂。
上述方法制备的为中药汤剂,本中药汤剂的服用方法为:1天分三次服用。也可1次性煎煮2天的药量,将制得的药液杀菌后灌装密封,在冰箱保鲜区以0-5℃冷藏,服用时先微加热即可。
该中药制剂可以制备成中药片剂、颗粒、药丸等多种形式,并不局限为汤剂和胶囊,适用于多种治疗方式,用药方式。
本发明中的各类中药的药性药理如下:
薏苡仁:味甘、淡、性凉,归脾、胃、肺经。功效:有利水渗透湿,健脾止泻,除痹,排脓,解毒散结的作用,用于水肿,脚气,小便不利,脾虚泄泻,湿痹拘挛,肺痈,肠痈;赘疣,癌肿。
麻黄:辛、微苦、温,归肺、膀胱经。功效:发汗解表,宣肺平喘,利水消肿,用于风寒表实证,胸闷喘咳,风水浮肿,风湿痹痛,阴疽,痰核。蜜麻黄性温偏润,辛散发汗作用缓和,增强了润肺止咳之功,以宣肺平喘止咳力胜。
青皮:味苦、辛、性温,归肝、胆、胃经。功效:有疏肝破气,消积化滞的功效,用于胸胁胀痛,疝气疼痛,乳癖,乳痈,食积气滞,脘腹胀痛。
陈皮:味苦、辛、性温,归肺、脾经。功效:理气健脾,燥湿化痰,用于脘腹胀满,食少吐泻,咳嗽痰多。
茵陈:味苦、辛、性微寒,归脾、胃、肝、胆经。功效:有清利湿热,利胆退黄,用于黄疸尿少,湿温暑湿,湿疮瘙痒。
郁金:辛、苦、寒,归肝、心、肺经。功效:活血止痛,行气解郁,清心凉血,利胆退黄,用于胸胁刺痛,胸痹心痛,经闭痛经,乳房胀痛,热病神昏,癫痫发狂,血热吐衄,黄疸尿赤。
厚朴:苦、辛、性温,归脾经、胃经、大肠经。功效:行气消积;燥湿除满;降逆平喘,用于食积气滞;腹胀便秘;湿阻中焦,脘痞吐泻;痰壅气逆;胸满喘咳。
大腹皮:辛,微温。入脾经、胃经、大肠经、小肠经。功效:行气宽中,行水消肿,用于湿阻气滞,脘腹胀闷,大便不爽,水肿胀满,脚气浮肿,小便不利。
鳖甲:咸、性微寒,归肝、肾经。功效:滋阴潜阳,退热除蒸,软坚散结,用于阴虚发热,骨蒸劳热,阴虚阳亢,头晕目眩,虚风内动,经闭,癥瘕,久疟,疟母。
穿山甲:咸、凉,入肝经、胃经。功效:滋阴,补血,用于治阴虚血少,腰膝痿弱,劳咳骨蒸,遗精,崩漏,月经不调,消渴,耳聋,目昏。
半边莲:辛、寒,入胃、大肠、小肠经。功效:清热解毒,消痈散结,利尿除湿,用于清热解毒、利尿消肿,治毒蛇咬伤、肝硬化腹水、晚期血吸虫病腹水、阑尾炎。
丹参:苦、微寒,归心、肝经。功效:活血祛瘀,通经止痛,清心除烦,凉血消痈,用于胸痹心痛,脘腹胁痛,瘕瘕积聚,热痹疼痛,心烦不眠,月经不调,痛经经闭,疮疡肿痛。
三棱:辛、苦、平,归肝、脾经。功效:破血行气,消积止痛,用于症瘕痞块,痛经,瘀血经闭,胸痹心痛,食积胀痛。
莪术:辛、苦、温,归肝、脾经。功效:破血行气,消积止痛,用于血瘀腹痛、肝脾肿大、心腹胀痛,积聚,妇女血瘀经闭,跌打损伤作痛饮食积滞。
黄芪:甘、微温,归肺、脾、肝、肾经。功效:保肝、利尿、抗衰老、抗应激、降压,用于表虚自汗,阴虚盗汗,急性肾炎水肿,慢性肾炎水肿、脾肾虚,阳气虚弱,疮疡溃破,肺气虚证,气虚衰弱。
白芍:苦、酸、微寒,归肝、脾经。功效:平肝止痛,养血调经,敛阴止汗,用于头痛眩晕,胁痛,腹痛,四肢挛痛,血虚萎黄,月经不调,自汗,盗汗。
猪苓:甘、淡、平,归心、脾、胃、肺、肾经。功效:利水渗湿,用于小便不利,水肿、泄泻,淋浊,带下。
甘草:甘、平,入脾、胃、肺经。功效:主治清热解毒、祛痰止咳、脘腹、心悸怔忡、脉结代、以及脾胃气虚、痈疽疮疡、咽喉肿痛。
本发明遵循中医“君臣佐使”的组方原则,全部成分来自于中国《药典》第五版收载的药物,选用的中药各组份符合中华人民共和国药品管理法之规定,利用各味中药的综合作用,对人体无毒无害。经小白鼠和大白鼠的急性毒性试验和蓄积性毒性试验表明被试验的动物未见任何毒性反应,经解剖观察血象、肝功能、各脏器组织形态学所见与对照组比较无差异,证明其药物安全可靠。
中医认为,肝硬化腹水属“鼓胀”范畴。《灵枢·水胀》曰:“鼓胀何如?岐伯曰:腹胀,身皆大,大与腹胀等也。色苍黄,腹筋起,此其候也。”鼓胀多因情志抑郁、饮食不节、嗜酒过多等原因导致肝失疏泄、脾气受损、水湿不运、气滞血瘀,久而久之,造成肝脾血瘀、水裹气结的鼓胀。治疗当以疏肝健脾、利水消胀、软坚活血为基本疗法。
本发明以水渗透湿、健脾止泻的薏苡仁为主药,以发汗解表、宣肺平喘、利水消肿的麻黄和疏肝破气、消积化滞的青皮为臣药,以破血行气、理气健脾、清利湿热、利胆退黄、行水消肿的陈皮、茵陈、郁金、厚朴、大腹皮、鳖甲、穿山甲、半边莲、丹参、三棱、莪术、黄芪、白芍、猪苓为佐药,以清热解毒的甘草为使药,配伍合理,虚实兼顾,补虚不忘实,泻实不忘虚,为虚实气化不行、气机钦疏、血行不畅的肝硬化腹水效果显著,疗效好,见效快,无耐药性,无任何副作用,治疗过程中无痛苦,并且价格低廉。
具体实施方式
下面结合实施例对本发明作进一步描述。
实施例1
一种治疗肝硬化腹水的中药制剂,由以下重量份的原料组成:薏苡仁15份、麻黄5份、青皮15份、陈皮17份、茵陈20份、郁金15份、厚朴22份、大腹皮11份、鳖甲25份、穿山甲20份、半边莲12份、丹参17份、三棱12份、莪术12份、黄芪10份、白芍15份、猪苓10份和甘草7份。
本实施例还提供了本中药制剂胶囊的制备方法,包括以下步骤:
1)按照所述的治疗肝硬化腹水的中药制剂的原料配比称取薏苡仁、麻黄、青皮、陈皮、茵陈、郁金、厚朴、大腹皮、鳖甲、穿山甲、半边莲、丹参、三棱、莪术、黄芪、白芍、猪苓和甘草,整理除杂后干燥;
2)将步骤1)干燥后的药材混合均匀后研磨成粉,过400目筛后在紫外杀菌灯灯光下灭菌2.5小时;
3)将步骤2)灭菌后的中药粉装入空胶囊中制成中药胶囊。
上述方法制备的为中药胶囊,其服用方法为,每日分早晚两次服用,每次5粒。
实施例2
一种治疗肝硬化腹水的中药制剂,由以下重量份的原料组成:薏苡仁13份、麻黄5份、青皮13份、陈皮15份、茵陈23份、郁金14份、厚朴20份、大腹皮13份、鳖甲10份、穿山甲23份、半边莲13份、丹参20份、三棱13份、莪术15份、黄芪12份、白芍10份、猪苓12份和甘草7份。
本实施例还提供了本中药制剂汤剂的制备方法,包括以下步骤:
1)将上述重量份的薏苡仁、麻黄、青皮、陈皮、茵陈、郁金、厚朴、大腹皮、鳖甲、穿山甲、半边莲、丹参、三棱、莪术、黄芪、白芍、猪苓和甘草,整理除杂后放入砂锅,注入1200ml的清水浸泡半小时;
2)将步骤1)中盛装中药药材和水的砂锅用武火煮沸,转用文火慢煮半小时,关火自然冷却至60-70℃,经滤网布过滤后得到一次药液;
3)将经过步骤2)处理后剩余的中药药渣中加水,武火煮沸后转用文火慢煮15分钟,关火自然冷却至60-70℃,经滤网布过滤后得到二次药液;
4)将步骤2)和步骤3)中得到的一次药液和二次药液混合,得到约600ml药液制剂,并搅拌均匀,自然冷却至室温后封装,得中药药液制剂。
上述方法制备的为中药汤剂,其服用方法为:一日三次服用,也可1次性煎煮2天的药量,将制得的药液杀菌后灌装密封,在冰箱保鲜区以0-5℃冷藏,服用时先微加热即可。
实施例3
一种治疗肝硬化腹水的中药制剂,由以下重量份的原料组成:薏苡仁13份、麻黄4份、青皮10份、陈皮20份、茵陈25份、郁金13份、厚朴18份、大腹皮13份、鳖甲17份、穿山甲30份、半边莲15份、丹参10份、三棱13份、莪术10份、黄芪13份、白芍12份、猪苓15份和甘草9份。
本实施例还提供了本中药制剂汤剂的制备方法,包括以下步骤:
1)将上述重量份的薏苡仁、麻黄、青皮、陈皮、茵陈、郁金、厚朴、大腹皮、鳖甲、穿山甲、半边莲、丹参、三棱、莪术、黄芪、白芍、猪苓和甘草,整理除杂后放入砂锅,注入1200ml的清水浸泡半小时;
2)将步骤1)中盛装中药药材和水的砂锅用武火煮沸,转用文火慢煮半小时,关火自然冷却至60-70℃,经滤网布过滤后得到一次药液;
3)将经过步骤2)处理后剩余的中药药渣中加水,武火煮沸后转用文火慢煮15分钟,关火自然冷却至60-70℃,经滤网布过滤后得到二次药液;
4)将步骤2)和步骤3)中得到的一次药液和二次药液混合,得到约600ml药液制剂,并搅拌均匀,自然冷却至室温后封装,得中药药液制剂。
上述方法制备的为中药汤剂,其服用方法为:一日三次服用,也可1次性煎煮2天的药量,将制得的药液杀菌后灌装密封,在冰箱保鲜区以0-5℃冷藏,服用时先微加热即可。
实施例4
一种治疗肝硬化腹水的中药制剂,由以下重量份的原料组成:薏苡仁12份、麻黄3份、青皮20份、陈皮19份、茵陈28份、郁金11份、厚朴15份、大腹皮15份、鳖甲12份、穿山甲23份、半边莲10份、丹参12份、三棱15份、莪术13份、黄芪13份、白芍12份、猪苓15份和甘草8份。
本实施例还提供了本中药制剂胶囊的制备方法,包括以下步骤:
1)按照所述的治疗肝硬化腹水的中药制剂的原料配比称取薏苡仁、麻黄、青皮、陈皮、茵陈、郁金、厚朴、大腹皮、鳖甲、穿山甲、半边莲、丹参、三棱、莪术、黄芪、白芍、猪苓和甘草,整理除杂后干燥;
2)将步骤1)干燥后的药材混合均匀后研磨成粉,过400目筛后在紫外杀菌灯灯光下灭菌2.5小时;
3)将步骤2)灭菌后的中药粉装入空胶囊中制成中药胶囊。
上述方法制备的为中药胶囊,其服用方法为,每日分早晚两次服用,每次5粒。
实施例5
一种治疗肝硬化腹水的中药制剂,由以下重量份的原料组成:薏苡仁10份、麻黄6份、青皮18份、陈皮18份、茵陈30份、郁金10份、厚朴25份、大腹皮10份、鳖甲23份、穿山甲15份、半边莲12份、丹参15份、三棱10份、莪术13份、黄芪15份、白芍13份、猪苓18份和甘草6份。
本实施例还提供了本中药制剂汤剂的制备方法,包括以下步骤:
1)将上述重量份的薏苡仁、麻黄、青皮、陈皮、茵陈、郁金、厚朴、大腹皮、鳖甲、穿山甲、半边莲、丹参、三棱、莪术、黄芪、白芍、猪苓和甘草,整理除杂后放入砂锅,注入1200ml的清水浸泡半小时;
2)将步骤1)中盛装中药药材和水的砂锅用武火煮沸,转用文火慢煮半小时,关火自然冷却至60-70℃,经滤网布过滤后得到一次药液;
3)将经过步骤2)处理后剩余的中药药渣中加水,武火煮沸后转用文火慢煮15分钟,关火自然冷却至60-70℃,经滤网布过滤后得到二次药液;
4)将步骤2)和步骤3)中得到的一次药液和二次药液混合,得到约600ml药液制剂,并搅拌均匀,自然冷却至室温后封装,得中药药液制剂。
上述方法制备的为中药汤剂,其服用方法为:一日三次服用,也可1次性煎煮2天的药量,将制得的药液杀菌后灌装密封,在冰箱保鲜区以0-5℃冷藏,服用时先微加热即可。
本发明的上述中药制剂进行了毒性试验,试验效果如下:
选取大、小白鼠各20只,雌、雄各半,分为对照组和给药组,体重相当,饲养条件一致,对照组不喂药,给药组每天喂药1次,每天记录各个小白鼠的身体状况、摄食、饮水、体重,试验持续六个月,与对照组相比,给药组小白鼠身体状况、摄食、饮水、体重增长均正常,且未见小白鼠生病或死亡,解剖后也未发现病变。提示该药安全性好,无毒副作用。
本发明同时对所给出的配方进行了临床疗效追踪,疗效汇总如下:
共统计患者63例,年龄35-67岁,平均年龄52岁,有9例效果不明显,治疗有效率为85.7%,治愈后患者均未发现复发迹象。
本发明的中药制剂的治疗案例如下:
患者李某,女,36岁。出现乏力、消瘦、面色晦暗,尿少、下肢水肿,腹腔积液、肝源性胸腔积液等症状,经诊断确诊为肝硬化腹水。来我处就诊,服用本药5个月后上述症状减轻,8个月后上述症状消失,停药至今未复发。
患者玉某,女,40岁。出现食欲减退、腹胀、胃肠功能紊乱、糖尿病、多尿、多食、月经失调等症状,经诊断确诊为肝硬化腹水。来我处就诊,服用本发明的中药6个月后症状减轻,继续服药2个月后上述症状消失,至今未复发。
患者季某,男,51岁。患者肝硬化腹水已有半年之久.腹大如鼓.两胁隐痛.下肢水肿20多天而前来就诊。近日大量吐血、便血。大便稀溏,小便量少,舌红,苔微黄,脉弦数。诊断为肝硬化腹水。来我处就诊,给予本发明的中药,服用3个月后,腹水减半,食欲大增,面有血色。继续服用45天,患者腹水全消,食欲大增,面色红润。一年后回访,未复发。
患者何某,男,67岁,退休职工。肝硬化病史3年,腹胀,尿少3月余,腹胀大如鼓,伴咳嗽1周,周身乏力,尿少,化验肝功能异常,B超提示:肝硬化腹水。来我处就诊,给予本发明的中药,服用2个月后,患者咳嗽减轻,咳少量白痰,无喘憋,大便通,尿量明显增多,腹胀明显减轻,继续服用本药40天,患者腹水基本消失,饮食增加,症状缓解。一年后回访,未复发。
患者刑某,男,51岁,工人。乙肝病毒携带14年,现已肝硬化2年,近1月腹胀、尿少、尿黄、乏力,饮酒史20余年,尿黄,肝功能异常,肝硬化腹水。来我处就诊,给予本发明的中药,服用3个月后,腹水消失,黄疸减轻,肝功能好转。此后2年一直继续服用本药,并定期化验检查,随访4年,肝功能稳定。
患者李某,女,42岁。曾因腹水入院,自觉腹胀、尿少、尿黄、乏力、大便溏软1月,化验肝功能异常,肝胆B超显示:肝硬化、腹水形成、脾大。查体、神志清楚、面色黎黑,面部毛细血管扩张,可见肝掌,腹部胀大如鼓,下肢轻度水肿、舌质暗红胖大,舌中裂纹,苔薄润。来我处就诊,给予本发明的中药,服用3个月后,腹水消失,肝功能明显好转。继续服用45天,患者食欲大增,面色红润。一年后回访,未复发。
可以理解的是,以上关于本发明的具体描述,仅用于说明本发明而并非受限于本发明实施例所描述的技术方案,本领域的普通技术人员应当理解,仍然可以对本发明进行修改或等同替换,以达到相同的技术效果;只要满足使用需要,都在本发明的保护范围之内。
Claims (6)
1.一种治疗肝硬化腹水的中药制剂,其特征在于:由以下重量份的原料组成:薏苡仁10-15份、麻黄3-6份、青皮10-20份、陈皮15-20份、茵陈20-30份、郁金10-15份、厚朴15-25份、大腹皮10-15份、鳖甲10-25份、穿山甲15-30份、半边莲10-15份、丹参10-20份、三棱10-15份、莪术10-15份、黄芪10-15份、白芍10-15份、猪苓10-18份和甘草6-9份。
2.根据权利要求1所述的一种治疗肝硬化腹水的中药制剂,其特征在于:由以下重量份的原料组成:薏苡仁13-15份、麻黄4-6份、青皮10-18份、陈皮15-19份、茵陈20-25份、郁金13-15份、厚朴18-22份、大腹皮11-13份、鳖甲17-23份、穿山甲15-23份、半边莲12-13份、丹参15-17份、三棱12-13份、莪术10-12份、黄芪10-12份、白芍13-15份、猪苓10-15份和甘草6-9份。
3.根据权利要求1所述的一种治疗肝硬化腹水的中药制剂,其特征在于:由以下重量份的原料组成:薏苡仁12份、麻黄3份、青皮20份、陈皮19份、茵陈28份、郁金11份、厚朴15份、大腹皮15份、鳖甲12份、穿山甲23份、半边莲10份、丹参12份、三棱15份、莪术13份、黄芪13份、白芍12份、猪苓15份和甘草8份。
4.一种如权利要求1-3任意一项所述的治疗肝硬化腹水的中药制剂的制备方法,其特征在于:包括以下步骤:
1)按照所述的治疗肝硬化腹水的中药制剂的原料配比称取薏苡仁、麻黄、青皮、陈皮、茵陈、郁金、厚朴、大腹皮、鳖甲、穿山甲、半边莲、丹参、三棱、莪术、黄芪、白芍、猪苓和甘草,整理除杂后干燥;
2)将步骤1)干燥后的药材混合均匀后研磨成粉,过筛后在紫外杀菌灯灯光下灭菌2.5小时;
3)将步骤2)灭菌后的中药粉装入空胶囊中制成中药胶囊。
5.根据权利要求4所述的一种治疗肝硬化腹水的中药制剂的制备方法,其特征在于:步骤2)中,所述的过筛用筛网目数为300-500目。
6.一种如权利要求1-3任意一项所述的治疗肝硬化腹水的中药制剂的制备方法,其特征在于:包括以下步骤:
1)按照所述的治疗肝硬化腹水的中药制剂的原料配比称取薏苡仁、麻黄、青皮、陈皮、茵陈、郁金、厚朴、大腹皮、鳖甲、穿山甲、半边莲、丹参、三棱、莪术、黄芪、白芍、猪苓和甘草,整理除杂后放入砂锅浸泡半小时;
2)将步骤1)中盛装中药药材和水的砂锅用武火煮沸,转用文火慢煮半小时,关火自然冷却至60-70℃,经滤网布过滤后得到一次药液;
3)将经过步骤2)处理后剩余的中药药渣中加水,武火煮沸后转用文火慢煮15分钟,关火自然冷却至60-70℃,经滤网布过滤后得到二次药液;
4)将步骤2)和步骤3)中得到的一次药液和二次药液混合,并搅拌均匀,自然冷却至室温后封装,得中药药液制剂。
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