CN109952299B - 用于制备蛋白降解靶向嵌合体的氟代羟脯氨酸衍生物 - Google Patents
用于制备蛋白降解靶向嵌合体的氟代羟脯氨酸衍生物 Download PDFInfo
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- CN109952299B CN109952299B CN201780070023.1A CN201780070023A CN109952299B CN 109952299 B CN109952299 B CN 109952299B CN 201780070023 A CN201780070023 A CN 201780070023A CN 109952299 B CN109952299 B CN 109952299B
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- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1615617.6 | 2016-09-14 | ||
| GB1615617.6A GB2554071A (en) | 2016-09-14 | 2016-09-14 | Small molecules |
| PCT/GB2017/052726 WO2018051107A1 (en) | 2016-09-14 | 2017-09-14 | Fluorohydroxyproline derivatives useful in the preparation of proteolysis targeted chimeras |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN109952299A CN109952299A (zh) | 2019-06-28 |
| CN109952299B true CN109952299B (zh) | 2023-04-18 |
Family
ID=57234771
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201780070023.1A Active CN109952299B (zh) | 2016-09-14 | 2017-09-14 | 用于制备蛋白降解靶向嵌合体的氟代羟脯氨酸衍生物 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US11234988B2 (enExample) |
| EP (1) | EP3512844A1 (enExample) |
| JP (1) | JP7316932B2 (enExample) |
| CN (1) | CN109952299B (enExample) |
| GB (1) | GB2554071A (enExample) |
| WO (1) | WO2018051107A1 (enExample) |
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| WO2017197046A1 (en) | 2016-05-10 | 2017-11-16 | C4 Therapeutics, Inc. | C3-carbon linked glutarimide degronimers for target protein degradation |
| CN109562113A (zh) | 2016-05-10 | 2019-04-02 | C4医药公司 | 用于靶蛋白降解的螺环降解决定子体 |
| CN121974842A (zh) | 2016-05-10 | 2026-05-05 | C4医药公司 | 用于靶蛋白降解的胺连接的c3-戊二酰亚胺降解决定子体 |
| CN109562107A (zh) | 2016-05-10 | 2019-04-02 | C4医药公司 | 用于靶蛋白降解的杂环降解决定子体 |
| CN110573507B (zh) | 2017-04-14 | 2023-11-14 | 邓迪大学 | 小分子 |
| EP4717317A3 (en) | 2017-06-20 | 2026-06-03 | C4 Therapeutics, Inc. | N/o-linked degrons and degronimers for protein degradation |
| CN118108706A (zh) | 2017-09-04 | 2024-05-31 | C4医药公司 | 戊二酰亚胺 |
| WO2019043208A1 (en) | 2017-09-04 | 2019-03-07 | F. Hoffmann-La Roche Ag | DIHYDROQUINOLINONES |
| WO2019043217A1 (en) | 2017-09-04 | 2019-03-07 | F. Hoffmann-La Roche Ag | DIHYDROBENZIMIDAZOLONES |
| EP3710002A4 (en) | 2017-11-16 | 2021-07-07 | C4 Therapeutics, Inc. | DEGRADER AND DEGRONE FOR TARGETED PROTEIN DEGRADATION |
| WO2019183523A1 (en) * | 2018-03-23 | 2019-09-26 | Genentech, Inc. | Hetero-bifunctional degrader compounds and their use as modulators of targeted ubiquination (vhl) |
| CN111902141A (zh) | 2018-03-26 | 2020-11-06 | C4医药公司 | 用于ikaros降解的羟脑苷脂结合剂 |
| WO2019204354A1 (en) | 2018-04-16 | 2019-10-24 | C4 Therapeutics, Inc. | Spirocyclic compounds |
| EP3578561A1 (en) | 2018-06-04 | 2019-12-11 | F. Hoffmann-La Roche AG | Spiro compounds |
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| WO2020027225A1 (ja) | 2018-07-31 | 2020-02-06 | ファイメクス株式会社 | 複素環化合物 |
| EP3897631A4 (en) | 2018-12-20 | 2022-11-23 | C4 Therapeutics, Inc. | TARGETED PROTEIN BREAKDOWN |
| ES2995214T3 (en) | 2019-03-06 | 2025-02-07 | C4 Therapeutics Inc | Heterocyclic compounds for medical treatment |
| KR20210141554A (ko) | 2019-03-21 | 2021-11-23 | 코디악 바이오사이언시즈, 인크. | 세포외 소포 접합체 및 이의 용도 |
| EP3941607A1 (en) | 2019-03-21 | 2022-01-26 | Codiak BioSciences, Inc. | Process for preparing extracellular vesicles |
| WO2020206608A1 (en) * | 2019-04-09 | 2020-10-15 | Ranok Therapeutics (Hangzhou) Co., Ltd. | Methods and compositions for targeted protein degradation |
| CN110885332B (zh) * | 2019-12-06 | 2022-03-18 | 中国人民解放军第二军医大学 | 一种PDEδ蛋白降解靶向嵌合体及其制备方法和应用 |
| US20230099727A1 (en) * | 2020-01-13 | 2023-03-30 | January Therapeutics, Inc. | Nanoparticle compositions |
| WO2021237100A1 (en) | 2020-05-21 | 2021-11-25 | Codiak Biosciences, Inc. | Methods of targeting extracellular vesicles to lung |
| CN113321700B (zh) * | 2020-06-02 | 2022-07-01 | 泰比瑞医药科技(石家庄)有限公司 | 一种降解靶蛋白的双功能化合物及其用途 |
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| WO2022066928A2 (en) | 2020-09-23 | 2022-03-31 | Codiak Biosciences, Inc. | Process for preparing extracellular vesicles |
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| CN114907386B (zh) * | 2022-03-11 | 2023-03-31 | 山东大学 | 一种hemtac小分子降解剂及其应用 |
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| WO2024240078A1 (en) * | 2023-05-19 | 2024-11-28 | The Chinese University Of Hong Kong | Compositions and methods related to protein labeling |
| WO2025049555A1 (en) | 2023-08-31 | 2025-03-06 | Oerth Bio Llc | Compositions and methods for targeted inhibition and degradation of proteins in an insect cell |
| CN116855471B (zh) * | 2023-09-04 | 2023-11-28 | 江苏申基生物科技有限公司 | 一种嘌呤核苷磷酸化酶突变体及其应用 |
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| CN122341612A (zh) | 2023-11-10 | 2026-07-03 | 普莱鲁德疗法有限公司 | 靶向kat6的化合物 |
| CN117756883B (zh) * | 2023-12-18 | 2024-10-11 | 江苏海洋大学 | 一种靶向乙酰胆碱酯酶的化合物及其制备方法和应用 |
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Also Published As
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| EP3512844A1 (en) | 2019-07-24 |
| US20190255066A1 (en) | 2019-08-22 |
| WO2018051107A1 (en) | 2018-03-22 |
| CN109952299A (zh) | 2019-06-28 |
| JP7316932B2 (ja) | 2023-07-28 |
| US11234988B2 (en) | 2022-02-01 |
| JP2019531290A (ja) | 2019-10-31 |
| GB201615617D0 (en) | 2016-10-26 |
| GB2554071A (en) | 2018-03-28 |
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