CN109893558A - One kind is removed obstruction in channels to relieve pain composition and its application - Google Patents
One kind is removed obstruction in channels to relieve pain composition and its application Download PDFInfo
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Abstract
The present invention relates to health product technology field, in particular to one kind is removed obstruction in channels to relieve pain composition and its application.The composition of removing obstruction in channels to relieve pain is made of geranium wilfordii, safflower, radix achyranthis bidentatae, Radix Angelicae Sinensis, radix paeoniae rubra and ramulus cinnamomi.Six-element raw material is well-chosen and the scientific and effective composition that goes out in inventive formulation, it removes obstruction in channels to relieve pain composition by the reasonably combined present invention that is made, the composition and manufactured health liquor effect experiment prove, can achieve the effect that it is extraordinary proceed blood cycle, wind-expelling pain-stopping and relaxing tendons and activating collaterals, meanwhile also having effects that alleviate menorrhalgia of cold-stagnation and blood-stasis type.
Description
Technical field
Remove obstruction in channels to relieve pain composition the present invention relates to one kind, more particularly to it is a kind of for make remove obstruction in channels to relieve pain, relaxing tendons and activating collaterals and
Composition and its application for alleviating dysmenorrhea, belong to field of health care products.
Background technique
Modern society, with the improvement of people ' s living standards, the increase and the accelerating rhythm of life of various pressure, Ren Menya
Health problem is on the rise.The study found that young people is since rhythm of life is fast, operating pressure is big, dog-eat-dog, interpersonal relationships are multiple
The miscellaneous, factors such as dinner party is more, diet is irregular, high sugar phitosite intake with high salt high in fat is more, amount of exercise lacks, so that young people exempts from
Epidemic disease power is low, and healthy energy is insufficient for body, and external chill damp heat easily takes advantage of a weak point in opponent's defence and invades limbs, causes qi and blood stagnation, obstruction of meridians and collaterals draws
Play dysmenorrhea.Therefore, there is phlegm wet, damp and hot, obstruction of the circulation of vital energy constitution in most of young people, and because its passages through which vital energy circulates blocks, qi and blood is obstructed, be easy
The problems such as existing memory decrease, easy headache, cervical vertebra pain and limbs joint pain, pain, acid, fiber crops, women is then easier pain occur
Seriously affected working and learning.With advancing age, immunity of organisms reduces the elderly.Old human organism's calcium substance
Loss makes body be easy to appear heavy osteoporosis, arthralgia, limbs, numb inability, skeleton pain, the stiff change of large joint
The problems such as shape, limitation of activity.For people under the premise of living standard improves, not only requirement will have rich material base, and
With greater need for rich spiritual prop, with this come it is comprehensive improve the quality of living, the deeper people of the theory of " anti-not sick, health care again "
The heart, health care product are also rapidly developed.
The idea that people pay attention to health care is more and more stronger, and the demand to all kinds of health care products is also increasingly stronger.Health liquor is
Most common a kind of health care product on the market, it is that will have the Chinese herbal medicine of certain efficacy effect or nutriment to deploy or make through wine
It makes, belongs to the mild drinking wine with health care function.Vast territory and abundant resources in China, there is the edible food cured abundant
Resource has and develops the advantageous condition of health food and beverage.Many of China's Chinese Traditional Medicine has enriching yin and nourishing kidney, qi and blood double
Benefit, activating microcirculation and removing stasis medicinal, dredging the channel, dispelling wind and eliminating dampness Chinese medicine, as geranium wilfordii, safflower, radix achyranthis bidentatae, Radix Angelicae Sinensis, radix paeoniae rubra, ramulus cinnamomi, American Ginseng,
The fleece-flower root, soft-shelled turtle, cordyceps sinensis, Morinda officinalis, fructus lycii, HERBA EPIMEDII, Herba Epimedii, ganoderma lucidum, queen bee crowd, pueraria lobata, ganoderma lucidum, deer are big-eared, Chinese
The Chinese medicines such as soft-shelled turtle, cordyceps sinensis are always counted as the panacea that Johnson & Johnson is healthy and strong, and contain important physiological activity more, can build up health, and promote
Hepatic and renal function adjusts body metabolism, has effects that delay fatigue, removes obstruction in channels to relieve pain, activating microcirculation and removing stasis medicinal, dispelling wind and eliminating dampness.Wine has pungent
Perfume (or spice) walks the effects of property altered, sweetness and bitterness pungent-warm, promoting blood circulation, network promoting blood circulation of relaxing, resisting cold dehumidifying, and is easy to absorb and distribute, and medicine-carried arrives
Everywhere up to whole body, in the civil laudatory title for having " length of hundred medicines ".Health liquor reaches promoting the circulation of qi and blood, dredging blood vessel, dissipates using wine as carrier
Tired promoting blood circulation, temperature sun is timid trembles with fear, the cold product that disappears, doctor stomach cold, strengthening the spleen and stomach, proposes spirit and priming uplink, help the effect of power of medicine, with rice wine and
The brewed health liquor of rare traditional Chinese medicine, that healthy attribute are just more strong.Therefore Traditional Chinese medicinal health-care wine because good effect, convenient for storage
It deposits, is in good taste, is easy to use, being suitable for the features such as majority of populations use, and favoring by masses.
Chinese patent 201510248819.4 discloses a kind of for making the group of the health liquor of activating microcirculation and removing stasis medicinal, dispelling wind and eliminating dampness
It closes object and health liquor, each component parts by weight is as follows: 5-15 parts of Morinda officinalis, 5-15 parts of aconiti preparata,radix, 5-15 parts of rhizoma corydalis, rhizome of davallia 5-
15 parts, 5-15 parts of radix rehmanniae recen, 7-23 parts of Caulis Spatholobi, 6-18 parts of radix paeoniae rubra, 5-15 parts of safflower, 5-15 parts of rhizome of chuanxiong, 5-15 parts of Cortex Eucommiae,
5-15 parts of ramulus cinnamomi, 5-15 parts of campanulaceae, 5-15 parts of Radix Angelicae Sinensis, 5-15 parts of peach kernel, 5-15 parts of radix achyranthis bidentatae, 5-15 parts of trigone, root of Chinese clematis 6-18
Part, 5-15 parts of pawpaw, 5-15 parts of the root of three-nerved spicebush, 10-30 parts of Radix Astragali, 5-15 parts of ginger.The present invention have softening blood vessel, activating microcirculation and removing stasis medicinal,
Dredging the channel, promoting qi circulation and relieving pain and the advantages of dispel wet, cold, sour, numb, pain.The invention component is more, and price is high, single effect.
Chinese patent 201610723515.3 discloses a kind of wine for relaxing muscles and tendons, it at being grouped as: it is heroubill 120g, red
Flower 45g, ramulus cinnamomi 65g, radix achyranthis bidentatae 75g, Radix Angelicae Sinensis 40g, radix paeoniae rubra 25g, olibanum 10g, myrrh 10g, Rhizoma Et Radix Notopterygii 10g, rhizome of chuanxiong 10g, Kadsura Root-bark
15g, root bark of tree peony 10g, Sargent gloryvine 10g, pueraria lobata 15g, Radix Glycyrrhizae 5g, Cortex Eucommiae 15g, ginseng 15g, semen coicis 5g, rhizome of davallia 15g, garden burnet 5g
And white wine 4500g, above-mentioned 20 taste medicinal material is ground into thick end, is dipped in white wine, after 35 days, removes the dregs of a decoction, as finished product, this
Invention has effects that relaxing muscles and tendons strong bone, blood circulation, is suitable for traumatic injury, rheumatic Bi syndrome, wind-cold syndrome and numbness, waist and knee skelagia etc.
Disease.But composition of raw materials of the present invention is more expensive and complicated, and manufacturing process cannot extract completely middle the effective elements of the medicine
Come, the nutrition absorption rate of raw material is lower, causes the waste of natural resources of Chinese medicinal materials.
Chinese patent 201711275012.5 discloses a kind of health liquor, is made of raw material from the following weight: Radix Salviae Miltiorrhizae 20-
40 parts, 20-40 parts of hawthorn, 5-20 parts of Radix Angelicae Sinensis, 5-20 parts of safflower, 3-10 parts of Radix Codonopsis, 500-100 parts of white wine.The preparation method comprises the following steps: pressing
Radix Salviae Miltiorrhizae, hawthorn, Radix Angelicae Sinensis, Radix Codonopsis are sliced by ratio；Danshen Tablets, haw flakes, Radix Angelicae Sinensis Tabellae, Radix Codonopsis piece, safflower are placed in white wine together
In, it is i.e. drinkable after impregnating 15 days.The present invention selects common Chinese herbal medicine to be made, and does not add any preservative, securely and reliably, described
Drug matching is reasonable.Gained health wine preparation method of the invention is simple, it is significant in efficacy, have no toxic side effect, there is qi and activate blood circulation, change
Stagnation resolvation rouge, the effect of removing obstruction in channels to relieve pain, to stabbing pain over the chest, it is fixed do not move, becoming severe at night, when or palpitation and uneasiness, purplish tongue, uneven pulse
Etc. the heart blood silt of symptoms patients with coronary heart disease it is especially effective.But manufacturing process of the present invention cannot be by middle the effective elements of the medicine
It extracts completely, effect is unsatisfactory.
Currently, having effects that the health care product removed obstruction in channels to relieve pain is many kinds of on the market, formula and effect are different, but majority is all
The disadvantages of there are composition of raw materials costly, price is higher, effect is unsatisfactory, and the nutrition absorption rate of raw material is generally relatively low,
Cause the waste of natural resources of Chinese medicinal materials.In addition there is the health liquor for function of removing obstruction in channels to relieve pain, also generally existing mouthfeel is poor in the prior art,
Long-term drinking is to stomach band come the defects of injury, comprehensive various factors, most people does not approve health liquor also.Therefore it provides a kind of
The composition removed obstruction in channels to relieve pain, the health liquor that price is low, good effect, in good taste, safe for drinking trust have important practical significance.
Summary of the invention
For composition of raw materials in the prior art costly, the disadvantages of price is higher and effect is unsatisfactory, the present invention wants
The technical issues of solution be to provide the composition of removing obstruction in channels to relieve pain that a kind of low price, good effect, in good taste and safe for drinking trust,
Health liquor, the present invention can reach except clearing and activating the channels and collaterals effect, can also alleviate menorrhalgia of cold-stagnation and blood-stasis type.
To achieve the above object, the invention provides the following technical scheme:
Remove obstruction in channels to relieve pain composition, be made of following raw material the present invention provides one kind: geranium wilfordii, safflower, radix achyranthis bidentatae, Radix Angelicae Sinensis,
Radix paeoniae rubra and ramulus cinnamomi.
Geranium wilfordii: for Mang ox Miao Ke plant Mang ox seedling.Nature and flavor: bitter, micro-pungent, it is mild-natured.Channel tropism: return liver, large intestine channel
Through.Effect: dispelling wind and removing obstruction in the meridians living, promoting blood circulation, clearing heat and promoting diuresis.The major functions: rheumatic arthralgia, numbness, muscles and bones is miserable, and traumatic injury is let out
It rushes down, dysentery, sore.
Safflower: for the dry flower of compositae plant safflower.Nature and flavor: acrid flavour, it is warm-natured.Channel tropism: converge to heart and liver channels.Effect: promoting blood circulation is logical
Through removing blood stasis and acesodyne.The major functions: being used for menostasis, dysmenorrhea, lochia , abdominal mass and lump, injury from falling down, sore swell and ache curative.
Radix achyranthis bidentatae: for the dry root of amaranthaceous plant radix achyranthis bidentatae.Nature and flavor: bitter, acid is put down.Channel tropism: return liver and kidney channel.Effect: nourishing liver and kidney,
Strengthening the bones and muscles, dispelling stasis of blood and stimulating the menstrual flow are ensuringd proper downward flow of the blood.The major functions: being used for soreness of waist and knee joint, muscles and bones is powerless, Jing Bi Disorder lump in the abdomen, dizziness due to hyperactivity of liver-YANG.
Radix Angelicae Sinensis: for the dry root of umbelliferae angelica.Nature and flavor: sweet, acrid, warm.Channel tropism: return liver, the heart, the spleen channel.Effect: it mends
Blood promoting blood circulation, regulating menstruation and relieving pain, moistening intestines and relaxing bowels.The major functions: being used for blood deficiency chlorosis, dizziness palpitaition, irregular menstruation, amenorrhea and algomenorrhea, cold of insufficiency type abdomen
Bitterly, dry constipation of intestines, rheumatic arthralgia, injury from falling down, ulcer sores.Prepared RADIX ANGELICAE SINENSIS with yellow rice wine blood circulation.For amenorrhea and algomenorrhea, rheumatic arthralgia,
Injury from falling down.
Radix paeoniae rubra: for ranunculaceae plant Chinese herbaceous peony or the dry root of river radix paeoniae rubra.Nature and flavor: it is bitter, it is slightly cold.Channel tropism: return liver warp.Effect:
Clearing heat and cooling blood, removing blood stasis and acesodyne.The major functions: being used for febrile virulent maculae, hematemesis and epistaxis, hot eyes tumour, liver-depressed hypochondrium pain, amenorrhea and algomenorrhea , Disorder lump in the abdomen
Abdominal pain, injury from falling down, carbuncle swells sore.
Ramulus cinnamomi: the dry twig of lauraceae plant cortex cinnamomi.Nature and flavor: it is acrid flavour, sweet, it is warm-natured.Channel tropism: return lung, the heart, bladder meridian.Function
Effect: inducing sweat and dispelling exogenous evils, eliminating cold to stop pain, activating YANG and prormoting functioning of QI.The major functions: being used for anemofrigid cold, all pains of congealing cold with blood stasis, phlegm retention, blood stagnation syndrome, the heart
Throb with fear.
To sum up, the raw material in inventive formulation is well-chosen scientific and effective Chinese medicine, by reasonably combined and
Processing, composition of removing obstruction in channels to relieve pain of the invention is made, have the effect of it is good proceed blood cycle, wind-expelling pain-stopping.
Preferably, the composition of removing obstruction in channels to relieve pain, is made of the raw material of following parts by weight: 25-30 parts of geranium wilfordii, safflower
10-16 parts, 15-21 parts of radix achyranthis bidentatae, 10-15 parts of Radix Angelicae Sinensis, 10-14 parts of radix paeoniae rubra and 15-20 parts of ramulus cinnamomi.
It is further preferred that the composition of removing obstruction in channels to relieve pain, is made of the raw material of following parts by weight: 27-28 parts of geranium wilfordii,
12-14 parts of safflower, 17-19 parts of radix achyranthis bidentatae, 11-14 parts of Radix Angelicae Sinensis, 11-13 parts of radix paeoniae rubra and 16-19 parts of ramulus cinnamomi.
It is highly preferred that the composition of removing obstruction in channels to relieve pain, is made of the raw material of following parts by weight: 25 parts of geranium wilfordii, safflower 10
Part, 15 parts of radix achyranthis bidentatae, 10 parts of Radix Angelicae Sinensis, 10 parts of radix paeoniae rubra and 15 parts of ramulus cinnamomi.
The present invention provides the preparation methods of the composition of removing obstruction in channels to relieve pain, and are made according to this field customary preparation methods,
Preferably, the preparation method, comprising: by geranium wilfordii, safflower, radix achyranthis bidentatae, Radix Angelicae Sinensis, radix paeoniae rubra and ramulus cinnamomi with water refluxing extraction, mention
It takes liquid concentrated, dry, composition is made.
Preferably, the quality of the water be geranium wilfordii, safflower, radix achyranthis bidentatae, Radix Angelicae Sinensis, radix paeoniae rubra and ramulus cinnamomi quality sum 9-14
Times；It is highly preferred that the quality of the water is 12 times of geranium wilfordii, safflower, radix achyranthis bidentatae, Radix Angelicae Sinensis, radix paeoniae rubra and ramulus cinnamomi quality sum.
Preferably, the temperature of the refluxing extraction is 92-98 DEG C, is extracted 3 times, each 2.5h.
Preferably, the concentration is 65 DEG C using vacuum concentration, the temperature of concentration.
The present invention provides the compositions of removing obstruction in channels to relieve pain to remove obstruction in channels to relieve pain health care product, drug and/or functional food in preparation
Application in product.
The present invention provides a kind of health liquors with the effect of removing obstruction in channels to relieve pain, including the composition of removing obstruction in channels to relieve pain, sugarcane
Sugar and white wine.
Preferably, the parts by weight of the sucrose are 460 parts, and the mass fraction of white wine is 900 parts, the body of ethyl alcohol in white wine
Fraction is 34%.
The present invention also provides the preparation methods of the health liquor, comprising the following steps:
(1) composition that will remove obstruction in channels to relieve pain is added in the white wine of formula ratio, and soak is made in closed immersion；
(2) soak that step (1) obtains is filtered, obtains filtrate and the dregs of a decoction, the dregs of a decoction are squeezed, is pressed
Squeeze liquid；Filtrate and pressed liquor are merged, health liquor stoste is obtained；
(3) sucrose of formula ratio is added in the health liquor stoste obtained to step (2), stirring and dissolving, standing obtain supernatant
Liquid；
(4) the supernatant tune alcohol content for obtaining step (3) is 34% to get the health liquor of removing obstruction in channels to relieve pain.
Preparation method described in above-mentioned technical proposal, preferably, the time of closed immersion described in step (1) be
38d, temperature are 22 DEG C.
Compared with prior art, the beneficial effects of the present invention are: (1) raw material selection simplicity is simplified, formula is scientific and reasonable,
Price is low, good effect；(2) present invention can reach extraordinary health-care effect, can proceed blood cycle, wind-expelling pain-stopping and relaxing muscles and tendons are lived
Blood；(3) it is demonstrated experimentally that the present invention is other than having effects that remove obstruction in channels to relieve pain, also there is significant effective to menorrhalgia of cold-stagnation and blood-stasis type
Relaxation effect；(5) health liquor of the invention is in good taste, and safe for drinking is effective, is suitble to long-term drinking.
Specific embodiment
Embodiment 1
One kind is removed obstruction in channels to relieve pain composition, is made of the raw material of following parts by weight: geranium wilfordii, safflower, radix achyranthis bidentatae, Radix Angelicae Sinensis, radix paeoniae rubra
And ramulus cinnamomi；
The preparation method of the composition of removing obstruction in channels to relieve pain include: by geranium wilfordii 25g, safflower 10g, radix achyranthis bidentatae 15g, Radix Angelicae Sinensis 10g,
After radix paeoniae rubra 10g and ramulus cinnamomi 15g cleaning, with 1020g drinking water, 95 DEG C refluxing extraction 3 times, each 2.5h, then 65 DEG C of vacuum are dense
Contracting, drying, obtain composition of removing obstruction in channels to relieve pain.
Embodiment 2
One kind is removed obstruction in channels to relieve pain composition, is made of the raw material of following parts by weight: geranium wilfordii, safflower, radix achyranthis bidentatae, Radix Angelicae Sinensis, radix paeoniae rubra
And ramulus cinnamomi；
The preparation method of the composition of removing obstruction in channels to relieve pain include: by geranium wilfordii 27g, safflower 13g, radix achyranthis bidentatae 18g, Radix Angelicae Sinensis 12g,
After radix paeoniae rubra 12g and ramulus cinnamomi 17g cleaning, with 891g drinking water, 92 DEG C refluxing extraction 3 times, each 2.5h, then 65 DEG C of vacuum are dense
Contracting, drying, obtain composition of removing obstruction in channels to relieve pain.
Embodiment 3
One kind is removed obstruction in channels to relieve pain composition, is made of the raw material of following parts by weight: geranium wilfordii, safflower, radix achyranthis bidentatae, Radix Angelicae Sinensis, radix paeoniae rubra
And ramulus cinnamomi；
The preparation method of the composition of removing obstruction in channels to relieve pain include: by geranium wilfordii 30g, safflower 16g, radix achyranthis bidentatae 21g, Radix Angelicae Sinensis 15g,
After radix paeoniae rubra 14g and ramulus cinnamomi 20g cleaning, with 1624g drinking water, 98 DEG C refluxing extraction 3 times, each 2.5h, then 65 DEG C of vacuum are dense
Contracting, drying, obtain composition of removing obstruction in channels to relieve pain.
Embodiment 4
One kind is removed obstruction in channels to relieve pain composition, is made of the raw material of following parts by weight: geranium wilfordii, safflower, radix achyranthis bidentatae, Radix Angelicae Sinensis, radix paeoniae rubra
And ramulus cinnamomi；
The preparation method of the composition of removing obstruction in channels to relieve pain include: by geranium wilfordii 25g, safflower 10g, radix achyranthis bidentatae 17g, Radix Angelicae Sinensis 11g,
After radix paeoniae rubra 11g and ramulus cinnamomi 16g cleaning, with 1080g drinking water, 95 DEG C refluxing extraction 3 times, each 2.5h, then 65 DEG C of vacuum are dense
Contracting, drying, obtain composition of removing obstruction in channels to relieve pain.
Embodiment 5
One kind is removed obstruction in channels to relieve pain composition, is made of the raw material of following parts by weight: geranium wilfordii, safflower, radix achyranthis bidentatae, Radix Angelicae Sinensis, radix paeoniae rubra
And ramulus cinnamomi；
The preparation method of the composition of removing obstruction in channels to relieve pain include: by geranium wilfordii 28g, safflower 14g, radix achyranthis bidentatae 15g, Radix Angelicae Sinensis 10g,
After radix paeoniae rubra 10g and ramulus cinnamomi 15g cleaning, with 1104g drinking water, 95 DEG C refluxing extraction 3 times, each 2.5h, then 65 DEG C of vacuum are dense
Contracting, drying, obtain composition of removing obstruction in channels to relieve pain.
Embodiment 6
One kind is removed obstruction in channels to relieve pain composition, is made of the raw material of following parts by weight: geranium wilfordii, safflower, radix achyranthis bidentatae, Radix Angelicae Sinensis, radix paeoniae rubra
And ramulus cinnamomi；
The preparation method of the composition of removing obstruction in channels to relieve pain include: by geranium wilfordii 27g, safflower 12g, radix achyranthis bidentatae 19g, Radix Angelicae Sinensis 14g,
After radix paeoniae rubra 13g and ramulus cinnamomi 19g cleaning, with 1248g drinking water, 95 DEG C refluxing extraction 3 times, each 2.5h, then 65 DEG C of vacuum are dense
Contracting, drying, obtain composition of removing obstruction in channels to relieve pain.
Embodiment 7
A kind of health liquor removed obstruction in channels to relieve pain, comprising the following steps:
(1) after cleaning geranium wilfordii 25g, safflower 10g, radix achyranthis bidentatae 15g, Radix Angelicae Sinensis 10g, radix paeoniae rubra 10g and ramulus cinnamomi 15g, with 900ml
The closed immersion of white wine that alcoholic strength is 34%, soaking temperature are 22 DEG C, after impregnating 38 days, obtain soak；
(2) soak that step (1) obtains is filtered, obtains filtrate and the dregs of a decoction, the dregs of a decoction are squeezed, is pressed
Squeeze liquid；Filtrate and pressed liquor are merged, health liquor stoste is obtained；
(3) 460g sucrose is added in the health liquor stoste obtained to step (2), stirring 3h makes it dissolve, in 4 DEG C of temperature
Lower standing 15d, obtains supernatant；
(4) the supernatant tune alcohol content for obtaining step (3) is 34%, is stirred to get the health liquor of removing obstruction in channels to relieve pain.
Comparative example 1
The composition the difference from embodiment 1 is that one kind is removed obstruction in channels to relieve pain is made of: geranium wilfordii the raw material of following parts by weight
24g, safflower 9g, radix achyranthis bidentatae 14g, Radix Angelicae Sinensis 8g, radix paeoniae rubra 5g and ramulus cinnamomi 13g；
The preparation method of composition of removing obstruction in channels to relieve pain is same as Example 1.
Comparative example 2
A kind of relaxing tendons and activating collaterals composition is prepared by the raw material in prior art China patent CN201610723515.3；
The relaxing tendons and activating collaterals preparation method of composition is same as Example 1.
Comparative example 3: a kind of relaxing tendons and activating collaterals is prepared by the embodiment in prior art China patent CN201610723515.3
Wine.
Experimental example 1: experimental animal and rearing conditions
KM female mice and male mice, weight 18-20g, SPF grade, Liaoning Province's Quality of Experimental Animals quality certification serial number:
211002300029111, it is purchased from the long-living Biotechnology Ltd. in Liaoning, experimental animal production licence number: SCXK-
(the Liao Dynasty) 2015-0001.
Wistar female rats and male rat, weight 200-230g, SPF grade, Jilin Province's Quality of Experimental Animals quality certification
Serial number: 201800021935；Wistar female rats and male rat, weight 200-230g, SPF grade, Jilin Province experimental animal
Certification of fitness serial number: 201800021990, it is purchased from this experimental animal Technology Co., Ltd. of Changchun hundred million, experimental animal production
Credit number: SCXK- (Ji) 2016-0003.This item experiment is examined by experimental animal Ethics Committee, Jilin Academy of Chinese Medicine Sciences
Core passes through, and meets experimental animal Ethics Committee regulation.
Cleaning grade animal housing, Jilin Academy of Chinese Medicine Sciences, experimental animal use credit number: SYXK (Ji) 2015-0009
(barrier system), experimental animal room temperature: 19-23 DEG C；Relative humidity 40-65%；Illumination: 12 hours bright, 12 hours dark alternatings.
Cage tool, cage lid are replaced 2-3 times weekly, and all animal feeding cage tools and padding use after passing through autoclave sterilization, keep cage tool
Cleaning, it is dry.
Feed maintains feed using large and small mouse, by corn, dregs of beans, fish meal, flour, wheat bran, salt, calcium bicarbonate, stone
The composition such as powder, multivitamin, various trace elements and amino acid, pulls together feed corporation,Ltd purchased from Beijing Australia, section.Feed is raw
It produces credit number: raising card (2014) 06054 in capital.Batch number:
18013221,18033211 and 18043241.
The pure water for the KFL-400 water purification machine preparation that drinking water is produced using Kai Fulong Science and Technology Ltd., filling disinfection
Drinking bottle in, for mouse free water.
The experimental animal of all experimental examples of the present invention uses above-mentioned mouse and rat.
Experimental example 2: to dysmenorrhea effect experiment caused by Progynova and oxytocin
Make model drug: Progynova (estradiol valerate tablet), specification: 1mg, manufacturing enterprise: DELPHARM Lille
S.A.S, batch number: 368A；Oxytocin injection, specification: 1mL:10 unit, manufacturing enterprise: the rich former pharmacy of Ma'an Mountain is limited
Company.
The screening of dysmenorrhea model mouse, grouping and tested material are given: taking female mice 159 in experimental example 1, weight 18-
20g, it is primary that Progynova 2mg/kg is given in daily stomach-filling, and continuous 12 days, the 12nd day, after giving Progynova 1 hour, intraperitoneal injection
2U/ mouse oxytocin records writhing number in 20min.It selects writhing number in 5 times or more mouse, is that modeling is successfully small
The successful mouse of modeling is equally divided into model group by writhing number, white wine group, positive Chinese medicine group, positive Western medicine group, implemented by mouse
Example 1-6 group and comparative example 1-2 group, totally 12 groups, every group 10.Model control group stomach-filling distilled water 10mL/kg；White wine group stomach-filling is white
Wine 9.25mL/kg；Chinese medicine positive drug group stomach-filling Shao Fu Zu Yu Wan 5.55g/kg；Western medicine positive drug group stomach-filling ibuprofen sustained release capsules
0.2g/kg；Embodiment 1-6 and comparative example 1-2 group difference stomach-filling composition 0.52g/kg；It daily morning stomach-filling 1 time, continuously gives
Tested material 3 days, while continuing daily stomach-filling in afternoon Progynova 1mg/kg.
Progynova and the test of oxytocin induced mice dysmenorrhea and observation index: 1 hour after mouse difference stomach-filling on the 15th,
2U/ mouse oxytocin is injected intraperitoneally, with the following index of intelligent wireless camera record: (1) mouse pain (writhing) is hidden
Phase.(2) pain reaction number (writhing number) in 30min.Mouse web portion shrinks indent, trunk and hindlimb extension, remembers primary turn round
Precursor reactant.It is m- when incubation period=occur writhing for the first time to give the oxytocin time.The results are shown in Table 1.
Influence of the different embodiment and comparative examples of table 1 to writhing response number caused by mouse oxytocin
Note: * indicates that P < 0.05, * * indicate P < 0.01 compared with model control group, similarly hereinafter.
From embodiment 1, embodiment 4 and embodiment 5 as can be seen that when the ratio of the content of heroubill and safflower is 5:2,
Dysmenorrhea can be effectively relieved in prepared composition, more than the invention of this ratio range and existing invention, all without alleviating dysmenorrhea
Effect.
Experimental example 3: menorrhalgia of cold-stagnation and blood-stasis type effect experiment
Drug model: female rats is manufactured, weight 200-230g after adapting to three, chooses 146 close rats of weight
It is tested.Rat be randomly divided into blank control group, model control group, white wine group, Shao Fu Zu Yu Wan group, embodiment 1-6 group and
Comparative example 1-2 group.In addition to blank control group, estradiol benzoate injection is subcutaneously injected in other rats daily, continuously injects 10
It, the 1st day and the 10th day every injection 0.5mg, the 2-9 days every injection 0.2mg, from giving oestradiol benzoate the 4th day,
Corresponding drug, white wine group stomach-filling white wine 4.63mL/kg are given in stomach-filling respectively；Shao Fu Zu Yu Wan group stomach-filling Shao Fu Zu Yu Wan
2.78g/kg；Embodiment 1-6 and comparative example 1-2 group difference stomach-filling composition 0.52g/kg；Daily stomach-filling is primary, and continuous 7 days.The
9 days, in addition to blank control group, adrenalin hydrochloride 1mL/kg was subcutaneously injected in remaining each group, is injected 2 times, was spaced 4 hours.First
After secondary injection adrenalin hydrochloride 2 hours, rat is immersed in the ice water that water temperature is 4 DEG C, swim 5 minutes, causes acute cold solidifying
Blood stasis model, compared with blank control group, writhing number dramatically increases model group, and pain incubation period is obviously shortened, and two groups are compared
There were significant differences, indicates that model is set up.
1h after administration in 10th day, in addition to blank control group, other rats by intraperitoneal injection oxytocin 2U/ only, are observed in 30min
Each group rat pain reaction records each group rat in first time writhing time of occurrence and 30min with intelligent wireless camera record
Pain reaction number calculates pain incubation period and inhibiting rate.Writhing response shrinks indent with rat abdomen, and trunk is stretched with hind leg
Exhibition, buttocks and side limbs inward turning are that (note: does not occur for the index of uterus strong contraction (dysmenorrhea) incubation period of writhing response rat
Based on 30min).It is m- when incubation period=occur writhing for the first time to give the oxytocin time.Pain inhibiting rate %=(model group pain
Pain number-administration group pain number)/model group pain number × 100%.
The results are shown in Table 2, it will thus be seen that 4 groups of rat writhing numbers of embodiment 1 and experimental example substantially reduce, with model
Control group compares that there were significant differences.Two groups of difference have significant meaning (P < 0.01).Pain incubation period is obviously prolonged, with model group pair
There is notable difference according to comparing.Two groups of difference have very significant meaning (P < 0.05).
Remaining experimental example group and comparative example 1-2 group are reduced rat writhing number and pain incubation period trend, but and model
Group compares no significant difference (P > 0.05).
Shao Fu Zu Yu Wan rat writhing number significantly reduces, and has notable difference compared with model control group.Two groups of difference have
Significant meaning (P < 0.05).There is extension trend in pain incubation period, but no significant difference (P > 0.05) compared with model group.
Table 2 is removed obstruction in channels to relieve pain influence of the composition to writhing response number caused by acute cold blood stasis rat oxytocin
When the ratio of the content of heroubill and safflower is 5:2, cold blood stasis type can be effectively relieved in prepared composition
Dysmenorrhea, more than the invention of this ratio range and existing invention, all no the effect of alleviating menorrhalgia of cold-stagnation and blood-stasis type.
Experimental example 4: mouse ankle analgesic experiment
Mouse 120 in experimental example 1, weight 13-15g are taken, male and female are taken into account, after adapting to 2, random point 12 groups, control group,
White wine group, Chinese medicine positive drug group, Western medicine positive drug group, embodiment 1-6 group and comparative example 1-2 group.Control group stomach-filling distilled water
10mL/kg；White wine group stomach-filling white wine 9.25mL/kg；Chinese medicine positive drug group stomach-filling Shao Fu Zu Yu Wan 5.55g/kg；Western medicine positive drug
Group stomach-filling ibuprofen sustained release capsules 0.2g/kg；Embodiment 1-6 group and comparative example 1-2 group difference stomach-filling composition 0.52g/kg.Often
Day stomach-filling 1 time, continuous 7 days.1 hour after last stomach-filling, inserting needle at toes on the left of every mouse, the subcutaneous injection of ankle outer side
5% formalin, 50 μ L was licked with intelligent wireless camera record 0-10 minutes with mouse in two periods of 10-60 minute immediately
(mouse often lifts primary left back foot and licks sufficient number, puts down note once, licks repeatedly if holding in both hands metapedes, do not put down, only calculate one
It is secondary), the results are shown in Table 3.
3 composition PARA FORMALDEHYDE PRILLS(91,95) of table causes the influence of mice pain reaction
The composition analgesic effect of the invention raw material proportioning science better and of the invention than the prior art can be obtained from result to close
Reason, raw material proportioning are more than this range, and effect of removing obstruction in channels to relieve pain is poor.
Experimental example 5: the organoleptic test of prepared health liquor
10 people of volunteer is recruited, the personnel including each age stratum with lumbocrural pain, extremity numbness and dysmenorrhea symptom,
Everyone takes 10ml health liquor, gives a mark to the taste of health liquor made of composition of the present invention, and 10 points are full marks, right
Evaluation result is averaged, and the results are shown in Table 4.It can be seen that health liquor of the invention by result, although the medicinal material of addition does not have
The prior art is more, but its comfortable taste degree will be better than the prior art.
Table 4
| Embodiment 7 | Comparative example 3 | |
| Mouthfeel | 9.7 | 8.8 |
| Smell | 9.8 | 9.0 |
| Comfort level | 9.8 | 8.9 |
The foregoing is only a preferred embodiment of the present invention, but scope of protection of the present invention is not limited thereto,
Anyone skilled in the art in the technical scope disclosed by the present invention, according to the technique and scheme of the present invention and its
Inventive concept is subject to equivalent substitution or change, should be covered by the protection scope of the present invention.
Claims (10)
- The composition 1. one kind is removed obstruction in channels to relieve pain, it is characterised in that: be made of following raw material: geranium wilfordii, safflower, radix achyranthis bidentatae, Radix Angelicae Sinensis, radix paeoniae rubra And ramulus cinnamomi.
- 2. composition according to claim 1 of removing obstruction in channels to relieve pain, it is characterised in that: be made of the raw material of following parts by weight: old 25-30 parts of stork grass, 10-16 parts of safflower, 15-21 parts of radix achyranthis bidentatae, 10-15 parts of Radix Angelicae Sinensis, 10-14 parts of radix paeoniae rubra and 15-20 parts of ramulus cinnamomi.
- 3. composition according to claim 2 of removing obstruction in channels to relieve pain, it is characterised in that: be made of the raw material of following parts by weight: old 27-28 parts of stork grass, 12-14 parts of safflower, 17-19 parts of radix achyranthis bidentatae, 11-14 parts of Radix Angelicae Sinensis, 11-13 parts of radix paeoniae rubra and 16-19 parts of ramulus cinnamomi.
- 4. composition according to claim 3 of removing obstruction in channels to relieve pain, it is characterised in that: be made of the raw material of following parts by weight: old 25 parts of stork grass, 10 parts of safflower, 15 parts of radix achyranthis bidentatae, 10 parts of Radix Angelicae Sinensis, 10 parts of radix paeoniae rubra and 15 parts of ramulus cinnamomi.
- 5. the preparation method for composition of removing obstruction in channels to relieve pain described in -4 any one according to claim 1, it is characterised in that: by geranium wilfordii, Safflower, radix achyranthis bidentatae, Radix Angelicae Sinensis, radix paeoniae rubra and ramulus cinnamomi obtain extracting solution with water refluxing extraction, and extracting solution is concentrated, dry, and combination is made Object.
- 6. preparation method according to claim 5, it is characterised in that: the temperature of the refluxing extraction is 92-98 DEG C.
- 7. preparation method according to claim 5, it is characterised in that: the quality of the water be geranium wilfordii, safflower, radix achyranthis bidentatae, 9-14 times of Radix Angelicae Sinensis, radix paeoniae rubra and ramulus cinnamomi quality sum.
- 8. it is according to claim 1-4 remove obstruction in channels to relieve pain composition preparation remove obstruction in channels to relieve pain health care product, drug and/or Application in functional food.
- The health liquor 9. one kind is removed obstruction in channels to relieve pain, it is characterised in that: including the described in any item combinations of removing obstruction in channels to relieve pain of claim 1-4 Object, sucrose and white wine.
- 10. health liquor according to claim 9 of removing obstruction in channels to relieve pain, it is characterised in that: the sucrose and quality of white spirit number are It removes obstruction in channels to relieve pain 16 times of composition quality number.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109966355A (en) * | 2019-04-12 | 2019-07-05 | 吉林海通制药有限公司 | One kind is removed obstruction in channels to relieve pain liquid medicine and preparation method thereof |
| CN110353689A (en) * | 2019-07-19 | 2019-10-22 | 淄博职业学院 | A kind of writhing assay monitoring device |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109966355A (en) * | 2019-04-12 | 2019-07-05 | 吉林海通制药有限公司 | One kind is removed obstruction in channels to relieve pain liquid medicine and preparation method thereof |
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2019
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| CN109966355A (en) * | 2019-04-12 | 2019-07-05 | 吉林海通制药有限公司 | One kind is removed obstruction in channels to relieve pain liquid medicine and preparation method thereof |
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| 余传隆等: "《中国临床药物大辞典》", 31 August 2018, 中国医药科技出版社 * |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109966355A (en) * | 2019-04-12 | 2019-07-05 | 吉林海通制药有限公司 | One kind is removed obstruction in channels to relieve pain liquid medicine and preparation method thereof |
| CN110353689A (en) * | 2019-07-19 | 2019-10-22 | 淄博职业学院 | A kind of writhing assay monitoring device |
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