CN103623246B - A kind of Chinese medicine preparation for the treatment of hypertension and complication thereof - Google Patents
A kind of Chinese medicine preparation for the treatment of hypertension and complication thereof Download PDFInfo
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Abstract
The invention discloses a kind of Chinese medicine preparation for the treatment of hypertension and complication thereof, it is characterized in that: this Chinese medicine preparation is made up of Radix Codonopsis 15 grams, Rhizoma Atractylodis Macrocephalae (parched) 10 grams, 10 grams, Poria, Radix Angelicae Sinensis 15 grams, Rhizoma Chuanxiong 10 grams, 10 grams, the Radix Rehmanniae, the Radix Paeoniae Alba 10 grams, Radix Ophiopogonis 10 grams, Fructus Schisandrae Chinensis 10 grams, Radix Salviae Miltiorrhizae 10 grams, ripe Semen Ziziphi Spinosae 10 grams, Semen Platycladi 10 grams, Radix Polygoni Multiflori 10 grams, Semen Plantaginis 10 grams, 10 grams, Rhizoma Gastrodiae, the burnt Cortex Eucommiae 10 grams, Flos Chrysanthemi 10 grams, Radix Platycodonis 10 grams, 6 grams, Radix Glycyrrhizae.The advantage that Chinese medicine preparation of the present invention has that Costco Wholesale is low, treatment crowd scope is wide, has no side effect, treatment cycle is short, and the coronary heart disease that Chinese medicine preparation of the present invention causes hypertension and hypertension and apoplexy sequela have significant curative effect.
Description
Technical field
The invention belongs to technical field of Chinese medicines, be specifically related to a kind of Chinese medicine preparation for the treatment of hypertension and complication thereof.
Background technology
Hypertension is a kind of commonly encountered diseases of middle-aged and elderly people, and have essential hypertension and secondary hypertension two type, wherein, essential hypertension occupies hyperpietic's 2/3, is the most common hypertension symptom.Its pathogeny is that small artery external caliber diminishes or blood viscosity increases, cause Peripheral resistance too high caused by, cause increasing of blood volume and atrium output, long blood vessel is stiff causes coronary heart disease with medicated porridge sample arteriosclerosis.
Secondary hypertension is also symptomatic hypertension, and be that blood pressure concurrent in some lysis raises, wherein, renal hypertension is modal secondary hypertension, can cause renal hypertension disease and renal vascular.The Crack cause of renal hypertension is due to renal artery or its branch stenosis, cause atherosclerosis, muscle fiber hyperplasia, nonspecific arteritis, transplant rejection fibre modification, thus cause renal artery ischemia, thrombosis or thromboembolism and cause renal hypertension finally to cause apoplexy.
At present, treat hypertensive medicine for specific pathogeny, the hypertension often caused for site morbidity mechanism does not prove effective, obstinate then can lead to complications, and medicine used is only for hypertension, the complication caused for hypertension can not onset, even can bring side effect, threaten to patient vitals, make patient bear heavy psychological burden.
Summary of the invention
The object of the invention is to: a kind of Chinese medicine preparation for the treatment of hypertension and complication thereof is provided, adopt Common Chinese Herbs raw material, reasonably combined in conjunction with each medical material pharmacological properties, reach Costco Wholesale low and comprehensive effectively treatment hypertension and complication object thereof, especially, the coronary heart disease caused for hypertension and apoplexy sequela have remarkable result.
To achieve these goals, the present invention is by the following technical solutions:
Treat a Chinese medicine preparation for hypertension and complication thereof, the compositing formula of this Chinese medicine is:
Radix Codonopsis 15 grams, the Rhizoma Atractylodis Macrocephalae 10 grams, 10 grams, Poria, Radix Angelicae Sinensis 15 grams, Rhizoma Chuanxiong 10 grams, 10 grams, the Radix Rehmanniae, the Radix Paeoniae Alba 10 grams, Radix Ophiopogonis 10 grams, Fructus Schisandrae Chinensis 10 grams, Radix Salviae Miltiorrhizae 10 grams, ripe Semen Ziziphi Spinosae 10 grams, Semen Platycladi 10 grams, Radix Polygoni Multiflori 10 grams, Semen Plantaginis 10 grams, 10 grams, Rhizoma Gastrodiae, XIAKUQIU 10 grams, the burnt Cortex Eucommiae 10 grams, Flos Chrysanthemi 10 grams, Radix Platycodonis 10 grams, 6 grams, Radix Glycyrrhizae.
The Rhizoma Atractylodis Macrocephalae described in formula of the present invention is parch Rhizoma Atractylodis Macrocephalae charcoal, and its frying production method is: (1) Rhizoma Atractylodis Macrocephalae pretreatment: clear water is cleaned, and after then running through with rice-washed water, being placed on steaming in food steamer black is degree, dries section; (2) stir the Rhizoma Atractylodis Macrocephalae: wheat bran stirs Rhizoma Atractylodis Macrocephalae section, fries and is advisable to faint yellow, and sieve removes wheat bran, collect Rhizoma Atractylodis Macrocephalae section, wherein, stirring temperature is 200 DEG C, stirs time 10 ~ 15min; (3) parch Rhizoma Atractylodis Macrocephalae charcoal: iron pan or marmite parch are put in the Rhizoma Atractylodis Macrocephalae section stirred, fry to outer black in be advisable in khaki, parch temperature is 200 DEG C, and the parch time is 10 ~ 15min, collects Rhizoma Atractylodis Macrocephalae section, be Rhizoma Atractylodis Macrocephalae charcoal after being cooled to room temperature, stand-by.
Treat a Chinese medicine preparation for hypertension and complication thereof, preparation method is:
(1) take medical material according to ratio described in formula, clean by conventional method, dry, cut into slices;
(2) described medical material fragment is put into marmite or porcelain, add proper amount of clear water to submergence medical material 1 ~ 2cm, after soaking medical material 20min, be heated to 90 ~ 100 DEG C of decocting herbs, decocting time is 20min, leaches soup;
(3) in the described marmite holding medical material or porcelain, add clear water to submergence medical material 3 ~ 4cm, subsequently heat temperature raising decocting herbs, decocting time is 30min, and decocting temperature is 90 ~ 100 DEG C, leaches soup;
(4) soup that leaches of combining step (3), (4), being concentrated into relative density is 1.05, and vacuum drying dewaters, and collects solid product, and described product wears into fine powder under aseptic, free from dust condition, and fine powder crosses 120 mesh sieves, makes capsule, pill two kinds of dosage forms.
Treat a Chinese medicine preparation for hypertension and complication thereof, pharmacology analysis: described Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Poria, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Rehmanniae, the Radix Paeoniae Alba, Radix Glycyrrhizae are BAZHEN TANG, eight taste medical materials are reasonably combined has the curative effect that QI invigorating adjusts blood, blood circulation promoting and blood stasis dispelling; Described BAZHEN TANG coordinates Radix Ophiopogonis, Fructus Schisandrae Chinensis, has to strengthen cardiac muscle and shrink Diastolic Force normally, improve blood circulation, reply have a weak heart cause severe palpitation, irregularly intermittent and regularly intermittent pulse, raising vital capacity effect; Described BAZHEN TANG complex acid Semen Ziziphi Spinosae, Semen Platycladi, Radix Salviae Miltiorrhizae, have effect of nourishing YIN to benefit the heart, blood-enriching tranquillizing; Described BAZHEN TANG coordinates Semen Plantaginis, and improve renal function output, toxin is discharged with urine, alleviates the burden of kidney, the disease for the treatment of appearance extremity edema; Described BAZHEN TANG coordinates Radix Polygoni Multiflori, the Cortex Eucommiae, has the effect of the liver and the kidney tonifying, the dim eyesight for the treatment of dizziness; Described BAZHEN TANG coordinates XIAKUQIU, Rhizoma Gastrodiae, Flos Chrysanthemi, cures mainly excessive rising of liver-YANG, has a dizzy spell; Described BAZHEN TANG coordinates Radix Platycodonis, and Radix Platycodonis dispersing and elevation lung meridian edema caused by disorder of QI key medicine, gas promoting the circulation of blood band medicine is up, until focus.
Chinese medicine preparation of the present invention has the remarkable result of reconciling QI and blood, improving blood circulation, replying atrioventricular node valvular function, strengthen myocardium normal contraction and Diastolic Force, raising renal function output, enhancing endocrine function and urinary system normal function, there is the function promoting cerebrovascular, brain cell, cranial nerve vigor, improve immunity, have significant curative effect to hypertension, coronary heart disease and apoplexy sequela.
Instructions of taking of the present invention: take medicine every day 3 times, each 6 ~ 7 grams one month is a course for the treatment of, and onset in 2 ~ 3 days, 2 ~ 3 courses for the treatment of cure substantially.
Medication taboo of the present invention: carnivorous at the edible rich savoury of its treatments period taboo, because greasy closed the intestines and stomach, makes medicine absorb, does not reach therapeutic effect, even can produce high blood matter, cholesterol, triglyceride toxin; Abstain from smoking and drinking; Taboo animal component medicine; Taboo affects the medicine that blood pressure rises, as Radix Ginseng, the Radix Astragali, Fructus Lycii, Cornu Cervi Pantotrichum, Fructus Corni and LIUWEI DIHUANG WAN, the large heat of great Xin and drug toxicity.
The Clinical efficacy of Chinese medicine preparation of the present invention:
Diagnostic criteria: Chinese hypertension prevention and control guide (revised edition) blood pressure level in 2005, in table 1.
The classification of table 1. blood pressure level and index (mmHg)
Observational technique: make a definite diagnosis 200 routine hypertension and complication patient thereof according to above diagnostic criteria, its mild or moderate 32 example, moderate 74 example, severe 28 example, coronary heart disease 37 example, apoplexy sequela 29 example.Wherein, hyperpietic is according to the difference of blood pressure classification, and 1 ~ 3 course for the treatment of of Chinese medicine preparation allowing patient take example of the present invention according to the method described above to prepare, coronary heart disease and Patients with Apoplexy Sequela take 1 ~ 3 course for the treatment of of Chinese medicine preparation prepared by example of the present invention.
Hypertension curative effect judging standard:
Effective: 1. diastolic pressure more than decline 10mmHg, and reach normal range; Though diastolic pressure is not down to normally but decline 20mmHg or more;
Effective: 1. diastolic pressure declines not as good as 10mmHg, but reaches normal range; 2. diastolic pressure comparatively takes the front 10 ~ 19mmHg that declines of Chinese medicine preparation of the present invention, but does not reach normal range; 3. systolic pressure comparatively treats front 30 more than the mmHg that decline, and must possess wherein 1.
Invalid: not reach above standard.
Coronary heart disease curative effect judging standard:
Effective: 1. each symptom of coronary heart disease obviously alleviates, and reaches health status; 2. each symptom of coronary heart disease obviously alleviates, but does not reach health status.
Effective: each symptom of coronary heart disease is slightly alleviated, and does not reach health status.
Invalid: each symptom of coronary heart disease is unchanged.
Effect for the treatment of sequela of apoplexy criterion:
Effective: 1. blood glucose, urinary glucose determination, after taking medicine, blood glucose, glucose in urine symptom obviously alleviate, and reach normal range; 2. eosinophil numbers has showed increased after taking medicine, and reaches normal range; 3. computed tomography brain scan diagnosis, after taking medicine, diagnostic result is without apoplexy disease.
Effective: 1. blood glucose, urinary glucose determination, after taking medicine, blood glucose, glucose in urine symptom are slightly alleviated, and do not reach normal range; 2. eosinophil numbers increases after taking medicine slightly, does not reach normal range.
Invalid: apoplexy sequela disease is without any improvement.
Therapeutic effect statistical result, as table 2.
The above-mentioned result statistical description to clinical observation on the therapeutic effect, the treatment of Chinese medicine preparation of the present invention to hypertension has remarkable result, and the coronary heart disease caused hypertension, apoplexy sequela also have positive effect.
Compared with prior art, beneficial effect of the present invention is: adopt Common Chinese Herbs, and Costco Wholesale is low, treatment crowd scope is wide; Adopt Chinese herbal medicine to be nourishing type Chinese crude drug, to human body fanout free region, have no side effect; Treatment cycle of the present invention is 2 ~ 3 courses for the treatment of, short treating period; Chinese medicine preparation of the present invention, to regulate QI and blood for side, is sent out to various disease hypertension all onsets that mechanism causes, is especially had remarkable result for the complication such as coronary heart disease, apoplexy sequela that hypertension causes.
Specific implementation method
In order to technical scheme of the present invention is described, further illustrate below in conjunction with example.
Embodiment 1
Get the raw materials ready:
Radix Codonopsis 15 grams, Rhizoma Atractylodis Macrocephalae (parched) 10 grams, 10 grams, Poria, Radix Angelicae Sinensis 15 grams, Rhizoma Chuanxiong 10 grams, 10 grams, the Radix Rehmanniae, the Radix Paeoniae Alba 10 grams, Radix Ophiopogonis 10 grams, Fructus Schisandrae Chinensis 10 grams, Radix Salviae Miltiorrhizae 10 grams, ripe Semen Ziziphi Spinosae 10 grams, Semen Platycladi 10 grams, Radix Polygoni Multiflori 10 grams, Semen Plantaginis 10 grams, 10 grams, Rhizoma Gastrodiae, XIAKUQIU 10 grams, the burnt Cortex Eucommiae 10 grams, Flos Chrysanthemi 10 grams, Radix Platycodonis 10 grams, 6 grams, Radix Glycyrrhizae.
Pharmacy:
(1) above-mentioned medicinal raw material conventional method is cleaned, dries, cut into slices;
(2) described medical material fragment is put into marmite or porcelain, add proper amount of clear water to submergence medical material 1 ~ 2cm, after soaking medical material 20min, be heated to 90 ~ 100 DEG C of decocting herbs, decocting time is 20min, leaches soup;
(3) in the described marmite holding medical material or porcelain, add clear water to submergence medical material 3 ~ 4cm, subsequently heat temperature raising decocting herbs, decocting time is 30min, and decocting temperature is 90 ~ 100 DEG C, leaches soup;
(4) soup that leaches of combining step (3), (4), being concentrated into relative density is 1.05, and vacuum drying dewaters, collect solid product, described product wears into fine powder under aseptic, free from dust condition, and fine powder crosses 120 mesh sieves, make capsule, capule size is that every capsules contains 1.5 grams, medicated powder.
Embodiment 2
To get the raw materials ready same embodiment 1.
Pharmacy:
(1) above-mentioned medicinal raw material conventional method is cleaned, dries, cut into slices;
(2) described medical material fragment is put into marmite or porcelain, add proper amount of clear water to submergence medical material 1 ~ 2cm, after soaking medical material 20min, be heated to 90 ~ 100 DEG C of decocting herbs, decocting time is 20min, leaches soup;
(3) in the described marmite holding medical material or porcelain, add clear water to submergence medical material 3 ~ 4cm, subsequently heat temperature raising decocting herbs, decocting time is 30min, and decocting temperature is 90 ~ 100 DEG C, leaches soup;
(4) soup that leaches of combining step (3), (4), being concentrated into relative density is 1.05, and vacuum drying dewaters, and collects solid product, described product wears into fine powder under aseptic, free from dust condition, fine powder crosses 120 mesh sieves, and with deionized water moistening medicated powder, moisture content is 15%, watered pill technique is adopted to make the watered pill, vacuum drying, makes its moisture content be 5%, packs.
Claims (2)
1. treat a Chinese medicine preparation for hypertension and complication thereof, it is characterized in that: the compositing formula of described Chinese medicine preparation is: Radix Codonopsis 15 grams, the Rhizoma Atractylodis Macrocephalae 10 grams, 10 grams, Poria, Radix Angelicae Sinensis 15 grams, Rhizoma Chuanxiong 10 grams, 10 grams, the Radix Rehmanniae, the Radix Paeoniae Alba 10 grams, Radix Ophiopogonis 10 grams, Fructus Schisandrae Chinensis 10 grams, Radix Salviae Miltiorrhizae 10 grams, ripe Semen Ziziphi Spinosae 10 grams, Semen Platycladi 10 grams, Radix Polygoni Multiflori 10 grams, Semen Plantaginis 10 grams, 10 grams, Rhizoma Gastrodiae, the burnt Cortex Eucommiae 10 grams, Flos Chrysanthemi 10 grams, Radix Platycodonis 10 grams, 6 grams, Radix Glycyrrhizae.
2. a kind of Chinese medicine preparation for the treatment of hypertension and complication thereof as claimed in claim 1, is characterized in that: the described Rhizoma Atractylodis Macrocephalae is parch Rhizoma Atractylodis Macrocephalae charcoal.
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| CN108635497A (en) * | 2018-07-30 | 2018-10-12 | 佛山科学技术学院 | A kind of Chinese medicine preparation and preparation method thereof for treating hypertension |
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