CN103623246A - Traditional Chinese medicine preparation for treating hypertension and complication thereof - Google Patents
Traditional Chinese medicine preparation for treating hypertension and complication thereof Download PDFInfo
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- CN103623246A CN103623246A CN201310409224.3A CN201310409224A CN103623246A CN 103623246 A CN103623246 A CN 103623246A CN 201310409224 A CN201310409224 A CN 201310409224A CN 103623246 A CN103623246 A CN 103623246A
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Abstract
The invention discloses a traditional Chinese medicine preparation for treating hypertension and complication thereof. The traditional Chinese medicine preparation is characterized by comprising 15g of codonopsis pilosula, 10g of roasted white atractylodes rhizome, 10g of tuckahoe, 15g of angelica sinensis, 10g of ligusticum wallichii, 10g of dried radix rehmanniae, 10g of radix paeoniae alba, 10g of radix ophiopogonis, 10g of schisandra chinensis, 10g of root of red-rooted salvia, 10g of cooked jujube kernel, 10g of semen boitae, 10g of polygonum multiflorum, 10g of semen plantaginis, 10g of gastrodia elata, 10g of coked eucommia ulmoides, 10g of chrysanthemum, 10g of platycodon grandiflorum and 6g of liquorice. The traditional Chinese medicine preparation disclosed by the invention has the advantages of being low in price and cost, wide in range of treated population, free from a side effect, and short in treatment cycle. The traditional Chinese medicine preparation disclosed by the invention has a significant curative effect on hypertension, and sequelae of coronary disease and stroke caused by the hypertension.
Description
Technical field
The invention belongs to technical field of Chinese medicines, be specifically related to a kind of Chinese medicine preparation for the treatment of hypertension and complication thereof.
Background technology
Hypertension is a kind of commonly encountered diseases of middle-aged and elderly people, has two types of essential hypertension and secondary hypertensions, and wherein, essential hypertension occupies hyperpietic's 2/3, is the most common hypertension symptom.Its pathogeny is that small artery external caliber diminishes or blood viscosity increases, cause Peripheral resistance too high due to, cause increasing of blood volume and atrium output, blood vessel is stiff for a long time causes coronary heart disease with medicated porridge sample arteriosclerosis.
Secondary hypertension is also symptomatic hypertension, is hypertension concurrent in some lysis, and wherein, renal hypertension is modal secondary hypertension, can cause renal hypertension disease and renal vascular.The formation reason of renal hypertension is because renal artery Huo Qi branch is narrow, cause atherosclerosis, muscle fiber hyperplasia, nonspecific arteritis, transplant rejection fibre modification, thus cause renal artery ischemia, thrombosis or thromboembolism and cause that renal hypertension finally causes apoplexy.
At present, treat hypertensive medicine for specific pathogeny, the hypertension often causing for part pathogeny does not prove effective, obstinate can lead to complications, and medicine used is only for hypertension, the complication causing for hypertension can not onset, even can bring side effect, threaten to patient's life, make patient bear heavy psychological burden.
Summary of the invention
The object of the invention is to: a kind of Chinese medicine preparation for the treatment of hypertension and complication thereof is provided, adopt Common Chinese Herbs raw material, reasonably combined in conjunction with each medical material pharmacological properties, reach Costco Wholesale low and comprehensive effectively treatment hypertension and complication object thereof, especially, the coronary heart disease and the apoplexy sequela that for hypertension, cause have remarkable result.
To achieve these goals, the present invention is by the following technical solutions:
Treat a Chinese medicine preparation for hypertension and complication thereof, the compositing formula of this Chinese medicine is:
15 grams of Radix Codonopsis, 10 grams of the Rhizoma Atractylodis Macrocephalaes, 10 grams, Poria, 15 grams of Radix Angelicae Sinensis, 10 grams of Rhizoma Chuanxiongs, 10 grams, the Radix Rehmanniae, 10 grams of the Radix Paeoniae Albas, 10 grams of Radix Ophiopogonis, 10 grams of Fructus Schisandrae Chinensis, 10 grams of Radix Salviae Miltiorrhizaes, 10 grams of ripe Semen Ziziphi Spinosaes, 10 grams of Semen Platycladi, 10 grams of Radix Polygoni Multiflori, 10 grams of Semen Plantaginiss, 10 grams, Rhizoma Gastrodiae, 10 grams of XIAKUQIU, 10 grams of the burnt Cortexs Eucommiae, 10 grams of Flos Chrysanthemis, 10 grams of Radix Platycodoniss, 6 grams, Radix Glycyrrhizae.
The Rhizoma Atractylodis Macrocephalae described in the present invention's formula is parch Rhizoma Atractylodis Macrocephalae charcoal, and its frying production method is: (1) Rhizoma Atractylodis Macrocephalae pretreatment: clear water is cleaned, and after then running through with rice-washed water, is placed on the interior steaming of food steamer black in degree, dries section; (2) stir the Rhizoma Atractylodis Macrocephalae: wheat bran stirs Rhizoma Atractylodis Macrocephalae section, fry to faint yellow being advisable, sieve removes wheat bran, collects Rhizoma Atractylodis Macrocephalae section, and wherein, stirring temperature is 200 ℃, stirs time 10～15min; (3) parch Rhizoma Atractylodis Macrocephalae charcoal: iron pan or marmite parch are put in the Rhizoma Atractylodis Macrocephalae section stirring, fries to outer and is khaki in black and is advisable, and parch temperature is 200 ℃, and the parch time is 10～15min, is cooled to collect the Rhizoma Atractylodis Macrocephalae after room temperature and cut into slices, and is Rhizoma Atractylodis Macrocephalae charcoal, stand-by.
Treat a Chinese medicine preparation for hypertension and complication thereof, preparation method is:
(1) according to the described ratio of formula, take medical material, by conventional method, clean, dry, cut into slices;
(2) described medical material fragment is put into marmite or porcelain, add proper amount of clear water to submergence medical material 1～2cm, soak after medical material 20min, be heated to 90～100 ℃ of decocting herbs, decocting time is 20min, leaches soup;
(3) in the described marmite that holds medical material or porcelain, add clear water to submergence medical material 3～4cm, heat temperature raising decocting herbs subsequently, decocting time is 30min, decocting temperature is 90～100 ℃, leaches soup;
(4) soup that combining step (3), (4) leach, being concentrated into relative density is 1.05, and vacuum drying dewaters, and collects solid product, and described product is worn into fine powder under aseptic, free from dust condition, and fine powder is crossed 120 mesh sieves, makes capsule, two kinds of dosage forms of pill.
Treat a Chinese medicine preparation for hypertension and complication thereof, pharmacology analysis: described Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Poria, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Rehmanniae, the Radix Paeoniae Alba, Radix Glycyrrhizae are BAZHEN TANG, the reasonably combined curative effect with QI invigorating tune blood, blood circulation promoting and blood stasis dispelling of eight taste medical materials; Described BAZHEN TANG coordinates Radix Ophiopogonis, Fructus Schisandrae Chinensis, has the normal Diastolic Force that shrinks of the cardiac muscle of enhancing, improves blood circulation, replys the effect of the severe palpitation that causes of having a weak heart, irregularly intermittent and regularly intermittent pulse, raising vital capacity; Described BAZHEN TANG complex acid Semen Ziziphi Spinosae, Semen Platycladi, Radix Salviae Miltiorrhizae, have the effect of nourishing YIN to benefit the heart, blood-enriching tranquillizing; Described BAZHEN TANG coordinates Semen Plantaginis, improves renal function output, and toxin is discharged with urine, alleviates the burden of kidney, the disease for the treatment of appearance extremity edema; Described BAZHEN TANG coordinates Radix Polygoni Multiflori, the Cortex Eucommiae, has the effect of the liver and the kidney tonifying, the dim eyesight for the treatment of dizziness; Described BAZHEN TANG coordinates XIAKUQIU, Rhizoma Gastrodiae, Flos Chrysanthemi, cures mainly excessive rising of liver-YANG, has a dizzy spell; Described BAZHEN TANG coordinates Radix Platycodonis, Radix Platycodonis dispersing and elevation lung meridian edema caused by disorder of QI key medicine, and gas promoting the circulation of blood band medicine is up, until focus.
Chinese medicine preparation of the present invention has reconciles QI and blood, improves blood circulation, replys atrioventricular node valvular function, strengthens myocardium normal contraction and Diastolic Force, raising renal function output, strengthens the remarkable result of endocrine function and urinary system normal function, there is cerebrovascular, brain cell, the cranial nerve vigor of promotion, improve immune function, hypertension, coronary heart disease and apoplexy sequela are had to significant curative effect.
Instructions of taking of the present invention: take medicine every day 3 times, each 6～7 grams one month is a course for the treatment of, onset in 2～3 days, substantially cure 2～3 courses for the treatment of.
Medication taboo of the present invention: the edible rich savoury of taboo is carnivorous during its treatment, because greasy sealing the intestines and stomach cannot absorb medicine, does not reach therapeutic effect, even can produce high blood matter, cholesterol, triglyceride toxin; Abstain from smoking and drinking; Taboo animal component medicine; Taboo affects the medicine of increased blood pressure, as Radix Ginseng, the Radix Astragali, Fructus Lycii, Cornu Cervi Pantotrichum, Fructus Corni and LIUWEI DIHUANG WAN, the large heat of great Xin and drug toxicity.
The Clinical efficacy of Chinese medicine preparation of the present invention:
Diagnostic criteria: Chinese hypertension prevention and control guide (revised edition) blood pressure level in 2005, in Table 1.
The classification of table 1. blood pressure level and index (mmHg)
Observational technique: make a definite diagnosis 200 routine hypertension and complication patient thereof according to above diagnostic criteria, its mild or moderate 32 examples, moderate 74 examples, severe 28 examples, coronary heart disease 37 examples, apoplexy sequela 29 examples.Wherein, hyperpietic, according to the difference of blood pressure classification, allows patient take according to the method described above 1～3 course for the treatment of of Chinese medicine preparation prepared by example of the present invention, and coronary heart disease and Patients with Apoplexy Sequela are taken 1～3 course for the treatment of of Chinese medicine preparation prepared by example of the present invention.
Hypertension curative effect judging standard:
Effective: 1. more than diastolic pressure decline 10mmHg, and to reach normal range; Though diastolic pressure is not down to normally, declined 20mmHg or more than;
Effective: 1. diastolic pressure declines not as good as 10mmHg, but has reached normal range; 2. diastolic pressure is taken the front 10～19mmHg of decline of Chinese medicine preparation of the present invention, but does not reach normal range; 3., more than systolic pressure is treated front decline 30 mmHg, must possess wherein 1.
Invalid: not reach above standard.
Coronary heart disease curative effect judging standard:
Effective: 1. each symptom of coronary heart disease obviously alleviates, and reaches health status; 2. each symptom of coronary heart disease obviously alleviates, but does not reach health status.
Effective: each symptom of coronary heart disease is slightly alleviated, and does not reach health status.
Invalid: each symptom of coronary heart disease is unchanged.
Effect for the treatment of sequela of apoplexy criterion:
Effective: 1. blood glucose, urinary glucose determination, after taking medicine, blood glucose, glucose in urine symptom obviously alleviate, and reach normal range; 2. acidophil number has showed increased after taking medicine, and reaches normal range; 3. computed tomography brain scan diagnosis, after taking medicine, diagnostic result is without apoplexy disease.
Effective: 1. blood glucose, urinary glucose determination, after taking medicine, blood glucose, glucose in urine symptom are slightly alleviated, and do not reach normal range; 2. acidophil number increases after taking medicine slightly, does not reach normal range.
Invalid: apoplexy sequela disease is without any improvement.
Therapeutic effect statistical result, as table 2.
The above-mentioned result statistical description to clinical observation on the therapeutic effect, Chinese medicine preparation of the present invention has remarkable result to the treatment of hypertension, and the coronary heart disease that hypertension is caused, apoplexy sequela also have positive effect.
Compared with prior art, beneficial effect of the present invention is: adopt Common Chinese Herbs, Costco Wholesale is low, treatment crowd scope is wide; Adopting Chinese herbal medicine is nourishing type Chinese crude drug, and human body, without injury, is had no side effect; Treatment cycle of the present invention is 2～3 courses for the treatment of, short treating period; Chinese medicine preparation of the present invention be take adjusting QI and blood as side, and various diseases are sent out to all onsets of hypertension that mechanism causes, the complication such as the coronary heart disease especially causing for hypertension, apoplexy sequela have remarkable result.
Specific implementation method
For technical scheme of the present invention is described, below in conjunction with example, further illustrate.
Embodiment 1
Get the raw materials ready:
15 grams of Radix Codonopsis, 10 grams of Rhizoma Atractylodis Macrocephalae (parched)s, 10 grams, Poria, 15 grams of Radix Angelicae Sinensis, 10 grams of Rhizoma Chuanxiongs, 10 grams, the Radix Rehmanniae, 10 grams of the Radix Paeoniae Albas, 10 grams of Radix Ophiopogonis, 10 grams of Fructus Schisandrae Chinensis, 10 grams of Radix Salviae Miltiorrhizaes, 10 grams of ripe Semen Ziziphi Spinosaes, 10 grams of Semen Platycladi, 10 grams of Radix Polygoni Multiflori, 10 grams of Semen Plantaginiss, 10 grams, Rhizoma Gastrodiae, 10 grams of XIAKUQIU, 10 grams of the burnt Cortexs Eucommiae, 10 grams of Flos Chrysanthemis, 10 grams of Radix Platycodoniss, 6 grams, Radix Glycyrrhizae.
Pharmacy:
(1) above-mentioned medicinal raw material is cleaned, dries, cut into slices by conventional method;
(2) described medical material fragment is put into marmite or porcelain, add proper amount of clear water to submergence medical material 1～2cm, soak after medical material 20min, be heated to 90～100 ℃ of decocting herbs, decocting time is 20min, leaches soup;
(3) in the described marmite that holds medical material or porcelain, add clear water to submergence medical material 3～4cm, heat temperature raising decocting herbs subsequently, decocting time is 30min, decocting temperature is 90～100 ℃, leaches soup;
(4) soup that combining step (3), (4) leach, being concentrated into relative density is 1.05, vacuum drying dewaters, collect solid product, described product is worn into fine powder under aseptic, free from dust condition, and fine powder is crossed 120 mesh sieves, make capsule, capsule specification is that every capsules contains 1.5 grams, medicated powder.
Embodiment 2
Same embodiment 1 gets the raw materials ready.
Pharmacy:
(1) above-mentioned medicinal raw material is cleaned, dries, cut into slices by conventional method;
(2) described medical material fragment is put into marmite or porcelain, add proper amount of clear water to submergence medical material 1～2cm, soak after medical material 20min, be heated to 90～100 ℃ of decocting herbs, decocting time is 20min, leaches soup;
(3) in the described marmite that holds medical material or porcelain, add clear water to submergence medical material 3～4cm, heat temperature raising decocting herbs subsequently, decocting time is 30min, decocting temperature is 90～100 ℃, leaches soup;
(4) soup that combining step (3), (4) leach, being concentrated into relative density is 1.05, and vacuum drying dewaters, and collects solid product, described product is worn into fine powder under aseptic, free from dust condition, fine powder is crossed 120 mesh sieves, and with deionized water moistening medicated powder, moisture content is 15%, adopt watered pill technique to make the watered pill, vacuum drying, making its moisture content is 5%, packing.
Claims (2)
1. a Chinese medicine preparation for the treatment of hypertension and complication thereof, is characterized in that: the compositing formula of described Chinese medicine preparation is: 15 grams of Radix Codonopsis, 10 grams of the Rhizoma Atractylodis Macrocephalaes, 10 grams, Poria, 15 grams of Radix Angelicae Sinensis, 10 grams of Rhizoma Chuanxiongs, 10 grams, the Radix Rehmanniae, 10 grams of the Radix Paeoniae Albas, 10 grams of Radix Ophiopogonis, 10 grams of Fructus Schisandrae Chinensis, 10 grams of Radix Salviae Miltiorrhizaes, 10 grams of ripe Semen Ziziphi Spinosaes, 10 grams of Semen Platycladi, 10 grams of Radix Polygoni Multiflori, 10 grams of Semen Plantaginiss, 10 grams, Rhizoma Gastrodiae, 10 grams of the burnt Cortexs Eucommiae, 10 grams of Flos Chrysanthemis, 10 grams of Radix Platycodoniss, 6 grams, Radix Glycyrrhizae.
2. a kind of Chinese medicine preparation for the treatment of hypertension and complication thereof as claimed in claim 1, is characterized in that: the described Rhizoma Atractylodis Macrocephalae is parch Rhizoma Atractylodis Macrocephalae charcoal.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107334952A (en) * | 2017-07-17 | 2017-11-10 | 上海市静安区中医医院 | Ear acupoint pasting, acupuncture Combined with Chinese Herbal treatment phlegm wet stop up Sheng type essential hypertension and its application |
| CN108635497A (en) * | 2018-07-30 | 2018-10-12 | 佛山科学技术学院 | A kind of Chinese medicine preparation and preparation method thereof for treating hypertension |
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2013
- 2013-09-10 CN CN201310409224.3A patent/CN103623246B/en active Active
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107334952A (en) * | 2017-07-17 | 2017-11-10 | 上海市静安区中医医院 | Ear acupoint pasting, acupuncture Combined with Chinese Herbal treatment phlegm wet stop up Sheng type essential hypertension and its application |
| CN107334952B (en) * | 2017-07-17 | 2020-12-04 | 上海市静安区中医医院 | Ear acupoint sticking and acupuncture combined traditional Chinese medicine for treating phlegm-dampness accumulation type primary hypertension and application thereof |
| CN108635497A (en) * | 2018-07-30 | 2018-10-12 | 佛山科学技术学院 | A kind of Chinese medicine preparation and preparation method thereof for treating hypertension |
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| CN103623246B (en) | 2015-08-19 |
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