CN109890359A - 用于口腔护理的多相口腔组合物 - Google Patents
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- CN109890359A CN109890359A CN201780066640.4A CN201780066640A CN109890359A CN 109890359 A CN109890359 A CN 109890359A CN 201780066640 A CN201780066640 A CN 201780066640A CN 109890359 A CN109890359 A CN 109890359A
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| FR3052086B1 (fr) * | 2016-06-07 | 2018-06-15 | Louis Vuitton Malletier | Systeme pour tester un parfum |
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| BR112021019721A2 (pt) * | 2019-04-16 | 2021-12-14 | Procter & Gamble | Composição bucal multifásica semissólida que compreende partículas de agente ativo hidrofílico |
| US10849729B2 (en) | 2019-04-16 | 2020-12-01 | The Procter & Gamble Company | Multi-phase oral care compositions |
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| AU2020294106A1 (en) | 2019-06-14 | 2021-12-16 | The Procter & Gamble Company | Device for applying emulsion compositions |
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| AU2020349427A1 (en) * | 2019-09-16 | 2022-03-31 | Align Technology, Inc. | Durable ornamental indicia carrier |
| CN114599311B (zh) * | 2019-10-22 | 2025-02-21 | 皇家飞利浦有限公司 | 牙齿美白系统 |
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| US20220054372A1 (en) * | 2020-08-24 | 2022-02-24 | The Procter & Gamble Company | Tooth whitening product |
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| KR102335087B1 (ko) * | 2021-04-13 | 2021-12-03 | 주식회사 오라팜 | 웨이셀라 사이베리아(Weissella cibaria) CMU 배양물을 유효성분으로 포함하는 치아미백용 조성물 |
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| US20230129930A1 (en) * | 2021-10-22 | 2023-04-27 | Zest Ip Holdings, Llc | Teeth whitening compositions, kits, and systems |
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| WO2025122687A1 (en) * | 2023-12-05 | 2025-06-12 | Creighton University | Polymeric ion releasing fillers |
| CN119454516A (zh) | 2024-11-18 | 2025-02-18 | 江西登特科技有限公司 | 一种护龈美白牙贴及其制备方法 |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020006388A1 (en) * | 1997-06-06 | 2002-01-17 | Sagel Paul Albert | Delivery systems for a tooth whitener |
| EP1733710A1 (en) * | 2005-06-17 | 2006-12-20 | The Procter & Gamble Company | Cohesive emulsion composition comprising a bleaching agent |
| CN1893917A (zh) * | 2003-12-17 | 2007-01-10 | 宝洁公司 | 递送漂白剂至牙齿的乳液组合物 |
| CN102961261A (zh) * | 2012-12-12 | 2013-03-13 | 广州安德健康科技有限公司 | 一种美白牙贴 |
| US20160074290A1 (en) * | 2012-10-17 | 2016-03-17 | The Procter & Gamble Company | Strip for the Delivery of an Oral Care Active and Methods for Applying Oral Care Actives |
| CN105640787A (zh) * | 2016-01-26 | 2016-06-08 | 浙江浙北药业有限公司 | 一种美白牙贴的制备方法 |
Family Cites Families (80)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2798053A (en) | 1952-09-03 | 1957-07-02 | Goodrich Co B F | Carboxylic polymers |
| US2835628A (en) | 1957-04-01 | 1958-05-20 | Jacob A Saffir | Means for treating teeth |
| US3506720A (en) | 1963-02-22 | 1970-04-14 | Geigy Chem Corp | Halogenated hydroxy-diphenyl ethers |
| US4013770A (en) | 1972-06-16 | 1977-03-22 | Canada Packers Limited | Antiviral 5-(substituted benzal) hydantoins |
| US3959458A (en) | 1973-02-09 | 1976-05-25 | The Procter & Gamble Company | Oral compositions for calculus retardation |
| US3988433A (en) | 1973-08-10 | 1976-10-26 | The Procter & Gamble Company | Oral compositions for preventing or removing stains from teeth |
| US4051234A (en) | 1975-06-06 | 1977-09-27 | The Procter & Gamble Company | Oral compositions for plaque, caries, and calculus retardation with reduced staining tendencies |
| GB1492660A (en) | 1975-10-13 | 1977-11-23 | Colgate Palmolive Co | Dentifrices |
| US5024701A (en) * | 1983-08-01 | 1991-06-18 | Hercules Incorporated | Denture adhesive composition |
| GB8615534D0 (en) | 1986-06-25 | 1986-07-30 | Beecham Group Plc | Composition |
| US5016784A (en) | 1990-02-15 | 1991-05-21 | Dexus Research Inc. | Applicator for highly reactive materials |
| MX9305120A (es) | 1992-09-04 | 1994-03-31 | Lubrizol Corp | Composiciones sobrebasificadas sulfuradas. |
| JPH07155184A (ja) | 1993-12-08 | 1995-06-20 | Ajinomoto Co Inc | 発酵法によるl−リジンの製造法 |
| US5512278A (en) | 1994-01-11 | 1996-04-30 | Phylomed Corporation | Ointment base useful for pharmaceutical preparations |
| US5713738A (en) * | 1995-12-12 | 1998-02-03 | Britesmile, Inc. | Method for whitening teeth |
| US5766011A (en) * | 1996-11-27 | 1998-06-16 | Sibner; Jeffrey A. | Dental bleaching composition and method |
| US5894017A (en) | 1997-06-06 | 1999-04-13 | The Procter & Gamble Company | Delivery system for an oral care substance using a strip of material having low flexural stiffness |
| US6136297A (en) | 1997-06-06 | 2000-10-24 | The Procter & Gamble Company | Delivery system for an oral care substance using a strip of material having low flexural stiffness |
| US5879691A (en) | 1997-06-06 | 1999-03-09 | The Procter & Gamble Company | Delivery system for a tooth whitener using a strip of material having low flexural stiffness |
| US5989569A (en) | 1997-06-06 | 1999-11-23 | The Procter & Gamble Company | Delivery system for a tooth whitener using a permanently deformable strip of material |
| US6045811A (en) | 1997-06-06 | 2000-04-04 | The Procter & Gamble Company | Delivery system for an oral care substance using a permanently deformable strip of material |
| BR0009452A (pt) | 1999-04-01 | 2002-01-08 | Unilever Nv | Composição de cuidado oral com um efeito de branqueamento aumentado dos dentes, e, uso de um composto peróxi e de um catalisador |
| US20070054233A1 (en) | 2003-07-22 | 2007-03-08 | Biolase Technology, Inc. | Device for dental care and whitening |
| US6514484B2 (en) | 2001-03-19 | 2003-02-04 | The Procter & Gamble Company | Systems for delivering a cosmetic and/or therapeutic active to oral surfaces using an integral carrier |
| US6509007B2 (en) | 2001-03-19 | 2003-01-21 | The Procter & Gamble Company | Oral care kits and compositions |
| US6746679B2 (en) * | 2001-08-02 | 2004-06-08 | Oral Health Clinical Services Llc | Tooth whitening hydrogels |
| ATE392863T1 (de) | 2001-08-17 | 2008-05-15 | Smithkline Beecham Plc | Streifen zur abgabe eines mundpflegewirkstoffes |
| US7842746B2 (en) | 2002-05-02 | 2010-11-30 | Archer-Daniels-Midland Company | Hydrogenated and partially hydrogenated heat-bodied oils and uses thereof |
| US7025950B2 (en) | 2002-05-09 | 2006-04-11 | The Procter & Gamble Company | Oral care compositions comprising dicarboxy functionalized polyorganosiloxanes |
| WO2004103303A2 (en) * | 2003-05-16 | 2004-12-02 | Britesmile Development, Inc. | Therapeutic dental composition |
| US20050064371A1 (en) | 2003-07-21 | 2005-03-24 | Soukos Nikos S. | Method and device for improving oral health |
| US20050036958A1 (en) | 2003-08-13 | 2005-02-17 | Jianxun Feng | Dental bleaching |
| JP2007502286A (ja) * | 2003-08-13 | 2007-02-08 | パーソナル・プロダクツ・カンパニー・ディヴィジョン・マクニール−ピーピーシー・インコーポレイテッド | 歯の漂白 |
| US20050036957A1 (en) * | 2003-08-15 | 2005-02-17 | Michael Prencipe | Tooth whitening dental tray and method of use |
| US8815215B2 (en) | 2003-08-15 | 2014-08-26 | Colgate-Palmolive Company | Hydrophobic tooth whitening system and methods of use |
| US20050143274A1 (en) * | 2003-12-17 | 2005-06-30 | Ghosh Chanchal K. | Compositions and methods of delivering bleaching agents to teeth |
| US20050137109A1 (en) * | 2003-12-17 | 2005-06-23 | The Procter & Gamble Company | Emulsion composition for delivery of bleaching agents to teeth |
| TW200534874A (en) | 2004-01-26 | 2005-11-01 | Colgate Palmolive Co | Dental-bleaching compositions and methods with reduced peroxide concentration |
| GB0414803D0 (en) | 2004-07-01 | 2004-08-04 | Glaxo Group Ltd | Composition |
| WO2006014897A2 (en) | 2004-07-26 | 2006-02-09 | Lawrence Eric S | Compact tooth whitening device |
| US20060045854A1 (en) * | 2004-08-27 | 2006-03-02 | Lynette Zaidel | Oral care composition with cross-linked polymer peroxide |
| US20060198795A1 (en) | 2005-11-07 | 2006-09-07 | Giniger Martin S | Multi-component oral care compositions |
| US9271902B2 (en) * | 2005-02-15 | 2016-03-01 | Martin S. Giniger | Whitening system capable of delivering effective whitening action |
| US20120134936A1 (en) * | 2005-03-18 | 2012-05-31 | Lg Household & Health Care Ltd. | Tooth Whitener |
| RU2375040C2 (ru) * | 2005-03-18 | 2009-12-10 | ЛДжи ХАУЗХОЛД ЭНД ХЭЛТ КЭА ЛТД. | Отбеливатель для зубов |
| US20070292459A1 (en) | 2005-07-18 | 2007-12-20 | Cooper Sarah M | Halloysite microtubule processes, structures, and compositions |
| CN101663017A (zh) | 2005-07-22 | 2010-03-03 | 宝洁公司 | 口腔护理产品 |
| US20120037038A1 (en) * | 2005-11-09 | 2012-02-16 | Jayanth Rajaiah | Denture adhesive compositions and methods |
| CN101365398A (zh) * | 2006-01-24 | 2009-02-11 | 施美妙(英国)有限公司 | 用于漂白牙齿的方法和装置 |
| CN101019812A (zh) | 2006-04-21 | 2007-08-22 | 阮仕星 | 一种弹性凝胶深层增白牙齿贴膜 |
| US20070280894A1 (en) * | 2006-06-02 | 2007-12-06 | The Procter & Gamble Company | Cohesive emulsion composition comprising a bleaching agent |
| CN200984244Y (zh) | 2006-09-05 | 2007-12-05 | 宁波太平洋电子有限公司 | 一种便携式牙齿美白仪 |
| DE102007013040A1 (de) | 2007-03-19 | 2008-09-25 | Deltamed Medizinprodukte Gmbh | Zahnbleichsystem |
| US20090081136A1 (en) * | 2007-09-24 | 2009-03-26 | Deepak Sharma | Compositions Useful For Tooth Whitening |
| JP2009126819A (ja) | 2007-11-22 | 2009-06-11 | Vmc Co Ltd | 歯のホワイトニング剤および歯をホワイトニングする方法 |
| CN101909582A (zh) * | 2008-01-11 | 2010-12-08 | 宝洁公司 | 含有微晶蜡的口腔护理递送体系 |
| US20090208543A1 (en) * | 2008-01-22 | 2009-08-20 | Oral Health Clinical Services | Method and apparatus for applying a protective oral care composition |
| WO2010098761A1 (en) | 2009-02-27 | 2010-09-02 | Leslie Cifuentes French | Intra-oral whitening device |
| US10688026B2 (en) | 2009-04-27 | 2020-06-23 | Premier Dental Products Company | Buffered microencapsulated compositions and methods |
| US8623388B2 (en) | 2009-10-29 | 2014-01-07 | The Procter & Gamble Company | Denture care composition |
| US9642687B2 (en) | 2010-06-15 | 2017-05-09 | The Procter & Gamble Company | Methods for whitening teeth |
| KR101537309B1 (ko) * | 2010-09-23 | 2015-07-22 | 리젠티스 가부시키가이샤 | 치아의 오염을 제거하기 위한 구강용 조성물 |
| RU2623144C2 (ru) | 2011-12-20 | 2017-06-22 | Колгейт-Палмолив Компани | Отбеливающие композиции для ухода за полостью рта |
| WO2013093743A1 (en) * | 2011-12-23 | 2013-06-27 | Koninklijke Philips Electronics N.V. | Dental whitening device |
| CN102614090A (zh) | 2012-04-24 | 2012-08-01 | 苏州维蒂卡科技有限公司 | 一种牙膏组合物 |
| EP2900200A2 (en) | 2012-08-13 | 2015-08-05 | Matthew Scott Spaid | Teeth whitening composition |
| JP6856316B2 (ja) * | 2012-09-14 | 2021-04-07 | プレミア デンタル プロダクツ カンパニー | マイクロカプセル化緩衝化組成物及び方法 |
| JP6431251B2 (ja) * | 2013-02-13 | 2018-11-28 | 株式会社メディプラス製薬 | 歯のホワイトニング剤およびホワイトニング方法 |
| JP5615968B1 (ja) | 2013-12-19 | 2014-10-29 | 株式会社エイ・アイ・シー | 歯牙用漂白剤、及び歯牙の漂白方法 |
| JP2016017072A (ja) * | 2014-07-11 | 2016-02-01 | リジェンティス株式会社 | 歯牙漂白剤 |
| WO2016131642A1 (en) | 2015-02-17 | 2016-08-25 | Koninklijke Philips N.V. | Single layer tooth whitening system |
| WO2017048217A1 (en) | 2015-09-14 | 2017-03-23 | Colgate-Palmolive Company | Whitening systems for hydrophobic whitening gels |
| JP2018537438A (ja) | 2015-11-12 | 2018-12-20 | セントリックス、インコーポレーテッド | 既定の用量の薬剤を歯に塗布するための歯科用組成物 |
| US20170172864A1 (en) * | 2015-12-18 | 2017-06-22 | Colgate-Palmolive Company | Tooth Whitening Compositions Comprising Peroxide Complex and Percarbonate Salt |
| AU2017350733B2 (en) | 2016-10-26 | 2020-08-20 | The Procter & Gamble Company | Tooth whitening |
| PL3315119T3 (pl) | 2016-10-26 | 2020-03-31 | The Procter And Gamble Company | Zestaw do wybielania zębów zawierający kompozycję do higieny jamy ustnej, nośnik dostarczający i źródło promieniowania elektromagnetycznego |
| US20220040061A1 (en) | 2016-10-26 | 2022-02-10 | The Procter & Gamble Company | Multi-phase oral composition for delivering oral care active agents |
| US10849729B2 (en) | 2019-04-16 | 2020-12-01 | The Procter & Gamble Company | Multi-phase oral care compositions |
| US11559473B2 (en) | 2019-04-16 | 2023-01-24 | The Procter & Gamble Company | Semisolid oral dispersions comprising active agents |
| WO2020219320A1 (en) | 2019-04-25 | 2020-10-29 | The Procter & Gamble Company | Oral care compositions for active agent delivery |
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Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020006388A1 (en) * | 1997-06-06 | 2002-01-17 | Sagel Paul Albert | Delivery systems for a tooth whitener |
| CN1893917A (zh) * | 2003-12-17 | 2007-01-10 | 宝洁公司 | 递送漂白剂至牙齿的乳液组合物 |
| EP1733710A1 (en) * | 2005-06-17 | 2006-12-20 | The Procter & Gamble Company | Cohesive emulsion composition comprising a bleaching agent |
| US20160074290A1 (en) * | 2012-10-17 | 2016-03-17 | The Procter & Gamble Company | Strip for the Delivery of an Oral Care Active and Methods for Applying Oral Care Actives |
| CN102961261A (zh) * | 2012-12-12 | 2013-03-13 | 广州安德健康科技有限公司 | 一种美白牙贴 |
| CN105640787A (zh) * | 2016-01-26 | 2016-06-08 | 浙江浙北药业有限公司 | 一种美白牙贴的制备方法 |
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