RU2019107791A - Многофазная композиция для перорального применения для доставки активных веществ для ухода за ротовой полостью - Google Patents
Многофазная композиция для перорального применения для доставки активных веществ для ухода за ротовой полостью Download PDFInfo
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Claims (19)
1. Многофазная композиция для применения в ротовой полости для доставки одного или более активных веществ, содержащая
a) от 0,002 мас.% до 15 мас.% водной фазы, содержащей активное вещество, по массе многофазной композиции;
b) гидрофобную фазу, причем гидрофобная фаза многофазной композиции выбрана из петролатума и его смесей;
причем отношение концентрации в мас.% активного вещества, присутствующего в водной фазе, к концентрации в мас.% активного вещества, присутствующего во всей многофазной композиции, составляет по меньшей мере 6;
причем концентрация активного вещества составляет до 10 мас.% многофазной композиции; и при этом гидрофобная фаза является преобладающей частью многофазной композиции.
2. Многофазная композиция по п. 1, в которой отношение концентрации в мас.% активного вещества, присутствующего в водной фазе, к концентрации в мас.% активного вещества, присутствующего во всей многофазной композиции, составляет по меньшей мере 25.
3. Многофазная композиция по п. 2, в которой отношение концентрации в мас.% активного вещества, присутствующего в водной фазе, к концентрации в мас.% активного вещества, присутствующего во всей многофазной композиции, составляет по меньшей мере 50.
4. Многофазная композиция по любому из пп. 1-3, в которой количество активного вещества находится в диапазоне от 1 мас.% до 5 мас.% многофазной композиции.
5. Многофазная композиция по любому из пп. 1-4, в которой количество капель водной фазы, которые присутствуют в квадратном сантиметре в двухмерной плоскости многофазной композиции с площадью поперечного сечения в двухмерной плоскости более 10 000 квадратных мкм, составляет не более 20 на квадратный сантиметр.
6. Многофазная композиция по п. 5, в которой количество капель водной фазы, которые присутствуют в квадратном сантиметре в двухмерной плоскости многофазной композиции с площадью поперечного сечения в двухмерной плоскости более 10 000 квадратных мкм, составляет не более 10 на квадратный сантиметр.
7. Многофазная композиция по любому из предшествующих пунктов, в которой среднеквадратичное отклонение концентрации пероксида в многофазной композиции, намазанной на пероксидные тест-полоски, измеренное с помощью процедуры, описанной в настоящем документе, составляет не более 50.
8. Многофазная композиция по п. 7, в которой среднеквадратичное отклонение концентрации пероксида в многофазной композиции, намазанной на пероксидные тест-полоски, измеренное с помощью процедуры, описанной в настоящем документе, составляет не более 25.
9. Многофазная композиция по любому из предшествующих пунктов, в которой средняя концентрация пероксида в многофазной композиции, намазанной на пероксидные тест-полоски, измеренная с помощью процедуры, описанной в настоящем документе, составляет от 1 до 100.
10. Многофазная композиция по любому из предшествующих пунктов, в которой средняя остаточная концентрация пероксида в многофазной композиции, намазанной на зубы, измеренная с помощью процедуры, описанной в настоящем документе, составляет от 20 до 200.
11. Многофазная композиция по любому из предшествующих пунктов, в которой активное вещество содержит по меньшей мере одно из реминерализирующего агента, агента против зубного камня, источника фторидных ионов, противомикробного средства, десенсибилизатора дентина, обезболивающего средства, противогрибкового средства, противовоспалительного средства, селективного антагониста H-2, селективного антагониста TRPM8, противокариесного средства, питательного вещества, эритрита или пробиотика.
12. Многофазная композиция по любому из предшествующих пунктов, причем эффективность активного вещества многофазной композиции, вычисленная по формуле -Δb* и измеренная согласно клиническому протоколу, описанному в настоящем документе, составляет по меньшей мере 1,5.
13. Многофазная композиция по любому из предшествующих пунктов, причем отношение эффективности отбеливания в многофазной композиции, вычисленной по формуле -Δb* и измеренной согласно клиническому протоколу, описанному в настоящем документе, к процентному содержанию отбеливающего агента во всей многофазной композиции составляет по меньшей мере 1,5.
14. Набор для доставки одного или более активных веществ, содержащий многофазную композицию для применения в ротовой полости по любому из пп. 1-13 и доставочный носитель.
15. Набор по п. 14, в котором доставочный носитель представляет собой полоску.
Applications Claiming Priority (15)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662413214P | 2016-10-26 | 2016-10-26 | |
| US201662413205P | 2016-10-26 | 2016-10-26 | |
| US201662413237P | 2016-10-26 | 2016-10-26 | |
| US201662413229P | 2016-10-26 | 2016-10-26 | |
| US201662413189P | 2016-10-26 | 2016-10-26 | |
| US201662413222P | 2016-10-26 | 2016-10-26 | |
| US201662413200P | 2016-10-26 | 2016-10-26 | |
| US62/413,222 | 2016-10-26 | ||
| US62/413,214 | 2016-10-26 | ||
| US62/413,205 | 2016-10-26 | ||
| US62/413,229 | 2016-10-26 | ||
| US62/413,189 | 2016-10-26 | ||
| US62/413,237 | 2016-10-26 | ||
| US62/413,200 | 2016-10-26 | ||
| PCT/US2017/057877 WO2018080998A1 (en) | 2016-10-26 | 2017-10-23 | Multi-phase oral composition for delivering oral care active agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2019107791A true RU2019107791A (ru) | 2020-09-21 |
| RU2019107791A3 RU2019107791A3 (ru) | 2020-09-21 |
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Family Applications (8)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2019108041A RU2019108041A (ru) | 2016-10-26 | 2017-10-23 | Многофазная композиция для использования в полости рта |
| RU2019114449A RU2019114449A (ru) | 2016-10-26 | 2017-10-23 | Набор для отбеливания зубов |
| RU2019114433A RU2019114433A (ru) | 2016-10-26 | 2017-10-23 | Отбеливание зубов |
| RU2019114548A RU2019114548A (ru) | 2016-10-26 | 2017-10-23 | Отбеливание зубов |
| RU2019108031A RU2717947C1 (ru) | 2016-10-26 | 2017-10-23 | Многофазная композиция для применения в полости рта для отбеливания зубов |
| RU2019107941A RU2019107941A (ru) | 2016-10-26 | 2017-10-23 | Многофазная композиция для применения в полости рта для ухода за ротовой полостью |
| RU2019107791A RU2019107791A (ru) | 2016-10-26 | 2017-10-23 | Многофазная композиция для перорального применения для доставки активных веществ для ухода за ротовой полостью |
| RU2019114453A RU2019114453A (ru) | 2016-10-26 | 2017-10-23 | Источник электромагнитного излучения и многофазная композиция для ухода за полостью рта |
Family Applications Before (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2019108041A RU2019108041A (ru) | 2016-10-26 | 2017-10-23 | Многофазная композиция для использования в полости рта |
| RU2019114449A RU2019114449A (ru) | 2016-10-26 | 2017-10-23 | Набор для отбеливания зубов |
| RU2019114433A RU2019114433A (ru) | 2016-10-26 | 2017-10-23 | Отбеливание зубов |
| RU2019114548A RU2019114548A (ru) | 2016-10-26 | 2017-10-23 | Отбеливание зубов |
| RU2019108031A RU2717947C1 (ru) | 2016-10-26 | 2017-10-23 | Многофазная композиция для применения в полости рта для отбеливания зубов |
| RU2019107941A RU2019107941A (ru) | 2016-10-26 | 2017-10-23 | Многофазная композиция для применения в полости рта для ухода за ротовой полостью |
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| Application Number | Title | Priority Date | Filing Date |
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| RU2019114453A RU2019114453A (ru) | 2016-10-26 | 2017-10-23 | Источник электромагнитного излучения и многофазная композиция для ухода за полостью рта |
Country Status (10)
| Country | Link |
|---|---|
| US (14) | US20180133122A1 (ru) |
| EP (2) | EP3936194A1 (ru) |
| JP (16) | JP2019534274A (ru) |
| CN (8) | CN109890358A (ru) |
| AU (16) | AU2017350737A1 (ru) |
| BR (8) | BR112019007904B1 (ru) |
| CA (8) | CA3040713A1 (ru) |
| MX (10) | MX2019004738A (ru) |
| RU (8) | RU2019108041A (ru) |
| WO (8) | WO2018080995A1 (ru) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR3052086B1 (fr) * | 2016-06-07 | 2018-06-15 | Louis Vuitton Malletier | Systeme pour tester un parfum |
| US20240024214A9 (en) * | 2016-10-26 | 2024-01-25 | The Procter & Gamble Company | Multi-phase oral composition for tooth whitening |
| WO2018080995A1 (en) | 2016-10-26 | 2018-05-03 | The Procter & Gamble Company | Multi-phase oral composition |
| KR102424317B1 (ko) * | 2018-12-04 | 2022-07-28 | 선진바이오(주) | 구강청정용 발포성 정제 및 그 제조방법 |
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2019
- 2019-04-23 MX MX2022000272A patent/MX2022000272A/es unknown
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2020
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2021
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2022
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2023
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2024
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