CN1098721A - 稠合的喹啉基二氢吡啶，其制备方法及其药用 - Google Patents

稠合的喹啉基二氢吡啶，其制备方法及其药用 Download PDF

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Publication number
CN1098721A
CN1098721A CN94104622A CN94104622A CN1098721A CN 1098721 A CN1098721 A CN 1098721A CN 94104622 A CN94104622 A CN 94104622A CN 94104622 A CN94104622 A CN 94104622A CN 1098721 A CN1098721 A CN 1098721A
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CN
China
Prior art keywords
carbon atoms
group
branched
optionally substituted
chain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN94104622A
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English (en)
Chinese (zh)
Inventor
S·戈德曼
J·施托尔特富斯
A·施特劳布
M·比切姆
R·格罗斯
S·赫比什
J·胡特
H·P·朗丁
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of CN1098721A publication Critical patent/CN1098721A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pyridine Compounds (AREA)
  • Saccharide Compounds (AREA)
CN94104622A 1993-04-27 1994-04-23 稠合的喹啉基二氢吡啶，其制备方法及其药用 Pending CN1098721A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP4313690.7 1993-04-27
DE4313690A DE4313690A1 (de) 1993-04-27 1993-04-27 Kondensierte Chinolyl-dihydropyridine, Verfahren zu ihrer Herstellung und ihre Verwendung in Arzneimitteln

Publications (1)

Publication Number Publication Date
CN1098721A true CN1098721A (zh) 1995-02-15

Family

ID=6486449

Family Applications (1)

Application Number Title Priority Date Filing Date
CN94104622A Pending CN1098721A (zh) 1993-04-27 1994-04-23 稠合的喹啉基二氢吡啶，其制备方法及其药用

Country Status (20)

Country Link
US (1) US5436342A (enExample)
EP (1) EP0622366B1 (enExample)
JP (1) JPH06321939A (enExample)
CN (1) CN1098721A (enExample)
AT (1) ATE145903T1 (enExample)
AU (1) AU5922594A (enExample)
CA (1) CA2121980A1 (enExample)
CZ (1) CZ99494A3 (enExample)
DE (2) DE4313690A1 (enExample)
DK (1) DK0622366T3 (enExample)
ES (1) ES2096368T3 (enExample)
FI (1) FI941911A7 (enExample)
GR (1) GR3022026T3 (enExample)
HU (1) HUT70488A (enExample)
IL (1) IL109417A0 (enExample)
MX (1) MX9403032A (enExample)
NO (1) NO941514L (enExample)
NZ (1) NZ260383A (enExample)
SK (1) SK48094A3 (enExample)
ZA (1) ZA942883B (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ297278A (en) * 1994-11-16 1999-06-29 Synaptic Pharma Corp 4-aryl dihydropyrimidine derivatives end medicaments
US6268369B1 (en) 1994-11-16 2001-07-31 Synaptic Pharmaceutical Corporation 5-(heterocyclic alkyl)-6-aryl-dihydropyrimidines
US6228861B1 (en) 1995-11-16 2001-05-08 Synaptic Pharmaceutical Corporation Dihydropyrimidines and uses thereof
US6172066B1 (en) 1996-05-16 2001-01-09 Synaptic Pharmaceutical Corporation Dihydropyrimidines and uses thereof
US6245773B1 (en) 1996-05-16 2001-06-12 Synaptic Pharmaceutical Corporation 5-(heterocyclic alkyl)-6-aryl-dihydropyrimidines
US6274585B1 (en) 1998-12-23 2001-08-14 Synaptic Pharmaceutical Corporation Dihydropyrimidines and uses thereof
US6680323B2 (en) 1998-12-23 2004-01-20 Synaptic Pharmaceutical Corporation Dihydropyrimidines and uses thereof
US6518279B2 (en) 1999-03-04 2003-02-11 Abbott Laboratories Cyclopentanone dihydropyridine compounds useful as potassium channel openers
US6720324B2 (en) 2000-07-05 2004-04-13 Synaptic Pharmaceutical Corporation Selective melanin concentrating hormone-1 (MCH1) receptor antagonists and uses thereof
JP2007505137A (ja) * 2003-09-10 2007-03-08 シンタ ファーマシューティカルズ コーポレイション 代謝性障害を処置または予防するためのジヒドロピリジン化合物
ES2426609T3 (es) 2009-02-18 2013-10-24 Bayer Intellectual Property Gmbh Derivados de 1,4-dihidropiridina sustituidos con indazol bi- y tricíclicos y usos de los mismos

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1552911A (en) * 1975-07-02 1979-09-19 Fujisawa Pharmaceutical Co 1,4 dihydropyridine derivatives and the preparation thereof
DE2752820A1 (de) * 1977-11-26 1979-05-31 Bayer Ag Neue nitrosubstituierte 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DE3412947A1 (de) * 1984-04-06 1985-10-17 Bayer Ag, 5090 Leverkusen Tetrahydothienopyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DE4011105A1 (de) * 1990-04-06 1991-10-10 Bayer Ag Neue 4-chinolyl-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
US5204472A (en) * 1990-04-06 1993-04-20 Bayer Aktiengesellschaft Quinoline and isoquinoline intermediates

Also Published As

Publication number Publication date
ZA942883B (en) 1995-01-16
US5436342A (en) 1995-07-25
HUT70488A (en) 1995-10-30
NO941514L (no) 1994-10-28
DE4313690A1 (de) 1994-11-03
JPH06321939A (ja) 1994-11-22
AU5922594A (en) 1994-11-03
FI941911L (fi) 1994-10-28
EP0622366A1 (de) 1994-11-02
FI941911A0 (fi) 1994-04-25
ATE145903T1 (de) 1996-12-15
NO941514D0 (enExample) 1994-04-26
DK0622366T3 (da) 1997-05-12
DE59401179D1 (de) 1997-01-16
FI941911A7 (fi) 1994-10-28
CA2121980A1 (en) 1994-10-28
ES2096368T3 (es) 1997-03-01
CZ99494A3 (en) 1995-01-18
NZ260383A (en) 1996-02-27
SK48094A3 (en) 1994-12-07
EP0622366B1 (de) 1996-12-04
IL109417A0 (en) 1994-07-31
HU9401193D0 (en) 1994-07-28
MX9403032A (es) 1995-01-31
GR3022026T3 (en) 1997-03-31

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C06 Publication
PB01 Publication
C01 Deemed withdrawal of patent application (patent law 1993)
WD01 Invention patent application deemed withdrawn after publication