CN109846777A - It is a kind of to have effects that alleviate composition of plant extracts of baby child's eczema and preparation method thereof, application - Google Patents
It is a kind of to have effects that alleviate composition of plant extracts of baby child's eczema and preparation method thereof, application Download PDFInfo
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Abstract
The present invention relates to cosmetic technical fields, more particularly to a kind of composition of plant extracts with alleviation baby child's eczema and preparation method thereof, application, based on medicinal material dry weight, it is described to have effects that the composition of plant extracts for alleviating baby child's eczema is made of the component of following mass percent: bitter orange 1~50%, Artemisia capillaris 1~50% and pueraria lobata 1~50%.The present invention has effects that alleviating effective component contained by the composition of plant extracts of baby child's eczema derives from plant extracts, class hormone-free, antihistaminic ingredient, each component is synergistic each other, inhibit starting, transmitting and the effective stage of eczema respectively, prevent and repair baby child's eczema skin from multipath, external source nocuity substance be can effectively avoid to stimulation and sensitization caused by baby child's skin, can be widely applied in the baby child's class cosmetics for alleviating baby child's eczema and reparation baby child's skin barrier.
Description
Technical field
The present invention relates to cosmetic technical field more particularly to a kind of plant extracts with alleviation baby child's eczema
Composition and preparation method thereof, application.
Background technique
Baby child's skin has horn cell small, and arrangement is close, and dermatoglyph is close, and skin island is small, and cuticula is thin, and sebum level is low,
The features such as natural moisturizing factor content is low, and then cause baby child's percutaneous permeability strong, transepidermal water loss rate height etc..Meanwhile baby is virgin
Immune system and nervous system development are not perfect, and the defence capability for causing baby child's skin to invade extraneous nocuity is poor.To sum up this
A little factors cause baby child's skin to be easy the invasion by external injury substance and go wrong.For different age group baby child's skin
Skin problem investigation discovery eczema is arranged in first (reference: BJ Children's Hospital's skin disease first visit case statistics point in 2008
Analysis).
Eczema is a kind of allergic skin diseases, and histologic characteristics show as intercellular edema of epidermis, with different degrees of
Acanthosis and the infiltration of superficial vein peripheral lymphocyte.Due to intercellular edema of epidermis, increase space between cells, skin " brick
Wall construction " is unstable, breaks ring original skin barrier, percutaneous water loss and increases；It is normal to affect skin for inflammatory cell infiltration
Metabolism, lipid, natural moisturizing factor and anti-inflammatory factors are reduced, and skin becomes dry, furfur, are easier to sensitivity；Due to skin barrier
Impaired, skin resists the decline of environmental stimuli ability, easy secondary infection.Therefore maintenance skin barrier and antiallergy are in eczema treatment
It is critically important.
Currently, the drug for the treatment of eczema is mostly the chemistry such as corticosteroid hormone, antihistaminic class, calcium agent, vitamins
Preparation, although can alleviate eczema symptom within a certain period of time, improper use or for a long time use, can cause to skin can not
Inverse physiology lesion, such as hypoevolutism.Therefore, it develops highly-safe, the both effectiveness good prevention of one kind and alleviation baby child is wet
The cosmetics of rash skin achieve the purpose that chemicals is avoided to have important research significance to the stimulation of baby child's skin.
Summary of the invention
The present invention uses for the drug improper use for overcoming traditional treatment eczema or long-time, and can cause to skin can not
The problem of inverse physiology lesion, provide it is a kind of it is highly-safe, stability is good, addition easily has effects that alleviation baby child's eczema
Composition of plant extracts, from number of ways prevention and maintenance baby child eczema skin, contained effective component derives from plant
Object extract, class hormone-free, antihistaminic ingredient meet green, natural trend instantly.
The present invention also provides a kind of preparation methods of composition of plant extracts alleviate with baby child's eczema, should
Method operating procedure is simple, and extraction time is short, consumes energy low, it can be achieved that continuous large-scale production.
Have effects that the composition of plant extracts for alleviating baby child's eczema is made up in baby child's class the present invention also provides a kind of
Application in product.
To achieve the goals above, the invention adopts the following technical scheme:
It is a kind of to have effects that alleviate the composition of plant extracts of baby child's eczema, it is described that there is alleviation based on medicinal material dry weight
The composition of plant extracts of baby child's eczema effect is made of the component of following mass percent: bitter orange 1~50%, Artemisia capillaris 1
~50% and pueraria lobata 1~50%.
Bitter orange, also known as Fructus Aurantii, bigarabe." haigoushen ": " Fructus Aurantii, which has, controls rubeola all over, as numb beans evil is itched in flesh ".Bitter orange
Main component has flavonoids, volatile oil, alkaloids, carbohydrate, tannin and a small amount of microelement etc..It is transported with stomach and intestine are adjusted
The pharmacological actions such as dynamic, invigorating gallbladder and removing gall-stone, antithrombotic, antitumor.Artemisia capillaris, ancient herbal medicine such as Shennong's Herbal and Compendium of Material Medica
Deng record: Artemisia capillaris has main rheumatism, fever and chills, perverse trend heat knot, jaundice and other effects.It is often that this is medicinal wet to treat in the Yi nationality, distributed over Yunnan, Sichuan and Guizhou
Rash itch.Contain a large amount of bioactive ingredients in Artemisia capillaris, which includes cumarin, chromone, flavones, organic acid, eggs
White matter and volatile oil etc..With cholagogue, liver protection, antipyretic, analgesia, anti-inflammatory, reducing blood lipid, enhance immune, cytoprotection, antitumor
Equal pharmacological actions.Pueraria lobata, famous Chinese medicine Yishui School founder Zhang Yuansu once used kudzuvine root for treating children's sore rash.It is recorded in " Bie Lu "
To pueraria lobata " metal-inflicted wound can be treated, is relieved pain, side of body wind pain ".Isoflavone compound, starch, dietary fiber are three kinds of masters contained in pueraria lobata
Ingredient is wanted, wherein osajin is main active, terpene, alkaloid, cumarin etc..With liver protecting, immunological regulation, resist
The pharmacological actions such as tumour, anti-inflammatory, anti-oxidant, protection angiocarpy, estrogen-like action.
Above-mentioned plant is the traditional parts of generic medicinal plants in China, and growth distribution is extensive, dual-purpose of drug and food, has battalion well
Feeding, health care and medical value, but the application for alleviating baby child's eczema has not been reported.The present invention creatively will be in above-mentioned three kinds
Medicinal material is compounded by certain proportion, and the flavones ingredient in bitter orange can be relieved horn cell damage, inhibit NF-kB access, is inhibited
Mast cell degranulation etc. has the function that prevention and maintenance baby child's eczema；Oriental wormwood parthenium extract by activation to T cell and
Activation regulation, participates in immunological regulation, and then improve body's immunity from many aspects；Isoflavones components Puerarin in pueraria lobata,
By inhibiting the antigen presentation capability of Dendritic Cells, secretion and the expanding capacity of T lymphocyte are reduced to alleviate inflammatory reaction,
Can also direct regulation and control inflammatory factor expression, block the activation of NF-kB access to mitigate inflammatory reaction.Pass through above-mentioned plant extract
Composition made of object compounding, contained plant extracts is synergistic each other, indispensable, inhibits the starting of eczema respectively, passes
It passs and the effective stage, prevent from multipath and repairs baby child's eczema skin, can effectively avoid external source nocuity substance to baby child's skin
Caused by stimulation and sensitization, the composition of plant extracts have alleviate eczema effect, while have reparation baby child's skin
The effect of skin barrier.
A kind of preparation method of the composition of plant extracts alleviate with baby child's eczema, comprising the following steps:
(1) bitter orange, Artemisia capillaris and pueraria lobata are weighed according to said ratio, mixing is obtained after mixing, by mixing ethanol water
It impregnates, carries out Continuous Countercurrent Extraction, filtering obtains extracting solution；
(2) extracting solution for obtaining step (1) carries out ultrafiltration, and nanofiltration obtains nanofiltration liquid；
(3) nanofiltration liquid for obtaining step (2) is concentrated, and with purification with macroreticular resin, collects eluent after elution；
(4) eluent for obtaining step (3) is concentrated, and 1,3-BDO is added, stirs evenly, and stands 12~36h, collects
Supernatant；
(5) supernatant that step (4) obtains is centrifuged, obtains centrifuged supernatant to get having alleviation baby virgin
The composition of plant extracts of eczema effect.
Existing effective component in Chinese medicine extract, and have the invalid components such as protein, starch, pectin, the biography generally extracted
System method be decocting method, circumfluence method and extraction, extraction time is long, and recovery rate is not high, and isolate and purify frequently with high speed from
The processes such as the heart, solvent extraction, flocculation sedimentation, alcohol precipitation, macroporous resin adsorption, it is complicated for operation, at high cost, the feature of environmental protection is poor, effectively at
Divide loss big.The present invention uses membrane separation technique effective component extracting, is one and penetrates film as separating medium, outside using selectivity
Under the promotion of boundary's energy or chemical potential difference, the specific components in extracting solution are realized with the isolation technics of separation, concentration and purification.Often
Membrane separation technique is divided into micro-filtration, ultrafiltration, nanofiltration and reverse osmosis.Extracting method of the invention compared with conventional separation techniques,
Have many advantages, such as energy-efficient, environmentally protective, inexpensive, highly selective.Extracting method of the present invention uses ultrafiltration-nanofiltration-macropore
Resin adsorption connection is realized separation, is purified, purification, and conventional method is compared, and can remove major part impurity, operation is easier, and effect is more
Good, extracting solution is more stable, and extraction time is short, consumes energy low, it can be achieved that continuous large-scale production.
Preferably, 5~20mL ethanol water is added in every gram of mixing in step (1)；The body of the ethanol water
Fraction is 10~80%；Soaking time is controlled in 2~48h；The temperature of Continuous Countercurrent Extraction is 30~80 DEG C, and extraction time is
1~4h, extraction time >=1；Filter type is plate compression, and filter sizes used are 0.4~30 μm.
Selecting filter sizes to be 0.4~30 μm mainly will filter the substances such as particle, silt, avoid blocking ultrafiltration membrane or receive
Filter membrane.
Preferably, ultrafiltration technology uses the ultrafiltration membrane by 1000~6000 dalton of molecular weight in step (2).
Preferably, nanofiltration technique uses the nanofiltration membrane by 40~1000 dalton of molecular weight in step (2).
Select above-mentioned molecular weight ultrafiltration membrane and nanofiltration membrane, it can be achieved that retention solution in suspended matter, colloid, protein,
The macromolecular substances such as bacterium, isolated small-molecule substance, to increase Transdermal absorption effect.
Preferably, eluant, eluent used in elution processes is that the ethyl alcohol that volume fraction is 10~95% is water-soluble in step (3)
Liquid.
Preferably, the cycles of concentration of the eluent is 10~20 times in step (4).
Preferably, the additive amount of the 1,3-BDO is 0.5~3 times of the volume of eluent in step (4).
1,3-BDO can increase the stability of object extractive composition solution, and additive amount needs strict control, additive amount
Excessively high resulting composition has irritation, is not suitable for baby child's skin；Additive amount is too low, and resulting composition solution is unstable, no
It is easy to maintain.
A kind of application having effects that the composition of plant extracts for alleviating baby child's eczema in baby child's class cosmetics, it is described
Baby child's class is used for cosmetic in alleviation baby child's eczema and reparation baby child's skin barrier.
Preferably, baby child's class cosmetics include creme, lotion, toner, gelling agent, facial mask and inuncts.
Therefore, the invention has the following beneficial effects:
(1) present invention has effects that alleviating effective component contained by the composition of plant extracts of baby child's eczema derives from
Plant extracts, class hormone-free, antihistaminic ingredient, each component is synergistic each other, inhibits starting, the transmitting of eczema respectively
And the effective stage, prevent from multipath and repair baby child's eczema skin, can effectively avoid external source nocuity substance to baby child's skin
Caused by stimulation and sensitization；
(2) extracting method of the present invention realizes separation, purifying, purification using ultrafiltration-nanofiltration-macroporous resin adsorption connection, compares
Conventional method can remove major part impurity, and operation is easier, and effect is more preferable, and extracting solution is more stable, and extraction time is short, consume energy low,
Continuous large-scale production can be achieved；
(3) composition of the invention has from number of ways prevention and maintenance baby child eczema skin and alleviates eczema effect, together
When have the function of repairing baby child's skin barrier, can be widely applied to alleviate baby child's eczema and repair baby child's skin barrier baby it is virgin
In class cosmetics.
Detailed description of the invention
Fig. 1 is the test result figure of Raw264.7 cell anti-inflammatory effect.
Fig. 2 is the influence result figure of 3D epidermis model E piKutis tissue morphology.
Specific embodiment
Below by specific embodiment, and in conjunction with attached drawing, the technical solutions of the present invention will be further described.
In the present invention, if not refering in particular to, all devices and raw material is commercially available or the industry is common are following
Method in embodiment is unless otherwise instructed conventional method in that art.
Embodiment 1
(1) bitter orange 20g, Artemisia capillaris 40g, pueraria lobata 40g are weighed, measures [liquor capacity (ml): medicinal material weight (g)] with 20 times
Ethanol water containing 80% impregnates 2h, carries out Continuous Countercurrent Extraction 1 time, each 1h at 30 DEG C, with the plate in 0.45 μm of aperture
Frame filters pressing, is prepared into ethanol extract；
(2) ethanol extract is first used to the ultrafiltration membrane for passing through 2000 dalton of molecular weight, then passes through 500 dalton of molecular weight
Nanofiltration membrane, obtain nanofiltration liquid；
(3) nanofiltration liquid is concentrated 10 times, is purified with macroporous absorbent resin, is eluted with 95% ethanol water,
Eluent is collected after elution；
(4) after eluent is concentrated 10 times, adds the 1,3-BDO of 3 times of volumes, stir evenly, 24 hours are stood, in collection
Clear liquid；
(5) centrifugally operated is carried out to supernatant, obtains centrifuged supernatant, include in prescription of the invention in centrifuged supernatant
The effective component needed has effects that alleviate the composition of plant extracts of baby child's eczema.
Embodiment 2
(1) bitter orange 30g, Artemisia capillaris 30g, pueraria lobata 40g are weighed, measures [liquor capacity (ml): medicinal material weight (g)] with 10 times
Ethanol water containing 10% impregnates 15h, carries out Continuous Countercurrent Extraction 2 times, each 1.5h at 40 DEG C, with 0.8 μm of aperture
Plate compression is prepared into ethanol extract；
(2) ethanol extract is first used to the ultrafiltration membrane for passing through 3000 dalton of molecular weight, then passes through 100 dalton of molecular weight
Nanofiltration membrane, obtain nanofiltration liquid；
(3) nanofiltration liquid is concentrated 50 times, is purified with macroporous absorbent resin, is eluted with 75% ethanol water,
Eluent is collected after elution；
(4) after eluent is concentrated 15 times, adds the 1,3-BDO of 0.5 times of volume, stir evenly, stand 36 hours, collect
Supernatant；
(5) centrifugally operated is carried out to supernatant, obtains centrifuged supernatant, include in prescription of the invention in centrifuged supernatant
The effective component needed has effects that alleviate the composition of plant extracts of baby child's eczema.
Embodiment 3
(1) bitter orange 5g, Artemisia capillaris 50g, pueraria lobata 45g are weighed, measures [liquor capacity (ml): medicinal material weight (g)] with 15 times
Ethanol water containing 30% impregnates 48h, carries out Continuous Countercurrent Extraction 3 times, each 0.5h at 65 DEG C, with 5.0 μm of apertures
Plate compression is prepared into ethanol extract；
(2) ethanol extract is first used to the ultrafiltration membrane for passing through 6000 dalton of molecular weight, then passes through 800 dalton of molecular weight
Nanofiltration membrane, obtain nanofiltration liquid；
(3) nanofiltration liquid is concentrated 40 times, is purified with macroporous absorbent resin, is eluted with 30% ethanol water,
Eluent is collected after elution；
(4) after eluent is concentrated 20 times, adds the 1,3-BDO of 1.5 times of volumes, stir evenly, stand 18 hours, collect
Supernatant；
(5) centrifugally operated is carried out to supernatant, obtains centrifuged supernatant, include in prescription of the invention in centrifuged supernatant
The effective component needed has effects that alleviate the composition of plant extracts of baby child's eczema.
Have effects that the composition of plant extracts for alleviating baby child's eczema does cell experiment to prepared by embodiment 1:
Raw264.7 cell, DMEM culture medium supplement 10%FBS, 1% dual anti-, cultivate under the conditions of 37 DEG C, 5% CO2.
Raw264.7 in logarithmic growth phase is subjected to cell suspension preparation, and carries out plating cells.100 μ L are added in 96 orifice plates
Density is 50000 cell/mL cell suspensions (=5000 cells/wells), in periphery holes (blank control) plus 100 μ L
PBS.Cell culture is for 24 hours until form semi-fusion single layer.Cell is rejuvenated, is attached and exponential increase during cultivating herein.The
Composition made from the embodiment 1 of various concentration and 1 μ g/ml LPS coprocessing is added within two days for 24 hours.Collect supernatant ELISA
Method measures IL-6, and detects cell viability with NR method.
Experimental result is as shown in Figure 1, on Raw264.7 cell, liquid plant extractive composition made from embodiment 1
Dose-dependent inhibition effect is presented to the IL-6 that LPS is induced in 0.03%~0.25% range, illustrates the plant extracts group
Closing object has the effect of alleviating eczema, can be widely applied to alleviate baby child's eczema and repairs baby child's class cosmetics of baby child's skin barrier
In.
Safety detection reality is done to the composition of plant extracts alleviate with baby child's eczema prepared by embodiment 1
It tests:
Use 3D epidermis model25 μ L samples are drawn using positive pressure pipettor and are added on model surface, are placed in 37
℃CO2In incubator, it is incubated for 48h.After the completion of incubation, processing is fixed using 4% paraformaldehyde in tissue, is fixed for 24 hours
Afterwards, model loop is cut down, carries out H&E dyeing processing, observation of taking pictures under microscope acquires picture.
Experimental result as shown in Fig. 2, 10% alleviate eczema mixture on 3D skin texture object without influence, further relate to
10% alleviation eczema mixture be it is safe, can be widely applied to alleviate baby child's eczema and repair baby child's skin barrier baby child's class
In cosmetics.
Embodiment 2-3 is obtained to be had effects that alleviate the test of the composition of plant extracts of baby child's eczema and embodiment 1
Method and results of property are suitable, and details are not described herein.
The foregoing is merely presently preferred embodiments of the present invention, is not intended to limit the present invention in any form, and is not surpassing
There are also other variations and modifications under the premise of technical solution documented by claim out.
Claims (10)
1. a kind of have effects that alleviate the composition of plant extracts of baby child's eczema, which is characterized in that described based on medicinal material dry weight
Have effects that the composition of plant extracts for alleviating baby child's eczema is made of the component of following mass percent: bitter orange 1~50%,
Artemisia capillaris 1~50% and pueraria lobata 1~50%.
2. a kind of preparation method of the composition of plant extracts alleviate as described in claim 1 with baby child's eczema,
Characterized by comprising the following steps:
(1) bitter orange, Artemisia capillaris and pueraria lobata are weighed according to said ratio, mixing are obtained after mixing, mixing is impregnated with ethanol water,
Continuous Countercurrent Extraction is carried out, filtering obtains extracting solution；
(2) extracting solution for obtaining step (1) carries out ultrafiltration, and nanofiltration obtains nanofiltration liquid；
(3) nanofiltration liquid for obtaining step (2) is concentrated, and with purification with macroreticular resin, collects eluent after elution；
(4) eluent for obtaining step (3) is concentrated, and 1,3-BDO is added, stirs evenly, and stands 12~36h, collects supernatant
Liquid；
(5) supernatant that step (4) obtains is centrifuged, obtains centrifuged supernatant to get having alleviation baby child's eczema
The composition of plant extracts of effect.
3. a kind of preparation side of composition of plant extracts alleviate with baby child's eczema according to claim 2
Method, which is characterized in that in step (1), 5~20mL ethanol water is added in every gram of mixing；The volume of the ethanol water
Score is 10~80%；Soaking time is controlled in 2~48h；The temperature of Continuous Countercurrent Extraction is 30~80 DEG C, extraction time 1
~4h, extraction time >=1；Filter type is plate compression, and filter sizes used are 0.4~30 μm.
4. a kind of preparation side of composition of plant extracts alleviate with baby child's eczema according to claim 2
Method, which is characterized in that in step (2), ultrafiltration technology uses the ultrafiltration membrane by 1000~6000 dalton of molecular weight.
5. a kind of preparation side of composition of plant extracts alleviate with baby child's eczema according to claim 2
Method, which is characterized in that in step (2), nanofiltration technique uses the nanofiltration membrane by 40~1000 dalton of molecular weight.
6. a kind of preparation side of composition of plant extracts alleviate with baby child's eczema according to claim 2
Method, which is characterized in that in step (3), eluant, eluent used in elution processes is the ethanol water that volume fraction is 10~95%.
7. a kind of preparation side of composition of plant extracts alleviate with baby child's eczema according to claim 2
Method, which is characterized in that in step (4), the cycles of concentration of the eluent is 10~20 times.
8. a kind of preparation side of composition of plant extracts alleviate with baby child's eczema according to claim 2
Method, which is characterized in that in step (4), the additive amount of the 1,3-BDO is 0.5~3 times of the volume of eluent.
9. a kind of have effects that the composition of plant extracts for alleviating baby child's eczema is made up in baby child's class as described in claim 1
Application in product, which is characterized in that baby child's class is used for cosmetic in alleviation baby child's eczema and reparation baby child's skin barrier.
10. application according to claim 9, which is characterized in that baby child's class cosmetics include creme, lotion, makeup
Water, gelling agent, facial mask and inuncts.
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| CN113262188A (en) * | 2021-06-23 | 2021-08-17 | 上海林清轩生物科技有限公司 | Plant extract for relieving eczema and preparation method and application thereof |
Citations (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104138561A (en) * | 2014-07-18 | 2014-11-12 | 济南环太机电技术有限公司 | Traditional Chinese medicine ointment for treating infantile eczema |
| CN105362817A (en) * | 2015-12-12 | 2016-03-02 | 杨献美 | Pharmaceutical composition for treating eczema |
| CN105362815A (en) * | 2015-12-07 | 2016-03-02 | 叶宗耀 | Traditional Chinese medicine composition for eczema treatment and preparation method of traditional Chinese medicine composition for eczema treatment |
| CN105477148A (en) * | 2015-12-31 | 2016-04-13 | 广西中医药大学 | External-washing Zhuang medicine composition for treating infantile eczema |
| CN105477132A (en) * | 2014-09-16 | 2016-04-13 | 吴春淼 | Children eczema treating traditional Chinese medicine formula |
| CN106074844A (en) * | 2016-06-16 | 2016-11-09 | 马宗胜 | One treats dermopathic formula and preparation method thereof |
| CN106266128A (en) * | 2016-08-12 | 2017-01-04 | 林海燕 | A kind of Chinese medicine composition treating infantile eczema |
| CN106692330A (en) * | 2017-03-02 | 2017-05-24 | 潘鑫 | Traditional Chinese medicine for treating eczema and preparation method of traditional Chinese medicine |
| CN106822339A (en) * | 2017-04-02 | 2017-06-13 | 陈建宏 | A kind of Chinese medicine composition for treating infant or childhood eczema and preparation method thereof |
| CN107582727A (en) * | 2017-11-09 | 2018-01-16 | 单县领翔金银花种植合作社 | A kind of medicine for treating childhood eczema and preparation method thereof |
| CN107661403A (en) * | 2016-11-11 | 2018-02-06 | 成都盛世光华生物科技有限公司 | A kind of preparation method for being used to treat dermatitis eczema medicine |
| CN107715029A (en) * | 2017-11-27 | 2018-02-23 | 张振中 | A kind of lotion for treating skin eczema and preparation method thereof |
| CN107753642A (en) * | 2017-12-19 | 2018-03-06 | 吴晓娟 | A kind of external application medicinal liquor for treating eczema |
| CN108014202A (en) * | 2016-11-01 | 2018-05-11 | 上海珈凯生物科技有限公司 | A kind of traditional Chinese medicine extract composition with anti-skin irritatin effect and preparation method thereof |
| CN108420937A (en) * | 2018-05-14 | 2018-08-21 | 中国人民解放军广州军区武汉总医院 | It is a kind of to treat chronic eczema Chinese medicine preparation and application method |
| CN108635540A (en) * | 2018-07-24 | 2018-10-12 | 谈其龙 | A kind of Chinese medicine ointment and preparation method thereof for treating skin eczema |
| CN108653594A (en) * | 2017-03-27 | 2018-10-16 | 朱凤玲 | A kind of Chinese medicine for treating dermatitis |
| CN109010525A (en) * | 2018-07-26 | 2018-12-18 | 百士泰（武汉）生物科技有限公司 | A kind of draft ferment ointment and its preparation method and application for treating eczema |
| CN109106883A (en) * | 2018-10-16 | 2019-01-01 | 苗怡文 | A kind of pharmaceutical composition for treating eczema |
-
2019
- 2019-02-01 CN CN201910102462.7A patent/CN109846777A/en active Pending
Patent Citations (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104138561A (en) * | 2014-07-18 | 2014-11-12 | 济南环太机电技术有限公司 | Traditional Chinese medicine ointment for treating infantile eczema |
| CN105477132A (en) * | 2014-09-16 | 2016-04-13 | 吴春淼 | Children eczema treating traditional Chinese medicine formula |
| CN105362815A (en) * | 2015-12-07 | 2016-03-02 | 叶宗耀 | Traditional Chinese medicine composition for eczema treatment and preparation method of traditional Chinese medicine composition for eczema treatment |
| CN105362817A (en) * | 2015-12-12 | 2016-03-02 | 杨献美 | Pharmaceutical composition for treating eczema |
| CN105477148A (en) * | 2015-12-31 | 2016-04-13 | 广西中医药大学 | External-washing Zhuang medicine composition for treating infantile eczema |
| CN106074844A (en) * | 2016-06-16 | 2016-11-09 | 马宗胜 | One treats dermopathic formula and preparation method thereof |
| CN106266128A (en) * | 2016-08-12 | 2017-01-04 | 林海燕 | A kind of Chinese medicine composition treating infantile eczema |
| CN108014202A (en) * | 2016-11-01 | 2018-05-11 | 上海珈凯生物科技有限公司 | A kind of traditional Chinese medicine extract composition with anti-skin irritatin effect and preparation method thereof |
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| CN106822339A (en) * | 2017-04-02 | 2017-06-13 | 陈建宏 | A kind of Chinese medicine composition for treating infant or childhood eczema and preparation method thereof |
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| CN109106883A (en) * | 2018-10-16 | 2019-01-01 | 苗怡文 | A kind of pharmaceutical composition for treating eczema |
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