CN106266128A - A kind of Chinese medicine composition treating infantile eczema - Google Patents

A kind of Chinese medicine composition treating infantile eczema Download PDF

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CN106266128A
CN106266128A CN201610704917.9A CN201610704917A CN106266128A CN 106266128 A CN106266128 A CN 106266128A CN 201610704917 A CN201610704917 A CN 201610704917A CN 106266128 A CN106266128 A CN 106266128A
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parts
herba
chinese medicine
medicine composition
herba artemisiae
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林海燕
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Xiang Meiqin
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/756—Phellodendron, e.g. corktree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/234—Cnidium (snowparsley)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/282—Artemisia, e.g. wormwood or sagebrush
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284—Atractylodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/534—Mentha (mint)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

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  • Health & Medical Sciences (AREA)
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Abstract

The present invention relates to a kind of Chinese medicine composition treating infantile eczema, be made up of Cortex Phellodendri, Cortex Dictamni, Herba Artemisiae Scopariae, Herba Menthae, Fructus Cnidii, the Radix Angelicae Dahuricae, Herba Portulacae, Herba Artemisiae Annuae, Borneolum Syntheticum, Rhizoma Atractylodis, this pharmaceutical composition has good curative effect to infantile eczema.

Description

A kind of Chinese medicine composition treating infantile eczema
Technical field
The present invention relates to a kind of Chinese medicine composition, particularly relate to a kind of Chinese medicine composition for treating infantile eczema.
Background technology
Eczema, also known as eczematoid dermatitis, or atoipc dermatitis, it is a kind of common allergic disease, mass-sends people Sick rate is about 0.1%-0.5%, and baby may be up to 5%.Along with extensively should of industrialized continuous progress, medicine for external use and cosmetics With, this disease sickness rate is in ascendant trend year by year, and due to the easy secondary bacterial infection of this sickly complexion, generation impetigo, scabies are swollen, regional nodes Knot inflammation, even septicemia or pyemia, cause serious consequence.And easily delay is for chronic, brings greatly to infant and the head of a family Mental burden, be unfavorable for the physical and mental health of children's, therefore paid close attention to by medical circle.
Summary of the invention
The goal of the invention of the present invention is to provide a kind of for for treating infantile eczema, to solve existing Therapeutic Method effect The poorest, or use hormone side effect big problem.
Chinese medicine composition of the present invention is by weight ratio: Cortex Phellodendri 18-22 part, Cortex Dictamni 18-22 part, Herba Artemisiae Scopariae 18-22 part, thin Lotus 16-20 part, Fructus Cnidii 16-20 part, Radix Angelicae Dahuricae 16-20 part, Herba Portulacae 13-17 part, Herba Artemisiae Annuae 13-17 part, Borneolum Syntheticum 13-17 part, grey Art 13-17 part.
Cortex Phellodendri 20 parts, Cortex Dictamni 20 parts, Herba Artemisiae Scopariae 20 parts, Herba Menthae 18 parts, Fructus Cnidii 18 parts, the Radix Angelicae Dahuricae 18 parts, Herba Portulacae 15 parts, Herba Artemisiae Annuae 15 parts, Borneolum Syntheticum 15 parts, Rhizoma Atractylodis 15 parts.
The preparation method of Chinese medicine composition of the present invention is: takes the mixing of above-mentioned raw material of Chinese medicine, is ground into 10～20 mesh coarse granules, Adding 60% ethanol 6 times (volume), extract three times with continuous 60 DEG C of microwave assisted extraction methods, extract is centrifuged separating, clean immersion Being concentrated into the thick paste that relative density is 1.20～1.30, vacuum drying, dried cream powder is broken, adds Yellow Vaselin, paraffin oil, is brewed into Paste, condensation, obtain ointment.
Cortex Phellodendri: heat clearing and damp drying, eliminating fire and detoxication.Modern pharmacy research proves, Cortex Phellodendri contains berberine, phellodendrine, Flos Magnoliae Liliflorae Alkali, jateorhizine, palm leaf coculine, candicine, Caulis menispermi appoint alkali, guanidine etc., have antibacterial, antiinflammatory, regulation immunologic function, anti-burst Infectionss etc. act on.
Cortex Dictamni: heat clearing and damp drying, removing toxic substances of dispeling the wind.Modern pharmacy research proves, Cortex Dictamni has the effects such as antibacterial, anticancer.
Herba Artemisiae Scopariae: clearing away heat-damp and promoting diuresis, promoting the function of the gallbladder to alleviate jaundice.Modern pharmacy research prove, Herba Artemisiae Scopariae have function of gallbladder promoting, liver function protecting, antipyretic, Antiinflammatory, blood fat reducing etc. act on.
Herba Menthae: wind-dispelling heat-dissipating, refresh oneself, throat.Modern pharmacy research proves, Herba Menthae contains menthol, and this material has Antipruritic, pain relieving, anticorrosion, stimulate, anaesthetize, refrigerant and antiinflammatory action.
Fructus Cnidii: warming the kidney to invigorate YANG, dampness, dispel the wind, parasite killing.Modern pharmacy research proves, Fructus Cnidii has disease-resistant former micro-life Thing effect, antifungic action, anti-allergy action, gonadotropic Effect.
The Radix Angelicae Dahuricae: expelling pathogenic wind from the body surface, dispersing cold for relieving pain, dehumidifying are sensible, detumescence and apocenosis.Modern pharmacy research proves, the Radix Angelicae Dahuricae has solution Heat, analgesia, antiinflammatory, the effect such as antibacterial.
Herba Portulacae: clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling.Modern pharmacy research proves, Herba Portulacae has antibacterial, antiviral, anti-true The effects such as bacterium, raising immunity.
Herba Artemisiae Annuae: clearing away summer-heat, except steam preventing the attack (or recurrence) of malaria.Modern pharmacy research proves, Herba Artemisiae Annuae has good antibacterial action, additionally There is the effect such as parasiticide, antipyretic, regulation immunity.
Borneolum Syntheticum: logical all keys, scattered stagnated fire, removing nebula improving eyesight, reducing swelling and alleviating pain.Modern pharmacy research proves, Borneolum Syntheticum contains dextrorotation dragon Brain, humulene, beta-elemene, caryophyllene etc., and oleanolic acid, alphitolic acid, asiatic acid, Borneolum Syntheticum are aromatic, erythrodiol Deng triterpenoid.There is good antibacterial, antiinflammatory action.
Rhizoma Atractylodis: drying damp and strengthening spleen, expelling wind and cold.Modern pharmacy research proves, Rhizoma Atractylodis extract can reduce bacterial drug resistance Generation, and suppress tumor cell.
In order to show that the present invention has good effect to infantile eczema, carry out following clinical trial:
1. physical data
Observe outpatient service infant 60 example altogether, be randomly divided into treatment group 30 example, matched group 30 example, be acute eczema and there is erosion The person of oozing out.Wherein, male 33 examples, female 27 example；Age 35d-6 year, average 2.2 years old；Stadium 2-30d, average 12d.Two groups sexual Not, age, the aspect such as disease compare, no significant difference (P ＞ 0.05), there is comparability.
2. Therapeutic Method
2.1 treatment groups
Obtaining ointment according to the method for embodiment 1, coat affected part, every day 2 times, 7d is a course for the treatment of, treats 1～3 The course for the treatment of judges curative effect.
2.2 matched group
3% boric acid solution cold wet compress, each 10～20min, every day 2 times, remaining same treatment group.Treatment group is with matched group the most not Endo-medicine.
3. criterion of therapeutical effect and result
Recovery from illness: skin lesion all disappears；Effective: skin lesion disappears more than 70%；Effective: skin lesion disappears more than 50%；Invalid: skin Damage disappears less than 50%.
3.2 therapeutic outcome
It is shown in Table 1
1 liang of table group comparitive study example (%)
* compared with matched group, P ＜ 0.05, there is significant difference
Pharmaceutical composition of the present invention has heat-clearing and toxic substances removing, dampness removing, parasite killing, effect of dispeling the wind, and treating both the principal and secondary aspects of a disease, this is boric acid etc. Wet chemical application can not be compared, and this is also the reason that two groups of case curative effects have significant difference, can be effectively prevented from simultaneously Absorb the disadvantage of poisoning.
Specific embodiment
Embodiment 1 Cortex Phellodendri 20g, Cortex Dictamni 20g, Herba Artemisiae Scopariae 20g, Herba Menthae 18g, Fructus Cnidii 18g, Radix Angelicae Dahuricae 18g, Herba Portulacae 15g, Herba Artemisiae Annuae 15g, Borneolum Syntheticum 15g, Rhizoma Atractylodis 15g.
The preparation method of Chinese medicine composition of the present invention is: takes the mixing of above-mentioned raw material of Chinese medicine, is ground into 10～20 mesh coarse granules, Adding 60% ethanol 6 times (volume), extract three times with continuous 60 DEG C of microwave assisted extraction methods, extract is centrifuged separating, clean immersion Being concentrated into the thick paste that relative density is 1.20～1.30, vacuum drying, dried cream powder is broken, adds Yellow Vaselin 200g, paraffin oil 200ml, is brewed into paste, condensation, obtains ointment.
Embodiment 2 Cortex Phellodendri 18g, Cortex Dictamni 18g, Herba Artemisiae Scopariae 18g, Herba Menthae 16g, Fructus Cnidii 16g, Radix Angelicae Dahuricae 16g, Herba Portulacae 13g, Herba Artemisiae Annuae 13g, Borneolum Syntheticum 13g, Rhizoma Atractylodis 13g.
The preparation method of Chinese medicine composition of the present invention is: takes the mixing of above-mentioned raw material of Chinese medicine, is ground into 10～20 mesh coarse granules, Adding 60% ethanol 6 times (volume), extract three times with continuous 60 DEG C of microwave assisted extraction methods, extract is centrifuged separating, clean immersion Being concentrated into the thick paste that relative density is 1.20～1.30, vacuum drying, dried cream powder is broken, adds Yellow Vaselin 200g, paraffin oil 200ml, is brewed into paste, condensation, obtains ointment.
Embodiment 3 Cortex Phellodendri 22g, Cortex Dictamni 22g, Herba Artemisiae Scopariae 22g, Herba Menthae 20g, Fructus Cnidii 20g, Radix Angelicae Dahuricae 20g, Herba Portulacae 17g, Herba Artemisiae Annuae 17g, Borneolum Syntheticum 17g, Rhizoma Atractylodis 17g.
The preparation method of Chinese medicine composition of the present invention is: takes the mixing of above-mentioned raw material of Chinese medicine, is ground into 10～20 mesh coarse granules, Adding 60% ethanol 6 times (volume), extract three times with continuous 60 DEG C of microwave assisted extraction methods, extract is centrifuged separating, clean immersion Being concentrated into the thick paste that relative density is 1.20～1.30, vacuum drying, dried cream powder is broken, adds Yellow Vaselin 200g, paraffin oil 200ml, is brewed into paste, condensation, obtains ointment.

Claims (6)

1. the Chinese medicine composition treating infantile eczema, it is characterised in that make the raw material of this pharmaceutical composition active component For: Cortex Phellodendri, Cortex Dictamni, Herba Artemisiae Scopariae, Herba Menthae, Fructus Cnidii, the Radix Angelicae Dahuricae, Herba Portulacae, Herba Artemisiae Annuae, Borneolum Syntheticum, Rhizoma Atractylodis.
2. Chinese medicine composition as claimed in claim 1, it is characterised in that in parts by weight, proportioning is Cortex Phellodendri 18-22 part, white Cortex Dictamni 18-22 part, Herba Artemisiae Scopariae 18-22 part, Herba Menthae 16-20 part, Fructus Cnidii 16-20 part, Radix Angelicae Dahuricae 16-20 part, Herba Portulacae 13-17 part, Herba Artemisiae Annuae 13-17 part, Borneolum Syntheticum 13-17 part, Rhizoma Atractylodis 13-17 part.
3. Chinese medicine composition as claimed in claim 1, it is characterised in that in parts by weight, proportioning is Cortex Phellodendri 20 parts, shaggy-fruited dittany Skin 20 parts, Herba Artemisiae Scopariae 20 parts, Herba Menthae 18 parts, Fructus Cnidii 18 parts, the Radix Angelicae Dahuricae 18 parts, Herba Portulacae 15 parts, Herba Artemisiae Annuae 15 parts, Borneolum Syntheticum 15 parts, grey Art 15 parts.
4. Chinese medicine composition as claimed in claim 1 or 2, it is characterised in that it is ointment.
5. Chinese medicine composition as claimed in claim 1 or 2, it is characterised in that preparation method is as follows: take the mixing of described raw material of Chinese medicine, powder It is broken into 10～20 mesh coarse granules, adds 60% ethanol 6 times (volume), extract three times with continuous 60 DEG C of microwave assisted extraction methods, extract Being centrifuged separating, clean immersion is concentrated into the thick paste that relative density is 1.20～1.30, vacuum drying, and dried cream powder is broken, adds Huang Vaseline, paraffin oil, be brewed into paste, condensation, obtains ointment.
6. Chinese medicine composition as claimed in claim 4, it is characterised in that preparation method is as follows: take Cortex Phellodendri 20g, Cortex Dictamni 20g, Herba Artemisiae Scopariae 20g, Herba Menthae 18g, Fructus Cnidii 18g, Radix Angelicae Dahuricae 18g, Herba Portulacae 15g, Herba Artemisiae Annuae 15g, Borneolum Syntheticum 15g, Rhizoma Atractylodis 15g, mixing, it is ground into 10 ～20 mesh coarse granules, add 60% ethanol 6 times (volume), extract three times with continuous 60 DEG C of microwave assisted extraction methods, extract carry out from The heart separates, and clean immersion is concentrated into the thick paste that relative density is 1.20～1.30, vacuum drying, and dried cream powder is broken, adds Yellow Vaselin 200g, paraffin oil 200ml, be brewed into paste, condensation, obtains ointment.
CN201610704917.9A 2016-08-12 2016-08-12 A kind of Chinese medicine composition treating infantile eczema Pending CN106266128A (en)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109771615A (en) * 2019-03-28 2019-05-21 昆明医科大学第一附属医院 A kind of dermatitis and eczema external fumigation and washing Chinese medicinal formulae
CN109846777A (en) * 2019-02-01 2019-06-07 上海珈凯生物科技有限公司 It is a kind of to have effects that alleviate composition of plant extracts of baby child's eczema and preparation method thereof, application
CN111729061A (en) * 2020-08-06 2020-10-02 湖南巨禧医药科技有限公司 Medicament for treating skin diseases and preparation method thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1768812A (en) * 2005-10-24 2006-05-10 高欲林 Medicinal composition for removing dampness to relieve itching and its preparation method and uses

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1768812A (en) * 2005-10-24 2006-05-10 高欲林 Medicinal composition for removing dampness to relieve itching and its preparation method and uses

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109846777A (en) * 2019-02-01 2019-06-07 上海珈凯生物科技有限公司 It is a kind of to have effects that alleviate composition of plant extracts of baby child's eczema and preparation method thereof, application
CN109771615A (en) * 2019-03-28 2019-05-21 昆明医科大学第一附属医院 A kind of dermatitis and eczema external fumigation and washing Chinese medicinal formulae
CN111729061A (en) * 2020-08-06 2020-10-02 湖南巨禧医药科技有限公司 Medicament for treating skin diseases and preparation method thereof

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