CN105288436A - Medicament for treatment of chronic eczema - Google Patents
Medicament for treatment of chronic eczema Download PDFInfo
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- CN105288436A CN105288436A CN201510895483.0A CN201510895483A CN105288436A CN 105288436 A CN105288436 A CN 105288436A CN 201510895483 A CN201510895483 A CN 201510895483A CN 105288436 A CN105288436 A CN 105288436A
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Abstract
The invention relates to a medicament for the treatment of chronic eczema, which is prepared from the following herbal materials in parts by weight: 6 parts of fructus amomi, 8 parts of fructus kochiae, 6 parts of vines of multiflower knotweed, 9 parts of loofah sponge, 8 parts of rhizoma acori graminei, 10 parts of yam, 6 parts of fructus gardeniae, 6 parts of bamboo leaves, 6 parts of phragmites communis, 8 parts of fructus citrus sarcodactylis, 6 parts of flos rosae rugosae, and 8 parts of herba cepbalanoplosis segeti. In the invention, fructus amomi has the effects of warming the spleen, dissipating dampness and promoting appetite, fructus kochiae has the effects of clearing heat, promoting diuresis, dispelling wind and eliminating tickles, vines of multiflower knotweed have the effects of nourishing blood, tranquilizing mind, expelling wind, and dredging collaterals, loofah sponge has the effects of expelling wind, dredging collaterals and activating blood circulation, rhizoma acori graminei has the effects of soothing nerves and resolving dampness, yam has the effects of tonifying spleen and promoting salivation, fructus gardeniae has the effects of clearing away heat, purging pathogenic fire and clearing away toxic materials, bamboo leaves and the phragmites communis have the effects of clearing away heat and relieving fidgetness, fructus citrus sarcodactylis has the effects of regulating the flow of Qi and the middle Jiao and removing dampness to reduce phlegm, flos rosae rugosae has the effect of promoting qi to activate blood, and herba cepbalanoplosis segeti has the effects of cooling blood to remove stasis. Through the combined use of the herbal materials above, the medicament jointly achieves the effects of warming the spleen, dissipating dampness, promoting appetite, dispelling wind, eliminating tickles, cooling blood to remove stasis, activating blood to dredge vessels, and regulating the flow of Qi and the middle Jiao, thereby achieving the purpose of treating chronic eczema. Clinical experiments show that the medicament can treat chronic eczema safely and effectively.
Description
Technical field
The present invention relates to a kind of Chinese medicine, be specifically related to a kind of medicine being used for the treatment of chronic eczema.
Background technology
Eczema is a kind of scytitis reaction caused because the internal and external factor of complexity excites.Chronic eczema is generally limited to and has infiltration and plumpness, and acute pruritus, easily recurs.
How because acute, subacute eczema recurrent exerbation develop and form, also can start namely to present chronic inflammatory disease.Illing skin infiltrates and thickens, and becomes kermesinus and pigmentation.When not healing lastingly, skin lesion stricture of vagina is greatly thicker, and performance is dry and easily chap.Be common in the places such as shank, hands, foot, the fossa cubitalis, pudendum, anus.
Conscious violent pruritus, erythema, pimple, papulovesicle or vesicle are in flakes intensive, easily ooze out, indefinite border, are dispersed in little pimple, papulovesicle around, often accompany erosion, incrustation, as secondary infection, can occur pustule or pus crusts.The suitable then inflammation of process alleviates, and skin lesion can disappear after 2 ~ 3 weeks, but normal recurrent exerbation also can transfer to subacute or chronic.
General control principle
Find anaphylactogen as far as possible; Avoid various environmental stimuli; Avoid easy sensitization and irritable food.
Innerlich anwenden thing
One or both antihistamine drug, itch because eczema mostly is play in evening, respectively take once after best dinner or just before going to bed.Generally should not use oral or intramuscular injection glucocorticoid.Also available treatment by Chinese herbs.
External used medicine
Local topical glucocorticoid emulsifiable paste, if desired can package.Immunosuppressant therapy agent is as better in tacrolimus, arsenic Mei Mosi curative effect, also can alleviate the side effect of life-time service external hormone.
Summary of the invention
The present invention aims to provide a kind of medicine being used for the treatment of chronic eczema, by selecting suitable medical material and proportioning thereof, reaches the object of safe and effective healing chronic eczema.
In order to achieve the above object, the present invention is by the following technical solutions:
A kind of medicine being used for the treatment of chronic eczema, it is characterized in that, it is prepared from by the raw medicinal material of following weight proportion: Fructus Amomi 6 parts, the Fructus Kochiae 8 parts, Caulis Polygoni Multiflori 6 parts, Retinervus Luffae Fructus 9 parts, Rhizoma Acori Graminei 8 parts, Rhizoma Dioscoreae 10 parts, Fructus Gardeniae 6 parts, 6 parts, Folium Bambusae, Rhizoma Phragmitis 6 parts, Fructus Citri Sarcodactylis 8 parts, Flos Rosae Rugosae 6 parts, Herba Cirsii 8 parts.
Below in conjunction with theories of Chinese materia medica, beneficial effect of the present invention is described:
Inventor thinks, primary disease, by damp-heat in the spleen and stomach, outward by ailment said due to cold or exposure, is fought mutually and formed, pathogenesis be the course of disease with the passing of time, enter blood and enter network, therefore see that meridians block, stagnation of QI-blood, ying-qi is got along well, thus skin loses to moisten and supports and send out for this reason sick, and therefore treatment is upper should blood circulation and channel invigorating be main, helps with heat clearing and damp drying.
The present invention uses: the removing dampness of Fructus Amomi warming the spleen is whetted the appetite; Fructus Kochiae clearing away heat-damp and promoting diuresis dispels the wind except itching; Caulis Polygoni Multiflori nourishing blood to tranquillize the mind, wind dispelling dredging collateral; Retinervus Luffae Fructus wind dispelling dredging collateral is invigorated blood circulation; Rhizoma Acori Graminei is calmed the nerves removing dampness; Rhizoma Dioscoreae spleen reinforcing is promoted the production of body fluid; Fructus Gardeniae clearing away heat-fire detoxifies; Folium Bambusae, Rhizoma Phragmitis clearing heat and relieving fidgetness; Fructus Citri Sarcodactylis regulating the flow of Qi and the middle Jiao drying dampness to eliminate phlegm; Flos Rosae Rugosae circulation of qi promoting and blood; Herba Cirsii cooling blood and removing stasis.All medicines share, and play warming the spleen removing dampness appetizing altogether, dispel the wind except itching, the effect of cooling blood and removing stasis, blood circulation and channel invigorating, regulating the flow of Qi and the middle Jiao, reach the object for the treatment of chronic eczema.
Below in conjunction with clinical laboratory data, beneficial effect of the present invention is described:
1, physical data
1.1 clinical data
Inventor collects 60 routine patients with chronic eczema between in October, 2013 in October, 2014 altogether.Be divided at random: treatment group 30 example, matched group 30 example.Wherein treatment group man 18 example, female 12 example, 18 ~ 61 years old age, the course of disease 2 weeks to 15 months; Matched group man 20 example, female 10 example, 18 ~ 62 years old age, the course of disease 3 weeks to 18 months.The data there was no significant differences such as two groups of sexes, age, courses of disease, have comparability.
1.2 diagnostic criteria
1.2.1 Western medicine diagnose standard: the course of disease is long, more can not be transformed because of acute, subacute eczema recurrent exerbation, also chronic inflammatory disease can be presented at the beginning, protracted course of disease, many limitations one place or many places, show as kermesinus or dim brown patch, infiltrate plump, above cover a small amount of squama or the fresh sample of tongue, edge is also clearer, little pimple, mound scar rash can be dispersed in, conscious acute pruritus around.
1.2.2 Standards of Chinese Medical Syndrome Differentiation: Chinese medical discrimination belongs to damp and hot strongly fragrant for a long time, the raw wind card of dryness-transformation, show as the course of disease long, pruritus recurrent exerbation, protracted course of disease, skin is shown in kermesinus or dim brown patch, infiltrate plump, above cover a small amount of squama or tongue diction sample, little pimple can be dispersed in around, tongue is dark red, and tongue is yellowish or greasy in vain.
1.3 cases are included in and exclusion standard
1.3.1 inclusive criteria (1) meets chronic eczema diagnostic criteria; (2) age was at 18 ~ 70 years old; (3) agreeing to participate in Clinical observation also can partner treatment person.
1.3.2 exclusion standard (1) merges the severe primary disease patients such as cardiovascular and cerebrovascular vessel, liver, kidney and hemopoietic system, psychotic; (2) gestation, preparation gestation or women breast-feeding their children; (3) to this medicine composition allergy sufferers; (4) prolonged application corticosteroid or immunosuppressant person; (5) infectious disease, local skin have wound or the infected.
2, Therapeutic Method
Matched group oral hydrochloride cetirizine sheet 10mg (revising Sichuan pharmaceutical Co. Ltd of Pharmaceutical group), every day 1.
The capsule that the oral the present invention for the treatment of group obtains according to specific embodiment 3, every day 3 times.Treat 1 week.
3, criterion of therapeutical effect and therapeutic outcome
3.1 criterion of therapeutical effect
The scoring of skin lesion form: with reference to " eczema area and Severity Index point system " (EASI point system), clinical manifestation is divided into 6, namely erythema (E), pimple (1), exfoliation (Er), incrustation (c), lichenization, ooze out, the severity of each clinical manifestation is with 0 ~ 3 point of score.0 be divided into without, 1 be divided into light, 2 be divided in, 3 points attach most importance to.Half fraction can be remembered, namely 0.5 point between various symptom score.The Score index of pruritus degree is as follows: 0 is divided into without scratchiness; 1 is divided into pruritus once in a while; 2 are divided into paroxysmal pruritus; 3 are divided into violent pruritus.Canonical reference " new Chinese medicine guideline of clinical investigations ", comprehensive therapeutic effect evaluation calculates curative effect rate with the total mark of pruritus, skin lesion area, skin lesion form (comprise erythema, pimple, erosion, form a scab, ooze out, form a scab).
Integration × 100% before curative effect rate=(before treatment the rear integration of integration-treatment)/treatment.
According to symptom improvement rate, be divided into clinical recovery, effective, effective, invalid 4 grades.
(1) fully recover: skin lesion disappears completely, transference cure, curative effect rate >=95%;
(2) effective: skin lesion major part disappears, and symptom obviously alleviates, 95% > curative effect rate >=70%;
(3) effective: skin lesion partial remission, symptom makes moderate progress, 70% > curative effect rate >=30%;
(4) invalid: skin lesion disappears not obvious, symptom does not alleviate or worsens on the contrary, curative effect rate < 30%.
3.2 treatment statistical results are in table 1.
Table 1 liang group comparitive study
Visible, the medicine that the present invention obtains can safe and effective treatment chronic eczema, and cure rate is high.
Detailed description of the invention
In order to understand better and implement the present invention, further illustrate the present invention below in conjunction with specific embodiment.
Embodiment 1
Take: Fructus Amomi 6 grams, the Fructus Kochiae 8 grams, Caulis Polygoni Multiflori 6 grams, Retinervus Luffae Fructus 9 grams, Rhizoma Acori Graminei 8 grams, Rhizoma Dioscoreae 10 grams, Fructus Gardeniae 6 grams, 6 grams, Folium Bambusae, Rhizoma Phragmitis 6 grams, Fructus Citri Sarcodactylis 8 grams, Flos Rosae Rugosae 6 grams, Herba Cirsii 8 grams; Add 8 times of water gagings, decoct 1.5 hours, filter; Filtering residue adds 6 times of water gagings, decocts 1 hour, filters; Merging filtrate, is concentrated into 120 grams, must meet the decoct of adult normal's one day consumption.
Be used for the treatment of chronic eczema.Oral, daily once.
Embodiment 2
Take: Fructus Amomi 6 grams, the Fructus Kochiae 8 grams, Caulis Polygoni Multiflori 6 grams, Retinervus Luffae Fructus 9 grams, Rhizoma Acori Graminei 8 grams, Rhizoma Dioscoreae 10 grams, Fructus Gardeniae 6 grams, 6 grams, Folium Bambusae, Rhizoma Phragmitis 6 grams, Fructus Citri Sarcodactylis 8 grams, Flos Rosae Rugosae 6 grams, Herba Cirsii 8 grams; Add 10 times of water gagings, decoct 2 hours, filter; Filtering residue adds 8 times of water gagings, decocts 1.5 hours, filters; Merging filtrate, concentrated, dry, packaging, must meet the powder of adult normal's one day consumption.
Be used for the treatment of chronic eczema.Oral, every bu is taken for twice sooner or later.
Embodiment 3
Take: Fructus Amomi 6 grams, the Fructus Kochiae 8 grams, Caulis Polygoni Multiflori 6 grams, Retinervus Luffae Fructus 9 grams, Rhizoma Acori Graminei 8 grams, Rhizoma Dioscoreae 10 grams, Fructus Gardeniae 6 grams, 6 grams, Folium Bambusae, Rhizoma Phragmitis 6 grams, Fructus Citri Sarcodactylis 8 grams, Flos Rosae Rugosae 6 grams, Herba Cirsii 8 grams; Add 6 times of water gagings, decoct 3 times, each decoction 1 hour, merges decoction liquor, concentrated, dry, incapsulates shell, must meet the capsule of adult normal's one day consumption.
Be used for the treatment of chronic eczema.Oral, every bu morning, noon and afternoon take for three times.
Claims (4)
1. one kind is used for the treatment of the medicine of chronic eczema, it is characterized in that, it is prepared from by the raw medicinal material of following weight proportion: Fructus Amomi 6 parts, the Fructus Kochiae 8 parts, Caulis Polygoni Multiflori 6 parts, Retinervus Luffae Fructus 9 parts, Rhizoma Acori Graminei 8 parts, Rhizoma Dioscoreae 10 parts, Fructus Gardeniae 6 parts, 6 parts, Folium Bambusae, Rhizoma Phragmitis 6 parts, Fructus Citri Sarcodactylis 8 parts, Flos Rosae Rugosae 6 parts, Herba Cirsii 8 parts.
2. a kind of medicine being used for the treatment of chronic eczema as claimed in claim 1, it is characterized in that, its preparation method is: take: Fructus Amomi 6 parts, the Fructus Kochiae 8 parts, Caulis Polygoni Multiflori 6 parts, Retinervus Luffae Fructus 9 parts, Rhizoma Acori Graminei 8 parts, Rhizoma Dioscoreae 10 parts, Fructus Gardeniae 6 parts, 6 parts, Folium Bambusae, Rhizoma Phragmitis 6 parts, Fructus Citri Sarcodactylis 8 parts, Flos Rosae Rugosae 6 parts, Herba Cirsii 8 parts; Add 8 times of water gagings, decoct 1.5 hours, filter; Filtering residue adds 6 times of water gagings, decocts 1 hour, filters; Merging filtrate, is concentrated into 120 parts, obtains decoct; Above-mentioned part all refers to weight portion.
3. a kind of medicine being used for the treatment of chronic eczema as claimed in claim 1, it is characterized in that, its preparation method is: take: Fructus Amomi 6 parts, the Fructus Kochiae 8 parts, Caulis Polygoni Multiflori 6 parts, Retinervus Luffae Fructus 9 parts, Rhizoma Acori Graminei 8 parts, Rhizoma Dioscoreae 10 parts, Fructus Gardeniae 6 parts, 6 parts, Folium Bambusae, Rhizoma Phragmitis 6 parts, Fructus Citri Sarcodactylis 8 parts, Flos Rosae Rugosae 6 parts, Herba Cirsii 8 parts; Add 10 times of water gagings, decoct 2 hours, filter; Filtering residue adds 8 times of water gagings, decocts 1.5 hours, filters; Merging filtrate, concentrated, dry, packaging, obtains powder; Above-mentioned part all refers to weight portion.
4. a kind of medicine being used for the treatment of chronic eczema as claimed in claim 1, it is characterized in that, its preparation method is: take: Fructus Amomi 6 parts, the Fructus Kochiae 8 parts, Caulis Polygoni Multiflori 6 parts, Retinervus Luffae Fructus 9 parts, Rhizoma Acori Graminei 8 parts, Rhizoma Dioscoreae 10 parts, Fructus Gardeniae 6 parts, 6 parts, Folium Bambusae, Rhizoma Phragmitis 6 parts, Fructus Citri Sarcodactylis 8 parts, Flos Rosae Rugosae 6 parts, Herba Cirsii 8 parts; Add 6 times of water gagings, decoct 3 times, each decoction 1 hour, merges decoction liquor, concentrated, dry, incapsulates shell, obtains capsule; Above-mentioned part all refers to weight portion.
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| CN201510895483.0A CN105288436A (en) | 2015-12-03 | 2015-12-03 | Medicament for treatment of chronic eczema |
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| CN201510895483.0A CN105288436A (en) | 2015-12-03 | 2015-12-03 | Medicament for treatment of chronic eczema |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2017265179B2 (en) * | 2016-11-29 | 2018-10-25 | Zhejiang Strong Pharmaceutical Co., Ltd. | Pharmaceutical composition for treating eczema and method for preparation thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102327460A (en) * | 2011-09-23 | 2012-01-25 | 隋玉兰 | Medicament for treating eczema |
| CN103202903A (en) * | 2013-04-11 | 2013-07-17 | 徐樊 | Traditional Chinese medicine preparation for treating skin eczema |
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2015
- 2015-12-03 CN CN201510895483.0A patent/CN105288436A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102327460A (en) * | 2011-09-23 | 2012-01-25 | 隋玉兰 | Medicament for treating eczema |
| CN103202903A (en) * | 2013-04-11 | 2013-07-17 | 徐樊 | Traditional Chinese medicine preparation for treating skin eczema |
Non-Patent Citations (2)
| Title |
|---|
| 程法森: "消风散治湿疹", 《浙江中医药大学学报》 * |
| 陈彩云: "自拟除湿止痒散治疗慢性湿疹疗效观察", 《云南中医中药杂志》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2017265179B2 (en) * | 2016-11-29 | 2018-10-25 | Zhejiang Strong Pharmaceutical Co., Ltd. | Pharmaceutical composition for treating eczema and method for preparation thereof |
| US10413582B2 (en) | 2016-11-29 | 2019-09-17 | Zhejiang Strong Pharmaceutical Co., Ltd. | Pharmaceutical composition for treating eczema and method for preparation thereof |
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Application publication date: 20160203 |