CN109845740B - Insecticidal composition containing flucloxapyroxad and bishydrazide insecticide - Google Patents
Insecticidal composition containing flucloxapyroxad and bishydrazide insecticide Download PDFInfo
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- CN109845740B CN109845740B CN201910055624.6A CN201910055624A CN109845740B CN 109845740 B CN109845740 B CN 109845740B CN 201910055624 A CN201910055624 A CN 201910055624A CN 109845740 B CN109845740 B CN 109845740B
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- China
- Prior art keywords
- flucloxapyroxad
- methoxyfenozide
- tebufenozide
- chromafenozide
- active ingredient
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Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses an insecticidal composition containing flucloxapyroxad and dihydrazide insecticide, which comprises an active ingredient A and an active ingredient B, wherein the active ingredient A is selected from flucloxapyroxad, and the active ingredient B is selected from any one of the following compounds: tebufenozide, methoxyfenozide, chlorfenozide and chromafenozide; and the weight ratio of the active ingredient A to the active ingredient B is 1:80-80:1. The composition has synergistic effect on various pests which harm agricultural production, reduces the dosage of pesticides, reduces the residual quantity of the pesticides on crops, reduces environmental pollution, is safe to people and livestock, has good environmental compatibility, and is not easy to generate drug resistance.
Description
Technical Field
The invention belongs to the technical field of pesticides, and particularly relates to application of an insecticidal composition containing flucloxapyroxad diamide and bishydrazide insecticide in controlling crop pests.
Background
Crop diseases and insect pests are one of main agricultural disasters in China, and have the characteristics of multiple types, large influence and frequent outbreaks of disasters, and the occurrence range and the severity of the crop diseases and insect pests often cause great losses to national economy of China, particularly agricultural production. The following kinds of plant diseases and insect pests are common for crops in China: rice leaf rollers, chilo suppressalis, asparagus caterpillar, plutella xylostella, rice planthoppers, powdery mildew, corn borers, cotton bollworms, wheat rust, cotton aphids, rice sheath blight, rice blast, wheat aphids, wheat red spiders, locust, wheat scab and the like have become serious plant diseases and insect pests which seriously affect agricultural production in China. Because of the long-term use of chemical pesticides for prevention and control, pests generate different degrees of drug resistance to various chemical pesticides such as organic chlorine, organic phosphorus, carbamate, pyrethroid and the like, the prevention and control effect is obviously reduced, so that farmers have to increase the dosage to improve the prevention and control effect, but the safety of agricultural products is reduced.
The flucloxapyroxad is a novel compound which is independently innovated and developed by the company, belongs to benzamide pesticides, and can efficiently activate insect ryanodine (muscle) receptors so as to excessively release calcium ions in intracellular calcium libraries, thereby leading to paralysis and death of insects. Has high activity on larvae of lepidoptera pests, broad insecticidal spectrum and good persistence. The active ingredient shows extremely obvious selectivity difference on the mammal and the pest ryanodine receptor, and the safety on the mammal and other vertebrates is greatly improved.
The main mechanism of action of bishydrazide pesticides is growth regulator, which affects ecdysone receptor of pests. Common bishydrazide pesticides tebufenozide, methoxyfenozide, chlorfenozide, chromafenozide and the like.
Tebufenozide (Tebufenozide): belongs to an insect growth regulator, is a novel bionic pesticide for promoting the molting of lepidoptera pests, acts on an insect molting hormone receptor to cause early maturity of insect larvae, early molting to cause death, or forms malformed pupae and malformed adults to cause chemical sterilization.
Methoxyfenozide (Methoxyfenozide): belongs to dihydrazide insect growth regulator-ecdysone pesticide, and can interfere with normal growth and development of insect and inhibit ingestion. The methoxyfenozide has strong insecticidal object selectivity, high selective insecticidal activity on lepidoptera pests, mainly contact-killing effect and certain systemic effect. The pesticide has opposite action mechanism with the pesticide for inhibiting pest molting, and can be used for preventing and treating pest in whole larva stage. Is safe to beneficial insects and mites and is environment-friendly.
Chlorantraniliprole (halofenazide): belongs to an ecdysone receptor agonist, acts on an insect ecdysone receptor and is a systemic insecticide. Chlorantraniliprole can cause premature molting of insects, mainly affects larval stage of insects, can reduce reproductive capacity, and has certain ovicidal activity.
Chromafenozide (Chromafenozide): ecdysone agonists can prevent binding sites of insect ecdysone receptor proteins, cause premature ripening,、incomplete and lethal ecdysis. After the dosage, the larvae may stop feeding due to molting. Can be used for preventing and treating lepidoptera larva of rice, fruit tree, vegetable, tea tree, cotton, beans and forestry. Has no obvious influence on the vitality, growth and emergence rate of non-target terrestrial and aquatic plants.
In the actual process of agricultural production, the most easily generated problem of pest control is the generation of pest resistance. The compounding of different varieties of components is a common method for preventing and controlling resistant pests. Different components are compounded, and whether a certain compounding is synergistic, additive or antagonistic is judged according to the actual application effect. In most cases, the compounding effect of the pesticide is additive effect, the actual synergy is less, and especially the compounding with obvious synergy and high co-toxicity coefficient is less. Through the compound research of the inventor, the flucloxapyroxad can generate good synergistic effect after being compounded with tebufenozide, methoxyfenozide, chlorfenozide and chromafenozide, and the related report about the compounding of the flucloxad diamide with tebufenozide, methoxyfenozide, chlorfenozide and chromafenozide is not disclosed.
Disclosure of Invention
The invention aims to provide the insecticidal composition containing the fluorine-containing chlorantraniliprole, which has the advantages of synergistic effect, low use cost, good control effect and long lasting period.
An insecticidal composition containing flucloxapyroxad and dihydrazide insecticide comprises an active ingredient A and an active ingredient B as active ingredients; the active component A is flucloxapyroxad and the active component B is bishydrazide insecticide.
Further, the active component B bishydrazide pesticide is preferably tebufenozide, methoxyfenozide, chlorfenozide or chromafenozide.
Further, according to the insecticidal composition disclosed by the invention, the weight ratio of the active ingredient A to the active ingredient B is 1:80-80:1.
Further, the preferred weight ratio of active ingredient a to active ingredient B is: the weight ratio of the flucloxapyroxad to the tebufenozide is 1:40-3:1; the weight ratio of the flucloxapyroxad to the methoxyfenozide is 1:30-10:1; the weight ratio of the flubendiamide to the chlorantraniliprole is 1:30-20:1; the weight ratio of the flucloxapyroxad to the chromafenozide is 1:20-10:1.
Further, the preferred weight ratio of active ingredient a to active ingredient B is: the weight ratio of the flucloxapyroxad to the tebufenozide is 1:30-2:1; the weight ratio of the flucloxapyroxad to the methoxyfenozide is 1:20-3:1; the weight ratio of the flubendiamide to the chlorantraniliprole is 1:30-5:1; the weight ratio of the flucloxapyroxad to the chromafenozide is 1:3-5:1.
The insecticidal composition containing the flucloxapyroxad and the bishydrazide insecticide is applied to controlling crop pests, wherein the crops comprise grain crops, bean crops, fiber crops, sugar crops, melon crops, fruit crops, dried fruit crops, hobby crops, rhizome crops, oil crops, flower crops, medicinal crops, raw material crops and green manure pasture crops; the pests include plutella xylostella, noctuid, cotton bollworm, diamond back moth, leaf roller, chilo suppressalis and peach fruit borer.
The invention relates to an insecticidal composition containing flucloxapyroxad and bishydrazide insecticide, which consists of active ingredients and auxiliary ingredients allowed by pesticides.
Further, the auxiliary components of the pesticide preparation comprise a carrier and an auxiliary agent.
Further, the carrier is one, two or three of a solvent or a filler, and the water is preferably deionized water.
Further, the solvent is selected from the group consisting of N, N-dimethylformamide, cyclohexanone, toluene, xylene, dimethyl sulfoxide, methanol, ethanol, trimethylcyclohexanone, N-octyl pyrrolidone, ethanolamine, triethanolamine, isopropylamine. N-methylpyrrolidone, propanol, butanol, ethylene glycol, diethylene glycol, ethylene glycol methyl ether, butyl ether, ethanolamine, isopropylamine, ethyl acetate or acetonitrile.
Further, the filler is selected from one or a mixture of more of kaolin, diatomite, bentonite, attapulgite, white carbon black, starch or light calcium carbonate.
Further, the auxiliary agent at least comprises a surfactant, and other functional auxiliary agents such as an antifreezing agent, a thickening agent, a stabilizing agent, a disintegrating agent, a defoaming agent and the like can be added according to different use occasions and requirements.
Further, the surfactant is one or four selected from an emulsifier, a dispersant, a wetting agent or a penetrating agent; the surfactant is a single agent or a compound preparation of a common nonionic surfactant or an anionic surfactant.
Further, the other functional auxiliary agents are selected from one or five of antifreezing agents, thickening agents, stabilizing agents, disintegrating agents or defoaming agents.
Further, the emulsifier is selected from one or more of nonylphenol 500# (calcium alkylbenzenesulfonate), OP series phosphate (nonylphenol polyoxyethylene ether phosphate), 600# phosphate (phenylphenol polyoxyethylene ether phosphate), styrene polyoxyethylene ether ammonium sulfate, magnesium alkyldiphenyl ether disulfonate, triethanolamine salt, nonylphenol 400# (benzyl dimethyl phenol polyoxyethylene ether), nonylphenol 700# (alkylphenol formaldehyde resin polyoxyethylene ether), nonylphenol 36# (phenethyl phenol formaldehyde resin polyoxyethylene ether), nonylphenol 1600# (phenethyl phenol polyoxyethylene polypropylene ether), ethylene oxide-propylene oxide block copolymer, OP series (nonylphenol polyoxyethylene ether), BY series (castor oil polyoxyethylene ether), nonylphenol 33# (alkylaryl polyoxyethylene polyoxypropylene ether), span series (sorbitan monostearate) polyoxyethylene ether), tween series (sorbitan polyoxyethylene ether) or AEO series (fatty alcohol polyoxyethylene ether).
Further, the dispersing agent is selected from one or more of polycarboxylate, lignosulfonate, alkylphenol ethoxylate formaldehyde condensate sulfate, calcium alkylbenzenesulfonate, naphthalene sulfonate formaldehyde condensate sodium salt, alkylphenol ethoxylate, fatty amine ethoxylate, fatty acid ethoxylate or glycerin fatty acid ester ethoxylate.
Further, the wetting agent is selected from one or more of sodium dodecyl sulfate, sodium dodecyl benzene sulfonate, nekal BX, wetting penetrating agent F, chinese honeylocust fruit powder, silkworm excrement or soapberry powder.
Further, the penetrating agent is selected from one or a mixture of more of penetrating agent JFC (fatty alcohol polyoxyethylene ether), penetrating agent T (diisooctyl maleate sulfonate), azone or organic silicon.
Further, the antifreezing agent is selected from one or a mixture of more of ethylene glycol, propylene glycol, glycerol or urea.
Further, the thickener is selected from one or more of xanthan gum, polyvinyl alcohol, bentonite, carboxymethyl cellulose or magnesium aluminum silicate.
Further, the stabilizer is selected from one or a mixture of more of epoxidized soybean oil, epichlorohydrin, BHT, ethyl acetate and triphenyl phosphate.
Further, the disintegrating agent is selected from one or a mixture of more of bentonite, urea, ammonium sulfate, aluminum chloride, low-substituted hydroxypropyl cellulose, lactose, citric acid, succinic acid or sodium bicarbonate.
Further, the defoamer is selected from one or a mixture of more of silicone oil, silicone compounds, C10-C20 saturated fatty acid compounds or C8-C10 fatty alcohol compounds.
All of the above materials are commercially available.
The insecticidal composition of the present invention may be diluted by a user before use or used directly.
The insecticidal composition of the present invention can be prepared by a general processing method well known to those skilled in the art, namely, after the active substance is mixed with a liquid solvent or a solid carrier, one or more surfactants such as dispersing agents, stabilizers, wetting agents, binders, antifoaming agents, disintegrating agents, anti-freezing agents and the like are added. The insecticidal composition can be processed into any pesticide acceptable dosage form according to the requirement, wherein the preferred dosage form is as follows: suspending agent, wettable powder, water dispersible granule and microemulsion.
Further, the weight percentage of the active components in the composition is 0.5-90% of the total weight, preferably 5-80%. The range of active ingredient content varies according to the type of formulation. Typically, the liquid formulation contains from 1% to 70% by weight of active substance, preferably from 5% to 50%; the solid preparation contains 5 to 80% by weight of active substance, preferably 10 to 80%.
Further, the composition is prepared into a suspending agent, and the suspending agent comprises the following components in percentage by weight: 0.5 to 50 percent of active ingredient A, 0.5 to 50 percent of active ingredient B, 1 to 10 percent of dispersing agent, 1 to 10 percent of wetting agent, 0.01 to 2 percent of defoaming agent, 0 to 2 percent of thickening agent, 0 to 8 percent of antifreeze agent and the balance of deionized water.
Further, the composition is prepared into wettable powder, and the components and the content thereof are preferably as follows: 0.5 to 60 percent of active ingredient A, 0.5 to 80 percent of active ingredient B, 1 to 12 percent of dispersing agent, 1 to 8 percent of wetting agent and the balance of filler.
Further, the composition is prepared into water dispersible granules, and the composition and the content are preferably as follows: 0.5 to 60 percent of active ingredient A, 0.5 to 80 percent of active ingredient B, 1 to 12 percent of dispersing agent, 1 to 8 percent of wetting agent, 1 to 10 percent of disintegrating agent, 0 to 8 percent of binding agent and the balance of filling material.
Further, the components and the content of the microemulsion prepared by the composition are preferably as follows: 0.5 to 50 percent of active ingredient A, 0.5 to 50 percent of active ingredient B, 3 to 25 percent of emulsifier, 1 to 10 percent of solvent, 0 to 8 percent of antifreeze agent, 0.01 to 2 percent of defoamer and deionized water which make up the balance.
The invention has the advantages that:
(1) After the flucloxapyroxad is compounded with one of tebufenozide, methoxyfenozide, chlorfenozide and chromafenozide, the compound insecticidal composition has obvious synergy and lasting effect;
(2) The plant extract has high activity on crops including grain crops, economic crops (oil crops, vegetable crops and hobby crops), industrial raw material crops, feed crops, plutella xylostella of medicinal crops and the like, noctuid, cotton bollworm, diamond back moth, leaf roller, striped rice borer, peach fruit borer and the like;
(3) The dosage of the pesticide is reduced, the residual quantity of the pesticide on crops is reduced, and the environmental pollution is lightened;
(4) Is safe to human and livestock, has good environmental compatibility, and the preparation has enhanced adhesive force and rain wash resistance.
Description of the preferred embodiments
Example 1:9% Flucoxapa diamide tebufenozide suspending agent (1:2)
The formula comprises the following components: 3% of flucloxapyroxad, 6% of tebufenozide, 4% of lignosulfonate, 3.2% of nekal BX, 0.9% of silicone oil, 2% of xanthan gum, 2% of ethylene glycol and the balance of deionized water.
The preparation method comprises the following steps: according to the formula proportion, the active ingredients of flucloxapyroxad, tebufenozide, a surfactant and other functional auxiliary agents are sequentially placed in a reaction kettle, water is added and mixed uniformly, and the suspending agent is obtained through high-speed shearing, wet sanding and homogenizing and filtering.
Example 2:22% Flucoxapa diamide tebufenozide suspending agent (1:10)
The formula comprises the following components: 2% of flucloxapyroxad, 20% of tebufenozide, 4% of alkylphenol ethoxylates, 5% of nekal BX, 0.5% of silicone oil, 0.7% of xanthan gum, 5% of urea and the balance of deionized water.
The preparation method comprises the following steps: as above.
Example 3:40% Flucoxapa diamide tebufenozide suspending agent (1:1)
The formula comprises the following components: 20% of flucloxapyroxad, 20% of tebufenozide, 6% of lignosulfonate, 5% of sodium dodecyl sulfate, 0.6% of silicone oil, 1% of xanthan gum, 4% of ethylene glycol and the balance of deionized water.
The preparation method comprises the following steps: as above.
Example 4:20% Flucarbazide bisamide methoxyfenozide suspending agent (2:3)
The formula comprises the following components: 8% of flucloxapyroxad, 12% of methoxyfenozide suspending agent, 5% of alkylphenol ethoxylate, 4% of nekal BX, 0.6% of silicone oil, 1% of xanthan gum, 3% of urea and the balance of deionized water.
The preparation method comprises the following steps: as above.
Example 5:12% Flucoxapa amide methoxyfenozide suspending agent (1:5)
The formula comprises the following components: 2% of flucloxapyroxad, 10% of methoxyfenozide suspending agent, 5% of lignosulfonate, 3% of nekal BX, 0.5% of silicone oil, 1.2% of xanthan gum, 3% of glycol and the balance of deionized water.
The preparation method is the same as the above.
Example 6:40% Flucarbazide bisamide methoxyfenozide suspending agent (3:1)
The formula comprises the following components: 30% of flucloxapyroxad, 10% of methoxyfenozide suspending agent, 4% of alkylphenol ethoxylates, 2.8% of sodium dodecyl sulfate, 0.7% of silicone oil, 1% of xanthan gum, 4% of urea and the balance of deionized water.
The preparation method comprises the following steps: as above.
Example 7:41% Fluoxabendiamide-chlorantraniliprole suspension (1:40)
The formula comprises the following components: 1% of flucloxapyroxad, 40% of chlorfenozide, 4% of lignosulfonate, 2.8% of nekal BX, 0.6% of silicone oil, 0.9% of xanthan gum, 5% of ethylene glycol and the balance of deionized water.
The preparation method comprises the following steps: as above.
Example 8:15% Fluoxabendiamide-chlorantraniliprole suspending agent (1:1)
The formula comprises the following components: 7.5% of fluchlorantraniliprole, 7.5% of chlorantraniliprole, 8% of alkylphenol ethoxylates, 5% of sodium dodecyl sulfate, 1.6% of silicone oil, 0.9% of xanthan gum, 7% of urea and the balance of deionized water.
The preparation method comprises the following steps: as above.
Example 9:6% Fluoxabendiamide-chlorantraniliprole suspending agent (5:1)
The formula comprises the following components: 5% of flucloxapyroxad, 1% of chlorfenozide, 5% of lignosulfonate, 4% of nekal BX, 0.6% of silicone oil, 1% of xanthan gum, 3% of glycol and the balance of deionized water.
The preparation method comprises the following steps: as above.
Example 10:15% Flucoxapa diamide-chromafenozide suspending agent (1:2)
The formula comprises the following components: 5% of flucloxapyroxad, 10% of chromafenozide, 5% of alkylphenol ethoxylates, 3.8% of nekal BX, 0.5% of silicone oil, 1% of xanthan gum, 3% of urea and the balance of deionized water.
The preparation method comprises the following steps: as above.
Example 11:20% Flucarbazide bisamide-chromafenozide suspending agent (1:1)
The formula comprises the following components: 10% of flucloxapyroxad, 10% of chromafenozide, 6% of alkylphenol ethoxylates, 5% of sodium dodecyl sulfate, 0.4% of silicone oil, 1% of xanthan gum, 4% of urea and the balance of deionized water.
The preparation method comprises the following steps: as above.
Example 12:11% Flucoxapa diamide-chromafenozide suspending agent (10:1)
The formula comprises the following components: 10% of flucloxapyroxad, 1% of chromafenozide, 4% of lignosulfonate, 5% of sodium dodecyl sulfate, 0.5% of silicone oil, 0.8% of xanthan gum, 3% of urea and the balance of deionized water.
The preparation method is the same as above.
Example 13:42% Flucoxapa-tebufenozide wettable powder (1:20)
The formula comprises the following components: 2% of flucloxapyroxad, 40% of tebufenozide, 3.5% of fatty amine polyoxyethylene ether, 3% of nekal BX and the balance of diatomite.
The preparation method comprises the following steps: according to the formula proportion of the embodiment, the active ingredients of the flucloxapyroxad and the tebufenozide are added into a carrier, and a surfactant and other functional auxiliary agents are added into the carrier for mixing, and the wettable powder is prepared by mixing after jet milling.
Example 14:20% Flucoxapa-tebufenozide wettable powder (1:9)
The formula comprises the following components: 2% of flucloxapyroxad, 18% of tebufenozide, 1.5% of lignosulfonate, 2% of nekal BX and the balance of white carbon black.
The preparation method comprises the following steps: as above.
Example 15:15% flucloxapyroxad tebufenozide wettable powder (1:2)
The formula comprises the following components: 5% of flucloxapyroxad, 10% of tebufenozide, 3% of lignosulfonate, 4% of nekal BX and the balance of kaolin.
The preparation method comprises the following steps: as above.
Example 16:26% flucloxapyroxad methoxyfenozide wettable powder (1:25)
The formula comprises the following components: 1% of flucloxapyroxad, 25% of methoxyfenozide, 5% of lignosulfonate, 3% of sodium dodecyl benzene sulfonate, 2% of nekal BX and the balance of kaolin.
The preparation method comprises the following steps: as above.
Example 17:18% flucloxapyroxad methoxyfenozide wettable powder (1:5)
The formula comprises the following components: 3% of flucloxapyroxad, 15% of methoxyfenozide, 3.5% of fatty amine polyoxyethylene ether, 3% of nekal BX and the balance of diatomite.
The preparation method comprises the following steps: as above.
Example 18:15% flucloxapyroxad methoxyfenozide wettable powder (2:3)
The formula comprises the following components: 6% of flucloxapyroxad, 9% of methoxyfenozide, 7% of fatty amine polyoxyethylene ether, 4% of sodium dodecyl benzene sulfonate and the balance of diatomite.
The preparation method comprises the following steps: as above.
Example 19:31% Fluoxabendiamide-chlorantraniliprole wettable powder (1:30)
The formula comprises the following components: 1% of flubendiamide, 30% of chlorantraniliprole, 7% of polycarboxylate, 4% of sodium dodecyl benzene sulfonate and the balance of kaolin.
The preparation method comprises the following steps: as above.
Example 20:22% flubendiamide-chlorantraniliprole wettable powder (10:1)
The formula comprises the following components: 20% of flubendiamide, 2% of chlorantraniliprole, 1% of fatty amine polyoxyethylene ether, 3% of sodium dodecyl benzene sulfonate and the balance of kaolin.
The preparation method comprises the following steps: as above.
Example 21:30% flubendiamide-chlorantraniliprole wettable powder (1:2)
The formula comprises the following components: flucarbazide 10%, chlorfenozide 20%, alkylphenol ethoxylates 5%, wetting penetrant F3% and diatomite for the rest.
The preparation method comprises the following steps: as above.
Example 22:24% flucloxapyroxad-chromafenozide wettable powder (1:2)
The formula comprises the following components: flucarbazide 8%, chromafenozide 16%, lignosulfonate 6%, nekal BX5% and white carbon black make up the balance.
The preparation method comprises the following steps: as above.
Example 23:18% flucloxapyroxad-chromafenozide wettable powder (1:5)
The formula comprises the following components: 3% of flucloxapyroxad, 15% of chromafenozide, 7% of naphthalene sulfonic acid formaldehyde condensate, 4% of sodium dodecyl sulfate and the balance of kaolin.
The preparation method comprises the following steps: as above.
Example 24:10% flucloxapyroxad-chromafenozide wettable powder (1:1)
The formula comprises the following components: 5% of flucloxapyroxad, 5% of chromafenozide, 5% of alkylphenol ethoxylates, 3% of wetting penetrating agent F and the balance of diatomite.
The preparation method comprises the following steps: as above.
Example 25:15% flucloxapyroxad tebufenozide water dispersible granule (1:1)
The formula comprises the following components: 7.5% of flucloxapyroxad, 7.5% of tebufenozide, 4% of lignosulfonate, 3% of sodium dodecyl benzene sulfonate, 5% of aluminum chloride and the balance of white carbon black.
The preparation method comprises the following steps: according to the formula proportion of the embodiment, the active ingredients of the flucloxapyroxad and the tebufenozide are added into a carrier, and a surfactant and other functional auxiliary agents are added into the carrier, mixed, subjected to jet milling, added with 10-25% of water, and then kneaded, granulated, dried and screened to prepare a water dispersible granule product; or spraying water, granulating, drying, and sieving to obtain the final product.
Example 26:30% flucloxapyroxad tebufenozide water dispersible granule (1:2)
The formula comprises the following components: the composition comprises 10% of flucloxafen, 20% of tebufenozide, 5% of lignosulfonate, 3% of nekal BX, 4% of aluminum chloride and the balance of kaolin.
The preparation method comprises the following steps: as above.
Example 27:21% flucloxapyroxad tebufenozide water dispersible granule (1:20)
The formula comprises the following components: 1% of flucloxapyroxad, 20% of tebufenozide, 4% of naphthalene sulfonic acid formaldehyde condensate sodium salt, 6% of sodium dodecyl benzene sulfonate, 6% of bentonite and the balance of white carbon black.
The preparation method comprises the following steps: as above.
Example 28:30% flucloxapyroxad methoxyfenozide water dispersible granule (2:3)
The formula comprises the following components: 12% of flucloxapyroxad, 18% of methoxyfenozide, 8% of lignosulfonate, 5% of nekal BX, 4% of aluminum chloride and the balance of white carbon black.
The preparation method comprises the following steps: as above.
Example 29:18% flubendiamide methoxyfenozide water dispersible granule (1:5)
The formula comprises the following components: 3% of flucloxapyroxad, 15% of methoxyfenozide, 3% of lignosulfonate, 7% of nekal BX, 5% of aluminum chloride and the balance of kaolin.
The preparation method comprises the following steps: as above.
Example 30:20% flucloxapyroxad methoxyfenozide water dispersible granule (3:1)
The formula comprises the following components: 15% of flucloxapyroxad, 5% of methoxyfenozide, 5% of naphthalene sulfonic acid formaldehyde condensate sodium salt, 4% of nekal BX, 8% of aluminum chloride and the balance of kaolin.
The preparation method comprises the following steps: as above.
Example 31:41% Fluobendiamide-chlorantraniliprole water dispersible granule (1:40)
The formula comprises the following components: 1% of flubendiamide, 40% of chlorantraniliprole, 5% of lignosulfonate, 6% of sodium dodecyl benzene sulfonate, 7% of bentonite and the balance of white carbon black.
The preparation method comprises the following steps: as above.
Example 32:12% flubendiamide-chlorantraniliprole water dispersible granule (5:1)
The formula comprises the following components: flucarbazide 10%, chlorfenozide 2%, naphthalene sulfonic acid formaldehyde condensate sodium salt 6%, nekal BX8%, aluminum chloride 6% and kaolin for the rest.
The preparation method comprises the following steps: as above.
Example 33:10% flubendiamide-chlorantraniliprole water dispersible granule (1:1)
The formula comprises the following components: 5% of flucloxapyroxad, 5% of chlorfenozide, 5% of lignosulfonate, 8% of sodium dodecyl benzene sulfonate, 6% of aluminum chloride and the balance of kaolin.
The preparation method comprises the following steps: as above.
Example 34:20% flucloxapyroxad-chromafenozide water dispersible granule (1:1)
The formula comprises the following components: flucarbazide 10%, chromafenozide 10%, naphthalene sulfonic acid formaldehyde condensate sodium salt 5%, nekal BX4%, aluminum chloride 8% and kaolin balance.
The preparation method comprises the following steps: as above.
Example 35:11% flucloxapyroxad-chromafenozide water dispersible granule (10:1)
The formula comprises the following components: flucarbazide 10%, chromafenozide 1%, lignosulfonate 5%, sodium dodecyl benzene sulfonate 8%, aluminum chloride 6% and kaolin with the balance being.
The preparation method comprises the following steps: as above.
Example 36:24% flucloxapyroxad-chromafenozide water dispersible granule (5:1)
The formula comprises the following components: 20% of flucloxapyroxad, 4% of chromafenozide, 5% of naphthalene sulfonic acid formaldehyde condensate sodium salt, 4% of nekal BX, 8% of aluminum chloride and the balance of kaolin.
The preparation method comprises the following steps: as above.
Example 37:11% Flucoxapa diamide tebufenozide microemulsion (1:11)
The formula comprises the following components: 1% of flucloxapyroxad, 10% of tebufenozide, 3% of N, N-dimethylformamide, 11% of calcium alkylbenzenesulfonate and the balance of deionized water.
The preparation method comprises the following steps: according to the formula proportion of the embodiment, the active ingredients of the flucloxapyroxad, the tebufenozide and the cosolvent are completely dissolved, then other auxiliary agents are added, the mixture is uniformly mixed, finally water is added, and the microemulsion of the invention can be prepared after full stirring.
Example 38:3% Flucoxapa diamide tebufenozide microemulsion (1:2)
The formula comprises the following components: 1% of flucloxapyroxad, 2% of tebufenozide, 5% of N, N-dimethylformamide, 9% of alkylphenol formaldehyde resin polyoxyethylene ether and the balance of deionized water.
The preparation method comprises the following steps: as above.
Example 39:6% Flucoxapa diamide tebufenozide microemulsion (5:1)
The formula comprises the following components: 5% of flucloxapyroxad, 1% of tebufenozide, 4% of N, N-dimethylformamide, 9% of alkylphenol formaldehyde resin polyoxyethylene ether and the balance of deionized water.
The preparation method comprises the following steps: as above.
Example 40:5% Flucoxapa-methoxyfenozide microemulsion (2:3)
The formula comprises the following components: 2% of flucloxapyroxad, 3% of methoxyfenozide, 5% of N, N-dimethylformamide, 12% of calcium alkylbenzenesulfonate and the balance of deionized water.
The preparation method comprises the following steps: as above.
Example 41:6% Flucoxapa-methoxyfenozide microemulsion (1:5)
The formula comprises the following components: 1% of flucloxapyroxad, 5% of methoxyfenozide, 7% of N, N-dimethylformamide, 2% of calcium alkylbenzenesulfonate and the balance of deionized water.
The preparation method comprises the following steps: as above.
Example 42:4% Flucarbazide micro-emulsion of methofenozide (3:1)
The formula comprises the following components: 3% of flucloxapyroxad, 1% of methoxyfenozide, 6% of N, N-dimethylformamide, 9% of calcium alkylbenzenesulfonate and the balance of deionized water.
The preparation method comprises the following steps: as above.
Example 43:5% Fluoxabendiamide-chlorantraniliprole microemulsion (1:4)
The formula comprises the following components: 1% of flubendiamide, 4% of chlorantraniliprole, 1% of N, N-dimethylformamide, 11% of alkylphenol formaldehyde resin polyoxyethylene ether and the balance of deionized water.
The preparation method comprises the following steps: as above.
Example 44:6% Fluoxabendiamide-chlorantraniliprole microemulsion (5:1)
The formula comprises the following components: 5% of flubendiamide, 1% of chlorantraniliprole, 6% of N, N-dimethylformamide, 9% of calcium alkylbenzenesulfonate and the balance of deionized water.
The preparation method comprises the following steps: as above.
Example 45:2% Fluoxabendiamide-chlorantraniliprole microemulsion (1:1)
The formula comprises the following components: 1% of flubendiamide, 1% of chlorantraniliprole, 6% of N, N-dimethylformamide, 9% of calcium alkylbenzenesulfonate and the balance of deionized water.
The preparation method comprises the following steps: as above.
Example 46:2% Flucoxapa diamide-chromafenozide microemulsion (1:1)
The formula comprises the following components: 1% of flucloxapyroxad, 1% of chromafenozide, 6% of N, N-dimethylformamide, 9% of calcium alkylbenzenesulfonate and the balance of deionized water.
The preparation method comprises the following steps: as above.
Example 47:3% Flucoxapa diamide-chromafenozide microemulsion (1:2)
The formula comprises the following components: 1% of flucloxapyroxad, 2% of chromafenozide, 1% of N, N-dimethylformamide, 11% of alkylphenol formaldehyde resin polyoxyethylene ether and the balance of deionized water.
The preparation method comprises the following steps: as above.
Example 48:11% Flucoxapa diamide-chromafenozide microemulsion (10:1)
The formula comprises the following components: the composition comprises flucloxapyroxad 10%, chromafenozide 1%, N, N-dimethylformamide 6%, calcium alkylbenzenesulfonate 9% and deionized water for the rest.
The preparation method comprises the following steps: as above.
The tebufenozide, methoxyfenozide, chlorfenozide and chromafenozide in examples 1 to 48 are interchanged to prepare a new formulation.
Active cases:
the embodiment of the invention adopts a method combining indoor toxicity measurement and field test. Firstly, determining the co-toxicity coefficient (CTC) of two medicaments compounded according to a certain proportion through indoor toxicity measurement, wherein CTC is smaller than 80 and antagonistic action, CTC is larger than 120 and synergistic action is between 80 and 120, and then carrying out field test on the basis.
The test method comprises the following steps: soaking leaf in the liquid medicine for 5s, taking out, naturally drying, placing into insect-raising box, then inoculating test larva, raising at 25deg.C, repeating for 4 times, repeating 20 head of test larva, setting blank control, checking death number 48 hr after inoculation, calculating death rate and correcting death rate, calculating virulence regression equation, and calculating LC 50 Values. If the control mortality rate is > 10%, it is considered as an ineffective test. The calculation formula is as follows:
in LC form 50 The agent having a relatively small value is a standard agent, and its toxicity index TI is 100.
Theoretical toxicity index of the mixture tti=ti A ×P A +TI B ×P B
Wherein: p (P) A 、P B The weight ratio of the active ingredients A, B in the composition is respectively.
Wherein A is flucloxapyroxad; and B is one of tebufenozide, methoxyfenozide, chlorfenozide and chromafenozide.
Example 43: combined toxicity of chlorfluazuron and tebufenozide to cabbage caterpillar of cruciferae
Test pest: cabbage caterpillar of cruciferae family.
Test agent: the flucloxapyroxad technical and the tebufenozide technical are provided by the Heilier pharmaceutical company, inc.
And (3) test design: experiments prove that the effective Lethal Concentration (LC) of the flucloxapyroxad original drug and the tebufenozide original drug and the mixture of the two different proportions 50 ) And co-toxicity coefficient to determine the combined action type of the flucloxapyroxad diamide and tebufenozide in combination with cabbage caterpillars of the cruciferae.
TABLE 1 toxicity determination results analysis Table of Fluoxadiamide and tebufenozide compounded for cabbage caterpillar of Brassicaceae
As shown in Table 1, when the ratio of the flucloxapyroxad to the tebufenozide is 1:80-80:1, the co-toxicity coefficients are all greater than 80, which indicates that the mixture of the flucloxapyroxad and the tebufenozide shows additive or synergistic effect in the range of 1:80-80:1, and antagonism does not appear; when the mixing weight ratio of the flucloxapyroxad to the tebufenozide is 1:60-20:1, the co-toxicity coefficients are all larger than 120, which indicates that the mixing of the flucloxapyroxad and the tebufenozide shows synergistic effect in the weight ratio range; when the mixing weight ratio of the flucloxapyroxad to the tebufenozide is 1:40-3:1, the co-toxicity coefficients are all larger than 170, which indicates that the flucloxapyroxad and the tebufenozide show obvious synergy in the mixing weight ratio range; when the mixing weight ratio of the flucloxapyroxad to the tebufenozide is 1:30-2:1, the co-toxicity coefficients are both greater than 200, which indicates that the synergistic effect of the flucloxapyroxad and the tebufenozide is more prominent in the mixing weight ratio range.
The inventor experiments find that the flucloxapyroxad and tebufenozide have obvious synergism on the prevention and treatment of lepidoptera and homoptera insects such as plutella xylostella, white fly, leafhopper, asparagus caterpillar, cnaphalocrocis medinalis, chilo suppressalis, rice planthoppers, cotton bollworms, prodenia litura, aphids, mites and thrips when the mixing ratio of the flucloxapyroxad to the tebufenozide is 1:30, 1:20, 1:10, 1:5, 1:3, 1:2, 1:1 and 2:1, and the synergistic effect is obvious, and the co-toxicity coefficient is larger than 120.
Example 44: combined toxicity of flucloxapyroxad and methoxyfenozide to rice leaf rollers
Test pest: rice leaf roller
Test agent: the flucloxapyroxad technical and the methoxyfenozide technical are provided by the Heilier pharmaceutical company, inc.
And (3) test design: experiments prove that the effective Lethal Concentration (LC) of the mixture of the flucloxapyroxad active pharmaceutical ingredient and the methoxyfenozide active pharmaceutical ingredient with different proportions 50 ) And the co-toxicity coefficient is used for determining the combined action type of the flucloxapyroxad and methoxyfenozide for rice leaf rollers.
TABLE 2 toxicity determination results analysis Table of Fluoxadiamide and methoxyfenozide complex on rice leaf rollers
As shown in Table 2, when the ratio of the flucloxapyroxad to the methoxyfenozide to the rice leaf rollers is 1:80-80:1, the co-toxicity coefficients are all greater than 80, which indicates that the two are mixed within the range of 1:80-80:1 to show additive or synergistic effect and no antagonism; when the mixing weight ratio of the flucloxapyroxad to the methoxyfenozide is 1:60-70:1, the co-toxicity coefficients are all larger than 120, which indicates that the flucloxapyroxad and the methoxyfenozide show synergistic effect in the mixing weight ratio range; when the mixing weight ratio of the flucloxapyroxad to the methoxyfenozide is 1:30-10:1, the co-toxicity coefficients are all larger than 170, which indicates that the flucloxapyroxad and the methoxyfenozide show obvious synergy in the mixing weight ratio range; when the mixing weight ratio of the flucloxapyroxad to the methoxyfenozide is 1:20-3:1, the co-toxicity coefficients are all larger than 200, which indicates that the synergistic effect of the flucloxapyroxad and the methoxyfenozide is more prominent in the mixing weight ratio range.
The inventor experiments find that the flucloxapyroxad and methoxyfenozide have obvious synergistic effect on the prevention and treatment of lepidoptera, homoptera insects such as plutella xylostella, white fly, leafhopper, asparagus caterpillar, cnaphalocrocis medinalis, chilo suppressalis, rice planthopper, cotton bollworm, prodenia litura, aphid, mite and thrips when the mixing ratio of the flucloxapyroxad to the methoxyfenozide is 1:20, 1:10, 1:5, 1:3, 1:2, 1:1, 2:1, and 3:1, and the synergistic effect is obvious, and the co-toxicity coefficient is larger than 120.
Example 45: combined toxicity of flubendiamide and chlorantraniliprole on cabbage moth
Test pest: cabbage plutella xylostella
Test agent: the fipronil diamide crude drug and the chlorantraniliprole crude drug are provided by the Heilier pharmaceutical company, inc.
And (3) test design: experiments prove that the effective Lethal Concentration (LC) of the mixture of the flucloxapyroxad amide raw material and the chlorfenozide raw material and different proportions of the two 50 ) And the co-toxicity coefficient is used for determining the combined action type of the flucloxapyroxad and chlorfenozide on cabbage moth by mixing.
TABLE 3 toxicity determination results analysis Table of Fluocloprid bisamide and chlortebufenozide complex pair cabbage plutella xylostella
From Table 3, when the ratio of the flucloxapyroxad to the chlorfenozide to the cabbage plutella xylostella is 1:80-80:1, the co-toxicity coefficients are all larger than 80, which indicates that the two are mixed within the range of 1:80-80:1 to show additive or synergistic effect and no antagonism; when the mixing weight ratio of the flucloxapyroxad to the chlorfenozide is 1:60-50:1, the co-toxicity coefficients are all larger than 120, which indicates that the flucloxad bisamide and the chlorfenozide show synergistic effect in the mixing weight ratio range; when the mixing weight ratio of the flucloxapyroxad to the chlortebufenozide is 1:30-20:1, the co-toxicity coefficients are all larger than 170, which indicates that the flucloxapyroxad and the chlortebufenozide show obvious synergy in the mixing weight ratio range; when the mixing weight ratio of the flucloxapyroxad to the chlorfenozide is 1:30-5:1, the co-toxicity coefficients are all larger than 200, which indicates that the synergistic effect of the flucloxapyroxad and the chlorfenozide is more prominent in the mixing weight ratio range.
The inventor experiments find that the flucloxafen-sodium and chlortehydrazide have obvious synergistic effect on the prevention and treatment of lepidoptera, homoptera insects such as plutella xylostella, white fly, leafhoppers, asparagus caterpillar, cnaphalocrocis medinalis, chilo suppressalis, rice planthoppers, cotton bollworms, prodenia litura, aphids, mites and thrips of various crops when the mixing ratio of the flucloxafen-sodium to the chlortezide is 1:30, 1:20, 1:10, 1:5, 1:3, 1:2, 1:1, 2:1, 3:1 and 5:1, and the synergistic effect is obvious, and the co-toxicity coefficient is larger than 120.
Example 46: combined toxicity of flucloxapyroxad and chromafenozide to rice stem borer
Test pest: rice stem borer
Test agent: the flucloxapyroxad technical and the chromafenozide technical are provided by the Heilier pharmaceutical company, inc.
And (3) test design: experiments prove that the effective Lethal Concentration (LC) of the mixture of the flucloxapyroxad amide raw material and the chromafenozide raw material and different proportions of the two 50 ) And the co-toxicity coefficient is used for determining the combined action type of the flucloxapyroxad and the chromafenozide for rice stem borer.
Table 4 toxicity determination results analysis table of rice stem borer compounded by flucloxapyroxad and chromafenozide.
As shown in Table 4, when the ratio of the flucloxapyroxad amide to the chromafenozide to the rice stem borer is 1:80-80:1, the co-toxicity coefficients are all greater than 80, which indicates that the two are mixed within the range of 1:80-80:1 to show additive or synergistic effect and no antagonism; when the mixing weight ratio of the flucloxapyroxad to the chromafenozide is 1:70-50:1, the co-toxicity coefficients are all larger than 120, which indicates that the flucloxapyroxad and the chromafenozide show synergistic effect in the mixing weight ratio range; when the mixing weight ratio of the flucloxapyroxad to the chromafenozide is 1:20-10:1, the co-toxicity coefficients are all larger than 170, which indicates that the flucloxapyroxad and the chromafenozide show obvious synergy in the mixing weight ratio range; when the mixing weight ratio of the flucloxapyroxad to the chromafenozide is 1:3-5:1, the co-toxicity coefficients are all larger than 200, which indicates that the synergistic effect of the flucloxapyroxad and the chromafenozide is more prominent in the mixing weight ratio range.
The inventor experiments find that the flucloxapyroxad and the chromafenozide have obvious synergism when the mixing ratio of 1:3, 1:2, 1:1, 2:1, 3:1 and 5:1 on the control of lepidoptera and homoptera insects such as plutella xylostella, white fly, leafhopper, asparagus caterpillar, cnaphalocrocis medinalis, striped rice borer, rice planthopper, cotton bollworm, prodenia litura, aphid, mites and thrips of various crops, and the synergistic effect is obvious, and the co-toxicity coefficient is larger than 120.
Example 47: flucarbazide bisamide and active ingredient B and compound pesticide effect test for preventing and treating rice stem borer
Test agent: the example agents were developed and provided by the halier pharmaceutical company, inc.
Control agent: 10% of flubendiamide suspending agent, 20% of tebufenozide suspending agent, 24% of methoxyfenozide suspending agent, 10% of chlorfenozide microemulsion and 5% of chromafenozide suspending agent.
The rice stem borer pest index is investigated before the test drug, the drug is applied in the initial period of pest occurrence, the pest index is investigated 3 days and 7 days after the drug application, and the control effect is calculated. The test results are shown below:
table 5 field efficacy test of flucloxapyroxad and active ingredient B compounded on rice stem borer
As can be seen from table 5, after the flucloxapyroxad and the active ingredient B are compounded, the rice stem borer can be effectively prevented and treated, the preventing and treating effects are better than those of single dosage, the preventing and treating effects of the rice stem borer can be prevented and treated, and the preventing and treating effects are both more than 70% in 3 days after the medicine is taken, and are better than those of partial single dosage; the prevention effect is more than 80% 7 days after the medicine, and is superior to that of a single dose; the prevention effect is more than 85% after 14 days of the medicine, and the prevention effect is obviously superior to that of a single dose, which indicates that the prevention effect of the flucloxapyroxad diamide composition on rice stem borer is superior to that of a single dose, and the lasting period is longer. Has no adverse effect on target crops in the application range of the test.
Example 48: fluchiodiamide and active ingredient B and compound cabbage looper prevention and control drug effect test thereof
Test agent: the example agents were developed and provided by the halier pharmaceutical company, inc.
Control agent: 10% of flubendiamide suspending agent, 20% of tebufenozide suspending agent, 24% of methoxyfenozide suspending agent, 10% of chlorfenozide microemulsion and 5% of chromafenozide suspending agent.
The insect pest index of cabbage beet armyworm is investigated before the test, the pesticide is applied in the initial period of insect pest occurrence, and the insect pest index is investigated 1 day, 3 days and 7 days after pesticide application, and the control effect is calculated. The test results are shown below:
table 6 Fluochlorantraniliprole and active ingredient B and its compound test for controlling cabbage looper
As can be seen from table 6, after the flucloxapyroxad is compounded with the active ingredient B, cabbage asparagus caterpillar can be effectively prevented and treated, the prevention effect of the composition after 1 day of treatment is more than 70%, and the prevention effect is better than that of a single agent; the prevention effect of the fluorine-containing chlorantraniliprole composition is more than 85% in 3 days after the medicine and 7 days after the medicine, which is obviously superior to that of a single dose, and the prevention effect of the fluorine-containing chlorantraniliprole composition on cabbage caterpillar is superior to that of the single dose, and the lasting period is longer. Has no adverse effect on target crops in the application range of the test.
Claims (6)
1. The insecticidal composition containing the flucloxapyroxad and the dihydrazide insecticide is characterized in that active ingredients are active ingredients A and active ingredients B, wherein the active ingredients A are the flucloxapyroxad, and the active ingredients B are methoxyfenozide; the weight ratio of the flucloxapyroxad to the methoxyfenozide is 1:30-10:1.
2. The insecticidal composition of claim 1, wherein the weight ratio of flucloxapyroxad to methoxyfenozide is 1:20-3:1.
3. A pesticidal composition according to claim 1, wherein the weight of active ingredient in the composition is from 0.5% to 90% of the total weight.
4. A pesticidal composition according to any one of claims 1 to 3, wherein the composition is capable of being prepared in an agriculturally acceptable formulation.
5. The insecticidal composition according to claim 4, wherein the formulation is in particular a suspension, wettable powder, water dispersible granule or microemulsion.
6. Use of the insecticidal composition according to any one of claims 1 to 5 for controlling cnaphalocrocis medinalis.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910055624.6A CN109845740B (en) | 2019-01-22 | 2019-01-22 | Insecticidal composition containing flucloxapyroxad and bishydrazide insecticide |
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