CN109845746B - Insecticidal composition containing flucloxapyroxad and biological insecticide - Google Patents

Insecticidal composition containing flucloxapyroxad and biological insecticide Download PDF

Info

Publication number
CN109845746B
CN109845746B CN201910072438.3A CN201910072438A CN109845746B CN 109845746 B CN109845746 B CN 109845746B CN 201910072438 A CN201910072438 A CN 201910072438A CN 109845746 B CN109845746 B CN 109845746B
Authority
CN
China
Prior art keywords
flucloxapyroxad
active ingredient
following
balance
spinosad
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201910072438.3A
Other languages
Chinese (zh)
Other versions
CN109845746A (en
Inventor
葛家成
司国栋
杨志鹏
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hailir Pesticides and Chemicals Group Co Ltd
Original Assignee
Hailir Pesticides and Chemicals Group Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hailir Pesticides and Chemicals Group Co Ltd filed Critical Hailir Pesticides and Chemicals Group Co Ltd
Priority to CN202311764170.2A priority Critical patent/CN117751937A/en
Priority to CN201910072438.3A priority patent/CN109845746B/en
Publication of CN109845746A publication Critical patent/CN109845746A/en
Application granted granted Critical
Publication of CN109845746B publication Critical patent/CN109845746B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

The invention discloses an insecticidal composition containing flucloxapyroxad and a biological source insecticide, wherein the effective active ingredients comprise an active ingredient A and an active ingredient B, the active ingredient A is selected from the flucloxapyroxad, and the active ingredient B is selected from any one of the following: avermectin, spinosad, spinetoram, bacillus thuringiensis, milbemycin, emamectin benzoate (emamectin benzoate), sucrose octacarboxylate, beauveria bassiana, metarhizium anisopliae, nuclear polyhedrosis virus, cytoplasmic polyhedrosis virus and granulosis virus, and the weight ratio of the active component A to the active component B is 1:80-80:1. The composition has a synergistic effect on various pests which are harmful to agricultural production, reduces the dosage of pesticides, reduces the residual quantity of the pesticides on crops, reduces environmental pollution, is safe to people and livestock, has good environmental compatibility, and delays the generation of pest resistance.

Description

Insecticidal composition containing flucloxapyroxad and biological insecticide
Technical Field
The invention belongs to the technical field of pesticides, and relates to application of an insecticidal composition containing flucloxapyroxad and biological insecticide in controlling crop pests.
Background
Crop diseases and insect pests are one of main agricultural disasters in China, and have the characteristics of multiple types, large influence and frequent outbreaks of disasters, and the occurrence range and the severity of the crop diseases and insect pests often cause great losses to national economy of China, particularly agricultural production. The following kinds of plant diseases and insect pests are common for crops in China: the chemical pesticide has the advantages that rice leaf rollers, chilo suppressalis, asparagus caterpillar, plutella xylostella, rice planthoppers, powdery mildew, corn borers, cotton bollworms, wheat rust diseases, cotton aphids, rice sheath blight, rice blast, wheat aphids, wheat red spiders, locust, wheat scab and the like become serious plant diseases and insect pests seriously affecting agricultural production in China, and as chemical pesticide is used for a long time for preventing and controlling, the insect pests generate different degrees of pesticide resistance to various chemical pesticides such as organic chlorine, organic phosphorus, carbamate, pyrethroid and the like, the prevention and control effect is obviously reduced, so that farmers have to increase the dosage to improve the prevention and control effect, but the safety of agricultural products is reduced.
The flucloxapyroxad is a novel compound which is independently innovated and developed by the company, belongs to benzamide pesticides, and can efficiently activate insect ryanodine (muscle) receptors so as to excessively release calcium ions in intracellular calcium libraries, thereby leading to paralysis and death of insects. Has high activity on larvae of lepidoptera pests, broad insecticidal spectrum and good persistence. The active ingredient shows extremely obvious selectivity difference on the mammal and the pest ryanodine receptor, and the safety on the mammal and other vertebrates is greatly improved.
The biological pesticide is prepared by extracting and grinding biological metabolites serving as main insecticidal components through an artificial fermentation process, is used for killing pests, has small harm to the environment and is not easy to remain, and is one direction of the development of modern pesticides. Common biological source pesticides include avermectin, spinosad, spinetoram, bacillus thuringiensis, milbemycin, emamectin benzoate (emamectin benzoate), sucrose octacarboxylate, beauveria bassiana, metarhizium anisopliae, nuclear polyhedrosis virus, cytoplasmic polyhedrosis virus, and granulosis virus.
In the actual production process of agricultural production, the most easily generated problem of pest control is the generation of pest resistance. The composition of different action mechanisms is compounded, so that the method is a common method for preventing and controlling resistant pests. Different components are compounded, and whether certain compounding is synergistic, additive or antagonistic action is judged according to the actual application effect, and especially the compounding with obvious synergistic action and very high co-toxicity coefficient is less. The inventor researches show that the flucloxapyroxad and the biological source pesticide can produce good synergism after being compounded, and the related reports about the compounding of the flucloxapyroxad and the biological source pesticide are not disclosed.
Disclosure of Invention
The invention aims to provide an insecticidal composition containing chlorfluazuron and a biological source insecticide, which has the advantages of synergistic effect, low use cost and good control effect. The invention provides an insecticidal composition containing flucloxapyroxad and biological insecticide, wherein the effective active ingredients are active ingredients A and active ingredients B, and the weight ratio of the active ingredients A to the active ingredients B is 1: 80-80: 1, wherein the active component A is selected from flucloxapyroxad, and the active component B is selected from one of biological pesticides;
further, the active ingredient B biogenic insecticide is selected from: one of avermectin, spinosad, spinetoram, bacillus thuringiensis, milbemycin, emamectin benzoate (emamectin benzoate), sucrose octacarboxylate, beauveria bassiana, metarhizium anisopliae, nuclear polyhedrosis virus, cytoplasmic polyhedrosis virus, and granulosis virus;
further, the active ingredient B biological source pesticide is preferably avermectin, spinosad, ethyl spinosad, emamectin benzoate (emamectin benzoate) or emamectin;
the preferred weight ratio of the active ingredient A to the active ingredient B in the composition is 1: 80-80: 1, a step of;
Further, the preferable weight ratio of the flucloxapyroxad to the abamectin is 1:30-3:1; the weight ratio of the flucloxapyroxad to the spinosad is 1:30-3:1; the weight ratio of the flucloxapyroxad to the spinetoram is 1:20-5:1; the weight ratio of the flucloxapyroxad to the emamectin benzoate (emamectin benzoate) is 1:20-10:1;
further, the preferable weight ratio of the flucloxapyroxad to the avermectin is 1:20-1:1, and the weight ratio of the flucloxapyroxad to the spinosad is 1:10-2:1; the weight ratio of the flucloxapyroxad to the spinetoram is 1:10-3:1, and the weight ratio of the flucloxapyroxad to the emamectin benzoate (emamectin benzoate) is 1:5-5:1;
the invention provides an application of a flucloxapyroxad-containing insecticidal composition for controlling pests on crops, wherein the crops comprise grain crops, economic crops (oil crops, vegetable crops and hobby crops), industrial raw material crops, feed crops, medicinal crops and the like; the grain crops take rice, beans, potatoes, highland barley, broad beans and wheat as main crops; the cash crops are mainly oilseed, vines, mustard, flax, hemp, sunflower and the like; the vegetable crops mainly comprise radishes, cabbages, celery, chinese chives, garlic, onions, carrots, melons, lotus flowers, jerusalem artichoke, sword beans, coriander, lettuce, yellow flowers, peppers, cucumbers, tomatoes and the like; fruits include pear, apple, peach, apricot, walnut, plum, cherry, strawberry, chinese chestnut, etc., and wild fruits include sour pear, wild apricot, wild peach, agate, mountain cherry, sea buckthorn, strawberry, etc.; forage crops such as corn, green manure, milk vetch; the favorite crops include tobacco and coffee, and the medicinal crops include ginseng, angelica and honeysuckle;
The pests comprise lepidoptera pests and homoptera pests; preferably, the lepidoptera and homoptera insects are plutella xylostella, white fly, leafhopper, beet armyworm, cnaphalocrocis medinalis, rice planthoppers, chilo suppressalis, cotton bollworms, prodenia litura, aphids, mites and thrips;
the invention discloses an insecticidal composition containing flucloxapyroxad and biological insecticide, which consists of active ingredients and auxiliary ingredients allowed to be used by pesticides;
further, the auxiliary components of the pesticide preparation comprise a carrier and an auxiliary agent;
further, the carrier is one, two or three of water, a solvent or a filler, and the water is preferably deionized water;
further, the solvent is selected from one or more of N, N-dimethylformamide, cyclohexanone, toluene, xylene, dimethyl sulfoxide, methanol, ethanol, trimethylcyclohexanone, N-octyl pyrrolidone, ethanolamine, triethanolamine, isopropylamine, N-methylpyrrolidone, propanol, butanol, ethylene glycol, diethylene glycol, ethylene glycol methyl ether, butyl ether, ethanolamine, isopropylamine, ethyl acetate or acetonitrile;
further, the filler is selected from one or a mixture of more of kaolin, diatomite, bentonite, attapulgite, white carbon black, starch or light calcium carbonate;
Further, the auxiliary agent at least comprises a surfactant, and other functional auxiliary agents such as an antifreezing agent, a thickening agent, a stabilizing agent, a disintegrating agent, a defoaming agent and the like can be added according to different use occasions and requirements;
further, the surfactant is selected from one or four of an emulsifier, a dispersant, a wetting agent or a penetrating agent, and the surfactant is a single agent or a compound preparation of a common nonionic surfactant or an anionic surfactant;
further, the other functional auxiliary agents are selected from one or five of antifreezing agents, thickening agents, stabilizing agents, disintegrating agents and defoaming agents;
further, the emulsifier is selected from one or more of nonylphenol 500# (calcium alkylbenzenesulfonate), OP series phosphate (nonylphenol polyoxyethylene ether phosphate), 600# phosphate (phenylphenol polyoxyethylene ether phosphate), styrene polyoxyethylene ether ammonium sulfate, magnesium alkyldiphenyl ether disulfonate, triethanolamine salt, nonylphenol 400# (benzyl dimethyl phenol polyoxyethylene ether), nonylphenol 700# (alkylphenol formaldehyde resin polyoxyethylene ether), nonylphenol 36# (phenethyl phenol formaldehyde resin polyoxyethylene ether), nonylphenol 1600# (phenethyl phenol polyoxyethylene polypropylene ether), ethylene oxide-propylene oxide block copolymer, OP series (nonylphenol polyoxyethylene ether), BY series (castor oil polyoxyethylene ether), nonylphenol 33# (alkylaryl polyoxyethylene polyoxypropylene ether), span series (sorbitan monostearate) polyoxyethylene ether), tween series (sorbitan polyoxyethylene ether) or AEO series (fatty alcohol polyoxyethylene ether);
Further, the dispersing agent is selected from one or more of polycarboxylate, lignosulfonate, alkylphenol ethoxylate formaldehyde condensate sulfate, calcium alkylbenzenesulfonate, naphthalene sulfonate formaldehyde condensate sodium salt, alkylphenol ethoxylate, fatty amine ethoxylate, fatty acid ethoxylate or glycerin fatty acid ester ethoxylate;
further, the wetting agent is selected from one or a mixture of more of sodium dodecyl sulfate, sodium dodecyl benzene sulfonate, nekal BX, wetting penetrating agent F, chinese honeylocust fruit powder, silkworm excrement or soapberry powder;
further, the penetrating agent is selected from one or a mixture of more of penetrating agent JFC (fatty alcohol polyoxyethylene ether), penetrating agent T (diisooctyl maleate sulfonate), azone or organic silicon;
further, the antifreezing agent is selected from a mixture consisting of one or more of ethylene glycol, propylene glycol, glycerol or urea;
further, the thickener is selected from one or more of xanthan gum, polyvinyl alcohol, bentonite, carboxymethyl cellulose or magnesium aluminum silicate;
further, the stabilizer is selected from one or a mixture of more of epoxidized soybean oil, epichlorohydrin, BHT, ethyl acetate and triphenyl phosphate;
Further, the disintegrating agent is selected from one or a mixture of more of bentonite, urea, ammonium sulfate, aluminum chloride, low-substituted hydroxypropyl cellulose, lactose, citric acid, succinic acid or sodium bicarbonate;
further, the defoamer is selected from one or a mixture of more of silicone oil, silicone compounds, C10-C20 saturated fatty acid compounds or C8-C10 fatty alcohol compounds;
all of the above materials are commercially available.
The insecticidal composition can be processed into any dosage form acceptable in pesticides as required, wherein the preferable dosage form is wettable powder, water dispersible granules, suspending agent, suspending emulsion, aqueous emulsion and microemulsion;
further, the total weight of the active components in the composition of the invention accounts for 0.5 to 90 percent, preferably 5 to 80 percent of the total weight of the preparation; the content range of the active component is different according to different preparation types; typically, the liquid formulation contains from 1% to 70% by weight of active substance, preferably from 5% to 50%; the solid preparation contains 5-80% of active substance by weight, preferably 10-80%;
further, the composition is prepared into wettable powder, and the components and the content of the wettable powder are preferably as follows: 0.1 to 80 percent of active ingredient A, 0.1 to 60 percent of active ingredient B, 2 to 10 percent of dispersing agent, 2 to 10 percent of wetting agent and the balance of filler;
Further, the composition is prepared into water dispersible granules, and the components and the content of the water dispersible granules are preferably as follows: 0.1 to 80 percent of active ingredient A, 0.1 to 60 percent of active ingredient B, 3 to 12 percent of dispersing agent, 1 to 8 percent of wetting agent, 1 to 10 percent of disintegrating agent and the balance of filling;
further, the composition is prepared into a suspending agent, and the suspending agent comprises the following components in percentage by weight: 0.1 to 50 percent of active ingredient A, 0.1 to 50 percent of active ingredient B, 2 to 10 percent of dispersing agent, 2 to 10 percent of wetting agent, 0.01 to 2 percent of defoaming agent, 0 to 2 percent of thickening agent, 0 to 8 percent of antifreeze agent and the balance of deionized water;
further, the composition is prepared into a suspending emulsion, and the components and the content of the suspending emulsion are preferably as follows: 0.1 to 50 percent of active ingredient A, 0.1 to 50 percent of active ingredient B, 2 to 10 percent of dispersing agent, 0.01 to 2 percent of defoaming agent, 0 to 15 percent of solvent, 0 to 2 percent of thickening agent, 2 to 12 percent of emulsifying agent, 0 to 8 percent of antifreeze agent, 0 to 3 percent of stabilizing agent and the balance of deionized water;
further, the composition is prepared into an aqueous emulsion, and the components and the content of the aqueous emulsion are preferably as follows: 0.1 to 50 percent of active ingredient A, 0.1 to 50 percent of active ingredient B, 1 to 30 percent of solvent, 1 to 15 percent of emulsifier, 0 to 8 percent of antifreeze agent, 0 to 2 percent of thickening agent, 0.01 to 2 percent of defoamer and the balance of deionized water;
Further, the composition is prepared into microemulsion, and the components and the content of the microemulsion are preferably as follows: 0.1-50% of active ingredient A, 0.1-50% of active ingredient B, 1-30% of solvent, 1-15% of emulsifier and the balance of deionized water;
the invention has the advantages that: 1) After the flucloxapyroxad is compounded with the biological source pesticide, the synergistic effect is obvious; 2) After the flucloxapyroxad is compounded with the biological source pesticide, the compound pesticide has higher control activity on common lepidoptera and homoptera pests of crops; 3) The dosage of the pesticide is reduced, the residual quantity of the pesticide on crops is reduced, and the environmental pollution is lightened; 3) Is safe to people and livestock and has good environmental compatibility.
Detailed Description
The invention is further illustrated by the following examples, which are given by weight, but are not limited thereto.
Example 1:15% flucloxapyroxad-avermectin wettable powder (2:1)
The formula comprises the following components: 10% of flucloxapyroxad, 5% of abamectin, 7% of naphthalene sulfonic acid formaldehyde condensate, 4% of sodium dodecyl sulfate and the balance of kaolin.
The preparation method comprises the following steps: according to the formula proportion of the embodiment, the active ingredients of the flucloxapyroxad and the abamectin are added into a carrier, and the surfactant and other functional auxiliary agents are added into the carrier for mixing, and the wettable powder is prepared by mixing after jet milling.
Example 2:10% Fluoxabendiamide abamectin wettable powder (1:1)
The formula comprises the following components: flucoxapyroxad 5%, abamectin wettable powder 5%, lignosulfonate 6%, nekal BX5% and white carbon black complement the balance.
The preparation method comprises the following steps: as above.
Example 3:20% Flucopia-avermectin wettable powder (1:39)
The formula comprises the following components: 0.5% of flucloxapyroxad, 19.5% of abamectin, 5% of alkylphenol ethoxylates, 3% of wetting penetrating agent F and the balance of diatomite.
The preparation method comprises the following steps: as above.
Example 4:12% Flucarbamide spinosad wettable powder (1:5)
The formula comprises the following components: 2% of flucloxapyroxad, 10% of spinosad, 3% of polycarboxylate, 1% of fatty amine polyoxyethylene ether, 3% of sodium dodecyl benzene sulfonate and the balance of kaolin.
The preparation method comprises the following steps: as above.
Example 5:15% Flucoxafen-spinosad wettable powder (2:1)
The formula comprises the following components: flucarbazide 10%, spinosad 5%, polycarboxylate 7%, sodium dodecyl benzene sulfonate 4% and kaolin balance.
The preparation method comprises the following steps: as above.
Example 6:25% Flucarbamide spinosad wettable powder (4:1)
The formula comprises the following components: 20% of flucloxapyroxad, 5% of spinosad, 6% of fatty amine polyoxyethylene ether, 4% of sodium dodecyl benzene sulfonate and the balance of kaolin.
The preparation method comprises the following steps: as above.
Example 7:25% Flucoxapa-spinetoram wettable powder (4:1)
The formula comprises the following components: 20% of flucloxapyroxad, 5% of spinetoram, 7% of fatty amine polyoxyethylene ether, 4% of sodium dodecyl benzene sulfonate and the balance of diatomite.
The preparation method comprises the following steps: as above.
Example 8:11% Flucoxapa-spinetoram wettable powder (10:1)
The formula comprises the following components: flucarbazone diamide 10%, spinetoram 1%, fatty amine polyoxyethylene ether 3.5%, nekal BX3% and diatomite for the rest.
The preparation method comprises the following steps: as above.
Example 9:25% Flucoxapa-emamectin-benzoate wettable powder (4:1)
The formula comprises the following components: 20% of flucloxapyroxad, 5% of emamectin benzoate, 5% of lignosulfonate, 3% of sodium dodecyl benzene sulfonate and 2% of nekal BX. The kaolin is used for supplementing the balance.
The preparation method comprises the following steps: as above.
Example 10:6% Flucoxapa-emamectin-benzoate wettable powder (5:1)
The formula comprises the following components: 6% of flucloxapyroxad, 1% of emamectin benzoate, 3% of lignosulfonate and 4% of nekal BX. The kaolin is used for supplementing the balance.
The preparation method comprises the following steps: as above.
Example 11:4% Fluobendiamide emamectin benzoate wettable powder (1:3)
The formula comprises the following components: 1% of flucloxapyroxad, 3% of emamectin benzoate, 1.5% of lignosulfonate and 2% of nekal BX. White carbon black makes up the balance.
The preparation method comprises the following steps: as above.
Example 12:9% Flucoxapa-emamectin-benzoate wettable powder (1:2)
The formula comprises the following components: 3% of flucloxapyroxad, 6% of emamectin benzoate, 3.5% of fatty amine polyoxyethylene ether, 3% of nekal BX and the balance of diatomite.
The preparation method comprises the following steps: as above.
Example 13:8% flucloxapyroxad-avermectin water dispersible granule (3:1)
The formula comprises the following components: 6% of flucloxapyroxad, 2% of abamectin, 4% of lignosulfonate, 3% of sodium dodecyl benzene sulfonate, 5% of aluminum chloride and the balance of white carbon black.
The preparation method comprises the following steps: according to the formula proportion of the embodiment, the active ingredients of the flucloxapyroxad and the abamectin are added into a carrier, and the surfactant and other functional additives are added into the carrier, mixed, crushed by air flow, added with 10 to 25 percent of water, and then kneaded, granulated, dried and screened to prepare a water dispersible granule product; or spraying water, granulating, drying, and sieving to obtain the final product.
Example 14:12% flucloxapyroxad-avermectin water dispersible granule (1:1)
The formula comprises the following components: 6% of flucloxapyroxad, 6% of abamectin, 5% of naphthalene sulfonic acid formaldehyde condensate sodium salt, 5% of nekal BX, 3% of bentonite and the balance of kaolin.
The preparation method comprises the following steps: as above.
Example 15:30% flucloxapyroxad-avermectin water dispersible granule (1:29)
The formula comprises the following components: 1% of flucloxapyroxad, 29% of abamectin, lignosulfonate, nekal BX, aluminum chloride and kaolin are used for the balance.
The preparation method comprises the following steps: as above.
Example 16:30% flucloxapyroxad spinosad water dispersible granule (1:2)
The formula comprises the following components: 10% of flucloxapyroxad, 20% of spinosad, 4% of naphthalene sulfonic acid formaldehyde condensate sodium salt, 6% of sodium dodecyl benzene sulfonate, 6% of bentonite and the balance of white carbon black.
The preparation method comprises the following steps: as above.
Example 17:10% flucloxapyroxad spinosad water dispersible granule (3:2)
The formula comprises the following components: 6% of flucloxapyroxad, 4% of spinosad, 8% of lignosulfonate, 5% of nekal BX, 4% of aluminum chloride and the balance of white carbon black.
The preparation method comprises the following steps: as above.
Example 18:25% flucloxapyroxad spinosad water dispersible granule (24:1)
The formula comprises the following components: 24% of flucloxapyroxad, 1% of spinosad, 4% of naphthalene sulfonic acid formaldehyde condensate sodium salt, 6% of sodium dodecyl benzene sulfonate, 7% of bentonite and the balance of white carbon black.
The preparation method comprises the following steps: as above.
Example 19:30% flucloxapyroxad-spinetoram water dispersible granule (1:29)
The formula comprises the following components: 1% of flucloxapyroxad, 29% of spinetoram, 3% of lignosulfonate, 7% of nekal BX, 5% of aluminum chloride and the balance of kaolin.
The preparation method comprises the following steps: as above.
Example 20:15% flucloxapyroxad-spinetoram water dispersible granule (1:2)
The formula comprises the following components: 5% of flucloxapyroxad, 10% of spinetoram, 5% of lignosulfonate, 4% of sodium dodecyl benzene sulfonate, 3% of bentonite and the balance of white carbon black.
The preparation method comprises the following steps: as above.
Example 21:45% flucloxapyroxad-spinetoram water dispersible granule (14:1)
The formula comprises the following components: fluchiodiamide 42%, spinetoram 3%, naphthalene sulfonic acid formaldehyde condensate sodium salt 5%, nekal BX4%, aluminum chloride 8% and kaolin balance.
The preparation method comprises the following steps: as above.
Example 22:25% flucloxapyroxad emamectin benzoate water dispersible granule (4:1)
The formula comprises the following components: 20% of flucloxapyroxad, 5% of emamectin benzoate, 5% of lignosulfonate, 6% of sodium dodecyl benzene sulfonate, 7% of bentonite and the balance of white carbon black.
The preparation method comprises the following steps: as above.
Example 23:6% Flucoxapa-emamectin-water dispersible granule (5:1)
The formula comprises the following components: flucoxapyroxad 5%, emamectin benzoate 1%, naphthalene sulfonic acid formaldehyde condensate sodium salt 6%, nekal BX8%, aluminum chloride 6%, and kaolin balance.
The preparation method comprises the following steps: as above.
Example 24:4% Fluobendiamide emamectin benzoate water dispersible granule (1:3)
The formula comprises the following components: 1% of flucloxapyroxad, 3% of emamectin benzoate, 5% of lignosulfonate, 8% of sodium dodecyl benzene sulfonate, 6% of aluminum chloride and the balance of kaolin.
The preparation method comprises the following steps: as above.
Example 25:10% Fluoxabendiamide avermectin suspending agent (2:3)
The formula comprises the following components: 4% of flucloxapyroxad, 6% of abamectin, 4% of lignosulfonate, 5% of sodium dodecyl sulfate, 0.5% of silicone oil, 0.8% of xanthan gum, 3% of urea and the balance of deionized water.
The preparation method comprises the following steps: according to the formula proportion, the active ingredients of flucloxapyroxad, abamectin, surfactant and other functional auxiliary agents are sequentially placed in a reaction kettle, water is added and mixed uniformly, and the product is obtained through high-speed shearing, wet sanding and homogenizing and filtering.
Example 26:4% Fluoxabendiamide avermectin suspending agent (1:3)
The formula comprises the following components: 1% of flucloxapyroxad, 3% of abamectin, 6% of alkylphenol ethoxylates, 5% of sodium dodecyl sulfate, 0.4% of silicone oil, 1% of xanthan gum, 4% of urea and the balance of deionized water.
The preparation method comprises the following steps: as above.
Example 27:15% Fluobendiamide avermectin suspension (4:1)
The formula comprises the following components: 12% of flucloxapyroxad, 3% of abamectin, 5% of alkylphenol ethoxylate, 3.8% of nekal BX, 0.5% of silicone oil, 1% of xanthan gum, 3% of urea and the balance of deionized water.
The preparation method comprises the following steps: as above.
Example 28:32% Flucarbamide spinosad suspension (1:3)
The formula comprises the following components: 8% of flucloxapyroxad, 24% of spinosad, 5% of lignosulfonate, 4% of nekal BX, 0.6% of silicone oil, 1% of xanthan gum, 3% of glycol and the balance of deionized water.
The preparation method comprises the following steps: as above.
Example 29:30% Flucopiamide spinosad suspension (1:2)
The formula comprises the following components: 10% of flucloxapyroxad, 20% of spinosad, 8% of alkylphenol ethoxylates, 5% of sodium dodecyl sulfate, 1.6% of silicone oil, 0.9% of xanthan gum, 7% of urea and the balance of deionized water.
The preparation method comprises the following steps: as above.
Example 30:20% Flucopiamide spinosad suspension (19:1)
The formula comprises the following components: 19% of flucloxapyroxad, 1% of spinosad, 4% of lignosulfonate, 2.8% of nekal BX, 0.6% of silicone oil, 0.9% of xanthan gum, 5% of ethylene glycol and the balance of deionized water.
The preparation method comprises the following steps: as above.
Example 31:20% Flucoxapa-spinetoram suspension (3:2)
The formula comprises the following components: 12% of flucloxapyroxad, 8% of spinetoram, 4% of alkylphenol ethoxylates, 2.8% of sodium dodecyl sulfate, 0.7% of silicone oil, 1% of xanthan gum, 4% of urea and the balance of deionized water.
The preparation method comprises the following steps: as above.
Example 32:12% Flucoxapa-spinetoram suspension (1:2)
The formula comprises the following components: 4% of flucloxapyroxad, 8% of spinetoram, 5% of lignosulfonate, 3% of nekal BX, 0.5% of silicone oil, 1.2% of xanthan gum, 3% of glycol and the balance of deionized water.
The preparation method comprises the following steps: as above.
Example 33:15% Flucoxapa-spinetoram suspension (2:1)
The formula comprises the following components: 10% of flucloxapyroxad, 5% of spinetoram, 5% of alkylphenol ethoxylate, 4% of nekal BX, 0.6% of silicone oil, 1% of xanthan gum, 3% of urea and the balance of deionized water.
The preparation method comprises the following steps: as above.
Example 34:4% Fluobendiamide emamectin-benzoate suspending agent (1:3)
The formula comprises the following components: 1% of flucloxapyroxad, 3% of emamectin benzoate, 6% of lignosulfonate, 5% of sodium dodecyl sulfate, 0.6% of silicone oil, 1% of xanthan gum, 4% of ethylene glycol and the balance of deionized water.
The preparation method comprises the following steps: as above.
Example 35:12% Fluobendiamide emamectin-benzoate suspending agent (5:1)
The formula comprises the following components: 10% of flucloxapyroxad, 2% of emamectin benzoate, 4% of alkylphenol ethoxylates, 5% of nekal BX, 0.5% of silicone oil, 0.7% of xanthan gum, 5% of urea and the balance of deionized water.
The preparation method comprises the following steps: as above.
Example 36:20% Fluobendiamide emamectin-benzoate suspending agent (19:1)
The formula comprises the following components: 19% of flucloxapyroxad, 1% of emamectin benzoate, 4% of lignosulfonate, 3.2% of nekal BX, 0.9% of silicone oil, 2% of xanthan gum, 2% of glycol and the balance of deionized water.
The preparation method comprises the following steps: as above.
Example 37:6% Flucopia-avermectin suspension emulsion (2:1)
The formula comprises the following components: 4% of flucloxapyroxad, 2% of abamectin, 6% of lignosulfonate, 0.5% of amide, 7% of ethanol, 1% of gelatin, 6% of calcium alkylbenzenesulfonate, 8% of glycerol, 1.5% of ethyl acetate and the balance of deionized water.
The preparation method comprises the following steps: adding solvent and surfactant into the active ingredient flucloxapyroxad according to the formula proportion of the embodiment, adding water, uniformly mixing, and preparing into aqueous emulsion by high-speed shearing; adding avermectin as active component into carrier, adding surfactant and other functional assistant, adding water, mixing, high-speed shearing, wet sanding to obtain suspending agent, high-speed shearing the suspending agent and water emulsion, homogenizing and filtering to obtain the final product.
Example 38:15% Flucopia-avermectin suspension emulsion (4:1)
The formula comprises the following components: 12% of flucloxapyroxad, 3% of abamectin, 5% of alkylphenol ethoxylates, 0.5% of organosilicon, 8% of ethanol, 1% of xanthan gum, 8% of alkylphenol formaldehyde resin polyoxyethylene ether, 4% of glycerol, 2% of ethyl acetate and the balance of deionized water.
The preparation method comprises the following steps: as above.
Example 39:15% Flucopia-spinosad suspoemulsion (2:3)
The formula comprises the following components: 6% of flucloxapyroxad, 9% of spinosad, 5% of alkylphenol ethoxylates, 0.5% of amide, 8% of ethanol, 0.6% of gelatin, 8% of calcium alkylbenzenesulfonate, 5% of glycerol, 3% of ethyl acetate and the balance of deionized water.
The preparation method comprises the following steps: as above.
Example 40:15% Flucopia-spinosad suspoemulsion (1:2)
The formula comprises the following components: 5% of flucloxapyroxad, 10% of spinosad, 5% of lignosulfonate, 0.6% of amide, 9% of ethanol, 0.7% of xanthan gum, 9% of calcium alkylbenzenesulfonate, 6% of glycerol, 2% of ethyl acetate and the balance of deionized water.
The preparation method comprises the following steps: as above.
Example 41:20% Flucopia-spinetoram suspension emulsion (2:3)
The formula comprises the following components: 8% of flucloxapyroxad, 12% of spinetoram, 5% of alkylphenol ethoxylates, 0.4% of organic silicon, 8% of ethanol, 0.5% of gelatin, 8% of alkylphenol formaldehyde resin polyoxyethylene ether, 4% of glycerol, 2.5% of ethyl acetate and the balance of deionized water.
The preparation method comprises the following steps: as above.
Example 42:30% Flucopia-spinetoram suspension emulsion (4:1)
The formula comprises the following components: 24% of flucloxapyroxad, 6% of spinetoram, 6% of lignosulfonate, 0.5% of amide, 6% of ethanol, 0.5% of xanthan gum, 9% of calcium alkylbenzenesulfonate, 6% of glycerol, 2% of ethyl acetate and the balance of deionized water.
The preparation method comprises the following steps: as above.
Example 43:5% Flucopia-emamectin-benzoate suspoemulsion (4:1)
The formula comprises the following components: 4% of flucloxapyroxad, 1% of emamectin benzoate, 5% of alkylphenol ethoxylates, 0.8% of organic silicon, 8% of ethanol, 1% of gelatin, 7% of alkylphenol formaldehyde resin polyoxyethylene ether, 5% of glycerol, 1% of ethyl acetate and the balance of deionized water.
The preparation method comprises the following steps: as above.
Example 44:4% Flucopia-emamectin-benzoate suspoemulsion (1:3)
The formula comprises the following components: 1% of flucloxapyroxad, 3% of emamectin benzoate, 4% of lignosulfonate, 0.5% of organic silicon, 7% of ethanol, 1% of xanthan gum, 8% of calcium alkyl benzene sulfonate, 6% of glycerol, 2% of ethyl acetate and the balance of deionized water.
The preparation method comprises the following steps: as above.
Example 45:10% flucloxapyroxad-avermectin emulsion in water (3:2)
The formula comprises the following components: 6% of flucloxapyroxad, 4% of abamectin, 6% of lignosulfonate, 0.5% of amide, 7% of ethanol, 1% of gelatin, 6% of calcium alkyl benzene sulfonate, 8% of glycerol and the balance of deionized water.
The preparation method comprises the following steps: the active ingredients of flucloxapyroxad and abamectin are added together with solvent, emulsifier and cosolvent according to the formula proportion of the embodiment, so as to be dissolved into uniform oil phase; mixing part of water, antifreeze and other pesticide auxiliary agents to form a uniform water phase; adding the oil phase into the water phase while stirring at high speed in a reaction kettle, slowly adding water until reaching a phase inversion point, starting a shearing machine to conduct high-speed shearing, adding the rest water, and shearing for about half an hour to form the aqueous emulsion.
Example 46:6% flucloxapyroxad-avermectin emulsion in water (1:2)
The formula comprises the following components: 2% of flucloxapyroxad, 4% of abamectin, 0.5% of amide, 8% of ethanol, 0.6% of gelatin, 8% of calcium alkylbenzenesulfonate, 5% of glycerol and the balance of deionized water.
The preparation method comprises the following steps: as above.
Example 47:10% Flucopiamide spinosad emulsion in water (1:1)
The formula comprises the following components: 5% of flucloxapyroxad, 5% of spinosad, 0.5% of organosilicon, 8% of ethanol, 1% of xanthan gum, 8% of alkylphenol formaldehyde resin polyoxyethylene ether, 4% of glycerol and the balance of deionized water.
The preparation method comprises the following steps: as above.
Example 48:40% flucloxapyroxad spinosad emulsion in water (1:19)
The formula comprises the following components: 2% of flucloxapyroxad, 38% of spinosad, 0.8% of organosilicon, 8% of ethanol, 1% of gelatin, 7% of alkylphenol formaldehyde resin polyoxyethylene ether, 5% of glycerol and the balance of deionized water.
The preparation method comprises the following steps: as above.
Example 49:30% flucloxapyroxad-spinetoram aqueous emulsion (1:1)
The formula comprises the following components: 15% of flucloxapyroxad, 15% of spinetoram, 0.5% of amide, 7% of ethanol, 1% of gelatin, 6% of calcium alkylbenzenesulfonate, 8% of glycerol and the balance of deionized water.
The preparation method comprises the following steps: as above.
Example 50:25% flucloxapyroxad-spinetoram aqueous emulsion (1:24)
The formula comprises the following components: 1% of flucloxapyroxad, 24% of spinetoram, 0.5% of amide, 6% of ethanol, 0.5% of xanthan gum, 9% of calcium alkylbenzenesulfonate, 6% of glycerol and the balance of deionized water.
The preparation method comprises the following steps: as above.
Example 51:4% Fluobendiamide emamectin-water emulsion (1:3)
The formula comprises the following components: 1% of flucloxapyroxad, 3% of emamectin benzoate, 0.5% of amide, 6% of ethanol, 0.5% of xanthan gum, 9% of calcium alkylbenzenesulfonate, 6% of glycerol and the balance of deionized water.
The preparation method comprises the following steps: as above.
Example 52:20% Flucopia-emamectin-water emulsion (9:1)
The formula comprises the following components: 18% of flucloxapyroxad, 2% of emamectin benzoate, 0.5% of organosilicon, 7% of ethanol, 1% of xanthan gum, 8% of calcium alkyl benzene sulfonate, 6% of glycerol and the balance of deionized water.
The preparation method comprises the following steps: as above.
Example 53:5% Flucopia-avermectin microemulsion (1:4)
The formula comprises the following components: 1% of flucloxapyroxad, 4% of abamectin, 3% of N, N-dimethylformamide, 11% of calcium alkylbenzenesulfonate and the balance of deionized water.
The preparation method comprises the following steps: according to the formula proportion of the embodiment, the active ingredients of the flucloxapyroxad, the avermectin and the cosolvent are completely dissolved, then other auxiliary agents are added, the mixture is uniformly mixed, finally water is added, and the product is obtained after full stirring.
Example 54:6% Flucopia-avermectin microemulsion (1:1)
The formula comprises the following components: 3% of flucloxapyroxad, 3% of abamectin, 5% of N, N-dimethylformamide, 9% of alkylphenol formaldehyde resin polyoxyethylene ether and the balance of deionized water.
The preparation method comprises the following steps: as above.
Example 55:5% Flucopiamide spinosad microemulsion (2:3)
The formula comprises the following components: 2% of flucloxapyroxad, 3% of spinosad, 6% of N, N-dimethylformamide, 9% of calcium alkylbenzenesulfonate and the balance of deionized water.
The preparation method comprises the following steps: as above.
Example 56:7.5% Flucopia-spinosad microemulsion (1:2)
The formula comprises the following components: 2.5% of flucloxapyroxad, 5% of spinosad, 4% of N, N-dimethylformamide, 9% of alkylphenol formaldehyde resin polyoxyethylene ether and the balance of deionized water.
The preparation method comprises the following steps: as above.
Example 57:10% Flucoxapa-spinetoram microemulsion (1:3)
The formula comprises the following components: 2.5% of flucloxapyroxad, 7.5% of spinetoram, 5% of N, N-dimethylformamide, 12% of calcium alkylbenzenesulfonate and the balance of deionized water.
The preparation method comprises the following steps: as above.
Example 58:6% Flucoxapa-spinetoram microemulsion (2:1)
The formula comprises the following components: 4% of flucloxapyroxad, 2% of spinetoram, 6% of N, N-dimethylformamide, 14% of alkylphenol formaldehyde resin polyoxyethylene ether and the balance of deionized water.
The preparation method comprises the following steps: as above.
Example 59:4% Fluobendiamide emamectin-benzoate microemulsion (1:3)
The formula comprises the following components: 1% of flucloxapyroxad, 3% of emamectin benzoate, 7% of N, N-dimethylformamide, 2% of calcium alkylbenzenesulfonate and the balance of deionized water.
The preparation method comprises the following steps: as above.
Example 60:10% Flucopia-emamectin-benzoate microemulsion (9:1)
The formula comprises the following components: 9% of flucloxapyroxad, 1% of emamectin benzoate, 1% of N, N-dimethylformamide, 11% of alkylphenol formaldehyde resin polyoxyethylene ether and the balance of deionized water.
The preparation method comprises the following steps: as above.
The avermectin, spinosad, spinetoram, emamectin benzoate, and emamectin benzoate in preparation examples 1 to 60 are exchanged to prepare a new preparation.
Indoor active cases
The embodiment of the invention adopts a method combining indoor toxicity measurement and field test. Firstly, determining the co-toxicity coefficient (CTC) of two medicaments compounded according to a certain proportion through indoor toxicity measurement, wherein CTC is smaller than 80 and antagonistic action, CTC is larger than 120 and synergistic action is between 80 and 120, and then carrying out field test on the basis.
The test method comprises the following steps: soaking leaf in the liquid for 5s, taking out, naturally drying, placing into insect-breeding box, inoculating test larva, breeding at 25deg.C, repeating for 4 times, repeating 20 times, checking dead number at 48 hr, calculating death rate and correcting death rate, calculating virulence regression equation, and calculating LC 50 Values were considered as invalid if the control mortality was > 10%. The calculation formula is as follows:
in LC form 50 The agent having a relatively small value is a standard agent, and its toxicity index TI is 100.
Toxicity index of the mixture tti=ti A ×P A +TI B ×P B
Wherein: p (P) A 、P B The proportion of the active ingredient A, B in the composition is respectively.
A is flucloxapyroxad.
B is one of avermectin, spinosad, spinetoram and emamectin benzoate.
Example 61: combined toxicity of flucloxapyroxad and abamectin to rice stem borer
Test pest: rice stem borer
Test agent: the fipronil diamide technical and the avermectin technical are provided by the sea li pharmaceutical company group Co.
And (3) test design: experiments prove that the half-Lethal Concentration (LC) of the mixture of the flucloxapyroxad original drug and the avermectin original drug in different proportions 50 ) And the co-toxicity coefficient is used for determining the combined action type of the flucloxapyroxad and abamectin mixed pair on rice stem borer.
TABLE 1 toxicity determination results of Fluochlorantraniliprole and abamectin mixture on rice stem borer
As shown in Table 1, when the ratio of flucloxapyroxad to abamectin to rice stem borer is 1:80-80:1, the co-toxicity coefficients are all greater than 80, which indicates that the two are mixed within the range of 1:80-80:1 to show additive or synergistic effect and no antagonism; when the mixing weight ratio of the flucloxapyroxad to the abamectin is 1:50-30:1, the co-toxicity coefficients are all larger than 120, which indicates that the flucloxapyroxad and the abamectin show synergistic effect in the mixing weight ratio range; when the mixing weight ratio of the flucloxapyroxad to the abamectin is 1:20-1:1, the co-toxicity coefficients are all larger than 170, which indicates that the flucloxapyroxad and the abamectin show obvious synergy in the mixing weight ratio range; when the mixing weight ratio of the flucloxapyroxad to the abamectin is 1:20-1:1, the co-toxicity coefficients are all larger than 200, which indicates that the synergistic effect of the flucloxapyroxad and the abamectin is more prominent in the mixing weight ratio range.
The inventor experiments find that the flucloxapyroxad and abamectin have obvious synergistic effect on the control of lepidoptera and homoptera insects such as plutella xylostella, white fly, leafhopper, asparagus caterpillar, cnaphalocrocis medinalis, rice planthopper, cotton bollworm, prodenia litura, aphid, mites and thrips of various crops when the mixing ratio is 1:20, 1:10, 1:5, 1:3, 1:2 and 1:1, and the synergistic effect is obvious, and the co-toxicity coefficient is larger than 120.
Example 62: combined toxicity of flucloxapyroxad and spinosad to rice planthoppers
Test pest: rice planthoppers
Test agent: the flucloxapyroxad technical and the spinosad technical are all provided by the Heilier pharmaceutical company, inc.
And (3) test design: experiments prove that the half-Lethal Concentration (LC) of the flucloxapyroxad original drug and the spinosad original drug and the mixture of the two different proportions 50 ) And co-toxicity coefficient to determine the combined action type of the flucloxapyroxad and spinosad on the rice planthoppers.
TABLE 2 toxicity Activity of Fluocloprid bisamide and spinosad on Rice planthoppers
As shown in Table 2, when the flucloxapyroxad and spinosad are mixed in the range of 1:80-80:1 on rice planthoppers, the co-toxicity coefficients are all larger than 80, which indicates that the flucloxapyroxad and spinosad both have additive or synergistic effects in the range of 1:80-80:1, and no antagonism is generated; when the mixing weight ratio of the flucloxapyroxad to the spinosad is 1:50-30:1, the co-toxicity coefficients are all larger than 120, which indicates that the flucloxapyroxad and the spinosad are synergistic in the mixing weight ratio range; when the mixing weight ratio of the flucloxapyroxad to the spinosad is 1:30-3:1, the co-toxicity coefficients are all larger than 170, which indicates that the flucloxapyroxad and the spinosad are obviously synergistic in the mixing weight ratio range; when the mixing weight ratio of the flucloxapyroxad to the spinosad is 1:10-2:1, the co-toxicity coefficients are both greater than 200, which indicates that the synergistic effect of the flucloxapyroxad and the spinosad is more prominent in the mixing weight ratio range.
The inventor experiments find that the flucloxafen and spinosad have obvious synergism on the control of lepidoptera and homoptera insects such as plutella xylostella, white fly, leafhopper, asparagus caterpillar, cnaphalocrocis medinalis, chilo suppressalis, cotton bollworms, prodenia litura, aphids, mites and thrips of various crops when the mixing ratio of the flucloxafen to the spinosad is 1:10, 1:5, 1:3, 1:2, 1:1 and 2:1, and the synergistic effect is obvious, and the co-toxicity coefficient is more than 120.
Example 63: combined toxicity of flucloxapyroxad and spinetoram on cabbage looper
Test pest: cabbage beet armyworm
Test agent: the flucloxapyroxad technical and the spinetoram technical are all provided by the Heilier pharmaceutical company, inc.
And (3) test design: experiments prove that the half-Lethal Concentration (LC) of the mixture of the flucloxapyroxad original drug and the spinetoram original drug with different proportions 50 ) And the co-toxicity coefficient is used for determining the combined action type of the flucloxapyroxad and spinetoram mixed pair cabbage looper.
TABLE 3 toxicity measurement results of Fluocloprid bisamide and spinetoram
/>
From Table 3, when the ratio of flucloxapyroxad to spinetoram is 1:80-80:1, the co-toxicity coefficients are all greater than 80, which indicates that the two are mixed within the range of 1:80-80:1 to show additive or synergistic effect and no antagonism; when the mixing weight ratio of the flucloxapyroxad to the spinetoram is 1:50-30:1, the co-toxicity coefficients are all larger than 120, which indicates that the flucloxapyroxad and the spinetoram are synergistic within the mixing weight ratio range; when the mixing weight ratio of the flucloxapyroxad to the spinetoram is 1:20-5:1, the co-toxicity coefficients are all larger than 170, which indicates that the flucloxapyroxad and the spinetoram are obviously synergistic in the mixing weight ratio range; when the mixing weight ratio of the flucloxapyroxad to the spinetoram is 1:10-3:1, the co-toxicity coefficients are all larger than 200, which indicates that the synergistic effect of the flucloxapyroxad and the spinetoram is more prominent in the mixing weight ratio range.
The inventor experiments find that the flucloxapyroxad and spinetoram have obvious synergism on the control of lepidoptera and homoptera insects such as plutella xylostella, white fly, leafhoppers, cnaphalocrocis medinalis, chilo suppressalis, rice planthoppers, cotton bollworms, prodenia litura, aphids, mites and thrips when the mixing ratio of the flucloxapyroxad to the spinetoram is 1:10, 1:5, 1:3, 1:2, 1:1, 2:1 and 3:1, and the synergistic effect is obvious, and the co-toxicity coefficient is more than 120.
Example 64: combined toxicity of flucloxapyroxad and emamectin benzoate on cabbage aphids
Test pest: cabbage aphid
Test agent: the fipronil diamide technical and the emamectin-block technical are provided by the Hailier pharmaceutical company, inc.
And (3) test design: experiments prove that the half-Lethal Concentration (LC) of the mixture of the flucloxapyroxad original drug and the emamectin benzoate in different proportions 50 ) And the co-toxicity coefficient is used for determining the combined action type of the flucloxapyroxad and emamectin benzoate for cabbage aphids.
TABLE 4 toxicity determination results of Fluoxadiamide and emamectin benzoate to cabbage aphids
/>
From Table 4, it can be seen that when the ratio of flucloxapyroxad to emamectin benzoate to white vegetable aphid is 1:80-80:1, the co-toxicity coefficient is greater than 80, which indicates that the two are mixed within the range of 1:80-80:1 to show additive or synergistic effect and no antagonism; when the mixing weight ratio of the flucloxapyroxad to the emamectin benzoate is 1:50-50:1, the co-toxicity coefficients are all larger than 120, which indicates that the flucloxapyroxad and the emamectin benzoate are synergistic within the mixing weight ratio range; when the mixing weight ratio of the flucloxapyroxad to the emamectin benzoate is 1:20-10:1, the co-toxicity coefficients are all greater than 170, which indicates that the flucloxapyroxad and the emamectin benzoate are obviously synergistic within the mixing weight ratio range; when the mixing weight ratio of the flucloxapyroxad to the emamectin benzoate is 1:5-5:1, the co-toxicity coefficients are all larger than 200, which indicates that the synergistic effect of the flucloxapyroxad and the emamectin benzoate is more prominent in the mixing weight ratio range.
The inventor experiments find that the flucloxapyroxad and emamectin benzoate have obvious synergism on the control of lepidoptera and homoptera insects such as plutella xylostella, whiteflies, leafhoppers, cnaphalocrocis medinalis, chilo suppressalis, rice planthoppers, cotton bollworms, prodenia litura, aphids, mites and thrips of various crops when the mixing ratio of the flucloxapyroxad to the emamectin benzoate is 1:3, 1:2, 1:1, 2:1 and 3:1, and the synergistic effect is obvious, and the co-toxicity coefficient is more than 120.
Case of field efficacy
The test medicament is researched and developed by the research and development center of the Hailier pharmaceutical industry group Co-Ltd, and the control medicament is selected from 10% flucloxapyroxad bisamide suspending agent, 5% avermectin emulsifiable concentrate, 10% spinosad suspending agent, 25% spinetoram water dispersible granule and 3% emamectin benzoate microemulsion, and is self-prepared.
Example 65: and (3) performing field pesticide effect test on the cabbage plutella xylostella by compounding the flubendiamide and the active ingredient B.
Test agent and field treatment: the test agents and amounts are shown in Table 5; the trial was set up for 4 replicates per treatment.
The test method comprises the following steps: according to the test design amount, the area of each processed cell is 15m 2 Repeat 4 times, randomization block arrangement. The number of insect population was investigated before administration and the control effect was investigated on days 1, 3 and 7 after administration. And 5 strains of fixed-point investigation and test of the larva quantity of each instar are selected by adopting a random 5-point sampling method. The number of remaining insect population was investigated on days 1, 3 and 7 after each treatment of drug administration.
Data analysis:
percent reduction of insect population = (number of insect population before treatment-number of insect population after treatment)/number of insect population before treatment x 100
Correction = (rate of reduction of insect population in treatment area-rate of reduction of insect population in control area) ×100/(100-rate of reduction of insect population in control area)
Test results: see table 5.
TABLE 5 results of experiments on efficacy of Fluochlorantraniliprole and active ingredient B in controlling cabbage diamond back moth
From Table 5, it is clear that the combination of the flucloxapyroxad and the active ingredient B can effectively control cabbage moth. The prevention effect is 71.54-73.01% 1 day after the application, and the prevention effect is higher than that of a single agent, but the prevention effect is general; the prevention effect is 81.09% -89% after 3 days of medicine, 86.95% -90.55% after 7 days of medicine, and is higher than that of single dosage, and the prevention effect accords with the drug effect index.
Within the application range of the test, the safety of target crops is not affected.
Example 66: the efficacy test of the flucloxapyroxad and the active ingredient B for preventing and controlling cabbage and beet armyworm is carried out by mixing.
Test agent and field treatment: the test agents and amounts are shown in Table 6; the trial was set up for 4 replicates per treatment.
The test method comprises the following steps: each application was repeated 1 time for 4 treatments according to the experimental design dose. 5 points were sampled prior to application, 2 cabbage markers were selected for each point, and the number of insect population was investigated. The number of live insects on the cabbage is investigated and marked 1 day, 3 days and 7 days after the application. Calculating the rate of reduction of insect population and correcting the control effect.
Data analysis:
percent reduction of insect population = (number of insect population before treatment-number of insect population after treatment)/number of insect population before treatment x 100
Correction = (rate of reduction of insect population in treatment area-rate of reduction of insect population in control area) ×100/(100-rate of reduction of insect population in control area)
Test results: see Table 6
Table 6 results of experiments on efficacy of Fluocloprid bisamide and active ingredient B in controlling cabbage and beet armyworm
As shown in table 6, after the flucloxapyroxad and the active ingredient B are mixed, cabbage looper can be effectively prevented and controlled, the prevention effect is not ideal 1 day after the application of the test agent, and the prevention effect is 65.44% -72.34%; the prevention effect is obvious after 3 days of medicine, and is 80.54 to 86.85 percent compared with a single dose; the prevention effect after 7 days of administration is obviously better than that of a single dose, and the prevention effect reaches more than 90%.
The test result shows that the test agent has general quick-acting property for preventing and controlling asparagus caterpillar, but has stronger lasting effect. However, compared with a single dose, the test agent can be obviously better than the single dose in preventing effect after 3 days of administration. Within the application range of the test, the safety of target crops is not affected.
Example 67: the efficacy test of the flucloxapyroxad and the active ingredient B for preventing and controlling rice stem borer.
Test agent and field treatment: the test agents and amounts are shown in Table 7; the trial was set up for 4 replicates per treatment.
The test method comprises the following steps: each application was repeated 1 time for 4 treatments according to the experimental design dose. 5 points were sampled prior to application, 2 cabbage markers were selected for each point, and the number of insect population was investigated. The number of live insects on the cabbage is investigated and marked 1 day, 3 days and 7 days after the application. Calculating the rate of reduction of insect population and correcting the control effect.
Data analysis:
percent reduction of insect population = (number of insect population before treatment-number of insect population after treatment)/number of insect population before treatment x 100
Correction = (rate of reduction of insect population in treatment area-rate of reduction of insect population in control area) ×100/(100-rate of reduction of insect population in control area)
Table 7 results of test on efficacy of Flucopiae bisamide and active ingredient B in controlling rice stem borer
As shown in Table 7, after the flucloxapyroxad and the active ingredient B are mixed, the rice stem borer can be effectively prevented and treated, and the lasting period is long. 1 day after the application, the control effect is 71.24 to 74.04 percent, and compared with the single-dose control effect, the single-dose control effect has no obvious advantage; 3 days after the application, the control effect is 85.52% -90.82%, and the control effect is better than that of a single agent; the prevention effect is 89.51% -92.07% after 7 days of drug application, and the prevention effect is obviously better than that of a single dose. Within the application range of the test, the safety of target crops is not affected.
Example 68: the efficacy test of the flucloxapyroxad and the active ingredient B for preventing and controlling rice planthoppers.
Test agent and field treatment: the test agents and amounts are shown in Table 8; the trial was set up for 4 replicates per treatment.
The test method comprises the following steps: the test cells were arranged in a random block of 4 replicates per treatment. The pesticide effect investigation adopts a parallel jump method, 10 points are investigated in each district, 2 rice clusters are investigated in each point, the rice clusters are beaten or shaken, the number of the plant hoppers floating on the water surface among the rice clusters is counted, the number of insect pests is investigated before pesticide application, the number of residual insects is investigated 3 days, 7 days and 14 days after pesticide application, and the reduction rate and the prevention and control effect of the insect pests in each treatment are calculated according to the number of plant hoppers before pesticide application and in each period after pesticide application.
Data analysis:
percent reduction of insect population = (number of insect population before treatment-number of insect population after treatment)/number of insect population before treatment x 100
Correction = (rate of reduction of insect population in treatment area-rate of reduction of insect population in control area) ×100/(100-rate of reduction of insect population in control area)
Table 8 results of test on efficacy of Fluocloprid bisamide and active ingredient B in controlling rice planthoppers
As shown in table 8, after the flucloxapyroxad and the active ingredient B are mixed, the rice planthoppers can be effectively prevented and treated. The prevention effect is higher than 90% in 7 days after the application, and is obviously better than that of a single dose; the prevention effect is higher than 85% 14 days after the application. The field efficacy test shows that after the flucloxapyroxad is mixed with the active ingredient B, the rice planthoppers can be effectively prevented and treated, and the lasting period is long. Within the application range of the test, the safety of target crops is not affected.
Example 69: and (3) performing an eggplant thrips prevention and treatment drug effect test by compounding flucloxapyroxad and the active ingredient B.
Test agent and field treatment: the test agents and amounts are shown in Table 9; the trial was set up for 4 replicates per treatment.
The test method comprises the following steps: labeling 10 eggplants in each cell, and investigating the cardinality of thrips before application; the number of remaining living insects was investigated for each strain 1 day, 3 days, and 7 days after the administration.
The drug effect calculation mode is as follows:
percent reduction of insect population = (number of insect population before treatment-number of insect population after treatment)/number of insect population before treatment x 100
Correction = (treatment area reduction rate-control area reduction rate)/(100-control area reduction rate) ×100
Test results: see table 9.
Table 9 results of experiments on efficacy of Fluocloxapa amide and active ingredient B in controlling eggplant thrips
From Table 9, it is clear that the flucloxapyroxad and the active ingredient B can effectively prevent and treat eggplant thrips after being mixed. The prevention and control effects are higher than 90% 1 day after the application, and are obviously better than those of single dosage; the prevention effect is higher than 85% in 3 days and 7 days after the administration, and is superior to that of single dosage. The field efficacy test data show that after the flucloxapyroxad is mixed with the active ingredient B, eggplant thrips can be effectively prevented and treated, and the lasting period is long. Within the application range of the test, the safety of target crops is not affected.
Example 70: and (3) the efficacy test of the flucloxapyroxad and the active ingredient B for preventing and controlling the apple peach fruit borer.
Test agent and field design: the test agents and dosages are shown in Table 10. Each treatment was repeated 4 times.
Time and method of application: the test was performed on a marily-Laiyx test base once at 1, 6, 2018.
The investigation method comprises the following steps: 2 fruiting trees are investigated in each district, 200 fruits are investigated in total at the middle-upper part around and in the crown of each fruit tree, the number of eggs and insects is recorded, and the control effect is calculated. The basal number was investigated before administration and 1 each of 6 and 12 days after administration. Meanwhile, whether the medicament has phytotoxicity to apple trees or not is observed.
The drug effect calculation method comprises the following steps:
control effect% = ((number of newly increased insects in control area-number of newly increased insects in treated area)/number of newly increased insects in control area) ×100
Test results: see table 10.
Table 10 results of experiments on efficacy of Fluochlorantraniliprole and active ingredient B in preventing and controlling apple peach fruit borer
As shown in table 10, after the flucloxapyroxad is mixed with the active ingredient B, the compound can effectively prevent and control the apple peach fruit borer, the preventing and controlling effect is higher than 80% in 6 days after the compound is applied, and the preventing and controlling effect is better than that of a single agent; the prevention and control effects are higher than 85% after 12 days of administration, and are obviously better than single-dose prevention and control effects. The field efficacy shows that the effect of preventing and controlling the apple peach fruit borer by mixing the flucloxapyroxad and the active ingredient B is superior to that of a single agent, and the lasting period is long. Within the application range of the test, the safety of target crops is not affected.
In addition, experiments in various places of the whole country show that after the flucloxapyroxad is compounded with abamectin, spinosad, spinetoram and emamectin benzoate, the common pest control effects on lepidoptera and homoptera insects such as plutella xylostella, whiteflies, leafhoppers, asparagus caterpillar, cnaphalocrocis medinalis, rice planthoppers, chilo suppressalis cotton bollworms, prodenia litura, aphids, mites, thrips and the like of various crops are over 90 percent, and the synergistic effect is obvious.

Claims (7)

1. The insecticidal composition containing the flucloxapyroxad and the biological source insecticide is characterized in that the effective active ingredients are active ingredient A and active ingredient B, the active ingredient A is the flucloxapyroxad, the active ingredient B is abamectin, and the weight ratio of the flucloxad to the abamectin is 1:30-3:1.
2. The insecticidal composition of claim 1, wherein the weight ratio of the flucloxapyroxad to the abamectin is 1:20-1:1.
3. A pesticidal composition according to claim 1, wherein the weight percentage of active ingredient in the composition is from 0.5% to 90% of the total weight.
4. A pesticidal composition according to claim 3, which comprises from 5% to 80% by weight of active ingredient.
5. An insecticidal composition according to any one of claims 1 to 4 which can be formulated into a variety of pesticidally acceptable formulations.
6. The insecticidal composition of claim 5, wherein said dosage form is a wettable powder, a water dispersible granule, a suspension, a suspoemulsion, an aqueous emulsion or a microemulsion.
7. The use of the insecticidal composition according to any one of claims 1 to 6 for controlling rice stem borers.
CN201910072438.3A 2019-01-25 2019-01-25 Insecticidal composition containing flucloxapyroxad and biological insecticide Active CN109845746B (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN202311764170.2A CN117751937A (en) 2019-01-25 2019-01-25 Insecticidal composition containing flucloxapyroxad and biological insecticide
CN201910072438.3A CN109845746B (en) 2019-01-25 2019-01-25 Insecticidal composition containing flucloxapyroxad and biological insecticide

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201910072438.3A CN109845746B (en) 2019-01-25 2019-01-25 Insecticidal composition containing flucloxapyroxad and biological insecticide

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN202311764170.2A Division CN117751937A (en) 2019-01-25 2019-01-25 Insecticidal composition containing flucloxapyroxad and biological insecticide

Publications (2)

Publication Number Publication Date
CN109845746A CN109845746A (en) 2019-06-07
CN109845746B true CN109845746B (en) 2024-01-23

Family

ID=66896187

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201910072438.3A Active CN109845746B (en) 2019-01-25 2019-01-25 Insecticidal composition containing flucloxapyroxad and biological insecticide
CN202311764170.2A Pending CN117751937A (en) 2019-01-25 2019-01-25 Insecticidal composition containing flucloxapyroxad and biological insecticide

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN202311764170.2A Pending CN117751937A (en) 2019-01-25 2019-01-25 Insecticidal composition containing flucloxapyroxad and biological insecticide

Country Status (1)

Country Link
CN (2) CN109845746B (en)

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103283734A (en) * 2012-02-23 2013-09-11 陕西韦尔奇作物保护有限公司 Cyantraniliprole/biological-source-containing pesticidal composition
CN103461352A (en) * 2012-06-07 2013-12-25 陕西美邦农药有限公司 Insecticidal composition containing chlorfenapyr benzamide and biological source class
CN103918673A (en) * 2013-01-16 2014-07-16 陕西汤普森生物科技有限公司 Insecticidal composition containing compound improved from chlorantraniliprole and biological-source insecticide
CN104186514A (en) * 2014-08-11 2014-12-10 广东中迅农科股份有限公司 Pesticide composition containing cyhalodiamide
CN104430406A (en) * 2014-12-02 2015-03-25 广西安泰化工有限责任公司 Insecticidal composition containing cyhalodiamide and application of insecticidal composition
CN104798798A (en) * 2014-01-26 2015-07-29 沈阳化工研究院有限公司 Binary composition and application thereof
CN105669643A (en) * 2013-12-05 2016-06-15 江西天人生态股份有限公司 O-carboxamido benzamide derivative based on ryanodine receptor, and preparation method and application thereof
CN105724389A (en) * 2016-04-19 2016-07-06 陕西上格之路生物科学有限公司 Dispersible oil suspension containing chlorantraniliprole
CN105994310A (en) * 2016-06-21 2016-10-12 南京华洲药业有限公司 Composite insecticide composition containing cyantraniliprole and avermectin and application thereof
CN107980789A (en) * 2017-11-28 2018-05-04 广东真格生物科技有限公司 A kind of Pesticidal combination containing fourth chlorantraniliprole and its application
CN108605940A (en) * 2016-12-10 2018-10-02 海利尔药业集团股份有限公司 A kind of fluorine chlorine worm bisamide insecticide and its application

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103283734A (en) * 2012-02-23 2013-09-11 陕西韦尔奇作物保护有限公司 Cyantraniliprole/biological-source-containing pesticidal composition
CN103461352A (en) * 2012-06-07 2013-12-25 陕西美邦农药有限公司 Insecticidal composition containing chlorfenapyr benzamide and biological source class
CN103918673A (en) * 2013-01-16 2014-07-16 陕西汤普森生物科技有限公司 Insecticidal composition containing compound improved from chlorantraniliprole and biological-source insecticide
CN105669643A (en) * 2013-12-05 2016-06-15 江西天人生态股份有限公司 O-carboxamido benzamide derivative based on ryanodine receptor, and preparation method and application thereof
CN104798798A (en) * 2014-01-26 2015-07-29 沈阳化工研究院有限公司 Binary composition and application thereof
CN104186514A (en) * 2014-08-11 2014-12-10 广东中迅农科股份有限公司 Pesticide composition containing cyhalodiamide
CN104430406A (en) * 2014-12-02 2015-03-25 广西安泰化工有限责任公司 Insecticidal composition containing cyhalodiamide and application of insecticidal composition
CN105724389A (en) * 2016-04-19 2016-07-06 陕西上格之路生物科学有限公司 Dispersible oil suspension containing chlorantraniliprole
CN105994310A (en) * 2016-06-21 2016-10-12 南京华洲药业有限公司 Composite insecticide composition containing cyantraniliprole and avermectin and application thereof
CN108605940A (en) * 2016-12-10 2018-10-02 海利尔药业集团股份有限公司 A kind of fluorine chlorine worm bisamide insecticide and its application
CN107980789A (en) * 2017-11-28 2018-05-04 广东真格生物科技有限公司 A kind of Pesticidal combination containing fourth chlorantraniliprole and its application

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
伍均锋等.悬浮剂.《农药安全使用技术》.河北科学技术出版社,2016,(第1版),第7页. *
刘广文等.微乳剂.《现代农药剂型加工技术》.化学工业出版社,2013,(第1版),第357、373页. *
刘广文等.有机溶剂对浊点的影响.《现代农药剂型加工技术》.化学工业出版社,2013,(第1版),第366页. *
匿名.农药正式登记审批规范、农药正式登记审批标准.《中华人民共和国农业农村部，http://www.moa.gov.cn/》.2017,第1-8页. *
匿名.农药登记资料要求.《中华人民共和国农业农村部，http://www.moa.gov.cn/》.2017,第1-22页. *
种植业管理司.农药登记试验管理办法.《中华人民共和国农业农村部，http://www.moa.gov.cn/》.2017,第1-9页. *

Also Published As

Publication number Publication date
CN109845746A (en) 2019-06-07
CN117751937A (en) 2024-03-26

Similar Documents

Publication Publication Date Title
CN102771510B (en) Insecticidal composition containing fosthiazate
CN104585224A (en) Pesticide composition containing fluensulfone and pyrethroid insecticide
CN101444221B (en) Composite containing oxadiazines and pyrromonazole pesticide
CN109845740B (en) Insecticidal composition containing flucloxapyroxad and bishydrazide insecticide
CN109845746B (en) Insecticidal composition containing flucloxapyroxad and biological insecticide
CN116210712A (en) Insecticidal composition containing diafenthiuron and application thereof
CN114982762A (en) Insecticidal composition and application thereof
CN109258651A (en) A kind of Pesticidal combination containing bromine worm fluorobenzene bisamide and capillary
CN112568224B (en) Insecticidal composition containing chlorfenapyr flubendiamide and diafenthiuron
CN115176805A (en) Pesticide composition containing spiromesifen and application thereof
CN112237194B (en) Insecticidal composition containing cycloartemia
CN109845745B (en) Composition containing flucloxapyroxad and benzoylurea insecticides
CN111937888A (en) Insecticidal composition and application thereof
CN111789123A (en) Insecticidal composition containing fluorine-containing chlorantraniliprole
CN113796384B (en) Insecticidal composition containing bistrifluron and chlorfenapyr
CN111436445A (en) Insecticidal composition containing trifluoro-benzene pyrimidine
CN105265460B (en) Insecticide acaricide composition and its application
CN114287442B (en) Insecticidal composition containing bistrifluron
CN112514910B (en) Insecticidal composition containing sulfoxaflor and bistrifluron
CN109907045B (en) Composition containing fluorine-containing chlorantraniliprole and pyrethroid insecticide
CN115735934A (en) Agricultural insecticidal composition and application thereof
CN115868499A (en) Compound agricultural insecticide containing bromofenoxaprop-p-fluorobenzene bisamide and application thereof
CN111296471A (en) Composite pesticide containing indoxacarb and flubendiamide
CN111466390A (en) Insecticidal composition containing tetrachlorantraniliprole and flupyradifurone and application thereof
CN116439244A (en) Insecticidal composition and application thereof

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant