CN109843302B - 用于治疗疾病的化合物、组合物和方法 - Google Patents

用于治疗疾病的化合物、组合物和方法 Download PDF

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CN109843302B
CN109843302B CN201780054031.7A CN201780054031A CN109843302B CN 109843302 B CN109843302 B CN 109843302B CN 201780054031 A CN201780054031 A CN 201780054031A CN 109843302 B CN109843302 B CN 109843302B
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aryl
heteroaryl
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independently
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CN109843302A (zh
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R.P.艾耶
A.谢里
S.帕德马纳班
G.梅赫
S.周
S.恰拉
R.H.吉米
D.可莱利
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Yingwox Pharmaceutical Co ltd
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F Star Therapeutics Ltd
Sperovie Biosciences Inc
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    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
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    • C07H19/16—Purine radicals
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    • C07H19/213—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids containing cyclic phosphate
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0029—Parenteral nutrition; Parenteral nutrition compositions as drug carriers
    • A—HUMAN NECESSITIES
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    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
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    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
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CN201780054031.7A 2016-07-06 2017-07-06 用于治疗疾病的化合物、组合物和方法 Active CN109843302B (zh)

Applications Claiming Priority (17)

Application Number Priority Date Filing Date Title
US201662359039P 2016-07-06 2016-07-06
US62/359039 2016-07-06
US201662363118P 2016-07-15 2016-07-15
US62/363118 2016-07-15
US201662403530P 2016-10-03 2016-10-03
US62/403530 2016-10-03
US201662411424P 2016-10-21 2016-10-21
US62/411424 2016-10-21
US201762444141P 2017-01-09 2017-01-09
US62/444141 2017-01-09
US201762462679P 2017-02-23 2017-02-23
US62/462679 2017-02-23
US201762470746P 2017-03-13 2017-03-13
US62/470746 2017-03-13
US201762508846P 2017-05-19 2017-05-19
US62/508846 2017-05-19
PCT/US2017/040882 WO2018009648A1 (en) 2016-07-06 2017-07-06 Compounds, compositions, and methods for the treatment of disease

Publications (2)

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CN109843302A CN109843302A (zh) 2019-06-04
CN109843302B true CN109843302B (zh) 2022-11-29

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EP (1) EP3481402A4 (https=)
JP (3) JP7100227B2 (https=)
KR (1) KR102569881B1 (https=)
CN (1) CN109843302B (https=)
AU (1) AU2017293781B2 (https=)
CA (1) CA3029644A1 (https=)
IL (1) IL264049B2 (https=)
MX (2) MX392605B (https=)
MY (1) MY199689A (https=)
SG (1) SG11201811709WA (https=)
TW (1) TWI689514B (https=)
WO (1) WO2018009648A1 (https=)

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