CN109805193A - Beta-hydroxy-β methylbutanoic acid system's substance alleviates weanling pig immunological stress in preparation and promotees the application in muscle growth feed - Google Patents
Beta-hydroxy-β methylbutanoic acid system's substance alleviates weanling pig immunological stress in preparation and promotees the application in muscle growth feed Download PDFInfo
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- 230000008799 immune stress Effects 0.000 title claims abstract description 27
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Abstract
Alleviate weanling pig immunological stress in preparation the invention discloses a kind of beta-hydroxy-β methylbutanoic acid system's substance and promotees the application in muscle growth feed.Alleviating weanling pig immunological stress and promoting muscle growth feed includes beta-hydroxy-β methylbutanoic acid system's substance and basal diet, and beta-hydroxy-β methylbutanoic acid system substance accounts for the 0.6%-1.2% of basal diet quality total amount.Beta-hydroxy-β methylbutanoic acid system substance of the invention can reduce weanling pig average daily gain and average daily gain, improve feed-weight ratio, improve average daily gain and average daily gain, feed-weight ratio is reduced, the decline of weaned piglets and the reduction of lean meat percentage caused by injection lipopolysaccharides are alleviated.
Description
Technical field
The invention belongs to herding or feed development technical fields, specifically, being related to a kind of beta-hydroxy-β methylbutanoic acid system
Compound alleviates weanling pig immunological stress in preparation and promotees the application in muscle growth feed.
Background technique
Immunological stress causes serious influence to pig breeding industry, and causes very huge economic loss.Immunological stress is usual
After referring to animal inoculation pvaccination vaccine (such as aftosa, swine fever vaccine), for body while generating immune response, itself is also by one
Determine the damage of degree, such as individual allergy, a small number of body temperature increase, and most anorexia, metabolism changes, and growth slows down, and breeding cycle extends
The phenomenon that.In Pig Industry industry, vaccine plays an important role prevention and control infectious disease, on the one hand immunity inoculation is protected
Infringement of the animal body from cause of disease, on the other hand also the stress factor special as one kind causes immunological stress, to body
Certain damage is caused, this damage not only influences the growth and development and production performance of animal, but also may cause a small number of animals
Death.It also include the pathogen or non-pathogen in feeding environment in addition, the immunological stress of broad sense, such as bacterium, virus, interior
Toxin (i.e. lipopolysaccharides) and heterologous protein etc. stimulate immunological stress caused by the immune system of pig.
Studies have shown that resist the disease to animal, maintains health be beneficial for the immune response of appropriateness, however work as body by
When pathogen or non-pathogen in vaccine or environment stimulate, immune system is often in a kind of high level activation state, especially scorching
Property cell factor, such as interleukins (IL) -1 β, IL-6 and tumor necrosis factor (TNF)-α excessive secretion are exempted to generate
Epidemic disease stress problem.These cell factors cause by the direct effect to target tissue or by acting on neuroendocrine system
The activation of hypothalamus-pituitary-adrenal axis causes the change in a series of behaviors of animal and metabolism.The typical case changed in behavior
It is characterized in animal fever, anorexia；Change in metabolism is that body will be used to grow and the nutriment of skeletal muscle deposition turns on
The immune system for maintaining high level activation, causes the speed of growth to decline, and feed conversion rate reduces, and skeletal muscle, which decomposes, to be accelerated, and synthesis subtracts
Slowly, it eventually leads to musculature negative nitrogen balance and growth of animal is slow.
Chinese patent (application number: 108606179 A of CN) disclose it is a kind of alleviation piglet immunological stress feed addictive
And preparation method thereof, it is made of 3.0 parts of compound Chinese herbs, 2.0 parts of glutamine and 1.0 parts of tea polyphenols；The compound Chinese herb,
Be made of following Chinese medicine: 20 parts of rhizoma anemarrhenae, 12 parts of Mao Xiang, 12 parts of borneol, 18 parts of radix paeoniae rubra, 14 parts of keel, 18 parts of radix rehmanniae recen, gold
25 parts of honeysuckle flower, 8 parts of radix gentianae, 20 parts of cordate houttuynia, 12 parts of Herba Andrographitis, 12 parts of wilsonii, 10 parts of Rhizoma Chuanxiong, 8 parts of Radix Codonopsis, campanulaceae 15
Part, 8 parts of Radix Notoginseng.The additive can alleviate immunological stress caused by piglet normal immunological, improve immunological stress phase piglet day
Feed intake and daily gain reduce feedstuff-meat ratio.However, additive component is excessive in feed, higher cost.
Chinese patent (application number: 103694107 A of CN) is open, and to provide a kind of preparation process simple, environmentally protective, former
Material is Ke Xunhuanliyong, at low cost, feed addictive beta-hydroxy-Beta-methyl butyric acid (HMB) of stable and reliable product quality, high income
The preparation method of calcium.Therefore, has the preparation method of the production technology HMB less expensive compared with simple, cost at present.
Currently, in pig production, mostly using multidimensional or glucose drinking-water for turn group, reload, Changes in weather when
Resisting stress and vaccine inoculation front and back and the growth promotion in later period.These measures are to good because that stress have caused by transport, environmental change etc.
Good relaxation effect, however, the effect is unsatisfactory to systemic immune response is mitigated.Therefore, the function of immunological stress resistance is developed
Property feed is of great significance.
Beta-hydroxy-Beta-methyl butyric acid (HMB) is the mesostate of leucine, is the natural work of the green generated in vivo
Property ingredient, be leucine play protein metabolism adjusting function core substance.No. 1 bulletin of the Ministry of Public Health in 2011 ratifies HMB
For calcium salt as new resource food, a kind of novel anabolism nutritional agents of the person that is then widely used as high-intensity exercise can be reduced flesh
The protein depletion of meat tissue facilitates muscle recovery and reduces because of muscle damage caused by overworked.Many studies have shown that
In human clinical trial and animal disease model, HMB can reduce inflammatory reaction, to many diseases associated with inflammation (such as AIDS,
Morbus cardiacus, chronic lung disease, rheumatoid arthritis) play protective effect.However, related HMB is as weanling pig feed
Additive alleviates its immunological stress and the research of its muscle growth is promoted to be rarely reported both at home and abroad.
Summary of the invention
In view of this, the present invention is directed to above-mentioned problem, provides a kind of beta-hydroxy-β methylbutanoic acid system's substance and preparing
Alleviate weanling pig immunological stress and promotees the application in muscle growth feed.
In order to solve the above-mentioned technical problem, it is slow in preparation that the invention discloses a kind of beta-hydroxy-β methylbutanoic acid based compounds
It solves weanling pig immunological stress and promotees the application in muscle growth feed.
Optionally, beta-hydroxy-β methylbutanoic acid system substance include beta-hydroxy-β methylbutanoic acid based compound, derivative or
Free acid form beta-hydroxy-β methylbutanoic acid system substance.
Optionally, beta-hydroxy-β methylbutanoic acid system derivative includes beta-hydroxy-β methylbutanoic acid metabolin, beta-hydroxy-β first
Base butyrate, beta-hydroxy-β methylbutyrate or beta-hydroxy-β methylbutanoic acid lactone.
Optionally, beta-hydroxy-β methylbutyrate includes methyl esters and ethyl ester.
Optionally, beta-hydroxy-β methylbutanoic acid lactone includes isovaleryl lactone.
Optionally, beta-hydroxy-β methylbutanoic acid salt includes beta-hydroxy-β methylbutanoic acid sodium, beta-hydroxy-β methylbutanoic acid potassium, β-
Hydroxy-beta methylbutanoic acid chromium, beta-hydroxy-β methylbutanoic acid calcium, beta-hydroxy-β methylbutanoic acid magnesium, beta-hydroxy-β methylbutanoic acid alkali metal
With beta-hydroxy-β methylbutanoic acid alkaline-earth metal.
Optionally, alleviating weanling pig immunological stress and promoting muscle growth feed includes beta-hydroxy-β methylbutanoic acid system substance
And basal diet, beta-hydroxy-β methylbutanoic acid system substance account for the 0.6%-1.2% of basal diet quality total amount.
The invention also discloses the preparation methods of a kind of alleviation weanling pig immunological stress and rush muscle growth feed, by β-
Hydroxy-beta methylbutanoic acid system's substance, which is mixed with basal diet or covered as coating, to be administered on basal diet.
Compared with prior art, the present invention can be obtained including following technical effect:
Weanling pig average daily gain and average day feeding can be improved in beta-hydroxy-β methylbutanoic acid system substance of the invention
Amount reduces feed-weight ratio.
Beta-hydroxy-β methylbutanoic acid system of the present invention substance improves average daily gain and average daily gain, reduces material weight
Than.
Beta-hydroxy-β methylbutanoic acid system of the present invention substance alleviates the decline of weaned piglets caused by injection lipopolysaccharides
With the reduction of lean meat percentage.
Beta-hydroxy-β methylbutanoic acid system of the present invention substance alleviates piglet muscle protein caused by injection lipopolysaccharides and degrades.
Beta-hydroxy-β methylbutanoic acid system of the present invention substance alleviates piglet inflammation caused by injection lipopolysaccharides.
Certainly, it implements any of the products of the present invention it is not absolutely required to while reaching all the above technical effect.
Specific embodiment
Carry out the embodiment that the present invention will be described in detail below in conjunction with embodiment, whereby to the present invention how application technology hand
Section solves technical problem and reaches the realization process of technical effect to fully understand and implement.
The invention discloses a kind of beta-hydroxy-β methylbutanoic acid system substances (HMB) to alleviate weanling pig immunological stress in preparation
And the application in rush muscle growth feed.
Wherein, beta-hydroxy-β methylbutanoic acid system substance includes beta-hydroxy-β methylbutanoic acid based compound, derivative or trip
From sour form (C5H10O3), shown in structural formula such as formula (I).
Beta-hydroxy-β methylbutanoic acid system derivative includes beta-hydroxy-β methylbutanoic acid metabolin, beta-hydroxy-β methylbutanoic acid
Salt, beta-hydroxy-β methylbutyrate and beta-hydroxy-β methylbutanoic acid lactone.
Beta-hydroxy-β methylbutyrate includes methyl esters and ethyl ester.Beta-hydroxy-β methylbutanoic acid lactone includes in isovaleryl
Ester.Beta-hydroxy-β methylbutanoic acid salt includes beta-hydroxy-β methylbutanoic acid sodium, beta-hydroxy-β methylbutanoic acid potassium, beta-hydroxy-β methyl fourth
Sour chromium, beta-hydroxy-β methylbutanoic acid calcium, beta-hydroxy-β methylbutanoic acid magnesium, beta-hydroxy-β methylbutanoic acid alkali metal and beta-hydroxy-β first
Base butyric acid alkaline-earth metal.
Alleviating weanling pig immunological stress and promoting muscle growth feed includes beta-hydroxy-β methylbutanoic acid system's substance and basis
Daily ration, beta-hydroxy-β methylbutanoic acid system substance account for the 0.6%-1.2% of basal diet quality total amount.
These EXPERIMENTAL EXAMPLEs are non-limiting.In embodiment include any type of HMB, including CaHMB and
HMBFA.Concentration additionally, this invention is not limited to the HMB used in these embodiments；The HMB of lower and high amount is also at this
In the range of invention.These embodiments are by HMB making coatings, but HMB also may be mixed in in feed, or can be added
Into the water of animal.
Embodiment 1
A kind of alleviation weanling pig immunological stress and to promote muscle growth feed include beta-hydroxy-β methylbutanoic acid calcium and basis
Daily ration, beta-hydroxy-β methylbutanoic acid calcium account for the 0.6% of basal diet quality total amount.
Embodiment 2
Alleviating weanling pig immunological stress and promoting muscle growth feed includes beta-hydroxy-β methylbutanoic acid calcium and basal diet,
Beta-hydroxy-β methylbutanoic acid calcium accounts for the 1.2% of basal diet quality total amount.
Embodiment 3
Alleviating weanling pig immunological stress and promoting muscle growth feed includes beta-hydroxy-β methylbutanoic acid lactone and basic day
Grain, beta-hydroxy-β methylbutanoic acid lactone account for the 0.9% of basal diet quality total amount.
Embodiment 4
Using 2 × 2 factor designs, the wean Chang-Bai piglet of 21 age in days health similar in 48 weight is chosen, is randomly divided into 6
Processing group: 1. control group (feeding basal diet)；2. LPS group (feeding basal diet, injects LPS, e. coli serotype O55:
B5, Sigma company)；3. LPS+0.60%HMB group (adds 0.60%HMB-Ca, purity 99.2%, Zhangjiagang in basal diet
General biochemical Co., Ltd is thought in city, injects LPS)；4. LPS+1.20%HMB group (is added 1.20%HMB-Ca, is injected in basal diet
LPS).Every group of 8 pigs, separated raising.Basal diet is prepared referring to NRC (2012) piglet nutrition requirement.Experimental period 15 days,
The next day that LPS group is respectively from feeding experiment the 1st day to piglet, is incremented by intraperitoneal injection LPS, initially injects by 80 μ g/kg BW, after
Injection dosage is incremented by 30% every time, and (Jia Anfeng, Feng Jinghai, Zhang Minhong, waiting to be incremented by the lipopolysaccharide-induced Chronic immune of injection stress be right
The influence Animal nutrition journal of piglet growth performance, 2015,27:1868-1874), the life of control group and HMB group injection equivalent
Manage salt water.
Seen from table 1, compared with the control group, injection lipopolysaccharides reduce weanling pig average daily gain (- 53.33%, P <
0.0001) with average daily gain (- 28.53%, P < 0.01), feed-weight ratio (+40.38%, P < 0.01) is improved.With lipopolysaccharides
Group is compared, and improves average daily gain (+57.14%, P > 0.05) and average day using HMB-Ca of the present invention (0.6%)
Feed intake (+13.09%, P > 0.05) reduces feed-weight ratio (- 23.66%, P > 0.05).In addition, being compared with control group, inject
Lipopolysaccharides improve muscle tissue proteins degradation rate (+64.79%, P < 0.05), reduce weanling pig lean meat percentage (-
8.53%, P < 0.05).Compared with lipopolysaccharide group, muscle tissue protein is reduced using HMB-Ca of the present invention (0.6%)
Matter degradation rate (13.68%, P > 0.05) improves lean meat percentage (+4.37%, P > 0.05).This shows the beta-hydroxy-Beta-methyl
Butyric acid based compound alleviates the decline of weaned piglets and the reduction of lean meat percentage caused by injection lipopolysaccharides.
Influence of 1 HMB of table to weaned piglets and lean meat percentage after injection lipopolysaccharides
Note: the female difference person of colleague's shoulder marking-up indicates significant difference (P < 0.05).
Compared as shown in Table 2 with control group, injection lipopolysaccharides improve piglet blood inflammatory factor IL-1 β (+3.12 times,
P < 0.05), the concentration of IL-6 (+4.93 times, P < 0.05) and TNF-α (+1.6 times, P < 0.05).Compared with lipopolysaccharide group, use
HMB-Ca (0.6%) of the present invention reduce piglet blood inflammatory factor IL-1 β (- 1.88 times, P < 0.05), IL-6 (-
1.74 times, P>0.05) and TNF-α (- 1.33 times, P<0.05) concentration.This shows the beta-hydroxy-Beta-methyl butyric acid based compound
Alleviate piglet inflammation caused by injection lipopolysaccharides.
Influence of 2 HMB of table to piglet blood inflammatory factor concentration after injection lipopolysaccharides
Note: the female difference person of colleague's shoulder marking-up indicates significant difference (P < 0.05).
Above description has shown and described several preferred embodiments of invention, but as previously described, it should be understood that invention is not
It is confined to form disclosed herein, should not be regarded as an exclusion of other examples, and can be used for various other combinations, modification
And environment, and can be carried out within that scope of the inventive concept describe herein by the above teachings or related fields of technology or knowledge
Change.And changes and modifications made by those skilled in the art do not depart from the spirit and scope of invention, then it all should be in the appended power of invention
In the protection scope that benefit requires.
Claims (8)
1. a kind of beta-hydroxy-β methylbutanoic acid system's substance is alleviated weanling pig immunological stress in preparation and is promoted in muscle growth feed
Application.
2. application according to claim 1, which is characterized in that beta-hydroxy-β methylbutanoic acid system substance includes beta-hydroxy-β first
Base butyric acid based compound, derivative or free acid form beta-hydroxy-β methylbutanoic acid system substance.
3. application according to claim 1, which is characterized in that beta-hydroxy-β methylbutanoic acid system derivative includes beta-hydroxy-β
Methylbutanoic acid metabolin, beta-hydroxy-β methylbutanoic acid salt, beta-hydroxy-β methylbutyrate or beta-hydroxy-β methylbutanoic acid lactone.
4. application according to claim 3, which is characterized in that beta-hydroxy-β methylbutyrate includes methyl esters and ethyl ester.
5. application according to claim 4, which is characterized in that beta-hydroxy-β methylbutanoic acid lactone includes in isovaleryl
Ester.
6. application according to claim 3, which is characterized in that beta-hydroxy-β methylbutanoic acid salt includes beta-hydroxy-β methyl fourth
Sour sodium, beta-hydroxy-β methylbutanoic acid potassium, beta-hydroxy-β methylbutanoic acid chromium, beta-hydroxy-β methylbutanoic acid calcium, beta-hydroxy-β methyl fourth
Sour magnesium, beta-hydroxy-β methylbutanoic acid alkali metal and beta-hydroxy-β methylbutanoic acid alkaline-earth metal.
7. application according to any claim from 1 to 6, which is characterized in that alleviate weanling pig immunological stress and
Promoting muscle growth feed includes beta-hydroxy-β methylbutanoic acid system's substance and basal diet, and beta-hydroxy-β methylbutanoic acid system substance accounts for base
The 0.6%-1.2% of plinth daily ration quality total amount.
8. a kind of preparation method alleviated weanling pig immunological stress and promote muscle growth feed, which is characterized in that by beta-hydroxy-
β methylbutanoic acid system's substance, which is mixed with basal diet or covered as coating, to be administered on basal diet.
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| US5028440A (en) * | 1990-01-30 | 1991-07-02 | Iowa State University Research Foundation, Inc. | Method of raising meat producing animals to increase lean tissue development |
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