CN109790583B - 对肺腺癌亚型分型的方法 - Google Patents

对肺腺癌亚型分型的方法 Download PDF

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CN109790583B
CN109790583B CN201780044229.7A CN201780044229A CN109790583B CN 109790583 B CN109790583 B CN 109790583B CN 201780044229 A CN201780044229 A CN 201780044229A CN 109790583 B CN109790583 B CN 109790583B
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sample
hla
biomarker
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CN109790583A (zh
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H·法鲁基
M·莱-高德曼
G·梅休
J·赛罗德
C·佩鲁
D·N·海耶斯
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University of North Carolina at Chapel Hill
Genecentric Diagnostics Inc
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
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  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
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  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CN201780044229.7A 2016-05-17 2017-05-17 对肺腺癌亚型分型的方法 Active CN109790583B (zh)

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US201662337645P 2016-05-17 2016-05-17
US201662337591P 2016-05-17 2016-05-17
US62/337,645 2016-05-17
US62/337,591 2016-05-17
US201662396587P 2016-09-19 2016-09-19
US62/396,587 2016-09-19
US201662420836P 2016-11-11 2016-11-11
US62/420,836 2016-11-11
US201662425717P 2016-11-23 2016-11-23
US62/425,717 2016-11-23
PCT/US2017/033110 WO2017201165A1 (en) 2016-05-17 2017-05-17 Methods for subtyping of lung adenocarcinoma

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CN109790583B (zh) 2016-05-17 2023-08-25 基因中心治疗公司 对肺腺癌亚型分型的方法
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CA3090912A1 (en) 2018-02-13 2019-08-22 Genecentric Therapeutics, Inc. Methods for subtyping of bladder cancer
US11414698B2 (en) * 2018-03-22 2022-08-16 Chang Gung Medical Foundation Chang Gung Memorial Hospital At Chiayi Method of quantifying mutant allele burden of target gene
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CA3115922A1 (en) 2018-10-09 2020-04-16 Genecentric Therapeutics, Inc. Detecting cancer cell of origin
EP3867869A1 (en) * 2018-10-18 2021-08-25 Verily Life Sciences LLC Systems and methods for using image processing to generate inferences of biomarker for immunotherapy
CN112442535A (zh) * 2019-08-27 2021-03-05 上海善准生物科技有限公司 原发性肺腺癌分子分型及生存风险基因群及诊断产品和应用
AU2020364234A1 (en) * 2019-10-11 2022-04-07 Bioventures, Llc Use of simultaneous marker detection for assessing difuse glioma and responsiveness to treatment
CN112034185A (zh) * 2020-09-11 2020-12-04 上海市胸科医院 Gpr110、vegfr、cd34在鉴别肺腺癌亚型中的用途
CN112530595A (zh) * 2020-12-21 2021-03-19 无锡市第二人民医院 一种基于多分支链式神经网络的心血管疾病分类方法和装置
US20240182984A1 (en) * 2021-03-30 2024-06-06 Genecentric Therapeutics, Inc. Methods for assessing proliferation and anti-folate therapeutic response
CN113687076B (zh) * 2021-07-14 2024-03-01 郑州大学 一种可用于肺腺癌早期诊断的联合检测血清标志物及其应用
WO2023010327A1 (zh) * 2021-08-04 2023-02-09 杭州浙大迪迅生物基因工程有限公司 一种人白三烯受体CysLTR2 mRNA RT-PCR检测用引物探针组和试剂盒
CN113903400B (zh) * 2021-10-29 2024-10-01 复旦大学附属华山医院 免疫相关疾病分子分型和亚型分类器的分类方法、系统
CN113981093B (zh) * 2021-11-26 2023-06-16 大连医科大学附属第一医院 Inpp4b基因表达量的检测剂在制备用于预测肺腺癌放疗敏感性的试剂盒的应用
CN114480644A (zh) * 2022-01-07 2022-05-13 深圳市龙华区人民医院 肺腺癌基于代谢基因的分子分型
CN114574589B (zh) * 2022-04-28 2022-08-16 深圳市第二人民医院(深圳市转化医学研究院) 标志物znf207在制备肺腺癌诊断试剂中的应用及诊断试剂盒
WO2023244582A1 (en) * 2022-06-13 2023-12-21 The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Lung cancer-related biomarkers and methods of using the same
CN115896282A (zh) * 2022-08-02 2023-04-04 上海市同仁医院 一种对甲状腺微小乳头状癌进行分子分型的方法以及分子标志物应用
CN115747332A (zh) * 2022-10-13 2023-03-07 复旦大学附属中山医院 一种检测肺腺癌smad4突变的试剂盒
CN115862876B (zh) * 2023-03-02 2023-05-26 北京师范大学 基于免疫微环境基因群预测肺腺癌患者预后的装置
CN116403648B (zh) * 2023-06-06 2023-08-01 中国医学科学院肿瘤医院 一种基于多维分析建立的小细胞肺癌免疫新分型方法
CN117491636B (zh) * 2023-11-21 2026-02-06 郑州大学 一种用于肺癌诊断的生物标志物及其应用
CN117635612A (zh) * 2024-01-25 2024-03-01 天津博思特医疗科技有限责任公司 一种肺部ct图像的识别方法
CN118460691B (zh) * 2024-07-11 2024-10-15 浙江省血液中心 用于hla基因多重扩增的引物组合物、应用和基因分型方法
CN119876392B (zh) * 2025-01-06 2025-08-12 上海市第六人民医院 一种用于辅助诊断肺腺癌骨转移的生物标志物
CN120445960B (zh) * 2025-05-07 2026-01-27 广州医科大学附属第一医院（广州呼吸中心） 一种外泌体表面标志物鉴别乳腺癌亚型的方法
CN121687186A (zh) * 2026-02-12 2026-03-17 山东大学齐鲁医院 H2ac19在肺腺癌检测以及治疗中的应用

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CN109790583A (zh) 2019-05-21
US20190338365A1 (en) 2019-11-07
EP3458612B1 (en) 2023-11-15
JP2019516407A (ja) 2019-06-20
JP7241353B2 (ja) 2023-03-17
WO2017201165A1 (en) 2017-11-23
CN116987790A (zh) 2023-11-03
US12139763B2 (en) 2024-11-12
EP3458612A1 (en) 2019-03-27
US10934595B2 (en) 2021-03-02
EP3458612A4 (en) 2020-02-26
US20210222254A1 (en) 2021-07-22
CA3024747A1 (en) 2017-11-23

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