CN109771568A - A kind of biological agent and preparation method for inhibiting scar and promoting wound healing - Google Patents
A kind of biological agent and preparation method for inhibiting scar and promoting wound healing Download PDFInfo
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- CN109771568A CN109771568A CN201910134028.7A CN201910134028A CN109771568A CN 109771568 A CN109771568 A CN 109771568A CN 201910134028 A CN201910134028 A CN 201910134028A CN 109771568 A CN109771568 A CN 109771568A
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- essential oil
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Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention belongs to medical technical fields; disclose it is a kind of inhibition scar and promote wound healing biological agent and preparation method, inhibit scar and promote wound healing biological agent by: Herba Andrographitis 12g~18g, cow-bezoar 15g~19g, conyza blinii 5g~11g, cactus 5g~11g, cordate houttuynia 9g~15g, bletilla striata 10g~16g, polygonum cuspidate 8g~12g, radix paeoniae rubra 3g~7g, Radix Astragali 6g~14g, field thistle 3g~5g, campanulaceae 8g~14g, pomegranate peel essential oil 1g~3g, Peppermint essential oil 25g~29g are formed.The present invention has light granatum fragrance and pleasant mint smell, and peppermint can also bring clear refrigerant cool feeling, feeling of pain of releiving to skin so that while inhibiting scar and promote wound healing can mood placating, spirit can be made to improve.
Description
Technical field
The invention belongs to medical technical field more particularly to a kind of biology systems for inhibiting scar and promoting wound healing
Agent and preparation method.
Background technique
Currently, the prior art commonly used in the trade is such that
Wound healing refers to body by external force, and the tissues such as skin occur more answering process, packet after detachment or defect
The complex combination that the regeneration and granulation tissue hyperplasia, cicatricial tissue for including various tissues are formed, the collaboration for showing various processes are made
With；The basic process of the wound healing of wound: acute inflammation stage → hyperplasia phase → cicatrization phase → epidermis and other groups
Knit regeneration.According to degree of injury and whether there is or not infection, wound healing can be divided into first intention, healing by second intention, three phases heal these three
Type；Therefore, during wound is healed easily formed and scar；Scar be after various wounds it is caused just
The normal mode of appearance of skin histology and the general designation of tissue pathologies change, it is product inevitable in human body processes of wound repair.
Scar growth is more than certain limit, and various complication, the destruction of shape and functional activity obstacle etc., to trouble will occur
Person brings huge human body pain and mental suffering, the scar especially burnt, scald, left after severe trauma.
But the drug that existing correlation deposits into wound healing cannot play the role of good inhibition scar simultaneously；And
Good promotion wound healing cannot be played the role of simultaneously by inhibiting the drug of scar；The existing drug slow effect for inhibiting scar,
Ingredient is single, and bactericidal effect is poor, and safety is low；The drug of existing wound healing, smell is bad, and drug effect is bad, and slow effect are prolonged
Long healing time.
In conclusion problem of the existing technology is:
(1) the existing related drug for promoting wound healing cannot play the role of good inhibition scar simultaneously；And press down
The drug of scar processed cannot play the role of good promotion wound healing simultaneously；
(2) the existing drug slow effect for inhibiting scar, ingredient is single, and bactericidal effect is poor, and safety is low；
(3) drug of existing wound healing, smell is bad, and drug effect is bad, slow effect, extends healing time.
Summary of the invention
In view of the problems of the existing technology, the present invention provides the biology systems of a kind of inhibition scar and promotion wound healing
Agent and preparation method.
The invention is realized in this way it is a kind of inhibit scar and promote wound healing biological agent by Herba Andrographitis 12g~
18g, cow-bezoar 15g~19g, conyza blinii 5g~11g, cactus 5g~11g, cordate houttuynia 9g~15g, bletilla striata 10g~16g, tiger
Cane 8g~12g, radix paeoniae rubra 3g~7g, Radix Astragali 6g~14g, field thistle 3g~5g, campanulaceae 8g~14g, granatum 1g~3g and peppermint 25g
~29g composition.
Another object of the present invention is to provide the preparation sides of a kind of inhibition scar and the biological agent for promoting wound healing
Method, specifically includes the following steps:
Step 1: take Herba Andrographitis, cow-bezoar, conyza blinii, cactus, cordate houttuynia, the bletilla striata, polygonum cuspidate, radix paeoniae rubra, Radix Astragali, field thistle,
Campanulaceae, granatum and peppermint are pre-processed；
Step 2: by Herba Andrographitis, cow-bezoar, conyza blinii, cactus, cordate houttuynia, the bletilla striata, polygonum cuspidate, radix paeoniae rubra, Radix Astragali, field thistle,
5~15 times of distilled water are added in campanulaceae, impregnate 8h~12h, carry out fried 2h~4h using boiling machine, filtering obtains Chinese medicine liquid, stays
Chinese medicine slag；
Step 3: Chinese medicine liquid is concentrated, and obtains the concentrated liquid of tradition Chinese medicine；Chinese medicine slag is carried out using micronizer after drying
It crushes, obtains Chinese medicine slag fine powder；
Step 4: pomegranate peel essential oil is prepared using cold-press；Microwave-assisted acquisition peppermint essence is cooperated using way of distillation extraction
Oil, it is spare；
Ultra micro Chinese medicine slag fine powder, pomegranate peel essential oil and Peppermint essential oil: being successively added in the concentrated liquid of tradition Chinese medicine by step 5, warp
Homogeneous, sterilization to get.
Further, in step 1, pretreatment includes:
(1) Herba Andrographitis, cow-bezoar, conyza blinii, cactus, cordate houttuynia, the bletilla striata, polygonum cuspidate, radix paeoniae rubra, Radix Astragali, field thistle, tangerine are chosen
Stalk, granatum and peppermint；(2) impurity is removed；(3) it cleans；(4) it dries；(5) it sterilizes.
Further, in step 4, the preparation of pomegranate peel essential oil:
(1) it takes granatum to carry out disinfection, cleans, chopping processing；
(2) broken wall juicing is carried out to granatum using wall-breaking machine according to cold-press；
(3) essential oil is eluted with shower water again, is filtered, is separated, disinfection obtains pomegranate peel essential oil.
Further, in step 4, the preparation of Peppermint essential oil:
(1) fresh mint leaf is taken, cleaned, sterilized；
(2) 1h~3h is distilled using steam distillation, cooperation is microwave-assisted, and microwave power is 280W~300W, microwave
Time 3min~4min extracts 3 times up to peppermint leaf essential oil.
In conclusion advantages of the present invention and good effect are as follows:
The biological agent provided by the invention for inhibiting scar and promoting wound healing, can reach simultaneously and inhibit scar, promote
It is quick into the effect of wound healing, it effectively shortens the time required to wound healing, and the present invention has light granatum fragrance
With pleasant mint smell, peppermint can also bring clear refrigerant cool feeling, feeling of pain of releiving to skin so that inhibit scar and
Promote wound healing while can mood placating, spirit can be made to improve.Inhibition scar provided by the invention and promotion wound healing
Biological agent can improve the permeability of surface of a wound blood vessel, reduce and prevent to ooze out, keep the surface of a wound dry, prevent from infecting, dredge micro-
Circulation, improves the blood supply of affected part, makes surface of a wound immediate union, reduce the generation of scar.
Detailed description of the invention
Fig. 1 is the preparation method process of inhibition scar and the biological agent for promoting wound healing provided in an embodiment of the present invention
Figure.
Specific embodiment
In order to make the objectives, technical solutions, and advantages of the present invention clearer, with reference to embodiments, to the present invention
It is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, it is not used to
Limit the present invention.
It is provided in an embodiment of the present invention to inhibit scar and promote the biological agent of wound healing by Herba Andrographitis 12g~18g, ox
Yellow 15g~19g, conyza blinii 5g~11g, cactus 5g~11g, cordate houttuynia 9g~15g, bletilla striata 10g~16g, polygonum cuspidate 8g~
12g, radix paeoniae rubra 3g~7g, Radix Astragali 6g~14g, field thistle 3g~5g, campanulaceae 8g~14g, granatum 1g~3g and peppermint 25g~29g
Composition.
It elaborates with reference to the accompanying drawing to application principle of the invention；
As shown in Figure 1, the preparation side of the biological agent provided in an embodiment of the present invention for inhibiting scar and promoting wound healing
Method, specifically includes the following steps:
S101: Herba Andrographitis, cow-bezoar, conyza blinii, cactus, cordate houttuynia, the bletilla striata, polygonum cuspidate, radix paeoniae rubra, Radix Astragali, field thistle, tangerine are taken
Stalk, granatum and peppermint are pre-processed.
S102: by Herba Andrographitis, cow-bezoar, conyza blinii, cactus, cordate houttuynia, the bletilla striata, polygonum cuspidate, radix paeoniae rubra, Radix Astragali, field thistle, tangerine
5~15 times of distilled water are added in stalk, impregnate 8h~12h, carry out fried 2h~4h using boiling machine, filtering obtains Chinese medicine liquid, stay
The dregs of a decoction.
S103: Chinese medicine liquid is concentrated, and obtains the concentrated liquid of tradition Chinese medicine；Chinese medicine slag carries out powder using micronizer after drying
It is broken, obtain Chinese medicine slag fine powder.
S104: pomegranate peel essential oil is prepared using cold-press；Microwave-assisted acquisition Peppermint essential oil is cooperated using way of distillation extraction,
It is spare.
S105: successively ultra micro Chinese medicine slag fine powder, pomegranate peel essential oil and Peppermint essential oil are added in the concentrated liquid of tradition Chinese medicine, through equal
Matter, sterilization to get.
In step S101, pretreatment provided in an embodiment of the present invention includes:
(1) Herba Andrographitis, cow-bezoar, conyza blinii, cactus, cordate houttuynia, the bletilla striata, polygonum cuspidate, radix paeoniae rubra, Radix Astragali, field thistle, tangerine are chosen
Stalk, granatum and peppermint；(2) impurity is removed；(3) it cleans；(4) it dries；(5) it sterilizes.
In step S104, the preparation of pomegranate peel essential oil provided in an embodiment of the present invention:
(1) it takes granatum to carry out disinfection, cleans, chopping processing.
(2) broken wall juicing is carried out to granatum using wall-breaking machine according to cold-press.
(3) essential oil is eluted with shower water again, is filtered, is separated, disinfection obtains pomegranate peel essential oil.
In step S104, the preparation of Peppermint essential oil provided in an embodiment of the present invention:
(1) fresh mint leaf is taken, cleaned, sterilized.
(2) 1h~3h is distilled using steam distillation, cooperation is microwave-assisted, and microwave power is 280W~300W, microwave
Time 3min~4min extracts 3 times up to peppermint leaf essential oil.
Application principle of the invention is further described below with reference to Pharmacological Analysis.
Herba Andrographitis: bitter, it is cold in nature.There are clearing heat and detoxicating, anti-inflammatory, swelling and pain relieving effect.
Cow-bezoar: for the calculus in the gall-bladder of bovid ox or buffalo, bile duct or common hepatic duct, bitter but sweet flavor is cool in nature.With clear
The heart, resolving sputum, cholagogue, relieving convulsion effect
Conyza blinii: for the false fluffy small Artemisia santonica of platymiscium of composite family, major function are as follows: heat clearing and inflammation relieving, purging fire for removing toxin.Bitter, property
It is cold.
Cactus: for the root and stem of Cactaeous plants cactus and green cactus.With the promoting flow of qi and blood circulation, cooling blood and hemostasis,
The efficacy of removing toxicity for detumescence effect.Bitter, it is cold in nature.
Cordate houttuynia: for the dry aerial parts of saururaceae plant houttuynia cordata.Acrid flavour, it is cold.It can clearing heat and detoxicating, detumescence treatment
Sore, promoting urination and removing dampness, clearing away heat to cure dysentery, stomach strengthening and digestion promoting
The bletilla striata: for the dry tuber of the orchid bletilla striata.Bitter, sweet, puckery, cold nature.With astringing to arrest bleeding, detumescence and promoting granulation
The effect of.
Polygonum cuspidate: for the dry rhizome and root of polygonaceae plant polygonum cuspidate.It is clearing heat and detoxicating with removing dampness through diuresis and removing jaundice, removing blood stasis and acesodyne, cough-relieving
The effect of resolving sputum.Mildly bitter flavor, cold nature.
Radix paeoniae rubra: for the dry root of ranunculaceae plant radix paeoniae rubra or river radix paeoniae rubra.Bitter, cold nature.There are clearing heat and cooling blood, promoting blood circulation
The effect of.
Radix Astragali: for the root of leguminous mongolian scutellaria.Major function are as follows: invigorating qi for strengthening superficies, pus draining and toxin expelling, diuresis, myogenic.Property
Temperature, it is sweet in flavor.
Field thistle: for the dry aerial parts of compositae plant field thistle.It is sweet in flavor, bitter, it is cool in nature.With cooling blood and hemostasis, stasis of blood solution is dissipated
Poison disappear carbuncle the effect of.
Campanulaceae: for the dry root of Campanulaceae campanulaceae.With promoting the dispersing function of the lung, the effect of relieving sore-throat, eliminating the phlegm, apocenosis.It is bitter, pungent,
It is mild-natured.
Granatum: for the drying pericarp of Punicaceae plant pomegranate.With relieving diarrhea with astringents, the effect of hemostasis, expelling parasite.Sour,
It is puckery, it is warm-natured.
Peppermint: acrid flavour, it is cool in nature.With dispelling wind and heat from the body, the effect of head clearing, relieving sore-throat promoting eruption, soothing the liver promoting the circulation of qi.
Application principle of the invention is further described combined with specific embodiments below.
Embodiment 1
The biological agent provided in an embodiment of the present invention for inhibiting scar and promoting wound healing, according to the weight ratio, g number
By: Herba Andrographitis 12g, cow-bezoar 15g, conyza blinii 5g, cactus 5g, cordate houttuynia 9g, bletilla striata 10g, polygonum cuspidate 8g, radix paeoniae rubra 3g, Radix Astragali
6g, field thistle 3g, campanulaceae 8g, pomegranate peel essential oil 1g, Peppermint essential oil 25g composition.
Embodiment 2
The biological agent provided in an embodiment of the present invention for inhibiting scar and promoting wound healing, according to the weight ratio, g number
By: Herba Andrographitis 18g, cow-bezoar 19g, conyza blinii 11g, cactus 11g, cordate houttuynia 15g, bletilla striata 16g, polygonum cuspidate 12g, radix paeoniae rubra 7g,
Radix Astragali 14g, field thistle 5g, campanulaceae 14g, pomegranate peel essential oil 3g, Peppermint essential oil 29g composition.
Embodiment 3
The biological agent provided in an embodiment of the present invention for inhibiting scar and promoting wound healing, according to the weight ratio, g number
By: Herba Andrographitis 15g, cow-bezoar 17g, conyza blinii 8g, cactus 8g, cordate houttuynia 12g, bletilla striata 13g, polygonum cuspidate 10g, radix paeoniae rubra 5g, Huang
Stilbene 10g, field thistle 4g, campanulaceae 12g, pomegranate peel essential oil 2g, Peppermint essential oil 27g composition.
Embodiment 4: experiment
1, materials and methods
(1) material experiment animal: rabbit 60, male and female dual-purpose.
Experimental drug: antipruritic scar softening cream.Herba Andrographitis 15g, cow-bezoar 17g, conyza blinii 8g, cactus 8g, cordate houttuynia
12g, bletilla striata 12g, polygonum cuspidate 10g, radix paeoniae rubra 5g, Radix Astragali 10g, field thistle 4g, campanulaceae 9g, granatum 2g, peppermint 28g.
(2) method
1) by Herba Andrographitis 15g, cow-bezoar 17g, conyza blinii 8g, cactus 8g, cordate houttuynia 12g, bletilla striata 12g, polygonum cuspidate 10g,
The preparation side that radix paeoniae rubra 5g, Radix Astragali 10g, field thistle 4g, campanulaceae 9g, granatum 2g, peppermint 28g are provided according to the specific embodiment of the invention
Method prepares biological agent.
2) medicine is taken by 5mL/kg in rabbit auricular vein injecting anesthetic with 20% urethane.Every rabbit back cuts off 6cm
3 pieces of the hair-fields of × 6cm, respectively measures the region of 3cm × 4cm with ruler and picric acid is marked.It is cut off with scalpel along graticule
Epidermis, it is seen that thin film gently pulls striping, it is seen that stay a little blood, stop wound, rear each wound uses iodine disinfection.
Experimental group is uniformly coated with biological agent prepared by the present invention, and control group is coated with the antipruritic scar softening cream of equivalent, applies
It is wrapped up after medicine with sterile gauze, daily dressing 1 time simultaneously observes indices.
(3) result:
1) wound healing rate: respectively compared with blank group, the wound that can obviously increase rabbit is cured for experimental group and control group
Area is closed, but experimental group action is faster than with control group.
2) wound healing situation:
Experimental group: having the diffusate of 15 rabbit surface of a wound to disappear substantially on the 3rd day, and starts incrustation healing, and the 4th day all
Start to heal, averagely healing area there are 6 wounds to heal completely at the end of being about experiment in the 1/2, the 12nd day.
Control group: having the diffusate of 4 rabbit surface of a wound to disappear substantially on the 3rd day, and starts incrustation healing, and the 4th day all
Start to heal, averagely healing area there are 3 wounds to heal completely at the end of being about experiment in the 1/4, the 12nd day.
3) scar is observed:
Experimental group surface of a wound epidermis covers substantially, there is a little scar.
Control group epidermis has a small amount of covering, and scar is more.
Conclusion:
In summary three aspects, biological agent treatment wound effect provided by the invention is obvious, and mechanism may be to promote
It is rebuild into wound blood vessels, keeps good blood circulation, protection wound prevents from infecting, and inhibits the generation etc. of scar.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all in essence of the invention
Made any modifications, equivalent replacements, and improvements etc., should all be included in the protection scope of the present invention within mind and principle.
Claims (5)
1. a kind of biological agent for inhibiting scar and promoting wound healing, which is characterized in that the inhibition scar and promotion wound
Mouthful healing biological agent by Herba Andrographitis 12g~18g, cow-bezoar 15g~19g, conyza blinii 5g~11g, cactus 5g~11g,
Cordate houttuynia 9g~15g, bletilla striata 10g~16g, polygonum cuspidate 8g~12g, radix paeoniae rubra 3g~7g, Radix Astragali 6g~14g, field thistle 3g~5g, campanulaceae
8g-14g, granatum 1g~3g and peppermint 25g~29g composition.
2. a kind of inhibit scar as described in claim 1 and promote the preparation method of the biological agent of wound healing, feature exists
In, the preparation method of the biological agent for inhibiting scar and promoting wound healing, specifically includes the following steps:
Step 1: Herba Andrographitis, cow-bezoar, conyza blinii, cactus, cordate houttuynia, the bletilla striata, polygonum cuspidate, radix paeoniae rubra, Radix Astragali, field thistle, tangerine are taken
Stalk, granatum and peppermint are pre-processed；
Step 2: by Herba Andrographitis, cow-bezoar, conyza blinii, cactus, cordate houttuynia, the bletilla striata, polygonum cuspidate, radix paeoniae rubra, Radix Astragali, field thistle, campanulaceae
5~15 times of distilled water are added, impregnate 8h~12h, carry out fried 2h~4h using boiling machine, filtering obtains Chinese medicine liquid, stays Chinese medicine
Slag；
Step 3: Chinese medicine liquid is concentrated, and obtains the concentrated liquid of tradition Chinese medicine；Chinese medicine slag carries out powder using micronizer after drying
It is broken, obtain Chinese medicine slag fine powder；
Step 4: pomegranate peel essential oil is prepared using cold-press；Microwave-assisted acquisition Peppermint essential oil is cooperated using way of distillation extraction, it is standby
With；
Step 5: successively ultra micro Chinese medicine slag fine powder, pomegranate peel essential oil and Peppermint essential oil are added in the concentrated liquid of tradition Chinese medicine, through equal
Matter, sterilization to get.
3. inhibiting scar as described in claim 1 and promoting the preparation method of the biological agent of wound healing, which is characterized in that
In the step 1, pretreatment includes:
(1) choose Herba Andrographitis, cow-bezoar, conyza blinii, cactus, cordate houttuynia, the bletilla striata, polygonum cuspidate, radix paeoniae rubra, Radix Astragali, field thistle, campanulaceae,
Granatum and peppermint；(2) impurity is removed；(3) it cleans；(4) it dries；(5) it sterilizes.
4. inhibiting scar as described in claim 1 and promoting the preparation method of the biological agent of wound healing, which is characterized in that
In the step 4, the preparation of pomegranate peel essential oil:
(1) it takes granatum to carry out disinfection, cleans, chopping processing；
(2) broken wall juicing is carried out to granatum using wall-breaking machine according to cold-press；
(3) essential oil is eluted with shower water again, is filtered, is separated, disinfection obtains pomegranate peel essential oil.
5. inhibiting scar as described in claim 1 and promoting the preparation method of the biological agent of wound healing, which is characterized in that
In the step 4, the preparation of Peppermint essential oil:
(1) fresh mint leaf is taken, cleaned, sterilized；
(2) 1h~3h is distilled using steam distillation, cooperates microwave-assisted, microwave power 280
W~300W, microwave time 3min~4min extract 3 times up to peppermint leaf essential oil.
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Application publication date: 20190521 |