CN109730304A - A kind of folium cortex eucommiae tranquilizing the mind compound buccal lozenge and preparation method thereof - Google Patents
A kind of folium cortex eucommiae tranquilizing the mind compound buccal lozenge and preparation method thereof Download PDFInfo
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- CN109730304A CN109730304A CN201811597121.3A CN201811597121A CN109730304A CN 109730304 A CN109730304 A CN 109730304A CN 201811597121 A CN201811597121 A CN 201811597121A CN 109730304 A CN109730304 A CN 109730304A
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- cortex eucommiae
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- Medicinal Preparation (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
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Abstract
The invention discloses a kind of folium cortex eucommiae tranquilizing the mind compound buccal lozenges and preparation method thereof, the formula of compound buccal lozenge is (weight ratio): 10-15 parts of folium cortex eucommiae extract powder, 10-20 parts of composite functional micro mist, 70-80 parts of mannitol, 4-8 parts of xylitol, 3-5 parts of magnesium stearate, 0.1-0.3 parts of chitosan, 0.1-0.3 parts of book lotus brain；The formula of the composite functional micro mist is (weight ratio): semen ziziphi spinosae Ultramicro-powder: fushen's Ultramicro-powder: tuber fleeceflower stem Ultramicro-powder: seed of Oriental arborvitae Ultramicro-powder: eclipta Ultramicro-powder: cortex albiziae Ultramicro-powder: Radix Polygalae Ultramicro-powder=1:1:1:1:1:1:1.There is the folium cortex eucommiae tranquilizing the mind compound buccal lozenge prepared according to the present invention tranquilizing the mind to resist the health-care efficacies such as strongly fragrant, feeding smart sleeping, be suitable for the health care demand of white collar, brain worker in modern fast pace society, wide market.
Description
Technical field
The invention belongs to health food manufacture field, it is related to a kind of folium cortex eucommiae tranquilizing the mind compound buccal lozenge and preparation method thereof.
Background technique
With the rapid development of society, the work and life rhythm of people is increasingly accelerated, the dual-pressure of body and spirit
Also it increases with it, electronic product universal and is widely used, especially computer and mobile phone, seriously affect people after work
Rest, or even carry out big interference to Sleeping band, long-term work and rest is irregular, easily causes psychological anxieties, immunity function decline.Cause
This, a raising of research and development is immunized, the health care product of mental-tranquilization is of great significance.
Cortex Eucommiae is the distinctive rare tonic herb of China, and folium cortex eucommiae is rich in flavones, loose ester alcohol diglucoside, Geniposide
The various nutrient elements such as glycosides, chlorogenic acid, caffeic acid, aucubin, the minerals such as Yi Jitie, zinc, selenium have and clear liver and improve vision,
Tonify Qi of the kidney, regulating lipoid and reducing blood pressure, anti-inflammatory be antibacterial, strengthening the bones and muscles, anti-aging, it is antifatigue, increase many effects such as immunity.
It is more using folium cortex eucommiae as the functional beverage of primary raw material currently on the market, but lack a kind of mental-tranquilization and conveniently
The eucommia health care product lozenge taken.In addition, in existing folium cortex eucommiae leach extraction method, all not to the effective component of folium cortex eucommiae into
Row research, and analysis measurement only is carried out to its effective component, it can just produce the good product of health-care efficacy.
Inventor is engaged in the research of Cortex Eucommiae beverage for many years, for example " a kind of Cortex Eucommiae is multiple in the Chinese patent of my invention in 2013
Close the preparation method (application No. is 201310658168.7) of anti-fatigue functional beverage, a kind of removal folium cortex eucommiae extract liquor peculiar smell is matched
The method (application No. is 201310658201.6) of health drink processed, a kind of preparation method of Cortex Eucommiae appetite-stimulating health-care drink
(201310658256.7) " in, a kind of preparation method of Cortex Eucommiae drinks is related to, after folium cortex eucommiae is extracted, using ozone
The method of processing and bioencapsulation processing overcomes careless fishy smell, bitter taste and the astringent taste problem outstanding in Cortex Eucommiae extract liquor, and soaks
Take use by folium cortex eucommiae boiled at 100 DEG C and hot conditions under the critical process that carries out.The above patented technology focuses on solving
The problem that folium cortex eucommiae peculiar smell how is removed in the preparation of Cortex Eucommiae beverage, does not optimize adjustment to technique in practice, to prevent
Only or reduce process for preparation in effective ingredient (active material) loss, so that it is guaranteed that the health-care efficacy of beverage.
Summary of the invention
The invention proposes a kind of folium cortex eucommiae tranquilizing the mind compound buccal lozenges and preparation method thereof, former based on folium cortex eucommiae extract powder
Material, mixing are added to the extract powders such as semen ziziphi spinosae, fushen, tuber fleeceflower stem, the seed of Oriental arborvitae, eclipta, cortex albiziae, Radix Polygalae, compound are made and contains
Piece plays the health-care effect of mental-tranquilization；Process optimization link has been carried out in folium cortex eucommiae extraction simultaneously, has reduced effective ingredient
Loss, it is ensured that the health-care efficacy of lozenge.
The present invention is added to following auxiliary material on the basis of folium cortex eucommiae extract powder:
(1) semen ziziphi spinosae: containing multiple efficacies ingredients such as alkaloid, saponin(e and flavonoids, there is calmness, hypnosis throe, resist and shy
It faints, reducing blood lipid, raising are immunized, resist myocardial ischemia and arrhythmia cordis.Have effects that tonifying liver, calming heart, arrest sweating, promote the production of body fluid, by doctor
It is known as " sleeping fruit in east " with patient；(2) fushen: being the fungi colonized on pine tree, there is excreting dampness, invigorating the spleen, calming heart etc. and happy benefit
It is dynamic, support spirit, calm the nerves, mend it is tired, control that blood of having a guilty conscience is few, have ants in one's pants, be lying when sleeping the diseases such as not peaceful；(3) tuber fleeceflower stem: there is nourishing heart peace
The effect of mind, dispelling wind and removing obstruction in the meridians, is used for insomnia and dreamful sleep, the conditioning of tranquilizing and allaying excitement；(4) seed of Oriental arborvitae: containing unsaturated fatty acid, saponin(e,
The minerals such as volatile oil, calcium, phosphorus, iron and multivitamin, can mental-tranquilization, relax bowel and defecation.For restlessness of asrhenia type and insomnia, under memory
Drop, the conditioning of hypoimmunity；(5) eclipta: the deficiency of liver-yin and kidney-yin, vexed insomnia, tinnitus dizziness, protecting liver and detoxication can be controlled, reduces and turns
Adnosine deaminase etc.；(6) cortex albiziae: having tranquilizing the mind relieve stagnation, and promoting blood circulation disappears bitterly, and master is confused and worried, the function factors such as melancholy insomnia；(7) Radix Polygalae:
Containing saponin(e, Radix Polygalae ketone, alkaloid, polygalytol, glucide etc., there is tranquilizing the mind, intelligence development, calmness, hypnosis and anticonvulsant action.It will
Above-mentioned functional material combines, and more effect compound buccal lozenges are made, take convenient for daily.
Technical scheme is as follows:
A kind of folium cortex eucommiae tranquilizing the mind compound buccal lozenge is formulated as (weight ratio): 10-15 parts of folium cortex eucommiae extract powder, composite functional
10-20 parts of micro mist, 70-80 parts of mannitol, 4-8 parts of xylitol, 3-5 parts of magnesium stearate, 0.1-0.3 parts of chitosan, book lotus brain
0.1-0.3 parts；
The formula of the composite functional micro mist is (weight ratio): semen ziziphi spinosae Ultramicro-powder: fushen's Ultramicro-powder: tuber fleeceflower stem is super
Micro mist: seed of Oriental arborvitae Ultramicro-powder: eclipta Ultramicro-powder: cortex albiziae Ultramicro-powder: Radix Polygalae Ultramicro-powder=1:1:1:1:1:1:1.
A kind of preparation method of folium cortex eucommiae tranquilizing the mind compound buccal lozenge, comprising the following steps:
[1] preparation of folium cortex eucommiae extract powder:
[1.1] feedstock capture
After the fresh folium cortex eucommiae of acquisition is dried in 60-70 DEG C of drying tunnel, ventilation is stored in using black woven bag and is kept away
It is spare in the warehouse of light；
[1.2] water logging is extracted
By the folium cortex eucommiae after cleaning according to dry folium cortex eucommiae: the ratio of water=1:10-30 (mass ratio) carries out flooding extraction,
Temperature is 60-70 DEG C, and water logging extraction time is 3-4 hours；
[1.3] filtering and concentrating
It is 20-30% (mass ratio) that leaching liquor, which is concentrated into solid content,；
[1.4] protective agent adds
Food acids are added in concentrated slurry, so that pH value is 3.5-4.0, add the table sugar of 5% (mass ratio), so
The beta-cyclodextrin of 5%-10% (mass ratio) is added afterwards, folium cortex eucommiae concentrate is made；
[1.5] it is spray-dried
Cortex Eucommiae concentrate is placed in spray drying tower and is spray-dried, folium cortex eucommiae extract powder is prepared, wherein shutting out
The moisture content of Zhong Ye extract powder is 5%-10%；It is stand-by that the folium cortex eucommiae extract powder of preparation is placed in low-temperature storage in sterile aluminum foil bag；
[2] mixing granulation, tabletting
According to 10-15 parts of folium cortex eucommiae extract powder, 10-20 parts of composite functional micro mist, 70-80 parts of mannitol, xylitol 4-8
Part, 3-5 part of magnesium stearate, 0.1-0.3 parts of chitosan, the mass ratio of 0.1-0.3 parts of book lotus brain weighs and 70-90% is added after mixing
The ethyl alcohol of purity infiltrates, drying, tabletting after granulation；The formula of the composite functional micro mist is (weight ratio): semen ziziphi spinosae is super
Micro mist: fushen's Ultramicro-powder: tuber fleeceflower stem Ultramicro-powder: seed of Oriental arborvitae Ultramicro-powder: eclipta Ultramicro-powder: cortex albiziae Ultramicro-powder: Radix Polygalae ultra micro
Powder=1:1:1:1:1:1:1；
[3] it sterilizes
Finished product lozenge is subjected to ultraviolet sterilization or microwave disinfection, wherein the temperature of lozenge is controlled in 60- in microwave disinfection
70℃；
[4] it is packed and stored
Packaging, labeling, vanning and coding storage.
In the preparation method of above-mentioned folium cortex eucommiae tranquilizing the mind compound buccal lozenge, the moisture content of folium cortex eucommiae is lower than 13% in step [1.1].
In the preparation method of above-mentioned folium cortex eucommiae tranquilizing the mind compound buccal lozenge, the cleaning in step [1.2] be respectively adopted tap water and
Pure water carries out spray with pure water and cleans wherein folium cortex eucommiae is placed on conveyer belt after being cleaned in pond with tap water.
In the preparation method of above-mentioned folium cortex eucommiae tranquilizing the mind compound buccal lozenge, continuously extracted in step [1.2] using ultrasonic reverse back stream
Equipment extracts.
In the preparation method of above-mentioned folium cortex eucommiae tranquilizing the mind compound buccal lozenge, folium cortex eucommiae leaching liquor is placed in economic benefits and social benefits in step [1.3]
It is concentrated in inspissator.
In the preparation method of above-mentioned folium cortex eucommiae tranquilizing the mind compound buccal lozenge, food acids are citric acid in step [1.5].
In the preparation method of above-mentioned folium cortex eucommiae tranquilizing the mind compound buccal lozenge, table sugar is sucrose or fructose in step [1.4].
In the preparation method of above-mentioned folium cortex eucommiae tranquilizing the mind compound buccal lozenge, the leaving air temp of spray drying tower is in step [1.5]
50-60℃。
In the preparation method of above-mentioned folium cortex eucommiae tranquilizing the mind compound buccal lozenge, the time of step [3] ultraviolet sterilization is 15-20 points
Clock.
The technology projecting point that the present invention has is as follows:
1, the present invention is big for modern's operating pressure, sleep insufficiency, it is confused and worried the problems such as, preferably Cortex Eucommiae, wild jujube
Effect of Compound Anshen lozenge is made in benevolence, fushen, tuber fleeceflower stem, the seed of Oriental arborvitae, eclipta, cortex albiziae, Radix Polygalae, and wherein semen ziziphi spinosae, fushen, night hand over
Rattan, the seed of Oriental arborvitae, eclipta, cortex albiziae, Radix Polygalae are deployed by rational proportion, play the role of mental-tranquilization relieve stagnation, and Cortex Eucommiae is made
For rare invigorant, itself there are the nourishing effects such as strengthen immunity, anti-aging, at the same also have it is neutral it is mild, as ministerial drug
When the small property feature of repellency, can be with a variety of foods such as semen ziziphi spinosae, fushen, tuber fleeceflower stem, the seed of Oriental arborvitae, eclipta, cortex albiziae, Radix Polygalae
Medicinal material compatibility.After lozenge is taken for a long time, outside the health care requirement for meeting modern's mental-tranquilization relieve stagnation, moreover it is possible to play strengthening tendons
Bone, improves the composite efficacies such as immunity at anti-aging, nourishes, achieves many things at one stroke comprehensively.
2, the present invention is in the stabilization to nutritional ingredients such as Chlorogenic Acid in Eucommia ulmoides Oliv. Leaves, flavones, Geniposidic acid, Aucubins
Property, on the basis of the characteristics such as anti-oxidant further investigation, in conjunction with the characteristic of institute's synthetic beverage, to the illumination influenced in raw material preparation,
The factors such as temperature, pH value have carried out accurate control, substantially increase product nutrient substances content.
3, intermediate products of the present invention in beverage --- in extract powder preparation, to the loss characteristic of folium cortex eucommiae nutritional ingredient into
Research of having gone, so that the PH that prime cement is concentrated is 3.5-4.0 or so, has by addition citric acid or the scheme of other food acid agent
Effect prevents the loss of the ingredients such as flavones, chlorogenic acid, Geniposidic acid, adjust again in beverage preparation in later use prime cement
To suitable pH value, the peculiar mouthfeel of Cortex Eucommiae beverage is maintained.The table sugar that joined 5% in concentration prime cement simultaneously, passes through increasing
Add sucrose concentration to reduce dissolved oxygen amount, effectively inhibits the oxygenolysis of the substances such as flavones, chlorogenic acid.Wherein selection 5% is sugared adds
Dosage be comprehensively consider sugared part ratio it is dry to subsequent spray to the degree of protection of nutritional ingredient and too low sugar in caused by
Agglomeration, viscous wall etc. influence, and carry out the result of parameter optimization.Furthermore it is added to the beta-cyclodextrin of 5%-10% before spray drying,
The characteristics of using its embedding effect and granular material, under the premise of not influencing drying process with atomizing, realize nutritional ingredient
Retain.
4, the raw material in the present invention takes shading treatment in storage and preparation process, and folium cortex eucommiae is stored up using black woven bag
It deposits, reducing illumination influences the brings oxygenolysis such as chlorogenic acid, Geniposidic acid, Aucubin；Simultaneously by picking
Fresh folium cortex eucommiae is processed in time is prepared into folium cortex eucommiae concentration prime cement or eucommia ulmoides extract product, and arranges through overnutrition protection
Long term storage is applied, and logistics deployment is carried out according to the progress demand of subsequent beverage preparation, is avoided in traditional Cortex Eucommiae beverage preparation
Because of the long term storage bring nutrient loss of folium cortex eucommiae, at the same also reduce storage area and strange land end product preparation plus
The transportation cost in working hour has adapted to the place of production in modern plants extraction product manufacturing and has carried out raw material roughing extraction, strange land completion eventually
Hold product manufacturing sale with the new model of save the cost.
5, the present invention has carried out accurate control to temperature in extract powder preparation, so that drying, water logging are extracted, concentration is dry
Temperature in dry controls within 70 DEG C, these measures effectively prevent the loss of effective component in folium cortex eucommiae.
6, present invention employs microwave sterilization mode, temperature is continued to monitor in sterilization process, and by extending sterilization time,
Temperature is controlled 60-70 DEG C, using the collective effect of microwave heating effect and non-thermal effect, makes microbial body internal protein and physiology
Movable substance morphs, develops and delays and dead, achievees the purpose that food sterilizing, fresh-keeping, simultaneously because temperature control is 65
DEG C or so, to flavones, chlorogenic acid, two grape of Geniposidic acid, Aucubin and rosin spirit when reducing conventional high temperature sterilizing
The decomposition of glucoside improves the conservation rate of nutritional ingredient.Simultaneously in microwave sterilization, the product after packaging can be placed directly within micro-
It is carried out in wave sterilizer, facilitates execute-in-place.
Specific embodiment
Inventor is studied for a long period of time discovery, either the storage of folium cortex eucommiae, water logging extract or beverage preparation link in,
The nutritional ingredients such as chlorogenic acid, flavones, Geniposidic acid, Aucubin, Pinoresinol diglucoside can all occur in various degree
It decomposes and is lost, major influence factors have:
(1) storage time and illumination effect
In traditional folium cortex eucommiae beverage processing, drying of being exposed to the sun in the sunlight after the picking of fresh folium cortex eucommiae, in the form of cured leaf into
Row long term storage carries out water logging extraction to Cortex Eucommiae leaf raw material again according to demand in beverage preparation.And inventor and other scholars
Research achievement show that raw material in prolonged storage, is influenced by extraneous factor, especially illumination is to yellow in folium cortex eucommiae
Ketone, chlorogenic acid, Geniposidic acid, Aucubin and Pinoresinol diglucoside have large effect effect, under light illumination
It easily causes oxygenolysis and causes nutrition loss.
For the influence of illumination factor in raw material long term storage, the present invention abandoned traditional folium cortex eucommiae drying and
Storing mode disposably dries storage using drying machine after feedstock capture in the fall, and carries out water to folium cortex eucommiae as early as possible
Extraction process is soaked, manufactured folium cortex eucommiae extract powder, which is placed in freezer, to be stored.In addition, taken in raw material storage and preparation process
Shading treatment, folium cortex eucommiae select the storage of black woven bag, and the folium cortex eucommiae concentration prime cement after preparation is then placed on the aluminium foil of shading
Bag stored for extended periods, this mode not only reduce the loss of nutritional ingredient, and by the side of folium cortex eucommiae at source long term storage
Formula is changed to the long term storage of folium cortex eucommiae extract powder, greatly reduce storage area and strange land beverage preparation processing when transport at
This.
(2) influence of temperature parameter
Traditional folium cortex eucommiae extracts usually leaches dozens of minutes in the boiled water boiled, and the newest result of study of inventor
During showing Cortex Eucommiae beverage preparation, high temperature is to flavones, chlorogenic acid, two grape of Geniposidic acid, Aucubin and rosin spirit
Glucoside has large effect, and chlorogenic acid therein is heat-sensitive substance, when heating temperature is more than 70 DEG C, green original in leaching liquid
The content meeting rapid decrease of acid, it is therefore desirable to water soaking temperature be controlled, the present invention is continuously extracted using ultrasonic reverse back stream and set
It is standby to be extracted in temperature for 60-70 DEG C, while taking into account extracting efficiency, reduce the loss of nutritional ingredient.
(3) influence of pH value and sugar
The research achievement of inventor shows the protection of sugar content and pH value appropriate in beverage to nutritional ingredient in folium cortex eucommiae
It acts on more significant.Within the scope of certain sucrose concentration, the loss late of the ingredients such as flavones, chlorogenic acid is with sucrose concentration in beverage
Increase and reduce, this is because the increase of sugared content, declines the oxygen content in solution, inhibits the oxidation of flavones, chlorogenic acid
It decomposes.Therefore concentration prime cement preparation in be purposefully added 5% sucrose, meet the requirement that extract powder product stores for a long time, and
The sugar of the ratio has no effect on subsequent spray drying process.In later period beverage preparation according to production need be diluted with water sugar it is dense
Degree, will not influence the mouthfeel of product.
By on pH value on nutritional ingredient influence studies have shown that for eucommia bark flavone, resist under acidic environment
Oxidability is stronger, and antioxidant activity significantly reduces under alkaline environment；And for chlorogenic acid, Geniposidic acid, peach jaurel
For glucoside and Pinoresinol diglucoside, under acidic environment, thermal stability is also at preferable states, comprehensively consider it is different at
Point different to the influence degree of pH value, and combine drink and production process and organoleptic requirements, final choice is by the soda acid of concentrate
Degree is 3.5-4.0 by increasing the scheme of the food acids such as citric acid to deploy to PH, realizes flavones and chlorogenic acid to the maximum extent
Etc. Different Nutritions ingredient balance retain.
(4) embedding effect of beta-cyclodextrin
Inventor it has been investigated that, a certain proportion of beta-cyclodextrin is added in folium cortex eucommiae concentrate, can effectively inhibit
The loss of the nutritional ingredients such as flavones and chlorogenic acid, this is because beta-cyclodextrin main component is stable oligosaccharide, embedding is made
With the oxygenolysis for inhibiting the nutritional ingredients such as chlorogenic acid, flavones, thermal stability is improved.And suitable beta-cyclodextrin will not be right
The mouthfeel of product has an impact, and will not also impact to the process that Cortex Eucommiae concentrate spray drying prepares extract powder.
Embodiment one:
A kind of preparation method of folium cortex eucommiae tranquilizing the mind compound buccal lozenge, comprising the following steps:
[1] preparation of folium cortex eucommiae extract powder:
[1.1] feedstock capture
The fresh folium cortex eucommiae for harvesting the current year 6-9 month is placed in circulation drying tunnel and is dried at 60 DEG C, so that folium cortex eucommiae contains
Water rate is lower than 13%, and cured leaf is stored in spare in the warehouse of ventilation lucifugal using black woven bag；
[1.2] water logging is extracted
Folium cortex eucommiae to be cleaned, cleaning is divided into two steps: folium cortex eucommiae is placed in pond and is cleaned using tap water by the first step,
Wash off the dust on blade face；Folium cortex eucommiae after cleaning is placed on conveyer belt by second step, is dripped after carrying out spray cleaning using pure water
It is dry；
By the folium cortex eucommiae after cleaning according to dry Cortex Eucommiae leaf raw material: the ratio of water=1:10 (mass ratio) is placed in ultrasonic reverse back
It flows continuous extract equipment to extract, temperature is 60 DEG C, and water logging extraction time is 3 hours；The work of the ultrasonic continuous extract equipment of reverse back stream
It is that the high-frequency signal issued by ultrasonic wave is converted into the cell that mechanical oscillating wave destroys extract by energy converter as principle
Wall dissolves in effective component with free state and completes extraction process in water, and ensures that the effective component of water and extract is quickly melted
Dissolution is closed, while effective component is not destroyed, extraction time and efficiency are significantly improved.The equipment can be automatic at low temperature real
Existing continuous feed and continuous discharge, have the characteristics that water-saving, energy conservation, recovery rate are high.
[1.3] filtering and concentrating
Leaching liquor is placed in inspissator and is concentrated, being concentrated into solid content is 20% or so.Inspissator is preferably double
Inspissator is imitated, which can be had using external heat Natural Circulation and negative pressure of vacuum mode according to enrichment factor come selection parameter
The features such as evaporation rate is fast, and cocnentration factor is great, pollution-free, easy to clean.
[1.4] protective agent adds
Citric acid, uniform and monitoring potential stirring while adding, until pH value is 3.5 are added in concentrated slurry；
Sucrose is added according still further to the ratio of 5% (mass ratio), the beta-cyclodextrin of 10% (mass ratio) is then added, folium cortex eucommiae concentration is made
Liquid；
The purpose that food acids, table sugar and beta-cyclodextrin is added is to prevent the oxygen of nutritional ingredient in folium cortex eucommiae in concentrate
Change loss, extends shelf lives, and have no effect on subsequent drink mouthfeel.
[1.5] it is spray-dried
Cortex Eucommiae concentrate is placed in spray drying tower and is spray-dried, folium cortex eucommiae extract powder is prepared, control into
Air temperature is 100 DEG C, and leaving air temp is 50 DEG C, and the moisture content for the folium cortex eucommiae extract powder being prepared is 5%-10%；
Material enters the hot wind progress that drying tower is atomization, sends with air inlet fan in dryer section through centrifugal spraying disk in implementation
Heat exchange, surface of material moisture evaporate rapidly, are landed the cone below equipment by dry extract powder, humid air is by arranging in tower
Blower is discharged, and institute's band particle is down in cone through Bag filter recycling and is mixed with extract powder in exhaust gas, automatic through rotating blanking valve
It flows out in tower.
[1.6] it stores
Manufactured folium cortex eucommiae extract powder is canned into sterile aluminum foil bag in clean workplace, and in air-conditioned cold store or freezer
It is stored, is prepared for beverage and other products, wherein the storage temperature of freezer is -10~-5 DEG C.
[2] mixing granulation, tabletting
According to 10 parts of folium cortex eucommiae extract powder, 10 parts of composite functional micro mist, 70 parts of mannitol, 4 parts of xylitol, magnesium stearate
3 parts, 0.1 part of chitosan, the weight ratio of 0.1 part of book lotus brain is prepared；Wherein the formula of composite functional micro mist is (weight
Than): semen ziziphi spinosae Ultramicro-powder: fushen's Ultramicro-powder: tuber fleeceflower stem Ultramicro-powder: seed of Oriental arborvitae Ultramicro-powder: eclipta Ultramicro-powder: cortex albiziae ultra micro
Powder: Radix Polygalae Ultramicro-powder=1:1:1:1:1:1:1.Folium cortex eucommiae extract powder is according to the homemade product of previous process, remaining material
For commercially available up-to-standard products.Chitosan has certain bioadhesive, and epithelial cell mucin lubrication can be made to extend and contained
In piece effective component oral mucosa surface adsorption time, to promote the absorption of effective component.
The auxiliary materials such as xylitol, chitosan, mannitol are mixed and are mixed thoroughly, are sieved with 100 mesh sieve；Then by folium cortex eucommiae extract powder and again
It is uniformly mixed after closing functional micro mist sieving with auxiliary material, the ethyl alcohol of 70% purity is added, is mixed into wet feed；Wet feed is put into
It is granulated in pelletizer, crosses 16-18 mesh, dry 2 hours at a temperature of 60 DEG C, after 10-12 mesh, then by whole good pellet
Middle addition book lotus brain and magnesium stearate, are placed in tablet press machine and are pressed into lozenge.
[3] it sterilizes
Finished product lozenge is subjected to ultraviolet sterilization or microwave disinfection, wherein the time of ultraviolet sterilization is 15 minutes.Microwave
The temperature of lozenge is controlled at 60 DEG C in sterilization；Wherein the frequency of microwave is 2450MHz in microwave disinfection, and time of sterilizing is according to containing
Depending on the yield and microwave power of piece, the total plate count of drink and yeast bacterial content are no more than national regulations after sterilizing.
[4] it is packed and stored
Packaging, labeling, vanning and coding storage.
Embodiment two:
The preparation method of folium cortex eucommiae tranquilizing the mind compound buccal lozenge, comprising the following steps:
[1] preparation of folium cortex eucommiae extract powder:
[1.1] feedstock capture
The fresh folium cortex eucommiae for harvesting the current year 6-9 month is placed in circulation drying tunnel and is dried at 70 DEG C, so that folium cortex eucommiae contains
Water rate is lower than 13%, and cured leaf is stored in spare in the warehouse of ventilation lucifugal using black woven bag；
[1.2] water logging is extracted
Folium cortex eucommiae to be cleaned, cleaning is divided into two steps: folium cortex eucommiae is placed in pond and is cleaned using tap water by the first step,
Wash off the dust on blade face；Folium cortex eucommiae after cleaning is placed on conveyer belt by second step, is dripped after carrying out spray cleaning using pure water
It is dry；
By the folium cortex eucommiae after cleaning according to dry Cortex Eucommiae leaf raw material: the ratio of water=1:30 (mass ratio) is placed in ultrasonic reverse back
It flows continuous extract equipment to extract, temperature is 70 DEG C, and water logging extraction time is 4 hours；The work of the ultrasonic continuous extract equipment of reverse back stream
It is that the high-frequency signal issued by ultrasonic wave is converted into the cell that mechanical oscillating wave destroys extract by energy converter as principle
Wall dissolves in effective component with free state and completes extraction process in water, and ensures that the effective component of water and extract is quickly melted
Dissolution is closed, while effective component is not destroyed, extraction time and efficiency are significantly improved.The equipment can be automatic at low temperature real
Existing continuous feed and continuous discharge, have the characteristics that water-saving, energy conservation, recovery rate are high.
[1.3] filtering and concentrating
Leaching liquor is placed in inspissator and is concentrated, being concentrated into solid content is 30% or so.Inspissator is preferably double
Inspissator is imitated, which can be had using external heat Natural Circulation and negative pressure of vacuum mode according to enrichment factor come selection parameter
The features such as evaporation rate is fast, and cocnentration factor is great, pollution-free, easy to clean.
[1.4] protective agent adds
Citric acid, uniform and monitoring potential stirring while adding, until pH value is 4.0 are added in concentrated slurry；
Sucrose is added according still further to the ratio of 5% (mass ratio), the beta-cyclodextrin of 5% (mass ratio) is then added, folium cortex eucommiae concentration is made
Liquid；
The purpose that food acids, table sugar and beta-cyclodextrin is added is to prevent the oxygen of nutritional ingredient in folium cortex eucommiae in concentrate
Change loss, extend shelf lives, and since concentrate and extract powder are beverage and the intermediate product of other product configurations, and simultaneously
Subsequent drink mouthfeel is not influenced.
[1.5] it is spray-dried
Cortex Eucommiae concentrate is placed in spray drying tower and is spray-dried, folium cortex eucommiae extract powder is prepared, control into
Air temperature is 120 DEG C, and leaving air temp is 60 DEG C, and the moisture content for the folium cortex eucommiae extract powder being prepared is 5%-10%；
[1.6] it stores
Manufactured folium cortex eucommiae extract powder is canned into sterile aluminum foil bag in clean workplace, and in air-conditioned cold store or freezer
It is stored, is prepared for beverage and other products, wherein the storage temperature of freezer is -10~-5 DEG C.
[2] mixing granulation, tabletting
According to 15 parts of folium cortex eucommiae extract powder, 20 parts of composite functional micro mist, 80 parts of mannitol, 8 parts of xylitol, magnesium stearate
5 parts, 0.3 part of chitosan, the weight ratio of 0.3 part of book lotus brain is prepared；Wherein the formula of composite functional micro mist is (weight
Than): semen ziziphi spinosae Ultramicro-powder: fushen's Ultramicro-powder: tuber fleeceflower stem Ultramicro-powder: seed of Oriental arborvitae Ultramicro-powder: eclipta Ultramicro-powder: cortex albiziae ultra micro
Powder: Radix Polygalae Ultramicro-powder=1:1:1:1:1:1:1.Folium cortex eucommiae extract powder is according to the homemade product of previous process, remaining material
For commercially available up-to-standard products.Chitosan has certain bioadhesive, and epithelial cell mucin lubrication can be made to extend and contained
In piece effective component oral mucosa surface adsorption time, to promote the absorption of effective component.
The auxiliary materials such as xylitol, chitosan, mannitol are mixed and are mixed thoroughly, are sieved with 100 mesh sieve；Then by folium cortex eucommiae extract powder and again
It is uniformly mixed after closing functional micro mist sieving with auxiliary material, the ethyl alcohol of 90% purity is added, is mixed into wet feed；Wet feed is put into
It is granulated in pelletizer, crosses 16-18 mesh, dry 3 hours at a temperature of 70 DEG C, after 10-12 mesh, then by whole good pellet
Middle addition book lotus brain and magnesium stearate, are placed in tablet press machine and are pressed into lozenge.
Finished product lozenge is subjected to ultraviolet sterilization or microwave disinfection, wherein the time of ultraviolet sterilization is 20 minutes.Microwave
The temperature of lozenge is controlled at 70 DEG C in sterilization；Wherein the frequency of microwave is 2450MHz in microwave disinfection, and time of sterilizing is according to containing
Depending on piece yield and microwave power, the total plate count of drink and yeast bacterial content are no more than national regulations after sterilizing.
[4] it is packed and stored
Packaging, labeling, vanning and coding storage.
In order to be verified to above-mentioned technical effect, the present invention carried out respectively folium cortex eucommiae drying sunning comparative experiments,
Extraction temperature comparative experiments, pH value comparative experiments, pol comparative experiments, beta-cyclodextrin embedding experiment, and chromatographic column is used, according to
National standard measurement method determines the content of the nutritional ingredients such as flavones, chlorogenic acid, Pinoresinol diglucoside.Experimental result
It is as follows:
(1) drying sunning comparative experiments
The fresh folium cortex eucommiae of picking is divided into three parts of phase homogenous quantities, carried out respectively fresh leaf directly extract, the sun
Under dry with the drying experiment of 60-70 DEG C of machine, wherein dried under the sun and continue one week under ventilated environment in the fall, use is identical
Process conditions are completed water logging and are extracted.Every group is tested in triplicate, takes its average value, measures the relative amount of its nutritional ingredient.Knot
Fruit is as shown in table 1.
The drying sunning control experiment result of table 1
| Flavones retention rate | Chlorogenic acid retention rate | |
| Fresh folium cortex eucommiae water logging is extracted | 100% | 100% |
| Sun sunning | 86.7% | 83.5% |
| Machine drying | 95.2% | 94.4% |
1 experimental data of table explanation, using 60-70 DEG C of machine drying technology, than being dried under traditional sun to flavones and green
10% or so reserved can be improved in ortho acid.
(2) extraction temperature control experiment
The Folium Eucommiae of equal mass is placed in water logging in extractor to extract, only changes water soaking temperature, other parameters are identical,
Setting at a temperature of heat 30 minutes, then kept for 3 hours at 60 DEG C, measure the relative amount of its nutritional ingredient.Every group
It tests in triplicate, takes its average value, the results are shown in Table 2.
2 extraction temperature control experiment of table
| Extraction temperature | 100℃ | 90℃ | 80℃ | 70℃ | 60℃ | 50℃ |
| Chlorogenic acid | 75.2% | 80.4% | 88.5% | 96.8% | 105.3% | 100% |
| Pinoresinol diglucoside | 73.3% | 79.1% | 85.5% | 92.2% | 98.2% | 100% |
2 experimental data of table explanation, extraction temperature are most important to the reservation of nutritional ingredient.
(3) pH value control experiment
Appropriate citric acid is added in leaching liquor, is adjusted pH to setting value, is kept in dark place 3 months at room temperature, measures its battalion
The relative amount formed point, every group is tested in triplicate, takes its average value, the results are shown in Table 3.
Table 3PH value control experiment
| PH value | 3.0 | 4.0 | 5.0 | 6.0 |
| Chlorogenic acid | 110.3% | 104.6% | 103.5% | 100% |
| Flavones | 114.3% | 109.1% | 102.8% | 100% |
3 experimental data of table explanation, leaching liquor is under acidic environment, conducive to the long-term preservation of nutriment.
(4) pol control experiment
Suitable amount of sucrose is added in leaching liquor, is adjusted sugar content, is kept in dark place 3 months at room temperature, measures its nutritional ingredient
Relative amount, every group is tested in triplicate, takes its average value, the results are shown in Table 4.
4 pol control experiment of table
| Sugar content | 0% | 5% | 10% | 15% | 20% | 25% | 30% |
| Chlorogenic acid | 83.4% | 92.0% | 94.6% | 97.1% | 97.2% | 97.9% | 100% |
| Flavones | 84.3% | 91.9% | 95.2% | 96.5% | 97.2% | 98.0% | 100% |
4 experimental data of table explanation, addition sucrose facilitate the long-term preservation of leaching liquor nutriment.
(5) beta-cyclodextrin embedding experiment
Suitable beta-cyclodextrin is added in leaching liquor, is adjusted adding proportion, is kept in dark place 3 months at room temperature, measures it
The relative amount of nutritional ingredient, every group is tested in triplicate, takes its average value, the results are shown in Table 5.
The embedding experiment of 5 beta-cyclodextrin of table
| Beta-cyclodextrin amount | 0% | 2% | 4% | 6% | 8% | 10% |
| Chlorogenic acid | 88.2% | 90.4% | 90.4% | 93.0% | 94.6% | 100% |
| Pinoresinol diglucoside | 90.2% | 93.6% | 93.0% | 95.6% | 97.8% | 100% |
5 experimental data of table explanation is added beta-cyclodextrin to folium cortex eucommiae leaching liquor, facilitates the long-term preservation of nutriment.
The present invention on influenced in beverage and other product configurations the temperature of folium cortex eucommiae nutritional ingredient, illumination, pH value, containing sugar
Amount etc. has carried out parameter optimization and accurate control, is used successfully in the preparation of extract powder, and further experiment shows this hair
It is bright that the retention rate of the nutritional ingredients such as flavones, chlorogenic acid improves 20%-30% compared with traditional folium cortex eucommiae extractive technique,
Effectively reduce the loss of nutritional ingredient in product, it is ensured that the health-care efficacy of Cortex Eucommiae leaf beverage.
There is tranquilizing the mind to resist the health-care efficacies such as strongly fragrant, feeding smart sleeping, fit for the folium cortex eucommiae tranquilizing the mind compound buccal lozenge prepared according to the present invention
Together in the health care demand of white collar, brain worker in modern fast pace society, wide market.
Claims (10)
1. a kind of folium cortex eucommiae tranquilizing the mind compound buccal lozenge, which is characterized in that the formula of compound buccal lozenge is (weight ratio): folium cortex eucommiae extract powder
10-15 parts, 10-20 parts of composite functional micro mist, 70-80 parts of mannitol, 4-8 parts of xylitol, 3-5 parts of magnesium stearate, chitosan
0.1-0.3 parts, 0.1-0.3 parts of book lotus brain；
The formula of the composite functional micro mist is (weight ratio): semen ziziphi spinosae Ultramicro-powder: fushen's Ultramicro-powder: tuber fleeceflower stem ultra micro
Powder: seed of Oriental arborvitae Ultramicro-powder: eclipta Ultramicro-powder: cortex albiziae Ultramicro-powder: Radix Polygalae Ultramicro-powder=1:1:1:1:1:1:1.
2. a kind of preparation method of folium cortex eucommiae tranquilizing the mind compound buccal lozenge, which comprises the following steps:
[1] preparation of folium cortex eucommiae extract powder:
[1.1] feedstock capture
After the fresh folium cortex eucommiae of acquisition is dried in 60-70 DEG C of drying tunnel, ventilation lucifugal is stored in using black woven bag
It is spare in warehouse；
[1.2] water logging is extracted
By the folium cortex eucommiae after cleaning according to dry folium cortex eucommiae: the ratio of water=1:10-30 (mass ratio) carries out flooding extraction, temperature
It is 60-70 DEG C, water logging extraction time is 3-4 hours；
[1.3] filtering and concentrating
It is 20-30% (mass ratio) that leaching liquor, which is concentrated into solid content,；
[1.4] protective agent adds
Food acids are added in concentrated slurry so that pH value be 3.5-4.0, add the table sugar of 5% (mass ratio), then plus
Folium cortex eucommiae concentrate is made in the beta-cyclodextrin for entering 5%-10% (mass ratio)；
[1.5] it is spray-dried
Cortex Eucommiae concentrate is placed in spray drying tower and is spray-dried, folium cortex eucommiae extract powder is prepared, wherein folium cortex eucommiae
The moisture content of extract powder is 5%-10%；It is stand-by that the folium cortex eucommiae extract powder of preparation is placed in low-temperature storage in sterile aluminum foil bag；
[2] mixing granulation, tabletting
According to 10-15 parts of folium cortex eucommiae extract powder, 10-20 parts of composite functional micro mist, 70-80 parts of mannitol, 4-8 parts of xylitol,
3-5 parts of magnesium stearate, 0.1-0.3 parts of chitosan, it is pure that 70-90% is added after the mass ratio of 0.1-0.3 parts of book lotus brain weighing mixing
The ethyl alcohol of degree infiltrates, drying, tabletting after granulation；The formula of the composite functional micro mist is (weight ratio): semen ziziphi spinosae ultra micro
Powder: fushen's Ultramicro-powder: tuber fleeceflower stem Ultramicro-powder: seed of Oriental arborvitae Ultramicro-powder: eclipta Ultramicro-powder: cortex albiziae Ultramicro-powder: Radix Polygalae Ultramicro-powder
=1:1:1:1:1:1:1；
[3] it sterilizes
Finished product lozenge is subjected to ultraviolet sterilization or microwave disinfection, wherein the temperature of lozenge is controlled at 60-70 DEG C in microwave disinfection；
[4] it is packed and stored
Packaging, labeling, vanning and coding storage.
3. the preparation method of folium cortex eucommiae tranquilizing the mind compound buccal lozenge according to claim 2, it is characterised in that: in step [1.1]
The moisture content of folium cortex eucommiae is lower than 13%.
4. the preparation method of folium cortex eucommiae tranquilizing the mind compound buccal lozenge according to claim 2, it is characterised in that: in step [1.2]
Cleaning tap water and pure water is respectively adopted, wherein folium cortex eucommiae is placed on conveyer belt after being cleaned in pond with tap water,
Spray is carried out with pure water to clean.
5. the preparation method of folium cortex eucommiae tranquilizing the mind compound buccal lozenge according to claim 2, it is characterised in that: in step [1.2]
It is extracted using the ultrasonic continuous extract equipment of reverse back stream.
6. the preparation method of folium cortex eucommiae tranquilizing the mind compound buccal lozenge according to claim 2, it is characterised in that: in step [1.3]
Folium cortex eucommiae leaching liquor is placed in dual-effect concentrator and is concentrated.
7. the preparation method of folium cortex eucommiae tranquilizing the mind compound buccal lozenge according to claim 2, it is characterised in that: in step [1.5]
Food acids are citric acid.
8. the preparation method of folium cortex eucommiae tranquilizing the mind compound buccal lozenge according to claim 2, it is characterised in that: in step [1.4]
Table sugar is sucrose or fructose.
9. the preparation method of folium cortex eucommiae tranquilizing the mind compound buccal lozenge according to claim 2, it is characterised in that: in step [1.5]
The leaving air temp of spray drying tower is 50-60 DEG C.
10. the preparation method of folium cortex eucommiae tranquilizing the mind compound buccal lozenge according to claim 2, it is characterised in that: step [3] is ultraviolet
The time of line sterilization is 15-20 minutes.
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107801999A (en) * | 2017-12-14 | 2018-03-16 | 东北林业大学 | A kind of folium cortex eucommiae buccal tablet with vasorelaxation action |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107801999A (en) * | 2017-12-14 | 2018-03-16 | 东北林业大学 | A kind of folium cortex eucommiae buccal tablet with vasorelaxation action |
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| 叶文峰: "杜仲叶、大蒜复合饮料的研制", 《食品科学》 * |
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Application publication date: 20190510 |