CN107801999A - A kind of folium cortex eucommiae buccal tablet with vasorelaxation action - Google Patents
A kind of folium cortex eucommiae buccal tablet with vasorelaxation action Download PDFInfo
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- CN107801999A CN107801999A CN201711335777.3A CN201711335777A CN107801999A CN 107801999 A CN107801999 A CN 107801999A CN 201711335777 A CN201711335777 A CN 201711335777A CN 107801999 A CN107801999 A CN 107801999A
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- cortex eucommiae
- folium cortex
- powder
- buccal tablet
- water solubility
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- 229940046011 buccal tablet Drugs 0.000 title claims abstract description 13
- 239000006189 buccal tablet Substances 0.000 title claims abstract description 13
- 230000009471 action Effects 0.000 title claims abstract description 10
- 230000001196 vasorelaxation Effects 0.000 title claims abstract description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 37
- 239000000843 powder Substances 0.000 claims abstract description 35
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical class [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims abstract description 18
- 239000000284 extract Substances 0.000 claims abstract description 16
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims abstract description 12
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims abstract description 12
- 239000000811 xylitol Substances 0.000 claims abstract description 12
- 235000010447 xylitol Nutrition 0.000 claims abstract description 12
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims abstract description 12
- 229960002675 xylitol Drugs 0.000 claims abstract description 12
- 235000019359 magnesium stearate Nutrition 0.000 claims abstract description 11
- 206010020772 Hypertension Diseases 0.000 claims abstract description 6
- 239000000463 material Substances 0.000 claims abstract description 6
- 238000002360 preparation method Methods 0.000 claims abstract description 6
- 206010012601 diabetes mellitus Diseases 0.000 claims abstract description 5
- 239000000203 mixture Substances 0.000 claims abstract description 5
- 239000002994 raw material Substances 0.000 claims abstract description 5
- 230000036772 blood pressure Effects 0.000 claims abstract description 4
- 235000013305 food Nutrition 0.000 claims abstract description 3
- 241000208688 Eucommia Species 0.000 claims description 16
- 238000000605 extraction Methods 0.000 claims description 11
- 238000000034 method Methods 0.000 claims description 8
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims description 7
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims description 7
- 241000208689 Eucommia ulmoides Species 0.000 claims description 7
- 229940041616 menthol Drugs 0.000 claims description 7
- 238000001694 spray drying Methods 0.000 claims description 7
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 5
- 229930195725 Mannitol Natural products 0.000 claims description 5
- 239000000594 mannitol Substances 0.000 claims description 5
- 235000010355 mannitol Nutrition 0.000 claims description 5
- 230000008569 process Effects 0.000 claims description 3
- 238000002137 ultrasound extraction Methods 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims 1
- 239000007937 lozenge Substances 0.000 claims 1
- 239000004552 water soluble powder Substances 0.000 claims 1
- 239000012153 distilled water Substances 0.000 abstract description 8
- 239000006286 aqueous extract Substances 0.000 abstract description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 13
- 235000019441 ethanol Nutrition 0.000 description 8
- 230000000694 effects Effects 0.000 description 4
- 241000196324 Embryophyta Species 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- 239000000706 filtrate Substances 0.000 description 3
- 238000001914 filtration Methods 0.000 description 3
- -1 flavone compound Chemical class 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 239000003826 tablet Substances 0.000 description 3
- 244000269722 Thea sinensis Species 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 210000003038 endothelium Anatomy 0.000 description 2
- 235000013402 health food Nutrition 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 229940124549 vasodilator Drugs 0.000 description 2
- 239000003071 vasodilator agent Substances 0.000 description 2
- 241000208686 Eucommiaceae Species 0.000 description 1
- 239000000899 Gutta-Percha Substances 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 240000000342 Palaquium gutta Species 0.000 description 1
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 102000012740 beta Adrenergic Receptors Human genes 0.000 description 1
- 108010079452 beta Adrenergic Receptors Proteins 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000008033 biological extinction Effects 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000009795 derivation Methods 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 210000002889 endothelial cell Anatomy 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 229930003944 flavone Natural products 0.000 description 1
- 235000011949 flavones Nutrition 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 229920000588 gutta-percha Polymers 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 230000002102 hyperpolarization Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 229930015704 phenylpropanoid Natural products 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 150000003505 terpenes Chemical class 0.000 description 1
- 235000007586 terpenes Nutrition 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
- 230000000304 vasodilatating effect Effects 0.000 description 1
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 1
- 238000003809 water extraction Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/20—Agglomerating; Granulating; Tabletting
- A23P10/28—Tabletting; Making food bars by compression of a dry powdered mixture
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Mycology (AREA)
- Nutrition Science (AREA)
- Botany (AREA)
- Molecular Biology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention is a kind of folium cortex eucommiae buccal tablet with vasorelaxation action.Using folium cortex eucommiae as raw material, cleaned, room temperature is dried in the shade, it is coarse powder to be crushed using pulverizer, distilled water is added to extract 2 times, merge extract solution twice and obtain folium cortex eucommiae water extract, the spray-dried obtained folium cortex eucommiae water solubility powder of folium cortex eucommiae aqueous extract, folium cortex eucommiae water solubility powder mix in proportion with auxiliary materials such as xylitol, magnesium stearates, and folium cortex eucommiae buccal tablet is made with tabletting machine.The buccal tablet that the present invention obtains has vasorelaxation action, is especially suitable for hypertension with diabetic population, is easy to carry, instant, preparation process is simple and easy, green, can be used as daily care food for reducing blood pressure.
Description
Art
The present invention relates to a kind of buccal tablet, more particularly to a kind of buccal tablet having no toxic side effect with vasorelaxation action
Invention and preparation.
Background technology
The bark of eucommia, it is China's endemic tree, is the Relict Plant that Eucommiaceae bark of eucommia category is only deposited, existing oneself is arranged as rare plant
Enter《Chinese Plants Red Data Book-rare extinction plants》.Bark of Eucommia Ulmoides is rare tonic herb,《Sheng Nong's herbal classic》In be listed in
Top grade.Folium cortex eucommiae is the Chinese medicine available for health food, its brewed in hot water in the integration of drinking and medicinal herbs raw material catalogue for defending planning commission's announcement
The directly preventing and treating taken to hypertension has the effect of fine, contains a variety of natural components in folium cortex eucommiae, mainly including lignanoids,
Iridoids, flavone compound, additionally containing Phenylpropanoid Glycosides class, polysaccharide, gutta-percha, terpene, several amino acids, dimension life
Element, mineral matter etc. other there is the natural component of biological activity.
Eucommia leaf extract has the existing document report of vasorelaxation action.Wang Menghua etc. in isolated vessel ring level,
Inquired into the vasodilatory mechanism of action of eucommia leaf extract, find eucommia leaf extract by promote endothelial cell discharge NO and
Directly activate beta receptor and produce vasodilator effect；The another vasodilator effect that has experiment and prove folium cortex eucommiae water extract be endothelium according to
Rely property, worked by endothelium derivation hyperpolarizing fac.In view of folium cortex eucommiae has vasorelaxation action, people carry out to it
The research to deepen continuously, its prospect developed in clinical practice is also very good, and product form on the market is mainly the bark of eucommia
Blood-pressure decreasing tea and Duzhong Jiangya Tablets.Eucommia bark depressor tea is drunk after brewed in hot water, existed for folium cortex eucommiae directly to be made to tealeaves form
Carry and take the shortcomings of inconvenient, active component dissolution is slow；Duzhong Jiangya Tablets is treat the clinical application thing of hypertension, for Du
Secondary skin (stir-fry) and the composite tablet of other Chinese medicines composition, are applicable crowd's narrow range.This product is with available for the Chinese medicine of health food Du
Zhong Ye is raw material, it is extracted, dust, the folium cortex eucommiae buccal tablet that the preparation technology such as tabletting obtains is easy to carry, instant, because will
The Icing Sugar for improving taste in formula is substituted with xylitol, and it is simple with diabetic population, whole preparation process to be especially suitable for hypertension
It is easy, green, daily care food for reducing blood pressure can be used as.
The content of the invention
It is an object of the invention to prepare it is a kind of be easy to carry, instant, be adapted to hypertension with diabetic population tool
There is the folium cortex eucommiae buccal tablet of vasorelaxation action.
In order to achieve the above object, the technical solution adopted by the present invention is：It is cleaned, dry in the shade, powder using folium cortex eucommiae as raw material
Extracted after broken, obtain bark of eucommia leaf extract, it is water-soluble that using spray drying process bark of eucommia leaf extract is prepared into folium cortex eucommiae
Property powder, folium cortex eucommiae buccal tablet is made with the auxiliary material mixed pressuring plate such as xylitol, magnesium stearate in proportion in folium cortex eucommiae water solubility powder.
Advantages of the present invention：
1st, preparation technology is simple, no toxic solvent, can carry out industrialized production.
2nd, folium cortex eucommiae used is the leaf that the age of tree is more than 25 years gutta-percha trees, ensures active component content.
3rd, folium cortex eucommiae water solubility powder, this powder dispersity is prepared using spray drying process in folium cortex eucommiae water extract
Well, dissolubility is good, is easy to absorb.
4th, it is xylitol to improve taste composition in being formulated, and is adapted to taking for diabetic population.
5th, mouth containing sheet form is easy to carry and taken.
Specific embodiment：
Embodiment of the present invention is described in further detail below：
The folium cortex eucommiae cleaning of gutta-percha tree of the age of tree more than 25 years, room temperature are dried in the shade, it is coarse powder to be crushed using pulverizer, is added
Enter the distilled water extraction of 10~20 times of its quality, the ultrasonic extraction time is 50~70 minutes, and Extracting temperature is 80~100 DEG C, is carried
Take 2 times, merge extract solution twice and obtain folium cortex eucommiae water extract.The spray-dried obtained folium cortex eucommiae of folium cortex eucommiae aqueous extract is water-soluble
Property powder, 100 DEG C~140 DEG C of spray drying EAT, feed rate 250mL~350mL/h, intake 60-80m3/min。
Folium cortex eucommiae water solubility powder is mixed in proportion with auxiliary materials such as xylitol, magnesium stearates, in parts by weight, unit for gram, respectively
Weigh 9~15 parts of folium cortex eucommiae water solubility powder, 15~20 parts of mannitol, 15~20 parts of xylitol, 0.5~1.5 part of menthol, firmly
0.5~1.5 part of fatty acid magnesium.Above-mentioned each material mixing in addition to menthol and magnesium stearate is uniform, spray into menthol ethanol
Solution, free adsorbing after ethanol is dried in 30-40 DEG C of baking oven, then by magnesium stearate (it is required that fineness reach 100 mesh with
On) added in said mixture and be well mixed by equivalent method of progressively increasing, with tabletting machine, every weight 1.5g~2.5g.
Embodiment 1
The leaf for the gutta-percha tree that the age of tree is 25 years is taken, room temperature is dried in the shade after being cleaned with water, and it is coarse powder to be crushed using pulverizer, is taken
Bark of eucommia leaf coarse powder 100g adds 1.5L distilled water, and Ultrasonic Heating extraction, extraction time 60min, Extracting temperature is 85 DEG C, mistake
Filter, filter residue add 1.0L distilled water and extracted again once by conditions above, and filtrate twice is merged after filtering, obtain the extraction of folium cortex eucommiae water
Thing 2.36L, folium cortex eucommiae aqueous extract is spray-dried, 120 DEG C, feed rate 300mL/h of spray drying EAT, air intake
Measure 65m3/ min, obtain folium cortex eucommiae water solubility powder 9.5g.Folium cortex eucommiae water solubility powder 5.0g, mannitol 9.5g are weighed respectively,
Xylitol 9.5g, it is well mixed；Menthol 0.48g is weighed, is dissolved in 3mL edible ethanols, is uniformly sprayed into above-mentioned powder, freely
Absorption is after drying ethanol in 35 DEG C of baking ovens；100 mesh magnesium stearate 0.52g are weighed to mix with above-mentioned powder by equivalent method of progressively increasing
Tabletting machine, every weight 2g are used after uniformly.
Embodiment 2
The leaf for the gutta-percha tree that the age of tree is 25 years is taken, room temperature is dried in the shade after being cleaned with water, and it is coarse powder to be crushed using pulverizer, is taken
Bark of eucommia leaf coarse powder 100g adds 1.0L distilled water, and Ultrasonic Heating extraction, extraction time 60min, Extracting temperature is 85 DEG C, mistake
Filter, filter residue add 1.5L distilled water and extracted again once by conditions above, and filtrate twice is merged after filtering, obtain the extraction of folium cortex eucommiae water
Thing 2.34L, folium cortex eucommiae aqueous extract is spray-dried, 130 DEG C, feed rate 330mL/h of spray drying EAT, air intake
Measure 75m3/ min, obtain folium cortex eucommiae water solubility powder 9.1g.Folium cortex eucommiae water solubility powder 5.5g, mannitol 9.0g are weighed respectively,
Xylitol 9.5g, it is well mixed；Menthol 0.55g is weighed, is dissolved in 3mL edible ethanols, is uniformly sprayed into above-mentioned powder, freely
Absorption is after drying ethanol in 35 DEG C of baking ovens；100 mesh magnesium stearate 0.45g are weighed to mix with above-mentioned powder by equivalent method of progressively increasing
Tabletting machine, every weight 2g are used after uniformly.
Embodiment 3
The leaf for the gutta-percha tree that the age of tree is 25 years is taken, room temperature is dried in the shade after being cleaned with water, and it is coarse powder to be crushed using pulverizer, is taken
Bark of eucommia leaf coarse powder 100g adds 1.2L distilled water, and Ultrasonic Heating extraction, extraction time 60min, Extracting temperature is 85 DEG C, mistake
Filter, filter residue add 1.3L distilled water and extracted again once by conditions above, and filtrate twice is merged after filtering, obtain the extraction of folium cortex eucommiae water
Thing 2.34L, folium cortex eucommiae aqueous extract is spray-dried, 140 DEG C, feed rate 350mL/h of spray drying EAT, air intake
Measure 80m3/ min, obtain folium cortex eucommiae water solubility powder 9.0g.Folium cortex eucommiae water solubility powder 6.0g, mannitol 9.0g are weighed respectively,
Xylitol 9.0g, it is well mixed；Menthol 0.5g is weighed, is dissolved in 3mL edible ethanols, is uniformly sprayed into above-mentioned powder, freely
Absorption is after drying ethanol in 35 DEG C of baking ovens；100 mesh magnesium stearate 0.5g are weighed to mix with above-mentioned powder by equivalent method of progressively increasing
Tabletting machine, every weight 2g are used after uniformly.
Claims (5)
- A kind of 1. folium cortex eucommiae buccal tablet with vasorelaxation action, it is characterised in that：It is cleaned, cloudy using folium cortex eucommiae as raw material Extracted after dry, crushing, obtain bark of eucommia leaf extract, bark of eucommia leaf extract is prepared into folium cortex eucommiae using spray drying process Folium cortex eucommiae mouth is made with auxiliary material mixed pressuring plates such as xylitol, magnesium stearates in proportion in water-soluble powder, folium cortex eucommiae water solubility powder Lozenge.The buccal tablet that the present invention obtains has vasorelaxation action, is especially suitable for hypertension companion's diabetic population, be easy to carry, Instant, preparation process is simple and easy, green, can be used as daily care food for reducing blood pressure.
- 2. according to the folium cortex eucommiae described in claim 1, it is characterised in that：Folium cortex eucommiae is the leaf of gutta-percha tree of the age of tree more than 25 years Son.
- 3. according to the bark of eucommia leaf extract described in claim 1, it is characterised in that：Folium cortex eucommiae extracts obtained solution with hot water, Extracting method is ultrasonic extraction, solid-liquid ratio 10:1~20:1, extraction time is 50~70 minutes, and Extracting temperature is 80~100 DEG C, extraction time is 2 times.
- 4. according to the folium cortex eucommiae water solubility powder described in claim 1, it is characterised in that：The spray-dried system of bark of eucommia leaf extract The powder obtained, it is characterised in that：100 DEG C~140 DEG C of EAT, feed rate 250ml~350ml/h, intake 60- 80m3/min。
- 5. mix pressure with auxiliary materials such as xylitol, magnesium stearates in proportion according to the folium cortex eucommiae water solubility powder described in claim 1 Folium cortex eucommiae buccal tablet is made in piece, it is characterised in that：In parts by weight, 9~15 parts of folium cortex eucommiae water solubility powder, mannitol 15~20 Part, 15~20 parts of xylitol, 0.5~1.5 part of menthol, 0.5~1.5 part of magnesium stearate.
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| CN201711335777.3A CN107801999A (en) | 2017-12-14 | 2017-12-14 | A kind of folium cortex eucommiae buccal tablet with vasorelaxation action |
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| CN201711335777.3A CN107801999A (en) | 2017-12-14 | 2017-12-14 | A kind of folium cortex eucommiae buccal tablet with vasorelaxation action |
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| CN201711335777.3A Pending CN107801999A (en) | 2017-12-14 | 2017-12-14 | A kind of folium cortex eucommiae buccal tablet with vasorelaxation action |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109349642A (en) * | 2018-12-26 | 2019-02-19 | 陕西天承生物科技股份有限公司 | A kind of folium cortex eucommiae compound buccal lozenge and preparation method thereof improved the immunity of the human body |
| CN109730304A (en) * | 2018-12-26 | 2019-05-10 | 陕西学前师范学院 | A kind of folium cortex eucommiae tranquilizing the mind compound buccal lozenge and preparation method thereof |
| CN109730305A (en) * | 2018-12-26 | 2019-05-10 | 陕西学前师范学院 | A kind of folium cortex eucommiae appetizing compound buccal lozenge and preparation method thereof |
| CN109757722A (en) * | 2018-12-26 | 2019-05-17 | 陕西学前师范学院 | A kind of folium cortex eucommiae improving eyesight compound buccal lozenge and preparation method thereof |
| CN112245464A (en) * | 2020-10-13 | 2021-01-22 | 天津益倍元天然产物技术有限公司 | Preparation method and application of eucommia ulmoides leaf extract for preventing and treating hypertensive renal injury |
| CN112438395A (en) * | 2019-09-05 | 2021-03-05 | 汪建民 | Eucommia ulmoides peptide effervescent buccal tablet |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103372047A (en) * | 2012-04-13 | 2013-10-30 | 刘青梅 | Eucommia bark buccal tablets and preparation method thereof |
-
2017
- 2017-12-14 CN CN201711335777.3A patent/CN107801999A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103372047A (en) * | 2012-04-13 | 2013-10-30 | 刘青梅 | Eucommia bark buccal tablets and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| XIN JIN，ET.AL: "Endothelium-derived Hyperpolarizing Factor (EDHF) Mediates Endothelium-dependent Vasodilator Effects of Aqueous Extracts from Eucommia ulmoides Oliv. Leaves in Rat Mesenteric Resistance Arteries", 《ACTA MEDICA OKAYAMA》 * |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109349642A (en) * | 2018-12-26 | 2019-02-19 | 陕西天承生物科技股份有限公司 | A kind of folium cortex eucommiae compound buccal lozenge and preparation method thereof improved the immunity of the human body |
| CN109730304A (en) * | 2018-12-26 | 2019-05-10 | 陕西学前师范学院 | A kind of folium cortex eucommiae tranquilizing the mind compound buccal lozenge and preparation method thereof |
| CN109730305A (en) * | 2018-12-26 | 2019-05-10 | 陕西学前师范学院 | A kind of folium cortex eucommiae appetizing compound buccal lozenge and preparation method thereof |
| CN109757722A (en) * | 2018-12-26 | 2019-05-17 | 陕西学前师范学院 | A kind of folium cortex eucommiae improving eyesight compound buccal lozenge and preparation method thereof |
| CN112438395A (en) * | 2019-09-05 | 2021-03-05 | 汪建民 | Eucommia ulmoides peptide effervescent buccal tablet |
| CN112245464A (en) * | 2020-10-13 | 2021-01-22 | 天津益倍元天然产物技术有限公司 | Preparation method and application of eucommia ulmoides leaf extract for preventing and treating hypertensive renal injury |
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