CN105343141A - Preparation method of chewable tablets of water chestnut shell extract - Google Patents
Preparation method of chewable tablets of water chestnut shell extract Download PDFInfo
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- CN105343141A CN105343141A CN201510821303.4A CN201510821303A CN105343141A CN 105343141 A CN105343141 A CN 105343141A CN 201510821303 A CN201510821303 A CN 201510821303A CN 105343141 A CN105343141 A CN 105343141A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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Abstract
The invention discloses a preparation method of chewable tablets of a water chestnut shell extract. The preparation method includes two steps of preparation of a water chestnut shell extract concrete and preparation of the chewing tablets: rinsing water chestnut shells with purified water, then drying, crushing, adding purified water, immersing, then boiling, carrying out reflux extraction, filtering, and volatilizing the filtrate with water bath to obtain a concentrated liquid; carrying out alcohol precipitation on the concentrated liquid, carrying out standing centrifugation, continuing to concentrate the supernatant, and thus obtaining the water chestnut shell extract concrete; and mixing the water chestnut shell extract concrete, mannitol, lactose, microcrystalline cellulose, aspartame and citric acid, then adding an edible hydroxypropyl methylcellulose solution to prepare a soft material, granulating, after drying and carrying out size stabilization of wet particles, adding magnesium stearate, and thus obtaining the chewable tablets. Flavonoids, polysaccharides, polyphenols and other active ingredients in the water chestnut shells can be effectively extracted, and the prepared chewable tablets have obvious pharmacological effects of resisting oxidization, protecting and caring liver, resisting anoxia, resisting fatigue and the like. The water chestnut shells are developed and utilized and are turned into treasure, and the added value of agricultural and sideline products is increased.
Description
Technical field
The invention belongs to Chinese medicine extraction preparing technical field, be specifically related to a kind of with the preparation method of the chewable tablet of the Fructus Trapae Quadrispinosae Shell of Water Chestnut Shell of Water Chestnut extract that is raw material.
Background technology
Pedicellus et Pericarpium Trapae, has another name called Pedicellus et Pericarpium Trapae, water Pedicellus et Pericarpium Trapae, wind Pedicellus et Pericarpium Trapae, is Trapaceae Pedicellus et Pericarpium Trapae platymiscium, is annual aquatic herbaceous plant, originates in all parts of the country, and wherein the distribution of subtropical zone, the Yangtze river basin at most.Pedicellus et Pericarpium Trapae sarcocarp is edible, has very high nutritive value, and the sarcocarp of Pedicellus et Pericarpium Trapae, stem and leaf, fruit stem, shell can be used as medicine, with shell, the base of a fruit for the best.The medicinal beginning of Shell of Water Chestnut is recorded in supplementary Amplifications of the Compendium of Materia Medica.Record according to " Chinese medicine sea ", Shell of Water Chestnut mildly bitter flavor, puckery, cool in nature, enter lung, spleen, large intestine three warp, there is the curative effect that detoxification sore treatment, relieving diarrhea with astringents, Qinghua are damp and hot.And now along with the development of science and technology, the research of Chinese scholars to Shell of Water Chestnut active component and pharmacological action also gets more and more.Through large quantity research, the active component existed in verified Shell of Water Chestnut mainly contains the compounds such as flavonoid, polysaccharide, Polyphenols, alkaloids, volatile oil, and there is the pharmacologically actives such as antioxidation, antitumor action, blood sugar reducing function, liver protection function, antibacterial and other effects, but in the market also without any Shell of Water Chestnut Related product, therefore, the present invention seeks to develop and utilize the wild Fructus Trapae Quadrispinosae Shell of Water Chestnut plucked then of Ezhou, Hubei Province Liangzi Lake, turn waste into wealth, to increase agricultural byproducts added value.
Summary of the invention
The object of the invention is to overcome the defect existed in prior art, a kind of preparation method of chewable tablet of Shell of Water Chestnut extract is provided, can effectively the active component in Shell of Water Chestnut be extracted, the obtained chewable tablet with pharmacological action.
In order to realize object of the present invention, the technical scheme of employing is:
A preparation method for the chewable tablet of Shell of Water Chestnut extract, is characterized in that, the preparation and the chewable tablet that comprise Shell of Water Chestnut extract extractum prepare two steps:
(1) preparation of Shell of Water Chestnut extract extractum:
Get Shell of Water Chestnut, reject rotten mouldy part wherein, dry in 60 DEG C of drying baker after rinsing by purified water, the Shell of Water Chestnut of drying is pulverized, cross 40 mesh sieves, remove fine powder wherein, obtain the Shell of Water Chestnut of pulverizing;
Take Shell of Water Chestnut 50 ~ 60g in the round-bottomed flask of 3000ml, add 1500 ~ 2000ml purified water and soak 1-2 hour post-heating to boiling, reflux, extract, 3h, filtered while hot, gets filtrate;
Filtering residue is extracting in water again, repeats extraction altogether 3 times, three filtrates is merged, and the volume that 70 ~ 80 DEG C of water-baths evaporate into described concentrated solution is 50 ~ 60ml, namely in every 1ml concentrated solution containing crude drug 1g;
Carry out precipitate with ethanol to concentrated solution afterwards, slowly in concentrated solution, add 50 ~ 70ml edible ethanol, limit edged constantly stirs, tie beaker mouth afterwards, prevent ethanol from volatilizing, leave standstill 12-24h, centrifugal (4000r/min after leaving standstill, 10min), remove precipitation, continue concentrated after supernatant being reclaimed ethanol, until concentrated solution density reaches 1.2 ~ 1.4 (measuring at 50-60 DEG C), i.e. obtained Shell of Water Chestnut extract extractum
(2) chewable tablet preparation;
It is for subsequent use that sucrose grinding shatters rear mistake 100 mesh sieve;
Get mannitol 20 ~ 45g, lactose 30 ~ 50g, microcrystalline Cellulose 30 ~ 55g, aspartame 2 ~ 5g, citric acid 1.5 ~ 4g mix in mortar, add Shell of Water Chestnut extract extractum 20 ~ 40g that described step (1) is obtained again, add the hypromellose cellulose solution soft material that 3 ~ 6ml concentration is 2%, cross 14 mesh sieve extruding to granulate, wet granular to be laid in pallet dry 20 ~ 30min in 50 ~ 60 DEG C of drying baker, granulate; Add again 1 ~ 2g magnesium stearate and described dry granule mix after tabletting, tablet machine is five rush rotary tablet machine, mould diameter 10mm, obtained chewable tablet finished product.
Preferably, containing Shell of Water Chestnut extract about 100 ~ 120mg in every tablet chewable tablets finished product, crude drug 550 ~ 650mg is equivalent to.
Preferably, in described step (1), the yield of Shell of Water Chestnut extract is greater than 15%.
Preferably, in described chewable tablet finished product, the broken hardness of described chewable tablet is 80 ~ 100N.
The beneficial effect that the present invention has:
Can effectively by the pyrite class in Shell of Water Chestnut, polysaccharide and Polyphenols isoreactivity constituents extraction out, obtained chewable tablet achieves good pharmacological effect with it white mice, has the pharmacological actions such as obvious antioxidation, hepatoprotective, anoxia enduring, resisting fatigue.Shell of Water Chestnut is developed and utilized, turns waste into wealth, add agricultural byproducts added value.
Accompanying drawing explanation
Fig. 1 is the flow chart of Shell of Water Chestnut extract extractum in preparation method of the present invention;
Fig. 2 is the flow chart that in preparation method of the present invention prepared by chewable tablet.
Detailed description of the invention
Below in conjunction with embodiment, the invention will be further described, but protection scope of the present invention is not only confined to embodiment.
Carry out analysis to the active component of raw material Shell of Water Chestnut to measure:
1. the assay of flavonoid
Flavone compound is present in natural plant widely, belongs to Secondary metabolites, has antioxidation, antitumor, improves the multiple physiological actions such as blood circulation.
In Shell of Water Chestnut water extract, flavones content measures and adopts AlCl3-acetate buffer development process, take rutin as reference substance, drawing standard curve, flavones content in calculation sample.
Calculating flavones content in sample is 10.32%.
2. polysaccharide
Polysaccharide is that occurring in nature exists maximum carbohydrates, and polysaccharide can remain cyto-architectural stable, storage power, and meanwhile, large quantity research proves, polysaccharide compound also has antitumor, immunity moderation power, reduces the functions such as blood glucose.
Shell of Water Chestnut water extract determination of polysaccharide adopts phenol-sulphuric acid colorimetry, take glucose as reference substance, drawing standard curve, polyoses content in calculation sample.
Calculating polyoses content in sample is 19.93%
3. Polyphenols
Polyphenol compound is the phenols secondary metabolite produced in plant and microorganism, is present in the plant food that some are common, as cacao bean, Semen sojae atricolor, puffed rice, red wine etc.Polyphenol compound has stronger antioxidation, can promote vasodilation, reduce inflammatory reaction.
Shell of Water Chestnut water extract polyphenol content measures and adopts Folin reagent development process, take gallic acid as reference substance, drawing standard curve, polyphenol content in calculation sample.
In this experiment, sample absorbance is 0.5680, and calculating polyphenol content in sample is 50.38%
Shown in composition graphs 1 and Fig. 2, a kind of preparation method of chewable tablet of Shell of Water Chestnut extract, is characterized in that, the preparation and the chewable tablet that comprise Shell of Water Chestnut extract extractum prepare two steps:
A preparation method for the chewable tablet of Shell of Water Chestnut extract, is characterized in that, the preparation and the chewable tablet that comprise Shell of Water Chestnut extract extractum prepare two steps:
(1) preparation of Shell of Water Chestnut extract extractum:
Get Shell of Water Chestnut, reject rotten mouldy part wherein, dry in 60 DEG C of drying baker after rinsing by purified water, the Shell of Water Chestnut of drying is pulverized, cross 40 mesh sieves, remove fine powder wherein, obtain the Shell of Water Chestnut of pulverizing;
Take Shell of Water Chestnut 50 ~ 60g in the round-bottomed flask of 3000ml, add 1500 ~ 2000ml purified water and soak 1-2 hour post-heating to boiling, reflux, extract, 3h, filtered while hot, gets filtrate;
Filtering residue is extracting in water again, repeats extraction altogether 3 times, three filtrates is merged, and the volume that 70 ~ 80 DEG C of water-baths evaporate into described concentrated solution is 50 ~ 60ml, namely in every 1ml concentrated solution containing crude drug 1g;
Carry out precipitate with ethanol to concentrated solution afterwards, slowly in concentrated solution, add 50 ~ 70ml edible ethanol, limit edged constantly stirs, tie beaker mouth afterwards, prevent ethanol from volatilizing, leave standstill 12-24h, centrifugal (4000r/min after leaving standstill, 10min), remove precipitation, continue concentrated after supernatant being reclaimed ethanol, until concentrated solution density reaches 1.3 (measuring at 50-60 DEG C), i.e. obtained Shell of Water Chestnut extract extractum, the yield of Shell of Water Chestnut extract is 18%.
(2) chewable tablet preparation;
It is for subsequent use that sucrose grinding shatters rear mistake 100 mesh sieve;
Get mannitol 20 ~ 45g, lactose 30 ~ 50g, microcrystalline Cellulose 30 ~ 55g, aspartame 2 ~ 5g, citric acid 1.5 ~ 4g mix in mortar, add Shell of Water Chestnut extract extractum 20 ~ 40g that described step (1) is obtained again, add the hypromellose cellulose solution soft material that 3 ~ 6ml concentration is 2%, cross 14 mesh sieve extruding to granulate, wet granular to be laid in pallet dry 20 ~ 30min in 50 ~ 60 DEG C of drying baker, granulate; Add again 1 ~ 2g magnesium stearate and described dry granule mix after tabletting, tablet machine is five rush rotary tablet machine, mould diameter 10mm, obtained chewable tablet finished product.Containing Shell of Water Chestnut extract about 100 ~ 120mg in every tablet chewable tablets finished product, be equivalent to crude drug 550 ~ 650mg.
Detect obtained chewable tablet end product quality, result is as follows:
Outward appearance: this product is sepia disc-shaped, sheet shape is consistent, unilateral bright and clean, neat in edge, uniform color.Without unfilled corner, speckle, glutinous punching, loose pieces, sliver etc.
Tablet weight variation: get test sample 20, after accurately weighed gross weight, obtains average sheet weight, accurately weighed every sheet weight again, comparatively, what exceed limit test of weight variation must not exceed two panels to the heavy or designation card anharmonic ratio of every sheet weight and average sheet, and must not have 1 times of 1 overrun.Result is as shown in the table:
| Average sheet weighs or designation card weight | Difference limit |
| Below 0.30g | ±7.5％ |
| 0.30g and more than 0.30g | ±5％ |
Hardness: get test sample 10, is placed in tablet between two pressing plates, and prolong the pressurization of Tablet diameter direction, when tablet is broken, pressure is hardness, and its hardness range controls at 80-100N.
Friability: get total amount and be about 6.5g test sample, blow away test sample surface powder, accurately weighed.Be placed in friability instrument cylinder, rotate 100 times, 25 times/min, altogether 4min.Experiment terminates rear taking-up test sample, and test sample is without fracture, be full of cracks or crushing phenomenon.Continue accurately weighed after blowing away test sample surface powder, twice weighed difference is no more than 1% of test sample gross weight.
Test the pharmacological action of the chewable tablet of obtained Shell of Water Chestnut extract, result is as follows:
1. antioxidation
Experimental studies results shows, the reducing power of Shell of Water Chestnut extract is suitable with Vc with scavenging ability of DPPH free radical, and be greater than BHT, and general flavone content is higher, Scavenging activity is stronger; The ability of Shell of Water Chestnut extract scavenging hydroxyl much larger than Vc and BHT, and for the clearance rate of ultra-oxygen anion free radical all more than more than 50%.
2. interior antioxidation action
Experimental studies results shows, various dose Shell of Water Chestnut water extract can GSH-Px vigor in raising Normal Mouse Serum in various degree, (P < 0.05).Shell of Water Chestnut water extract also can improve Normal Mouse Serum SOD vigor, and along with the increase of dosage, its effect is stronger, and high dose medicament can significantly improve SOD vigor (P<0.05).The Shell of Water Chestnut extract of low middle high dose significantly can reduce MDA content (P<0.05) in mice serum, shows that Shell of Water Chestnut water extract has good interior antioxidation action.
2. resisting fatigue, resisting oxygen lack
Experimental studies results shows, the Shell of Water Chestnut water extract of various dose can time-to-live of increase mice in various degree, but and there was no significant difference, illustrate that Shell of Water Chestnut extract is not obvious to mice resisting oxygen lack.
Observed the antifatigue effect of Shell of Water Chestnut extract by mice pole-climbing and swimming test, experiment shows: the obvious reduction (P<0.01) compared with blank group of middle dosage group and high dose group mice serum urea nitrogen content.The measurement result display of mice serum lactic acid content, middle dosage group, high dose group serum content obviously reduce, but compared with blank group (P<0.01).The Shell of Water Chestnut water extract of various dose all can increase hepatic glycogen content, and increases along with the increase of dosage, all has significant difference (P<0.05) compared with blank group.
3. liver protection function
The Chinese liquor of 56% causes mouse liver injury, and observe Shell of Water Chestnut effect, experimental studies results shows, Shell of Water Chestnut can protect Mouse Liver function, and hepatocyte injury alleviates.
With the acute hepatic injury mice of tetrachloro-methane induction for experimental subject, research Shell of Water Chestnut extract is to the therapeutical effect of acute hepatic injury mice, result proves, Shell of Water Chestnut extract all significantly can reduce MDA content in GPT, GOD content in hepatic injury mice serum and murine liver tissue, and SOD vigor can be significantly improved, liver dysfunction alleviates.
Above embodiment only in order to the present invention is described and and unrestricted technical scheme described in the invention; Therefore, although this description with reference to each above-mentioned embodiment to present invention has been detailed description, those of ordinary skill in the art should be appreciated that and still can modify to the present invention or equivalent to replace; And all do not depart from technical scheme and the improvement thereof of the spirit and scope of the present invention, it all should be encompassed in right of the present invention.
Claims (4)
1. a preparation method for the chewable tablet of Shell of Water Chestnut extract, is characterized in that, the preparation and the chewable tablet that comprise Shell of Water Chestnut extract extractum prepare two steps:
(1) preparation of Shell of Water Chestnut extract extractum:
Get Shell of Water Chestnut, reject rotten mouldy part wherein, dry in 60 DEG C of drying baker after rinsing by purified water, the Shell of Water Chestnut of drying is pulverized, cross 40 mesh sieves, remove fine powder wherein, obtain the Shell of Water Chestnut of pulverizing;
Take Shell of Water Chestnut 50 ~ 60g in the round-bottomed flask of 3000ml, add 1500 ~ 2000ml purified water and soak 1-2 hour post-heating to boiling, reflux, extract, 3h, filtered while hot, gets filtrate;
Filtering residue is extracting in water again, repeats extraction altogether 3 times, three filtrates is merged, and the volume that 70 ~ 80 DEG C of water-baths evaporate into described concentrated solution is 50 ~ 60ml, namely in every 1ml concentrated solution containing crude drug 1g;
Carry out precipitate with ethanol to concentrated solution afterwards, slowly in concentrated solution, add 50 ~ 70ml edible ethanol, limit edged constantly stirs, tie beaker mouth afterwards, prevent ethanol from volatilizing, leave standstill 12-24h, centrifugal (4000r/min after leaving standstill, 10min), remove precipitation, continue concentrated after supernatant being reclaimed ethanol, until concentrated solution density reaches 1.2 ~ 1.4 (measuring at 50-60 DEG C), i.e. obtained Shell of Water Chestnut extract extractum
(2) chewable tablet preparation;
It is for subsequent use that sucrose grinding shatters rear mistake 100 mesh sieve;
Get mannitol 20 ~ 45g, lactose 30 ~ 50g, microcrystalline Cellulose 30 ~ 55g, aspartame 2 ~ 5g, citric acid 1.5 ~ 4g mix in mortar, add Shell of Water Chestnut extract extractum 20 ~ 40g that described step (1) is obtained again, add the hypromellose cellulose solution soft material that 3 ~ 6ml concentration is 2%, cross 14 mesh sieve extruding to granulate, wet granular to be laid in pallet dry 20 ~ 30min in 50 ~ 60 DEG C of drying baker, granulate; Add again 1 ~ 2g magnesium stearate and described dry granule mix after tabletting, tablet machine is five rush rotary tablet machine, mould diameter 10mm, obtained chewable tablet finished product.
2. preparation method according to claim 1, is characterized in that, containing Shell of Water Chestnut extract about 100 ~ 120mg in every tablet chewable tablets finished product.
3. preparation method according to claim 1, is characterized in that, in described step (1), the yield of Shell of Water Chestnut extract is greater than 15%.
4. preparation method according to claim 1, is characterized in that, in described chewable tablet finished product, the broken hardness of described chewable tablet is 80 ~ 100N.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106689102A (en) * | 2017-01-09 | 2017-05-24 | 湖北科技学院 | Door pulling device of self-power-generating intelligent continuous mouse trapping cage |
| CN106889173A (en) * | 2017-02-06 | 2017-06-27 | 武汉轻工大学 | A kind of Shell of Water Chestnut chromocor extract with bacteriostatic activity and its preparation method and application |
| CN110507678A (en) * | 2019-07-26 | 2019-11-29 | 江苏省中国科学院植物研究所 | Application of the water chestnut shell extract on preparation treatment hyperlipemia drug or health care product |
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| CN102319276A (en) * | 2011-09-28 | 2012-01-18 | 河南大学 | Application of trapa acornis nakai shell extract to preparation of medicaments for protecting livers |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106689102A (en) * | 2017-01-09 | 2017-05-24 | 湖北科技学院 | Door pulling device of self-power-generating intelligent continuous mouse trapping cage |
| CN106889173A (en) * | 2017-02-06 | 2017-06-27 | 武汉轻工大学 | A kind of Shell of Water Chestnut chromocor extract with bacteriostatic activity and its preparation method and application |
| CN110507678A (en) * | 2019-07-26 | 2019-11-29 | 江苏省中国科学院植物研究所 | Application of the water chestnut shell extract on preparation treatment hyperlipemia drug or health care product |
| CN110507678B (en) * | 2019-07-26 | 2021-09-07 | 江苏省中国科学院植物研究所 | Application of water chestnut shell extract in preparing medicine for treating hyperlipemia |
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