CN104398683A - Traditional Chinese medicine for treating constipation, preparation method and application thereof - Google Patents

Traditional Chinese medicine for treating constipation, preparation method and application thereof Download PDF

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CN104398683A
CN104398683A CN201410625060.2A CN201410625060A CN104398683A CN 104398683 A CN104398683 A CN 104398683A CN 201410625060 A CN201410625060 A CN 201410625060A CN 104398683 A CN104398683 A CN 104398683A
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chinese medicine
constipation
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朱海燕
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/24—Apocynaceae (Dogbane family), e.g. plumeria or periwinkle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/704—Polygonum, e.g. knotweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/74—Rubiaceae (Madder family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/758—Zanthoxylum, e.g. pricklyash
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/80—Scrophulariaceae (Figwort family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/17—Preparation or pretreatment of starting material involving drying, e.g. sun-drying or wilting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/55—Liquid-liquid separation; Phase separation

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Abstract

The invention provides a traditional Chinese medicine for treating constipation. The traditional Chinese medicine is composed of the following traditional Chinese herbals: griffith woodsorrel herb, Japanese oxtongue herb, textile screw pine shoot, root or bark of tailed spicebush, and the like. The preparation method comprises steps of water extraction, alcohol precipitation, and spray-drying. The traditional Chinese medicine can be made into tablets, capsules, or particles. The traditional Chinese medicine is used to treat constipation.

Description

A kind of Chinese medicine and preparation method and application being used for the treatment of constipation
Technical field
The present invention relates to technical field of Chinese medicines, be specifically related to a kind of Chinese medicine and the preparation method and application that are used for the treatment of constipation.
Background technology
Constipation is a kind of symptom of various diseases, also can as the diagnosis of an independent disease, as chronic constipation.Concerning different patients, constipation has different implications.Common sympton is that defecation frequency obviously reduces, and defecation frequency is less than 3 times weekly, and excrement matter is stiff, often comprises defecation effort with difficult defecation sense, discharges difficulty, defecation is felt not to the utmost, defecation is time-consuming and need the pathological phenomenon of maneuver defecation assisting.The effective Therapeutic Method of current shortage.
Summary of the invention
Goal of the invention: in order to solve the problem, the object of the present invention is to provide a kind of Chinese medicine composition and the preparation method and application that are used for the treatment of constipation.
Technical scheme: the object of the invention is by following scheme realize:
Be used for the treatment of a Chinese medicine for constipation, it is extracted by the crude drug of following parts by weight and prepares: Herba Lysimachiae Insignis 12 parts, Radix Picridis Japonicae 14 parts, Folium Germen Pandani tectorii 14 parts, Radix seu Cortex Linderae Caudatae 8 parts, Radix Hydrangeae paniculatae 10 parts, Herba Lysimachiae foenum-graeci 14 parts, Flos Paulowniae 8 parts, Cortex Zanthoxyli ailanthoidis 10 parts, Caulis et Folium hedyotis hedyotideae 14 parts, Folium wrightiae pubescentis 12 parts, Caragana arborescens dish 10 parts, Herba Polygoni nepalensis 8 parts.
The described Chinese medicine being used for the treatment of constipation, preparation method comprises the steps: material merging of getting it filled, and uses conventional water extract-alcohol precipitation, spraying dry, adds adjuvant and makes capsule, tablet, granule.
The described application of Chinese medicine in the medicine of preparation treatment constipation being used for the treatment of constipation.
Described adjuvant is one or more of dextrin, lactose, starch, sucrose, glucose, microcrystalline Cellulose, mannose, methylcellulose, hydroxypropyl cellulose, carboxymethyl cellulose and stevioside.
Above-mentioned water extract-alcohol precipitation method is: decoct with water twice, first time adds water as the 8-12 times amount of medical material weight, decoct 1-2h, second time adds water as the 6-10 times amount of medical material weight, decoct 1-2h, collecting decoction, when being evaporated to 65 DEG C, relative density is the extractum of 1.15-1.20, adds ethanol and makes the percent by volume of alcohol content reach 75-85%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25-1.30, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, add adjuvant and make capsule, tablet, granule.
Above-mentioned spray drying condition is: inlet temperature is 100-120 DEG C, and leaving air temp is 80-90 DEG C, and temperature of charge is 70-90 DEG C, and atomizing pressure is 0.2-0.4 MPa, and spray velocity is 5-10ml/s.
Above-mentioned Herba Lysimachiae Insignis is the Herb of Ofthe Primulaceae SANYE Herba lysimachiae capillipedis, and the whole year can adopt, and has expelling wind and removing dampness, the effectiveness such as relaxing muscles and tendons to promote blood circulation.
Radix Picridis Japonicae is root or the herb of feverfew Fols Picridis fuscipilosae.Pathogenic fire purging, removing toxic substances, stasis-dispelling and pain-killing.
Folium Germen Pandani tectorii is the leaf bud of Pandanaceae plant Pandanus tectorius.Heat clearing away, removing heat from blood, removing toxic substances.Control measles, send out speckle, erysipelas, febrile disease due to summer-heat pathogen, gingival hemorrhage, malignant boil, medical education ` nets to collect and arranges rotten foot.
Radix seu Cortex Linderae Caudatae is root, leaf, the skin of canella Lindera caudata.Classification system Lindera caudata (Nees) Hook.f. hemostasia and promoting granulation, regulating QI to relieve pain.Control osteopatia sprain, wound congestive edema, hemorrhage, chest pain is coughed.
Radix Hydrangeae paniculatae is the root of saxifragaceae plant Hydrangea paniculata or Flos Caryophylli Hydrangea paniculata.Treating malaria disease, rotten larynx.
Herba Lysimachiae foenum-graeci is the whole herb with root of Ofthe Primulaceae Herba Lysimachiae foenum-graeci.Between 9 ~ October, plant is uprooped, remove silt on root, dry or dry in the shade.Cold-dispelling, wards off foul.Cure the wound cold, headache due to common cold, distension and fullness of the chest and abdomen, lower profit, seminal emission, nasal obstruction, toothache.
Flos Paulowniae is the flower of goatweed Paulownia Paulowniatomentosa (Thunb.) Steud..Bitter in the mouth; Cold in nature.Heat-clearing and toxic substances removing.Cure mainly: cough due to lung-heat; Acute tonsillitis; Bacillary dysentery; Acute bowel fire; Acute conjunctiva fire; Parotid gland fire; Furuncle and phyma; Skin ulcer tinea; Bronchitis
Cortex Zanthoxyli ailanthoidis is the bark of rutaceae Zanthoxylum ailanthoides, controls the effects such as married woman's joint pain in puerperal.Classification system Zanthoxylum ailanthoides Sieb.et Zucc..
Caulis et Folium hedyotis hedyotideae is Rubiaceae plants of Hedyotis Caulis et Folium hedyotis hedyotideae Hedyotis hedyotidea (DC.) Merr., is used as medicine with root, rattan, leaf.The whole year can adopt, and clean section is dried or using fresh herb.Sweet, light, cool.Root, rattan: dispelling, collateral-activating, detumescence hemostasis.For rheumatic arthritis, bleeding hemorrhoids, furuncle carbuncle, traumatic injury.
Folium wrightiae pubescentis is the leaf that apocynaceae plant hangs upside down pen, controls acute inflammation and infects.
Radix radermacherae sinicae, formal name used at school: Radermachera sinica) be the plant of Bignoniaceae Kidney bean Pterostyrax, the root of Radix radermacherae sinicae, leaf, fruit can be done medicinal, heat-clearing and toxic substances removing, dissipating blood stasis for subsidence of swelling.Generate heat for Sunstroke.Injury and bone fracture is controlled in external, venom, carbuncle.The present invention is used as medicine with root.
Herba Polygoni nepalensis is the herb of polygonaceae plant Nepal knotweed.Latin name: Polygonum nepalense Meissn., heat-clearing and toxic substances removing; Eliminating dampness and dredging channels.Main laryngopharynx swelling and pain; Conjunctival congestion; Gingival swelling and pain; Dysentery; Rheumatic arthralgia.
Beneficial effect: the present invention can be used for treating constipation.
Detailed description of the invention
Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.
1, embodiment is prepared:
Get Herba Lysimachiae Insignis 12g, Radix Picridis Japonicae 14g, Folium Germen Pandani tectorii 14g, Radix seu Cortex Linderae Caudatae 8g, Radix Hydrangeae paniculatae 10g, Herba Lysimachiae foenum-graeci 14g, Flos Paulowniae 8g, Cortex Zanthoxyli ailanthoidis 10g, Caulis et Folium hedyotis hedyotideae 14g, Folium wrightiae pubescentis 12g, Caragana arborescens dish 10g, Herba Polygoni nepalensis 8g medical material merges, decoct with water twice, first time adds water as 10 times amount of medical material weight, decoct 1.5h, second time adds water as 8 times amount of medical material weight, decoct 1.5h, collecting decoction, 0.07MPa, when being evaporated to 65 DEG C at 60-70 DEG C, relative density is the extractum of 1.15, adding 95% (v/v) ethanol makes alcohol content reach 75% (v/v), stir, leave standstill 24 hours, filter, filtrate is at 0.07MPa, under 65 DEG C of conditions, concentrating under reduced pressure one-tenth is 1.25 to relative density when 65 DEG C, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, (condition is inlet temperature is 100 DEG C, leaving air temp is 85 DEG C, temperature of charge is 80 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 5ml/s.), add appropriate amount of starch, dry granulation, cross 60 mesh sieves, load No. 1 capsule capsule.
Get Herba Lysimachiae Insignis 12g, Radix Picridis Japonicae 14g, Folium Germen Pandani tectorii 14g, Radix seu Cortex Linderae Caudatae 8g, Radix Hydrangeae paniculatae 10g, Herba Lysimachiae foenum-graeci 14g, Flos Paulowniae 8g, Cortex Zanthoxyli ailanthoidis 10g, Caulis et Folium hedyotis hedyotideae 14g, Folium wrightiae pubescentis 12g, Caragana arborescens dish 10g, Herba Polygoni nepalensis 8g medical material merges, decoct with water twice, first time adds water as 12 times amount of medical material weight, decoct 2h, second time adds water as 10 times amount of medical material weight, decoct 2h, collecting decoction, 0.07MPa, when being evaporated to 65 DEG C at 60-70 DEG C, relative density is the extractum of 1.20, adding 95% (v/v) ethanol makes alcohol content reach 85% (v/v), stir, leave standstill 24 hours, filter, filtrate is at 0.07MPa, under 65 DEG C of conditions, concentrating under reduced pressure one-tenth is 1.30 to relative density when 65 DEG C, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, (condition is inlet temperature is 120 DEG C, leaving air temp is 90 DEG C, temperature of charge is 90 DEG C, atomizing pressure is 0.4 MPa, spray velocity is 10ml/s.), add appropriate amount of starch, dextrin, Icing Sugar, lactose, microcrystalline Cellulose one or more adjuvants wherein, mix homogeneously, with appropriate 80% (v/v) ethanol wet, soft material processed, crosses 30 mesh sieves and granulates, in 70 ~ 80 DEG C of dryings, with 60 mesh sieve granulate, tabletting, sugar coating, obtains tablet.
Get Herba Lysimachiae Insignis 12g, Radix Picridis Japonicae 14g, Folium Germen Pandani tectorii 14g, Radix seu Cortex Linderae Caudatae 8g, Radix Hydrangeae paniculatae 10g, Herba Lysimachiae foenum-graeci 14g, Flos Paulowniae 8g, Cortex Zanthoxyli ailanthoidis 10g, Caulis et Folium hedyotis hedyotideae 14g, Folium wrightiae pubescentis 12g, Caragana arborescens dish 10g, Herba Polygoni nepalensis 8g medical material merges, decoct with water twice, first time adds water as 10 times amount of medical material weight, decoct 1.5h, second time adds water as 8 times amount of medical material weight, decoct 1.5h, collecting decoction, 0.07MPa, when being evaporated to 65 DEG C at 65 DEG C, relative density is the extractum of 1.15, adding 95% (v/v) ethanol makes alcohol content reach 80% (v/v), stir, leave standstill 24 hours, decompression filtrate recycling ethanol is also concentrated, filtrate is at 0.07MPa, under 65 DEG C of conditions, concentrating under reduced pressure one-tenth is 1.25 to relative density when 65 DEG C, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, (condition is inlet temperature is 110 DEG C, leaving air temp is 80 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.3 MPa, spray velocity is 7.5ml/s.), add suitable dextrin, soluble starch, lactose, sucrose, mannitol wherein one or more, with appropriate 80% (v/v) ethanol wet, soft material processed, cross 14 mesh sieves granulate, 70-80 DEG C of drying, 60 order granulate, obtain granule.
2, granule of the present invention is on the impact of mice with constipation Small intestine advance activity
2.1 animals: healthy ICR mice, male and female half and half, heavy 18-22g, is provided by Nanjing Medical University's animal center, production licence number SCXK (Soviet Union) 2002-0031.
2.2 medicines and reagent: prepare granule of the present invention by above-described embodiment, animal given low is with a kilogram calculating, and 5g crude drug/kg is low dosage, and dosage 10g crude drug/kg is middle dosage, and dosage 20g crude drug/kg is high dose.Positive drug phenolphthalein tablets (phenolphthalein sugar-tablet), Junan, Shandong Province pharmaceutical factory, dosage is 0.1g/kg.All the other reagent are domestic analytical pure.R-1132, Wujin pharmaceutical factory, 20120524.
2.3 processs of the test: get ICR mice 60, with the modeling of R-1132 50m/kg gavage, continuous 10 days, period normal diet, form Constipation Model, random packet, often organize about 10, male and female half and half, be divided into normal group, model group, positive drug group, granule of the present invention is high, in, low three dosage groups, administration is the same, successive administration 14d, before experiment, water 12h is can't help in fasting, 2h after last administration, gavage with the charcoal end arabic gum suspension lml/g that volume fraction is 5% respectively, each group of mice is put to death after 20min, cut open the belly and measure every Mus small intestinal charcoal end displacement and total small intestinal length, be converted into the percentage rate that charcoal end displacement accounts for total small intestinal length, t test and judge group difference, the results are shown in Table 1.
Table 1 granule of the present invention is on the impact (n=10) of mice with constipation Small intestine advance activity
Compare with model group, * * P<0.01 * P<0.05, compares with positive drug group, ##P<0.01 #P<0.05
2.4 results: medicine group of the present invention compares with model group, have and obviously promote mice with constipation Small intestine advance activity, promote gastrointestinal motility in mice, there is significant difference, compare with positive drug, medicine senior middle school of the present invention dosage group has significant difference in promotion mice with constipation Small intestine advance activity, and effect is better than positive drug.

Claims (3)

1. one kind is used for the treatment of the Chinese medicine of constipation, it is characterized in that, it is extracted by the crude drug of following parts by weight and prepares: Herba Lysimachiae Insignis 12 parts, Radix Picridis Japonicae 14 parts, Folium Germen Pandani tectorii 14 parts, Radix seu Cortex Linderae Caudatae 8 parts, Radix Hydrangeae paniculatae 10 parts, Herba Lysimachiae foenum-graeci 14 parts, Flos Paulowniae 8 parts, Cortex Zanthoxyli ailanthoidis 10 parts, Caulis et Folium hedyotis hedyotideae 14 parts, Folium wrightiae pubescentis 12 parts, Caragana arborescens dish 10 parts, Herba Polygoni nepalensis 8 parts.
2. the Chinese medicine being used for the treatment of constipation according to claim 1, is characterized in that, preparation method comprises the steps: material merging of getting it filled, and uses conventional water extract-alcohol precipitation, spraying dry, adds adjuvant and makes capsule, tablet, granule.
3. described in claim 1, be used for the treatment of the application of Chinese medicine in the medicine for the treatment of constipation of constipation.
CN201410625060.2A 2014-11-07 2014-11-07 Traditional Chinese medicine for treating constipation, preparation method and application thereof Withdrawn CN104398683A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105106542A (en) * 2015-09-19 2015-12-02 淄博齐鼎立专利信息咨询有限公司 Pharmaceutical preparation for treating constipation

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Publication number Priority date Publication date Assignee Title
CN102302692A (en) * 2011-09-05 2012-01-04 南京正宽医药科技有限公司 Traditional Chinese medicine composition for treating constipation, as well as preparation method and application thereof
CN102940718A (en) * 2012-12-08 2013-02-27 南京正宽医药科技有限公司 Traditional Chinese medicine composition for treating constipation, preparation method and application
CN103599263A (en) * 2013-12-10 2014-02-26 王小欧 Traditional Chinese medicine for haemorrhoids and preparation method thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102302692A (en) * 2011-09-05 2012-01-04 南京正宽医药科技有限公司 Traditional Chinese medicine composition for treating constipation, as well as preparation method and application thereof
CN102940718A (en) * 2012-12-08 2013-02-27 南京正宽医药科技有限公司 Traditional Chinese medicine composition for treating constipation, preparation method and application
CN103599263A (en) * 2013-12-10 2014-02-26 王小欧 Traditional Chinese medicine for haemorrhoids and preparation method thereof

Cited By (1)

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CN105106542A (en) * 2015-09-19 2015-12-02 淄博齐鼎立专利信息咨询有限公司 Pharmaceutical preparation for treating constipation

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Application publication date: 20150311