CN104800805A

CN104800805A - Medicine for treating frequent micturition

Info

Publication number: CN104800805A
Application number: CN201510213409.6A
Authority: CN
Inventors: 田丽华
Original assignee: Zibo Qidingli Patent Information Consulting Co Ltd
Current assignee: Zibo Qidingli Patent Information Consulting Co Ltd
Priority date: 2015-04-30
Filing date: 2015-04-30
Publication date: 2015-07-29

Abstract

The invention provides a medicine which achieves the purposes of treating frequent micturition by clearing heat, removing toxicity, nourishing the kidney and regulating vital energy. The active components contained in the medicine are prepared from the following raw materials in parts by weight: 20 parts of folium rhododendri daurici, 15 parts of filiform cassytha herb, 10 parts of gardenia jasminoides, 6 parts of radix scutellariae, 20 parts of forsythia suspensa, 15 parts of pinellia ternate, 6 parts of cortex magnoliae officinalis, 10 parts of caulis perillae, 10 parts of poria cocos, 15 parts of fructus aurantii, 6 parts of radix glycyrrhizae, 10 parts of pericarpium citri reticulatae, 15 parts of caulis bambusae in taeniis, 6 parts of dried ginger, 20 parts of Chinese jujubes and the like. A corresponding preparation method is adopted. The traditional Chinese medicine composition has the effect of treating the frequent micturition.

Description

A kind of medicine for the treatment of frequent micturition

Technical field

The present invention relates to technical field of Chinese medicines, be specifically related to a kind of Chinese medicine composition for the treatment of frequent micturition and its preparation method and application.

Background technology

Frequent micturition refers to that night urination is more than 3 times or 3 times, is greater than 4 persons and is called that severe nocturia increases, and is one of lower urinary tract symptom that old age is common.Pathologic is found in the many reasons such as property after property before kidney, kidney, kidney because of nocturia frequency that rope causes, also can be caused by spirituality factor.Not only affect sleep, also increase the probability of the generation of old breath person cardiovascular and cerebrovascular vessel emergency case and wound.Nocturia frequency is the performance of urinary dysfunction.Chronic urinary dysfunction treatment is more thorny, lacks desirable treatment means.

Summary of the invention

Goal of the invention: in order to solve the problem, the object of the present invention is to provide a kind of Chinese medicine composition for the treatment of frequent micturition and its preparation method and application.

Technical scheme: the object of the invention is by following scheme realize:

Be used for the treatment of a Chinese medicine composition for frequent micturition, its active component is prepared from by the raw material of following weight: Herba Epilobii Angustifoii 20 parts, Herba Casythae Filiformis 15 parts, Fructus Gardeniae 10 parts, Radix Scutellariae 6 parts, Fructus Forsythiae 20 parts, the Rhizoma Pinelliae 15 parts, Cortex Magnoliae Officinalis 6 parts, Caulis Perillae 10 parts, 10 parts, Poria, Fructus Aurantii 15 parts, 6 parts, Radix Glycyrrhizae, Pericarpium Citri Reticulatae 10 parts, Caulis Bambusae In Taenia 15 parts, Rhizoma Zingiberis 6 parts, 20 parts, Fructus Jujubae.

The described Chinese medicine composition being used for the treatment of frequent micturition, dosage form is granule, tablet, capsule.

The described Chinese medicine composition being used for the treatment of frequent micturition, preparation method step is: get above-mentioned medical material and mix, decoct with water twice, collecting decoction, when being concentrated into 65 DEG C, relative density is 1.10-1.20, adding ethanol makes the percent by volume of alcohol content reach 65-85%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.20-1.30 and reclaims ethanol, concentrated solution spraying dry, pulverize, obtain dry powder, finally add pharmaceutically acceptable excipient and make clinical acceptable granule, tablet, capsule.

The described Chinese medicine composition being used for the treatment of frequent micturition, preparation method decocts with water in process, and first time adds water as the 8-12 times amount of medical material weight, decocts 1-2h, and second time adds water as the 6-10 times amount of medical material weight, decocts 1-2h.

The described Chinese medicine composition being used for the treatment of frequent micturition, preparation method spray drying condition is: inlet temperature is 100-120 DEG C, and leaving air temp is 80-90 DEG C, and temperature of charge is 70-90 DEG C, and atomizing pressure is 0.2-0.4 MPa, and spray velocity is 5-10ml/s.

Be used for the treatment of the application of Chinese medicine composition in preparation treatment frequent micturition medicine of frequent micturition.

Herba Epilobii Angustifoii is Oenotheraceae willow herb platymiscium willow herb Chamaenerion angustifolium (L.) Scop., with root stock or all herbal medicine.Autumn adopts, and cleans and dries or using fresh herb.Restore menstrual flow and invigorate blood circulation, reducing swelling and alleviating pain.For menoxenia; Fracture is controlled in external, articular sprain.The present invention is with all herbal medicine.Herba Casythae Filiformis is the herb of canella dodder laurel.Latin name: Cassytha filiformis L. clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body.Treating the liver heat is become thin, cough due to lung-heat, jaundice, dysentery, epistaxis, stranguria with blood, carbuncle, scabies, scalds.All the other taste of Chinese medicine pharmacopeia kinds.

Beneficial effect:

The traditional Chinese medical science thinks that frequent micturition is that large frequent micturition knot is obstructed, and defecation time extends or involved and abstruse not smooth a kind of disease for stool, and how because internal organs accumulation of heat causes, heat-clearing and toxic substances removing and tonifying QI to produce body fluid are answered in treatment.In we, Radix calophylli membranacei, ribbon grass, Rhizoma et radix valerianae heat-clearing and toxic substances removing are monarch drug, Rhizoma Coptidis, Rhizoma Pinelliae Preparata, Fructus Trichosanthis, Caulis Bambusae In Taenia, Fructus Aurantii Immaturus, Semen Raphani, Fructus Hordei Germinatus, Pericarpium Arecae are ministerial drug, expel the heat-evil logical abdomen, increases monarch drug effect, Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription, for adjuvant, promote heat-clearing and toxic substances removing and the effect of monarch-minister drug, full side's compatibility, brings out the best in each other, play the power of heat-clearing and toxic substances removing altogether, be used for the treatment of frequent micturition.

Detailed description of the invention

Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.

1, embodiment is prepared

Embodiment 1: get Herba Epilobii Angustifoii 20g, Herba Casythae Filiformis 15g, Fructus Gardeniae 10g, Radix Scutellariae 6g, Fructus Forsythiae 20g, Rhizoma Pinelliae 15g, Cortex Magnoliae Officinalis 6g, Caulis Perillae 10g, Poria 10g, Fructus Aurantii 15g, Radix Glycyrrhizae 6g, Pericarpium Citri Reticulatae 10g, Caulis Bambusae In Taenia 15g, Rhizoma Zingiberis 6g, Fructus Jujubae 20g merges, decoct with water twice, first time adds water as 8 times amount of medical material weight, decoct 1h, second time adds water as 6 times amount of medical material weight, decoct 1h, collecting decoction, 0.07MPa, when being evaporated to 65 DEG C at 60-70 DEG C, relative density is 1.10, adding 95% (v/v) ethanol makes alcohol content reach 85% (v/v), stir, leave standstill 24 hours, decompression filtrate recycling ethanol is also concentrated, filtrate is at 0.07MPa, under 65 DEG C of conditions, concentrating under reduced pressure one-tenth is 1.30 to relative density when 65 DEG C, (condition is inlet temperature is 120 DEG C to spraying dry, leaving air temp is 80 DEG C, temperature of charge is 90 DEG C, atomizing pressure is 0.4 MPa, spray velocity is 10ml/s.), add starch 50g, mix homogeneously, with appropriate 80% (v/v) ethanol wet, soft material processed, cross 30 mesh sieves and granulate, in 70 ~ 80 DEG C of dryings, with 60 mesh sieve granulate, tabletting, sugar coating, subpackage, outer package, censorship is qualified, obtains tablet.

Embodiment 2: get Herba Epilobii Angustifoii 20g, Herba Casythae Filiformis 15g, Fructus Gardeniae 10g, Radix Scutellariae 6g, Fructus Forsythiae 20g, Rhizoma Pinelliae 15g, Cortex Magnoliae Officinalis 6g, Caulis Perillae 10g, Poria 10g, Fructus Aurantii 15g, Radix Glycyrrhizae 6g, Pericarpium Citri Reticulatae 10g, Caulis Bambusae In Taenia 15g, Rhizoma Zingiberis 6g, Fructus Jujubae 20g merges, decoct with water twice, first time adds water as 10 times amount of medical material weight, decoct 1.5h, second time adds water as 8 times amount of medical material weight, decoct 1.5h, collecting decoction, 0.07MPa, when being evaporated to 65 DEG C at 60-70 DEG C, relative density is 1.15, adding 95% (v/v) ethanol makes alcohol content reach 75% (v/v), stir, leave standstill 24 hours, decompression filtrate recycling ethanol is also concentrated, filtrate is at 0.07MPa, under 65 DEG C of conditions, concentrating under reduced pressure one-tenth is 1.25 to relative density when 65 DEG C, (condition is inlet temperature is 100 DEG C to spraying dry, leaving air temp is 90 DEG C, temperature of charge is 80 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 5ml/s.), add dextrin 50g, dry granulation, cross 60 mesh sieves, load No. 1 capsule capsule.

Embodiment 3: get Herba Epilobii Angustifoii 20g, Herba Casythae Filiformis 15g, Fructus Gardeniae 10g, Radix Scutellariae 6g, Fructus Forsythiae 20g, Rhizoma Pinelliae 15g, Cortex Magnoliae Officinalis 6g, Caulis Perillae 10g, Poria 10g, Fructus Aurantii 15g, Radix Glycyrrhizae 6g, Pericarpium Citri Reticulatae 10g, Caulis Bambusae In Taenia 15g, Rhizoma Zingiberis 6g, Fructus Jujubae 20g merges, decoct with water twice, first time adds water as 12 times amount of medical material weight, decoct 2h, second time adds water as 10 times amount of medical material weight, decoct 2h, collecting decoction, 0.07MPa, when being evaporated to 65 DEG C at 60-70 DEG C, relative density is 1.20, adding 95% (v/v) ethanol makes alcohol content reach 65% (v/v), stir, leave standstill 24 hours, decompression filtrate recycling ethanol is also concentrated, filtrate is at 0.07MPa, under 65 DEG C of conditions, concentrating under reduced pressure one-tenth is 1.25 to relative density when 65 DEG C, (condition is inlet temperature is 110 DEG C to spraying dry, leaving air temp is 85 DEG C, temperature of charge is 80 DEG C, atomizing pressure is 0.3 MPa, spray velocity is 7.5ml/s.), then add lactose 50g, with appropriate 80% (v/v) ethanol wet, soft material processed, cross 14 mesh sieves and granulate, 50-80 DEG C of drying, 60 order granulate, obtain granule.

2, clinical observation material

2.1 sample preparations: prepare clinical trial sample by above-described embodiment granule method, specification is 10g/ bag, is 13.5g/ bag containing crude drug amount.

2.2 clinical datas: observe 50 routine frequent micturition patients altogether, wherein male patient 25 example, female patient 25 example.52 years old-80 years old age.Nocturia frequency refers to that night total urination time is on average more than 3 times, total urination time at night person more than 4 times increase for nocturia severe, all get rid of strange property obstructive pulmonary disease, heart failure, renal failure and acute cerebrovascular more outside, get rid of maximum appearance reduction (as cisapride) of drug-induced wing glue and get rid of the cause of disease such as calculus, tumor and stimulate the frequent micturition caused.

2.3 efficacy assessment standards:

(1) cure: symptom disappears completely.(2), effective: nocturia number of times reduces to half.(3), invalid: symptom is without improvement.

2.4 Therapeutic Method: treatment group is taken and prepared clinical trial sample by above-described embodiment 3, every natural gift three oral meals 30 days were 1 course for the treatment of.

2.5 therapeutic outcomes: in Clinical practice the present invention, take medicine 50 routine frequent micturition patients, take medicine after 1 course for the treatment of, symptom is alleviated to some extent, and take medicine after 2 courses for the treatment of, symptom is obviously improved.In the routine patient of clinical experiment 50, cure 21 examples, effective 23 examples, invalid 6 examples, total effective rate is 88%.

Claims

1. be used for the treatment of a medicine for frequent micturition, it is characterized in that its active component is prepared from by the raw material of following weight: Herba Epilobii Angustifoii 20 parts, Herba Casythae Filiformis 15 parts, Fructus Gardeniae 10 parts, Radix Scutellariae 6 parts, Fructus Forsythiae 20 parts, the Rhizoma Pinelliae 15 parts, Cortex Magnoliae Officinalis 6 parts, Caulis Perillae 10 parts, 10 parts, Poria, Fructus Aurantii 15 parts, 6 parts, Radix Glycyrrhizae, Pericarpium Citri Reticulatae 10 parts, Caulis Bambusae In Taenia 15 parts, Rhizoma Zingiberis 6 parts, 20 parts, Fructus Jujubae.

2. be used for the treatment of the medicine of frequent micturition as claimed in claim 1, it is characterized in that dosage form is granule, tablet, capsule.

3. be used for the treatment of the medicine of frequent micturition as claimed in claim 1, it is characterized in that preparation method comprises the steps: get above-mentioned medical material and mix, decoct with water twice, collecting decoction, when being concentrated into 65 DEG C, relative density is 1.10-1.20, adding ethanol makes the percent by volume of alcohol content reach 65-85%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.20-1.30 and reclaims ethanol, concentrated solution spraying dry, pulverize, obtain dry powder, finally add pharmaceutically acceptable excipient and make clinical acceptable granule, tablet, capsule.

4. be used for the treatment of the medicine of frequent micturition as claimed in claim 1, it is characterized in that preparation method decocts with water in process, first time adds water as the 8-12 times amount of medical material weight, decocts 1-2h, and second time adds water as the 6-10 times amount of medical material weight, decocts 1-2h.

5. be used for the treatment of the medicine of frequent micturition as claimed in claim 1, it is characterized in that preparation method spray drying condition is: inlet temperature is 100-120 DEG C, leaving air temp is 80-90 DEG C, and temperature of charge is 70-90 DEG C, atomizing pressure is 0.2-0.4 MPa, and spray velocity is 5-10ml/s.

6. a kind of application of medicine in treatment frequent micturition medicine being used for the treatment of frequent micturition as claimed in claim 1.