CN105056256A - Traditional Chinese medicine gastrointestinal developing aid for B ultrasonic - Google Patents
Traditional Chinese medicine gastrointestinal developing aid for B ultrasonic Download PDFInfo
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- CN105056256A CN105056256A CN201510557652.XA CN201510557652A CN105056256A CN 105056256 A CN105056256 A CN 105056256A CN 201510557652 A CN201510557652 A CN 201510557652A CN 105056256 A CN105056256 A CN 105056256A
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Abstract
The invention belongs to the field of traditional Chinese medicine preparations and particularly provides a traditional Chinese medicine gastrointestinal developing aid for B ultrasonic, which is prepared from the following raw materials: 25 parts of knotweed rhizome, 20 parts of gigantism rhodobryum herb, 18 parts of codonopsis convolvulacea, 20 parts of veronicastrum herb, 18 parts of caulophyllum robustum, 20 parts of pinellia tuber, 15 parts of officinal magnolia bark, 20 parts of immature bitter orange, 20 parts of lotus leaf, 25 parts of dried orange peel, 25 parts of fructus amomi and 5 parts of licorice. The traditional Chinese medicine gastrointestinal developing aid provided by the invention can be used for B ultrasonic.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicine preparation, be specifically related to a kind of Chinese medicine gastrointestinal contrast agent for B ultrasonic.
Background technology
At present, for B ultrasonic gastrointestinal contrast agent, prior art describes the contrast agent be mixed with by the 100 order fine powders of Endoconcha Sepiae fine powder 80% and the Pseudobulbus Bletillae (Rhizoma Bletillae) 20%, to gastrointestinal disease, there is convergence, antacid effect, but weak point is patient take contrast agent after to produce strong echo luminous point not enough, reflecting effect is not good, and the display of coat of the stomach level is unintelligible; After patient takes this contrast agent, gastric acid strong reaction, has pain and sense of discomfort, is unfavorable for the ultrasonic contrast of gastrointestinal, can not applies this contrast agent to gastrorrhagia patient.For this reason, be bursting to develop more safely and effectively for the Chinese medicine gastrointestinal contrast agent of B ultrasonic.
Summary of the invention
In order to solve the problem, the object of the present invention is to provide a kind of Chinese medicine preparation for the treatment of vulval condyloma acuminatum disease.In order to reach this object, adopt following technical scheme:
Technical scheme: a kind of Chinese medicine gastrointestinal contrast agent for B ultrasonic, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: Rhizoma Polygoni Paleachi 25 parts, Rhodobryum giganteum(Hook.) Par. 20 parts, Radix Codonopsis Convolvulaceae 18 parts, Herba veronicastri villosuli 20 parts, Radix Caulophylli 18 parts, the Rhizoma Pinelliae 20 parts, Cortex Magnoliae Officinalis 15 parts, Fructus Aurantii Immaturus 20 parts, 20 parts, Folium Nelumbinis, Pericarpium Citri Reticulatae 25 parts, Fructus Amomi 25 parts, 5 parts, Radix Glycyrrhizae.
For the Chinese medicine gastrointestinal contrast agent of B ultrasonic, dosage form is granule, tablet, capsule.
The described Chinese medicine gastrointestinal contrast agent for B ultrasonic, preparation method comprises the steps: get above-mentioned medical material and mix, decoct with water twice, collecting decoction, when being concentrated into 65 DEG C, relative density is 1.10-1.20, adding ethanol makes the percent by volume of alcohol content reach 65-85%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.20-1.30 and reclaims ethanol, concentrated solution spraying dry, pulverize, obtain dry powder, finally add pharmaceutically acceptable excipient and make clinical acceptable granule, tablet, capsule.
The described Chinese medicine gastrointestinal contrast agent for B ultrasonic, decocts with water in preparation method in process, and first time adds water as the 8-12 times amount of medical material weight, decocts 1-2h, and second time adds water as the 6-10 times amount of medical material weight, decocts 1-2h.
The described Chinese medicine gastrointestinal contrast agent for B ultrasonic, in preparation method, spray drying condition is: inlet temperature is 100-120 DEG C, and leaving air temp is 80-90 DEG C, and temperature of charge is 70-90 DEG C, and atomizing pressure is 0.2-0.4 MPa, and spray velocity is 5-10ml/s.
The described application of Chinese medicine gastrointestinal contrast agent in the Chinese medicine gastrointestinal contrast agent preparing B ultrasonic for B ultrasonic.
Rhizoma Polygoni Paleachi is the rhizome of polygonaceae plant Rhizoma Polygoni Paleachi.Loose blood hemostasis, therapeutic method to keep the adverse QI flowing downwards pain relieving.Control chronic gastritis, taste-blindness rate, food stagnation, lump in the abdomen, menoxenia, edema, traumatic injury, traumatic hemorrhage.
Rhodobryum giganteum(Hook.) Par. is the herb that Bryaceae plant warms up ground great Ye moss.Bryophyte, body is comparatively large, and emerald green or summary are breen, somewhat gloss.Acrid in the mouth is bitter, flat.Can tranquillizing and allaying excitement, clear away heart-fire improving eyesight.Control heart disease, neurasthenia, sexual impotence.
Radix Codonopsis Convolvulaceae is campanulaceae Codonopsis plant Radix Codonopsis Convolvulaceae CodonopsisconvolvulaceaKurz., is used as medicine with root.Autumn excavates, and cleans and dries.Invigorating QI and blood, the lung moistening and production of body fluid promoting.For anemia, spontaneous perspiration, deficiency of lung-YIN is coughed, neurasthenia.
Herba veronicastri villosuli, Classification system Veronicastrumstenostachyum (Hemsl.) Yamazaki is stem and leaf or the root of the raw Herba veronicastri villosuli of goatweed axil or Herba veronicastri villosuli.Inducing diuresis to remove edema, dissipating blood stasis detoxifies.For ascites, edema, dysuria, menoxenia, amenorrhea, traumatic injury; Parotitis is controlled in external, furuncle, burn and scald, venom.
Radix Caulophylli is the root and rhizome of Berberidaceae plant Radix Caulophylli Caulopyhllumrobustum.Because its fibrous root is many carefully in aubergine, therefore obtain this name.Radix Caulophylli is perennial herb.Root stock is sturdy, horizontal walk, above the many aubergine fibrous roots of close life.Leaf is that 2-3 times palmates 3 go out compound leaf; Open yellow green little Hua, sepal petal-shaped, petal is linear.4-June blooms, 6-October result.Fruit is spheroidal berry, outer by white lead, atropurpureus time ripe, tool meat fruit stem.Be distributed in various places, Shennongjiawooded Area.Under being grown on the hillside of height above sea level 1260-3000 meters, the bright wet place of limes marginis.Regulating QI to relieve pain, expelling wind and activating blood circulation.For menoxenia, stomach abdomen pain, traumatic injury, rheumatalgia.The present invention is used as medicine with root and rhizome.
Pseudobulbus Pholidotae Chinensis is herb or the pseudobulb of monocotyledon medicine the orchid family peach family plant seed Pseudobulbus Pholidotae Chinensis.Replenishing YIN and removing heat.For pulmonary tuberculosis cough, cough with asthma QI rising in reverse order person.For the traumatic injury person of swelling and ache.The present invention is with all herbal medicine.All the other Chinese medicines are pharmacopeia kind.
Beneficial effect: the Chinese medicine contrast agent use safety that B ultrasonic of the present invention uses, no pain, hurtless measure, avirulence, without anaphylaxis, review time is short, video picture rate is high, easy to use, cost is low, for the early stage correct diagnosis of disease provides a kind of new technique, new method, for clinical diagnosis provides strong foundation, be ideal novel contrast agent, and preparation technology is simple, practical.
Detailed description of the invention
Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.
1, embodiment is prepared
Embodiment 1: get Rhizoma Polygoni Paleachi 25g, Rhodobryum giganteum(Hook.) Par. 20g, Radix Codonopsis Convolvulaceae 18g, Herba veronicastri villosuli 20g, Radix Caulophylli 18g, Rhizoma Pinelliae 20g, Cortex Magnoliae Officinalis 15g, Fructus Aurantii Immaturus 20g, Folium Nelumbinis 20g, Pericarpium Citri Reticulatae 25g, Fructus Amomi 25g, Radix Glycyrrhizae 5g merges, decoct with water twice, first time adds water as 8 times amount of medical material weight, decoct 1h, second time adds water as 6 times amount of medical material weight, decoct 1h, collecting decoction, 0.07MPa, when being evaporated to 65 DEG C at 60-70 DEG C, relative density is 1.10, adding 95% (v/v) ethanol makes alcohol content reach 85% (v/v), stir, leave standstill 24 hours, decompression filtrate recycling ethanol is also concentrated, filtrate is at 0.07MPa, under 65 DEG C of conditions, concentrating under reduced pressure one-tenth is 1.30 to relative density when 65 DEG C, (condition is inlet temperature is 120 DEG C to spraying dry, leaving air temp is 80 DEG C, temperature of charge is 90 DEG C, atomizing pressure is 0.4 MPa, spray velocity is 10ml/s.), add starch 50g, mix homogeneously, with appropriate 80% (v/v) ethanol wet, soft material processed, cross 30 mesh sieves and granulate, in 70 ~ 80 DEG C of dryings, with 60 mesh sieve granulate, tabletting, sugar coating, subpackage, outer package, censorship is qualified, obtains tablet.
Embodiment 2: get Rhizoma Polygoni Paleachi 25g, Rhodobryum giganteum(Hook.) Par. 20g, Radix Codonopsis Convolvulaceae 18g, Herba veronicastri villosuli 20g, Radix Caulophylli 18g, Rhizoma Pinelliae 20g, Cortex Magnoliae Officinalis 15g, Fructus Aurantii Immaturus 20g, Folium Nelumbinis 20g, Pericarpium Citri Reticulatae 25g, Fructus Amomi 25g, Radix Glycyrrhizae 5g merges, decoct with water twice, first time adds water as 10 times amount of medical material weight, decoct 1.5h, second time adds water as 8 times amount of medical material weight, decoct 1.5h, collecting decoction, 0.07MPa, when being evaporated to 65 DEG C at 60-70 DEG C, relative density is 1.15, adding 95% (v/v) ethanol makes alcohol content reach 75% (v/v), stir, leave standstill 24 hours, decompression filtrate recycling ethanol is also concentrated, filtrate is at 0.07MPa, under 65 DEG C of conditions, concentrating under reduced pressure one-tenth is 1.25 to relative density when 65 DEG C, (condition is inlet temperature is 100 DEG C to spraying dry, leaving air temp is 90 DEG C, temperature of charge is 80 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 5ml/s.), add dextrin 50g, dry granulation, cross 60 mesh sieves, load No. 1 capsule capsule.
Embodiment 3: get Rhizoma Polygoni Paleachi 25g, Rhodobryum giganteum(Hook.) Par. 20g, Radix Codonopsis Convolvulaceae 18g, Herba veronicastri villosuli 20g, Radix Caulophylli 18g, Rhizoma Pinelliae 20g, Cortex Magnoliae Officinalis 15g, Fructus Aurantii Immaturus 20g, Folium Nelumbinis 20g, Pericarpium Citri Reticulatae 25g, Fructus Amomi 25g, Radix Glycyrrhizae 5g merges, decoct with water twice, first time adds water as 12 times amount of medical material weight, decoct 2h, second time adds water as 10 times amount of medical material weight, decoct 2h, collecting decoction, 0.07MPa, when being evaporated to 65 DEG C at 60-70 DEG C, relative density is 1.20, adding 95% (v/v) ethanol makes alcohol content reach 65% (v/v), stir, leave standstill 24 hours, decompression filtrate recycling ethanol is also concentrated, filtrate is at 0.07MPa, under 65 DEG C of conditions, concentrating under reduced pressure one-tenth is 1.25 to relative density when 65 DEG C, (condition is inlet temperature is 110 DEG C to spraying dry, leaving air temp is 85 DEG C, temperature of charge is 80 DEG C, atomizing pressure is 0.3 MPa, spray velocity is 7.5ml/s.), then add lactose 50g, with appropriate 80% (v/v) ethanol wet, soft material processed, cross 14 mesh sieves and granulate, 50-80 DEG C of drying, 60 order granulate, obtain granule.
2, the present invention is on the impact of mice with constipation Small intestine advance activity
Animal, medicine, reagent: animal: healthy ICR mice, male and female half and half, heavy 18-22g, is provided by Shanghai Slac Experimental Animal Co., Ltd., production licence number SCXK (Shanghai) 2003-0003.Granule of the present invention is prepared by above-described embodiment 1; R-1132, Wujin pharmaceutical factory, 20140612.Phenolphthalein tablets (phenolphthalein sugar-tablet), Junan, Shandong Province pharmaceutical factory, specification: 100mg*100 sheet/box, lot number 20130721
Experimentation: get ICR mice 60, with the modeling of R-1132 50m/kg gavage, continuous 10 days, period normal diet, form Constipation Model, random packet, often organize about 10, male and female half and half, be divided into normal group, model group, positive drug group (giving phenolphthalein tablets), soft capsule of the present invention is high, in, low three dosage groups, administration is the same, successive administration 14d, before experiment, water 12h is can't help in fasting, 2h after last administration, gavage with the charcoal end arabic gum suspension lml/g that volume fraction is 5% respectively, each group of mice is put to death after 20min, cut open the belly and measure every Mus small intestinal charcoal end displacement and total small intestinal length, be converted into the percentage rate that charcoal end displacement accounts for total small intestinal length, t test and judge group difference, the results are shown in Table 1.
Table 1 the present invention is on the impact (n=10) of mice with constipation Small intestine advance activity
Compare with model group, * * P<0.01*P<0.05, compares with positive drug group, ##P<0.01#P<0.05
Result: the gastric peristalsis of Chinese medicine granules of the present invention is obviously hyperfunction, compares with blank group, can obviously promote gastrointestinal motility function.
Claims (6)
1. the Chinese medicine gastrointestinal contrast agent for B ultrasonic, it is characterized in that, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: Rhizoma Polygoni Paleachi 25 parts, Rhodobryum giganteum(Hook.) Par. 20 parts, Radix Codonopsis Convolvulaceae 18 parts, Herba veronicastri villosuli 20 parts, Radix Caulophylli 18 parts, the Rhizoma Pinelliae 20 parts, Cortex Magnoliae Officinalis 15 parts, Fructus Aurantii Immaturus 20 parts, 20 parts, Folium Nelumbinis, Pericarpium Citri Reticulatae 25 parts, Fructus Amomi 25 parts, 5 parts, Radix Glycyrrhizae.
2., as claimed in claim 1 for the Chinese medicine gastrointestinal contrast agent of B ultrasonic, it is characterized in that dosage form is granule, tablet, capsule.
3. as claimed in claim 1 for the Chinese medicine gastrointestinal contrast agent of B ultrasonic, it is characterized in that preparation method comprises the steps: get above-mentioned medical material and mix, decoct with water twice, collecting decoction, when being concentrated into 65 DEG C, relative density is 1.10-1.20, adding ethanol makes the percent by volume of alcohol content reach 65-85%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.20-1.30 and reclaims ethanol, concentrated solution spraying dry, pulverize, obtain dry powder, finally add pharmaceutically acceptable excipient and make clinical acceptable granule, tablet, capsule.
4. as claimed in claim 1 for the Chinese medicine gastrointestinal contrast agent of B ultrasonic, it is characterized in that decocting with water in process in preparation method, first time adds water as the 8-12 times amount of medical material weight, decocts 1-2h, and second time adds water as the 6-10 times amount of medical material weight, decocts 1-2h.
5. as claimed in claim 1 for the Chinese medicine gastrointestinal contrast agent of B ultrasonic, it is characterized in that in preparation method, spray drying condition is: inlet temperature is 100-120 DEG C, leaving air temp is 80-90 DEG C, and temperature of charge is 70-90 DEG C, atomizing pressure is 0.2-0.4 MPa, and spray velocity is 5-10ml/s.
6. according to claim 1 for the application of Chinese medicine gastrointestinal contrast agent in the Chinese medicine gastrointestinal contrast agent of B ultrasonic of B ultrasonic.
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| CN201510557652.XA CN105056256A (en) | 2015-09-03 | 2015-09-03 | Traditional Chinese medicine gastrointestinal developing aid for B ultrasonic |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105854036A (en) * | 2016-04-11 | 2016-08-17 | 王洪杰 | Ultrasound image diagnosis developing preparation and preparation method and application thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3931005A1 (en) * | 1989-09-14 | 1991-03-28 | Jacek Birnbaum | Ultrasound transmission medium - made by combining cold aq. soln. of potato starch and salt to hot aq. soln. of citric acid |
| CN1101857A (en) * | 1993-10-22 | 1995-04-26 | 杜军强 | Chinese medicine contrast agent for stomach B-ultrasonic and its preparation |
| CN101422622A (en) * | 2008-12-09 | 2009-05-06 | 秦峰 | B-ultrasonic traditional Chinese medicine imaging assistant and preparation method thereof |
| CN102302692A (en) * | 2011-09-05 | 2012-01-04 | 南京正宽医药科技有限公司 | Traditional Chinese medicine composition for treating constipation, as well as preparation method and application thereof |
-
2015
- 2015-09-03 CN CN201510557652.XA patent/CN105056256A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3931005A1 (en) * | 1989-09-14 | 1991-03-28 | Jacek Birnbaum | Ultrasound transmission medium - made by combining cold aq. soln. of potato starch and salt to hot aq. soln. of citric acid |
| CN1101857A (en) * | 1993-10-22 | 1995-04-26 | 杜军强 | Chinese medicine contrast agent for stomach B-ultrasonic and its preparation |
| CN101422622A (en) * | 2008-12-09 | 2009-05-06 | 秦峰 | B-ultrasonic traditional Chinese medicine imaging assistant and preparation method thereof |
| CN102302692A (en) * | 2011-09-05 | 2012-01-04 | 南京正宽医药科技有限公司 | Traditional Chinese medicine composition for treating constipation, as well as preparation method and application thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105854036A (en) * | 2016-04-11 | 2016-08-17 | 王洪杰 | Ultrasound image diagnosis developing preparation and preparation method and application thereof |
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Application publication date: 20151118 |