CN102940718A - Traditional Chinese medicine composition for treating constipation, preparation method and application - Google Patents
Traditional Chinese medicine composition for treating constipation, preparation method and application Download PDFInfo
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- 206010010774 Constipation Diseases 0.000 title claims abstract description 37
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- 240000003870 Ageratum houstonianum Species 0.000 abstract 1
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention provides a traditional Chinese medicine composition for treating constipation, a preparation method and an application. The traditional Chinese medicine composition is mainly composed of the following components in parts by weight:18-22 parts of ageratum, 55-65 parts of cortex magnoliae officinalis, 18-22 parts of paeonia lactiflora pallas, 8-12 parts of delavay soapberry pericarp seed, 8-12 parts of dried old orange peel, 13-17 parts of almond, 10-14 parts of semen trichosanthis, 10-14 parts of angelica and 18-22 parts of peach kernels, and the composition is prepared to oral liquid, tablets, capsules or granules by a corresponding preparation method. The traditional Chinese medicine composition has the functions of tonifying middle-Jiao and Qi and invigorating and activating spleen, and the traditional Chinese medicine composition is used for treating constipation.
Description
Technical field
The present invention relates to technical field of Chinese medicines, be specifically related to a kind of Chinese medicine composition and preparation method and application that are used for the treatment of constipation.
Background technology
Constipation is clinical common complicated symptom, rather than a kind of disease, refers to mainly that defecation frequency reduces, the feces amount reduces, feces is dry and hard, defecation effort etc.When above-mentioned symptom existed more than 2 kinds simultaneously, diagnosable was symptomatic constipation.Usually be reduced to the master with stool, general per 2 ~ 3 days or longer time defecation once (or weekly＜3 time) are constipation.The survey showed that to one group of Healthy People, and bowl evacuation habit mostly is every day 1 ~ 2 time or 1 time on the 1st ~ 2 (60%), and feces mostly is molding or soft stool; The defecation frequency of minority Healthy People can reach 3 times on the 1st (30%), or 3 days 1 time (10%), and feces is half-formed or be the sausage sample firmly just.Therefore must be in conjunction with the character of feces, bowl evacuation habit and defecation have or not difficulty to make to have or not the judgement of constipation at ordinary times for I.Be chronic constipation as surpassing 6 months.The method of traditional treatment constipation, the traditional Chinese medical science adopt " DACHENGQI TANG ", Radix Et Rhizoma Rhei more, Folium Sennae, and the stool of removing heat by catharsis such as magnesium sulfate, still dry and hard after the recurrence within the next few days; Doctor trained in Western medicine adopts " phenolphthalein sugar " relieving constipation more, or alleviates with " Kai Saitong ", and existing takes stopgap measures can not effect a permanent cure, and curative effect is unstable, and cure rate is lower, is generally 20%, easily the defective of recurrence.
Summary of the invention
Goal of the invention: in order to address the above problem, the object of the present invention is to provide a kind of Chinese medicine composition and preparation method and application that are used for the treatment of constipation.
Technical scheme: the objective of the invention is to realize by following scheme:
A kind of Chinese medicine composition that is used for the treatment of constipation, it is prepared by the raw material of following parts by weight: Herba Pogostemonis 18-22 part, Cortex Magnoliae Officinalis 55-65 part, Radix Paeoniae Alba 18-22 part, Semen Sapindi Delavayi 8-12 part, Radix Platycodonis 8-12 part, Semen Armeniacae Amarum 13-17 part, Semen Trichosanthis 10-14 part, Radix Angelicae Sinensis 10-14 part, Semen Persicae 18-22 part.
The above-mentioned Chinese medicine composition that is used for the treatment of constipation, it is prepared by the raw material of following parts by weight: 20 parts of Herba Pogostemoniss, 60 parts of Cortex Magnoliae Officinalis, 20 parts of the Radix Paeoniae Albas, 10 parts of Semen Sapindi Delavayis, 10 parts of Radix Platycodoniss, 15 parts in Semen Armeniacae Amarum, 12 parts of Semen Trichosanthis, 12 parts of Radix Angelicae Sinensis, 20 parts in Semen Persicae.
The above-mentioned Chinese medicine composition that is used for the treatment of constipation, described Chinese medicine composition add adjuvant and make oral beverage, tablet, capsule or granule after extracting.
The above-mentioned Chinese medicine composition that is used for the treatment of constipation, described adjuvant are one or more of dextrin, lactose, starch, sucrose, glucose, microcrystalline Cellulose, mannose, methylcellulose, hydroxypropyl cellulose, carboxymethyl cellulose and stevioside.
The preparation method of the above-mentioned Chinese medicine composition that is used for the treatment of constipation, it comprises the steps: to get Herba Pogostemonis, Cortex Magnoliae Officinalis, the Radix Paeoniae Alba, Semen Sapindi Delavayi, Radix Platycodonis, Semen Armeniacae Amarum, Semen Trichosanthis, Radix Angelicae Sinensis, the Semen Persicae medical material merges, decoct with water twice, collecting decoction, relative density is the extractum of 1.15-1.20 when being evaporated to 65 ℃, adding ethanol makes the percent by volume that contains the alcohol amount reach 75-85%, stir, leave standstill, filter, relative density was 1.25-1.30 when filtrate decompression was concentrated into 65 ℃, and Recycled ethanol, get concentrated solution, concentrated solution is added water and adjuvant is mixed with oral liquid, or with the concentrated solution spray drying, add adjuvant and make capsule, tablet, granule.
The above-mentioned preparation method that is used for the treatment of the Chinese medicine composition of constipation, in the step, decocting condition is: the 8-12 that adds for the first time water and be medical material weight doubly measures, and decocts 1-2h, and the 6-10 that adds water for the second time and be medical material weight doubly measures, and decocts 1-2h.
The preparation method of the above-mentioned Chinese medicine composition that is used for the treatment of constipation, in the step, the spray drying condition is: inlet temperature is 100-120 ℃, leaving air temp is 80-90 ℃, temperature of charge is 70-90 ℃, and atomizing pressure is the 0.2-0.4 MPa, and spray velocity is 5-10ml/s.
The above-mentioned application of Chinese medicine composition in the medicine of preparation treatment constipation that is used for the treatment of constipation.
Herba Pogostemonis, Cortex Magnoliae Officinalis, the Radix Paeoniae Alba, Radix Platycodonis, Semen Armeniacae Amarum, Semen Trichosanthis, Radix Angelicae Sinensis, Semen Persicae are the pharmacopeia kind among the present invention, and Semen Sapindi Delavayi is the fruits and seeds of Yunnan, sapindaceous plant river Fructus Sapindi Mukouossi.Latin plant animal mineral name: Sapindus delavayi (Franch.) Radlk.[Pancovia delavayi Franch.].
Beneficial effect:
1, from theory of Chinese medical science, Herba Pogostemonis, Cortex Magnoliae Officinalis air making-up and spleen enlivening are that regulating qi-flowing for harmonizing stomach, intestine moistening, the elimination distensions such as monarch drug, Semen Sapindi Delavayi, Radix Platycodonis, Semen Armeniacae Amarum, Semen Trichosanthis, Radix Angelicae Sinensis, the Radix Paeoniae Alba are that ministerial drug, Semen Persicae dyspepsia and intestinal stasis relieving are adjuvant among the we, all medicines are harmonious, play altogether invigorating the spleen and replenishing QI, spleen invigorating helps running usefulness, is used for the treatment of constipation.
2, Formulation of the present invention is reasonable, and compatibility is rigorous, through long-term clinical verification, determined curative effect.
3, the present invention consists of Chinese crude drug, has no side effect low price.
The specific embodiment
Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention only limits to following example, all technology that realizes based on foregoing of the present invention all belong to scope of the present invention.
1, in conjunction with the specific embodiment, the present invention is further described as follows:
2、
Listed weight proportion takes by weighing raw material required for the present invention in the according to the form below, unit: g
| Herba Pogostemonis | Cortex Magnoliae Officinalis | The Radix Paeoniae Alba | Semen Sapindi Delavayi | Radix Platycodonis | Semen Armeniacae Amarum | Semen Trichosanthis | Radix Angelicae Sinensis | Semen Persicae | |
| 1 | 18 | 65 | 18 | 12 | 8 | 17 | 10 | 14 | 18 |
| 2 | 20 | 60 | 20 | 10 | 10 | 15 | 12 | 12 | 20 |
| 3 | 22 | 55 | 22 | 8 | 12 | 13 | 14 | 10 | 22 |
3. Preparation Example
More than table Raw proportioning is example, may further comprise the steps:
Embodiment 1: get Herba Pogostemonis 18g, Cortex Magnoliae Officinalis 65g, Radix Paeoniae Alba 18g, Semen Sapindi Delavayi 12g, Radix Platycodonis 8g, Semen Armeniacae Amarum 17g, Semen Trichosanthis 10g, Radix Angelicae Sinensis 14g, Semen Persicae 18g medical material merges, decoct with water twice, add for the first time 10 times of amounts that water is medical material weight, decoct 1.5h, add for the second time 8 times of amounts that water is medical material weight, decoct 1.5h, collecting decoction, 0.07MPa, relative density is 1.15 extractum when being evaporated to 65 ℃ under 60-70 ℃, adding 95% (v/v) ethanol makes the alcohol amount of containing reach 75% (v/v), stir, left standstill 24 hours, filter, filtrate is at 0.07MPa, relative density was 1.25 when concentrating under reduced pressure became to 65 ℃ under 65 ℃ of conditions, and Recycled ethanol, get concentrated solution, (condition is that inlet temperature is 100 ℃ with the concentrated solution spray drying, leaving air temp is 85 ℃, temperature of charge is 80 ℃, and atomizing pressure is 0.2 MPa, and spray velocity is 5ml/s.), adding appropriate amount of starch, dry granulation is crossed 60 mesh sieves, and No. 1 capsule of packing into gets final product to get capsule.
Embodiment 2: get Herba Pogostemonis 20g, Cortex Magnoliae Officinalis 60g, Radix Paeoniae Alba 20g, Semen Sapindi Delavayi 10g, Radix Platycodonis 10g, Semen Armeniacae Amarum 15g, Semen Trichosanthis 12g, Radix Angelicae Sinensis 12g, Semen Persicae 20g medical material merges, decoct with water twice, add for the first time 8 times of amounts that water is medical material weight, decoct 1h, add for the second time 6 times of amounts that water is medical material weight, decoct 1h, collecting decoction, 0.07MPa, relative density is 1.20 when being evaporated to 65 ℃ under 60-70 ℃, add 95% (v/v) ethanol and make the alcohol amount of containing reach 80% (v/v), stir, left standstill 24 hours, filter, filtrate is at 0.07MPa, relative density was 1.30 when concentrating under reduced pressure became to 65 ℃ under 65 ℃ of conditions, and Recycled ethanol, got concentrated solution, filtration adds water and sucrose is mixed with oral liquid.
Embodiment 3: get Herba Pogostemonis 22g, Cortex Magnoliae Officinalis 55g, Radix Paeoniae Alba 22g, Semen Sapindi Delavayi 8g, Radix Platycodonis 12g, Semen Armeniacae Amarum 13g, Semen Trichosanthis 14g, Radix Angelicae Sinensis 10g, Semen Persicae 22g medical material merges, decoct with water twice, add for the first time 12 times of amounts that water is medical material weight, decoct 2h, add for the second time 10 times of amounts that water is medical material weight, decoct 2h, collecting decoction, 0.07MPa, relative density is 1.20 extractum when being evaporated to 65 ℃ under 60-70 ℃, adding 95% (v/v) ethanol makes the alcohol amount of containing reach 85% (v/v), stir, left standstill 24 hours, filter, filtrate is at 0.07MPa, relative density was 1.30 when concentrating under reduced pressure became to 65 ℃ under 65 ℃ of conditions, and Recycled ethanol, get concentrated solution, (condition is that inlet temperature is 120 ℃ with the concentrated solution spray drying, leaving air temp is 90 ℃, temperature of charge is 90 ℃, and atomizing pressure is 0.4 MPa, and spray velocity is 10ml/s.), adding appropriate amount of starch, dextrin, Icing Sugar, lactose, microcrystalline Cellulose one or more adjuvants wherein, mix homogeneously is with the moistening of an amount of 80% (v/v) ethanol, soft material processed is crossed 30 mesh sieves and is granulated, in 70 ~ 80 ℃ of dryings, with 60 mesh sieve granulate, tabletting, sugar coating gets tablet.
Embodiment 4: get Herba Pogostemonis 20g, Cortex Magnoliae Officinalis 60g, Radix Paeoniae Alba 20g, Semen Sapindi Delavayi 10g, Radix Platycodonis 10g, Semen Armeniacae Amarum 15g, Semen Trichosanthis 12g, Radix Angelicae Sinensis 12g, Semen Persicae 20g medical material merges, decoct with water twice, add for the first time 10 times of amounts that water is medical material weight, decoct 1.5h, add for the second time 8 times of amounts that water is medical material weight, decoct 1.5h, collecting decoction, 0.07MPa, relative density is 1.15 extractum when being evaporated to 65 ℃ under 65 ℃, adding 95% (v/v) ethanol makes the alcohol amount of containing reach 80% (v/v), stir, left standstill 24 hours, decompression filtrate recycling ethanol is also concentrated, filtrate is at 0.07MPa, relative density was 1.25 when concentrating under reduced pressure became to 65 ℃ under 65 ℃ of conditions, and Recycled ethanol, get concentrated solution, (condition is that inlet temperature is 110 ℃ with the concentrated solution spray drying, leaving air temp is 80 ℃, temperature of charge is 70 ℃, and atomizing pressure is 0.3 MPa, and spray velocity is 7.5ml/s.), add suitable dextrin, soluble starch, lactose, sucrose, mannitol wherein one or more, with the moistening of an amount of 80% (v/v) ethanol, soft material processed, cross 14 mesh sieves and granulate, 70-80 ℃ of drying, 60 order granulate get granule.
3. granule of the present invention is on the impact of mice with constipation intestinal propulsion motion
3.1 animal: healthy ICR mice, male and female half and half, heavy 18-22g is provided by Nanjing Medical University's animal center, production licence number SCXK(Soviet Union) 2002-0031.
3.2 medicine and reagent: press above-described embodiment 4 preparations granule of the present invention, namely get Herba Pogostemonis 20g, Cortex Magnoliae Officinalis 60g, Radix Paeoniae Alba 20g, Semen Sapindi Delavayi 10g, Radix Platycodonis 10g, Semen Armeniacae Amarum 15g, Semen Trichosanthis 12g, Radix Angelicae Sinensis 12g, Semen Persicae 20g medical material merges, decoct with water twice, add for the first time 10 times of amounts that water is medical material weight, decoct 1.5h, add for the second time 8 times of amounts that water is medical material weight, decoct 1.5h, collecting decoction, 0.07MPa, relative density is 1.15 extractum when being evaporated to 65 ℃ under 65 ℃, adds 95% (v/v) ethanol and makes the alcohol amount of containing reach 80% (v/v), stirs, left standstill 24 hours, decompression filtrate recycling ethanol is also concentrated, and filtrate is at 0.07MPa, relative density was 1.25 when concentrating under reduced pressure became to 65 ℃ under 65 ℃ of conditions, and Recycled ethanol, get concentrated solution, (condition is that inlet temperature is 110 ℃, and leaving air temp is 80 ℃, and temperature of charge is 70 ℃ with the concentrated solution spray drying, atomizing pressure is 0.3 MPa, and spray velocity is 7.5ml/s.), add suitable dextrin, with the moistening of an amount of 80% (v/v) ethanol, soft material processed, cross 14 mesh sieves and granulate 70-80 ℃ of drying, 60 order granulate, get granule 100g, be distributed into 10g granule/bag, contain crude drug 17.9g in every bag of granule, provided by Nanjing Zhengkuan Pharmaceutical Technology Co., Ltd., lot number 20100511, clinical people's consumption per day is each 1 bag, and every day 3 times, namely clinical people's consumption per day is the 53.7g crude drug, therefore determine that every mice consumption is the 53.7x0.0026=0.14g crude drug, calculate with kilogram, dosage is 7g crude drug/kg, and this is low dosage, dosage 14g crude drug/kg is middle dosage, and dosage 28g crude drug/kg is high dose.Phenolphthalein tablets (phenolphthalein sugar-tablet), Junan, Shandong Province pharmaceutical factory, specification: 100mg*100 sheet/box, lot number 20100106, people's consumption per day 0.8g/ days, being equivalent to every mice consumption is 0.8gx0.0026=0.002g, calculate with kilogram, dosage is 0.1g/kg, and take 3 times of amounts as dosage, namely positive group gives phenolphthalein tablets 0.3g/kg.All the other reagent are domestic analytical pure.R-1132, Wujin pharmaceutical factory, 20100324.
3.3 process of the test: get 60 of ICR mices, with the modeling of R-1132 50m/kg gavage, continuous 10 days, normal diet during this time, form Constipation Model, random packet, every group about 10, male and female half and half, be divided into normal group, model group, the positive drug group, granule of the present invention is high, in, low three dosage groups, administration is the same, successive administration 14d, fasting be can't help water 12h, 2h after the last administration before the experiment, be that 5% charcoal end arabic gum suspension lml/g gavages with volume fraction respectively, put to death behind the 20min and respectively organize mice, cut open the belly and measure every Mus small intestinal charcoal end displacement and small intestinal total length, be converted into the percentage rate that charcoal end displacement accounts for the small intestinal total length, t test and judge group difference the results are shown in Table 1.
Table 1 granule of the present invention is on the impact (n=10) of mice with constipation intestinal propulsion motion
Compare with model group, ##P＜0.01#P＜0.05 is compared with the positive drug group in * * P＜0.01*P＜0.05
The result: medicine group of the present invention and model group are relatively, obvious promotion mice with constipation intestinal propulsion motion is arranged, promote gastrointestinal motility in mice, has significant difference, compare with positive drug, medicine of the present invention senior middle school dosage group is promoting to have significant difference aspect the motion of mice with constipation intestinal propulsion, and effect is better than positive drug.
Claims (8)
1. Chinese medicine composition that is used for the treatment of constipation, it is characterized in that it is prepared by the raw material of following parts by weight: Herba Pogostemonis 18-22 part, Cortex Magnoliae Officinalis 55-65 part, Radix Paeoniae Alba 18-22 part, Semen Sapindi Delavayi 8-12 part, Radix Platycodonis 8-12 part, Semen Armeniacae Amarum 13-17 part, Semen Trichosanthis 10-14 part, Radix Angelicae Sinensis 10-14 part, Semen Persicae 18-22 part.
2. the Chinese medicine composition that is used for the treatment of constipation according to claim 1, it is characterized in that it is prepared by the raw material of following parts by weight: 20 parts of Herba Pogostemoniss, 60 parts of Cortex Magnoliae Officinalis, 20 parts of the Radix Paeoniae Albas, 10 parts of Semen Sapindi Delavayis, 10 parts of Radix Platycodoniss, 15 parts in Semen Armeniacae Amarum, 12 parts of Semen Trichosanthis, 12 parts of Radix Angelicae Sinensis, 20 parts in Semen Persicae.
3. the Chinese medicine composition that is used for the treatment of constipation according to claim 1 and 2 is characterized in that, described raw material adds adjuvant and makes oral beverage, tablet, capsule or granule after extracting.
4. the Chinese medicine composition that is used for the treatment of constipation according to claim 3, it is characterized in that described adjuvant is one or more of dextrin, lactose, starch, sucrose, glucose, microcrystalline Cellulose, mannose, methylcellulose, hydroxypropyl cellulose, carboxymethyl cellulose and stevioside.
5. claim 1 or the 2 described preparation methoies that are used for the treatment of the Chinese medicine composition of constipation, it is characterized in that, it comprises the steps: to get Herba Pogostemonis, Cortex Magnoliae Officinalis, the Radix Paeoniae Alba, Semen Sapindi Delavayi, Radix Platycodonis, Semen Armeniacae Amarum, Semen Trichosanthis, Radix Angelicae Sinensis, the Semen Persicae medical material merges, decoct with water twice, collecting decoction, relative density is the extractum of 1.15-1.20 when being evaporated to 65 ℃, adding ethanol makes the percent by volume that contains the alcohol amount reach 75-85%, stir, leave standstill, filter, relative density was 1.25-1.30 when filtrate decompression was concentrated into 65 ℃, and Recycled ethanol, get concentrated solution, concentrated solution is added water and adjuvant is mixed with oral liquid, or with the concentrated solution spray drying, add adjuvant and make capsule, tablet, granule.
6. the preparation method that is used for the treatment of the Chinese medicine composition of constipation according to claim 5 is characterized in that, in the step, decocting condition is: the 8-12 that adds for the first time water and be medical material weight doubly measures, decoct 1-2h, the 6-10 that adds water for the second time and be medical material weight doubly measures, and decocts 1-2h.
7. the preparation method that is used for the treatment of the Chinese medicine composition of constipation according to claim 5, it is characterized in that, in the step, the spray drying condition is: inlet temperature is 80-120 ℃, leaving air temp is 80-90 ℃, temperature of charge is 70-90 ℃, and atomizing pressure is the 0.2-0.4 MPa, and spray velocity is 5-10ml/s.
8. claim 1 or the 2 described application of Chinese medicine composition in the medicine of preparation treatment constipation that are used for the treatment of constipation.
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