CN102940718B - Traditional Chinese medicine composition for treating constipation, preparation method and application - Google Patents
Traditional Chinese medicine composition for treating constipation, preparation method and application Download PDFInfo
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- 206010010774 Constipation Diseases 0.000 title claims abstract description 35
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention provides a traditional Chinese medicine composition for treating constipation, a preparation method and an application. The traditional Chinese medicine composition is mainly composed of the following components in parts by weight:18-22 parts of ageratum, 55-65 parts of cortex magnoliae officinalis, 18-22 parts of paeonia lactiflora pallas, 8-12 parts of delavay soapberry pericarp seed, 8-12 parts of dried old orange peel, 13-17 parts of almond, 10-14 parts of semen trichosanthis, 10-14 parts of angelica and 18-22 parts of peach kernels, and the composition is prepared to oral liquid, tablets, capsules or granules by a corresponding preparation method. The traditional Chinese medicine composition has the functions of tonifying middle-Jiao and Qi and invigorating and activating spleen, and the traditional Chinese medicine composition is used for treating constipation.
Description
Technical field
The present invention relates to technical field of Chinese medicines, be specifically related to a kind of Chinese medicine composition and preparation method and application that are used for the treatment of constipation.
Background technology
Constipation is clinical common complicated symptom, rather than a kind of disease, mainly refers to that defecation frequency reduces, feces amount reduces, feces is dry and hard, defecation effort etc.When above-mentioned symptom exists two or more simultaneously, diagnosable is symptomatic constipation.Conventionally with stool, be reduced to master, general every 2 ~ 3 days or longer time defecation once (or <3 time weekly) are constipation.To one group of Healthy People, the survey showed that, and bowl evacuation habit mostly is every day 1 ~ 2 time or 1 time on the 1st ~ 2 (60%), and feces mostly is molding or soft stool; The defecation frequency of minority Healthy People can reach 3 times on the 1st (30%), or 3 days 1 time (10%), and feces is half-formed or be sausage sample firmly just.Therefore must be in conjunction with the character of feces, bowl evacuation habit and defecation have or not difficulty to make to have or not the judgement of constipation at ordinary times for I.As surpassed, within 6 months, be chronic constipation.The method of traditional treatment constipation, the traditional Chinese medical science adopts " DACHENGQI TANG ", Radix Et Rhizoma Rhei more, Folium Sennae, the stool of removing heat by catharsis such as magnesium sulfate, still dry and hard after recurrence within the next few days; Doctor trained in Western medicine adopts " phenolphthalein sugar " relieving constipation more, or alleviates with " Kai Saitong ", and existing takes stopgap measures can not effect a permanent cure, and curative effect is unstable, and cure rate is lower, is generally 20%, easily the defect of recurrence.
Summary of the invention
Goal of the invention: in order to address the above problem, the object of the present invention is to provide a kind of Chinese medicine composition and preparation method and application that are used for the treatment of constipation.
Technical scheme: the object of the invention is to realize by following scheme:
A Chinese medicine composition that is used for the treatment of constipation, it is prepared by the raw material of following parts by weight: Herba Pogostemonis 18-22 part, Cortex Magnoliae Officinalis 55-65 part, Radix Paeoniae Alba 18-22 part, Semen Sapindi Delavayi 8-12 part, Radix Platycodonis 8-12 part, Semen Armeniacae Amarum 13-17 part, Semen Trichosanthis 10-14 part, Radix Angelicae Sinensis 10-14 part, Semen Persicae 18-22 part.
The above-mentioned Chinese medicine composition that is used for the treatment of constipation, it is prepared by the raw material of following parts by weight: 20 parts of Herba Pogostemoniss, 60 parts of Cortex Magnoliae Officinalis, 20 parts of the Radix Paeoniae Albas, 10 parts of Semen Sapindi Delavayis, 10 parts of Radix Platycodoniss, 15 parts, Semen Armeniacae Amarum, 12 parts of Semen Trichosanthis, 12 parts of Radix Angelicae Sinensis, 20 parts, Semen Persicae.
The above-mentioned Chinese medicine composition that is used for the treatment of constipation, described Chinese medicine composition adds adjuvant and makes oral beverage, tablet, capsule or granule after extracting.
The above-mentioned Chinese medicine composition that is used for the treatment of constipation, described adjuvant is one or more of dextrin, lactose, starch, sucrose, glucose, microcrystalline Cellulose, mannose, methylcellulose, hydroxypropyl cellulose, carboxymethyl cellulose and stevioside.
The preparation method of the above-mentioned Chinese medicine composition that is used for the treatment of constipation, it comprises the steps: to get Herba Pogostemonis, Cortex Magnoliae Officinalis, the Radix Paeoniae Alba, Semen Sapindi Delavayi, Radix Platycodonis, Semen Armeniacae Amarum, Semen Trichosanthis, Radix Angelicae Sinensis, Semen Persicae medical material merges, decoct with water twice, collecting decoction, the extractum that while being evaporated to 65 ℃, relative density is 1.15-1.20, adding ethanol makes to reach 75-85% containing the percent by volume of alcohol amount, stir, standing, filter, when filtrate decompression is concentrated into 65 ℃, relative density is 1.25-1.30, and reclaim ethanol, obtain concentrated solution, concentrated solution is added to water and adjuvant is mixed with oral liquid, or concentrated solution spraying is dry, add adjuvant and make capsule, tablet, granule.
The above-mentioned preparation method that is used for the treatment of the Chinese medicine composition of constipation, in step, decocting condition is: the 8-12 that adds for the first time water and be medical material weight doubly measures, and decocts 1-2h, the 6-10 that adds for the second time water and be medical material weight doubly measures, and decocts 1-2h.
The preparation method of the above-mentioned Chinese medicine composition that is used for the treatment of constipation, in step, spraying drying condition is: inlet temperature is 100-120 ℃, leaving air temp is 80-90 ℃, temperature of charge is 70-90 ℃, and atomizing pressure is 0.2-0.4 MPa, and spray velocity is 5-10ml/s.
The application of the above-mentioned Chinese medicine composition that is used for the treatment of constipation in the medicine of preparation treatment constipation.
In the present invention, Herba Pogostemonis, Cortex Magnoliae Officinalis, the Radix Paeoniae Alba, Radix Platycodonis, Semen Armeniacae Amarum, Semen Trichosanthis, Radix Angelicae Sinensis, Semen Persicae are pharmacopeia kind, and Semen Sapindi Delavayi is the fruits and seeds of Yunnan, sapindaceous plant river Fructus Sapindi Mukouossi.Latin plant animal mineral name: Sapindus delavayi (Franch.) Radlk.[Pancovia delavayi Franch.].
Beneficial effect:
1, from theory of Chinese medical science, in we, Herba Pogostemonis, Cortex Magnoliae Officinalis air making-up and spleen enlivening are that regulating qi-flowing for harmonizing stomach, intestine moistening, the elimination distensions such as monarch drug, Semen Sapindi Delavayi, Radix Platycodonis, Semen Armeniacae Amarum, Semen Trichosanthis, Radix Angelicae Sinensis, the Radix Paeoniae Alba are that ministerial drug, Semen Persicae dyspepsia and intestinal stasis relieving are adjuvant, all medicines are harmonious, play altogether invigorating the spleen and replenishing QI, spleen invigorating helps running use, is used for the treatment of constipation.
2, Formulation of the present invention is reasonable, and compatibility is rigorous, through long-term clinical verification, determined curative effect.
3, the present invention consists of Chinese crude drug, have no side effect, and low price.
The specific embodiment
Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as to the scope of the above-mentioned theme of the present invention only limits to following example, all technology realizing based on foregoing of the present invention all belong to scope of the present invention.
1,, in conjunction with the specific embodiment, the present invention is further described as follows:
2、
According to the form below, listed weight proportion takes raw material required for the present invention, unit: g
| Herba Pogostemonis | Cortex Magnoliae Officinalis | The Radix Paeoniae Alba | Semen Sapindi Delavayi | Radix Platycodonis | Semen Armeniacae Amarum | Semen Trichosanthis | Radix Angelicae Sinensis | Semen Persicae | |
| 1 | 18 | 65 | 18 | 12 | 8 | 17 | 10 | 14 | 18 |
| 2 | 20 | 60 | 20 | 10 | 10 | 15 | 12 | 12 | 20 |
| 3 | 22 | 55 | 22 | 8 | 12 | 13 | 14 | 10 | 22 |
3. Preparation Example
More than showing Raw proportioning is example, comprises the following steps:
Embodiment 1: get Herba Pogostemonis 18g, Cortex Magnoliae Officinalis 65g, Radix Paeoniae Alba 18g, Semen Sapindi Delavayi 12g, Radix Platycodonis 8g, Semen Armeniacae Amarum 17g, Semen Trichosanthis 10g, Radix Angelicae Sinensis 14g, Semen Persicae 18g medical material merges, decoct with water twice, adding for the first time water is 10 times of amounts of medical material weight, decoct 1.5h, adding for the second time water is 8 times of amounts of medical material weight, decoct 1.5h, collecting decoction, 0.07MPa, the extractum that while being evaporated to 65 ℃ at 60-70 ℃, relative density is 1.15, adding 95% (v/v) ethanol makes to reach 75% (v/v) containing alcohol amount, stir, standing 24 hours, filter, filtrate is at 0.07MPa, when under 65 ℃ of conditions, concentrating under reduced pressure becomes to 65 ℃, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying, dry (condition is that inlet temperature is 100 ℃, leaving air temp is 85 ℃, temperature of charge is 80 ℃, atomizing pressure is 0.2 MPa, spray velocity is 5ml/s.), adding appropriate amount of starch, dry granulation, crosses 60 mesh sieves, packs No. 1 capsule into and gets final product to obtain capsule.
Embodiment 2: get Herba Pogostemonis 20g, Cortex Magnoliae Officinalis 60g, Radix Paeoniae Alba 20g, Semen Sapindi Delavayi 10g, Radix Platycodonis 10g, Semen Armeniacae Amarum 15g, Semen Trichosanthis 12g, Radix Angelicae Sinensis 12g, Semen Persicae 20g medical material merges, decoct with water twice, adding for the first time water is 8 times of amounts of medical material weight, decoct 1h, adding for the second time water is 6 times of amounts of medical material weight, decoct 1h, collecting decoction, 0.07MPa, while being evaporated to 65 ℃ at 60-70 ℃, relative density is 1.20, adding 95% (v/v) ethanol makes to reach 80% (v/v) containing alcohol amount, stir, standing 24 hours, filter, filtrate is at 0.07MPa, when under 65 ℃ of conditions, concentrating under reduced pressure becomes to 65 ℃, relative density is 1.30, and reclaim ethanol, obtain concentrated solution, filter, add water and sucrose is mixed with oral liquid.
Embodiment 3: get Herba Pogostemonis 22g, Cortex Magnoliae Officinalis 55g, Radix Paeoniae Alba 22g, Semen Sapindi Delavayi 8g, Radix Platycodonis 12g, Semen Armeniacae Amarum 13g, Semen Trichosanthis 14g, Radix Angelicae Sinensis 10g, Semen Persicae 22g medical material merges, decoct with water twice, adding for the first time water is 12 times of amounts of medical material weight, decoct 2h, adding for the second time water is 10 times of amounts of medical material weight, decoct 2h, collecting decoction, 0.07MPa, the extractum that while being evaporated to 65 ℃ at 60-70 ℃, relative density is 1.20, adding 95% (v/v) ethanol makes to reach 85% (v/v) containing alcohol amount, stir, standing 24 hours, filter, filtrate is at 0.07MPa, when under 65 ℃ of conditions, concentrating under reduced pressure becomes to 65 ℃, relative density is 1.30, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying, dry (condition is that inlet temperature is 120 ℃, leaving air temp is 90 ℃, temperature of charge is 90 ℃, atomizing pressure is 0.4 MPa, spray velocity is 10ml/s.), adding appropriate amount of starch, dextrin, Icing Sugar, lactose, microcrystalline Cellulose one or more adjuvants wherein, mix homogeneously, with the moistening of appropriate 80% (v/v) ethanol, soft material processed, crosses 30 mesh sieves and granulates, in 70 ~ 80 ℃ dry, with 60 mesh sieve granulate, tabletting, sugar coating, obtains tablet.
Embodiment 4: get Herba Pogostemonis 20g, Cortex Magnoliae Officinalis 60g, Radix Paeoniae Alba 20g, Semen Sapindi Delavayi 10g, Radix Platycodonis 10g, Semen Armeniacae Amarum 15g, Semen Trichosanthis 12g, Radix Angelicae Sinensis 12g, Semen Persicae 20g medical material merges, decoct with water twice, adding for the first time water is 10 times of amounts of medical material weight, decoct 1.5h, adding for the second time water is 8 times of amounts of medical material weight, decoct 1.5h, collecting decoction, 0.07MPa, the extractum that while being evaporated to 65 ℃ at 65 ℃, relative density is 1.15, adding 95% (v/v) ethanol makes to reach 80% (v/v) containing alcohol amount, stir, standing 24 hours, decompression filtrate recycling ethanol is also concentrated, filtrate is at 0.07MPa, when under 65 ℃ of conditions, concentrating under reduced pressure becomes to 65 ℃, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying, dry (condition is that inlet temperature is 110 ℃, leaving air temp is 80 ℃, temperature of charge is 70 ℃, atomizing pressure is 0.3 MPa, spray velocity is 7.5ml/s.), add suitable dextrin, soluble starch, lactose, sucrose, mannitol wherein one or more, with the moistening of appropriate 80% (v/v) ethanol, soft material processed, cross 14 mesh sieves and granulate, 70-80 ℃ dry, 60 order granulate, obtain granule.
3. the impact of granule of the present invention on the motion of mice with constipation intestinal propulsion
3.1 animals: healthy ICR mice, male and female half and half, heavy 18-22g, is provided by Nanjing Medical University's animal center, production licence number SCXK(Soviet Union) 2002-0031.
3.2 medicines and reagent: press above-described embodiment 4 preparation granule of the present invention, get Herba Pogostemonis 20g, Cortex Magnoliae Officinalis 60g, Radix Paeoniae Alba 20g, Semen Sapindi Delavayi 10g, Radix Platycodonis 10g, Semen Armeniacae Amarum 15g, Semen Trichosanthis 12g, Radix Angelicae Sinensis 12g, Semen Persicae 20g medical material merges, decoct with water twice, adding for the first time water is 10 times of amounts of medical material weight, decoct 1.5h, adding for the second time water is 8 times of amounts of medical material weight, decoct 1.5h, collecting decoction, 0.07MPa, the extractum that while being evaporated to 65 ℃ at 65 ℃, relative density is 1.15, adding 95% (v/v) ethanol makes to reach 80% (v/v) containing alcohol amount, stir, standing 24 hours, decompression filtrate recycling ethanol is also concentrated, filtrate is at 0.07MPa, when under 65 ℃ of conditions, concentrating under reduced pressure becomes to 65 ℃, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying, dry (condition is that inlet temperature is 110 ℃, leaving air temp is 80 ℃, temperature of charge is 70 ℃, atomizing pressure is 0.3 MPa, spray velocity is 7.5ml/s.), add suitable dextrin, with the moistening of appropriate 80% (v/v) ethanol, soft material processed, crossing 14 mesh sieves granulates, 70-80 ℃ dry, 60 order granulate, obtain granule 100g, be distributed into 10g granule/bag, in every bag of granule, contain crude drug 17.9g, by Nanjing Zhengkuan Pharmaceutical Technology Co., Ltd., provided, lot number 20100511, clinical people's consumption per day is each 1 bag, every day 3 times, be that clinical people's consumption per day is 53.7g crude drug, therefore determine that every mice consumption is 53.7x0.0026=0.14g crude drug, with a kilogram calculating, dosage is 7g crude drug/kg, this is low dosage, dosage 14g crude drug/kg is middle dosage, dosage 28g crude drug/kg is high dose.Phenolphthalein tablets (phenolphthalein sugar-tablet), Junan, Shandong Province pharmaceutical factory, specification: 100mg*100 sheet/box, lot number 20100106, people's consumption per day 0.8g/ days, being equivalent to every mice consumption is 0.8gx0.0026=0.002g, with a kilogram calculating, dosage is 0.1g/kg, and the 3 times of amounts of take are dosage, and positive group gives phenolphthalein tablets 0.3g/kg.All the other reagent are domestic analytical pure.R-1132, Wujin pharmaceutical factory, 20100324.
3.3 processs of the test: get 60 of ICR mices, with the modeling of R-1132 50m/kg gavage, continuous 10 days, normal diet during this time, form Constipation Model, random packet, every group approximately 10, male and female half and half, be divided into normal group, model group, positive drug group, granule of the present invention is high, in, low three dosage groups, administration is the same, successive administration 14d, before experiment, water 12h is can't help in fasting, 2h after last administration, the charcoal that is 5% by volume fraction respectively end arabic gum suspension lml/g gavages, after 20min, put to death and respectively organize mice, cut open the belly and measure every Mus small intestinal charcoal end displacement and small intestinal total length, be converted into the percentage rate that charcoal end displacement accounts for small intestinal total length, t test and judge group difference, the results are shown in Table 1.
The impact (n=10) of table 1 granule of the present invention on the motion of mice with constipation intestinal propulsion
With model group comparison, * * P<0.01*P<0.05, with the comparison of positive drug group, ##P<0.01#P<0.05
Result: medicine group of the present invention and model group comparison, there is obvious promotion mice with constipation intestinal propulsion motion, promote gastrointestinal motility in mice, there is significant difference, with positive drug comparison, medicine of the present invention senior middle school dosage group is promoting to have significant difference aspect the motion of mice with constipation intestinal propulsion, and effect is better than positive drug.
Claims (6)
1. a Chinese medicine composition that is used for the treatment of constipation, it is characterized in that, it is prepared by the raw material of following parts by weight: Herba Pogostemonis 18-22 part, Cortex Magnoliae Officinalis 55-65 part, Radix Paeoniae Alba 18-22 part, Semen Sapindi Delavayi 8-12 part, Radix Platycodonis 8-12 part, Semen Armeniacae Amarum 13-17 part, Semen Trichosanthis 10-14 part, Radix Angelicae Sinensis 10-14 part, Semen Persicae 18-22 part, preparation method comprises the steps: to get Herba Pogostemonis, Cortex Magnoliae Officinalis, the Radix Paeoniae Alba, Semen Sapindi Delavayi, Radix Platycodonis, Semen Armeniacae Amarum, Semen Trichosanthis, Radix Angelicae Sinensis, Semen Persicae medical material merges, decoct with water twice, collecting decoction, the extractum that while being evaporated to 65 ℃, relative density is 1.15-1.20, adding ethanol makes to reach 75-85% containing the percent by volume of alcohol amount, stir, standing, filter, when filtrate decompression is concentrated into 65 ℃, relative density is 1.25-1.30, and reclaim ethanol, obtain concentrated solution, concentrated solution is added to water and adjuvant is mixed with oral liquid, or concentrated solution spraying is dry, add adjuvant and make capsule, tablet, granule.
2. the Chinese medicine composition that is used for the treatment of constipation according to claim 1, it is characterized in that, it is prepared by the raw material of following parts by weight: 20 parts of Herba Pogostemoniss, 60 parts of Cortex Magnoliae Officinalis, 20 parts of the Radix Paeoniae Albas, 10 parts of Semen Sapindi Delavayis, 10 parts of Radix Platycodoniss, 15 parts, Semen Armeniacae Amarum, 12 parts of Semen Trichosanthis, 12 parts of Radix Angelicae Sinensis, 20 parts, Semen Persicae.
3. the Chinese medicine composition that is used for the treatment of constipation according to claim 1, it is characterized in that, described adjuvant is one or more of dextrin, lactose, starch, sucrose, glucose, microcrystalline Cellulose, mannose, methylcellulose, hydroxypropyl cellulose, carboxymethyl cellulose and stevioside.
4. the Chinese medicine composition that is used for the treatment of constipation according to claim 1, is characterized in that, in step, decocting condition is: the 8-12 that adds for the first time water and be medical material weight doubly measures, and decocts 1-2h, and the 6-10 that adds for the second time water and be medical material weight doubly measures, and decocts 1-2h.
5. the Chinese medicine composition that is used for the treatment of constipation according to claim 1, is characterized in that, in step, spraying drying condition is: inlet temperature is 80-120 ℃, and leaving air temp is 80-90 ℃, and temperature of charge is 70-90 ℃, atomizing pressure is 0.2-0.4 MPa, and spray velocity is 5-10ml/s.
6. the application of the Chinese medicine composition that is used for the treatment of constipation described in claim 1 or 2 in the medicine of preparation treatment constipation.
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