CN100336533C - Traditional Chinese medicinal prepn. for treating constipation of slow-remove type, and its prepn. method - Google Patents
Traditional Chinese medicinal prepn. for treating constipation of slow-remove type, and its prepn. method Download PDFInfo
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- CN100336533C CN100336533C CNB2005100126335A CN200510012633A CN100336533C CN 100336533 C CN100336533 C CN 100336533C CN B2005100126335 A CNB2005100126335 A CN B2005100126335A CN 200510012633 A CN200510012633 A CN 200510012633A CN 100336533 C CN100336533 C CN 100336533C
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Abstract
The present invention relates to a traditional Chinese medicament preparation for treating slow-transmission type constipation and a preparation method, which belongs to the technical field of medicaments. The present invention is used for solving the problem that the slow-transmission type constipation for patients can be cured after being cured for a long term. The present invention has the scheme that the medicament preparation comprises the medicinal ingredients of green rhizoma atractylodis alba, broomrape, officinal magnolia bark, tangerine peel, milk vetch, angelica, green rhizoma rehmanniae, prepared rehmannia root, clematis roots, peach seeds, tuckahoe, white paeony roots, etc. which are manufactured into capsules through the process steps of material matching, distillation, extraction, concentration, drying, capsule loading, etc. The medicament preparation eliminates the thinking set that cathartic has to be added for treating the constipation, and fully consider the physiological characteristics of the lung, the liver, the kidney, the spleen and the stomach of a human body to sketch out a formula. The traditional Chinese medicament preparation has the efficiencies of replenishing Qi, nourishing blood, moistening dryness, expelling pathogenic heat to loosen bowels and removing stagnant so as to attain the purposes of mutual causality of ascending and descending for liver and lung, and coordination between dryness and dampness for the spleen and the kidney, and has the characteristics of exact treatment effect and treatment for both manifestation and root causes of diseases. Clinical use shows that the traditional Chinese medicament preparation has preferable treatment effect, multiple items of indexes which are superior to the indexes of a comparison medicament group, and the effective rate reaches 100%.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation, particularly treat the Chinese medicine preparation of chronic slow-transit constipation, belong to medical technical field.
Background technology
Chronic slow-transit constipation is with gastrointestinal tract, and particularly colonic activity weakens, do not have just the obstipation that meaning, times of defecation are reduced to main feature, and its cause of disease is fuzzy so far, and treatment is difficulty very.Great majority are suffered from this sick patient and all took the treatment permeability of constipation or irritant laxative such as Radix Et Rhizoma Rhei, phenolphthalein, Folium Sennae etc. in being accepted the process of medical treatment, mostly be low dose of during beginning or take once in a while, develop into prolonged application gradually, and the prolonged application irritant laxative can cause neuropathy in mucous membrane of colon, smooth muscle and the wall.Some patient is to keep defecation by heavy dose of cathartic to the later stage, does not take not defecation of cathartic, dosage use bigger and bigger and effect worse and worse, form so-called " cathartic colon ", part patient finally need carry out colon and cut art entirely.Recent study is found, the pathological change of colon myenteric nerve plexus may be to cause this sick major reason in the enteric nervous system, therefore, the recovery of avoiding the colon myenteric nerve plexus further to be undermined the impaired enteric nervous system structure function of promotion in the treatment of chronic slow-transit constipation will have great importance for this disease of treatment, and animal experiment also shows, taking cathartic for a long time has tangible detrimental effect to enteric nervous system.At present, this has sure curative effect aspect sick to Chinese herbal medicine in treatment, has obtained effect preferably, mixes but Chinese medicinal formulae, is also often used at many prescription moderate stimulation cathartics, takes in a large number equally for a long time and can produce some adverse consequencess.
Summary of the invention
Technical problem to be solved by this invention provide a kind of with benefiting qi and nourishing blood moisturize, the circulation of qi promoting intestinal stasis relieving is the Therapeutic Principle, and can promote plexus nervorum pathology between colonic muscle to change the Chinese medicine preparation and the preparation method of recovery, good effect, treatment chronic slow-transit constipation that cure rate is high.
Alleged problem of the present invention is solved by following technical scheme:
A kind of Chinese medicine preparation for the treatment of chronic slow-transit constipation comprises the crude drug of following unit of weight: Rhizoma Atractylodis Macrocephalae 6～15, Herba Cistanches 10～20 in the composition, Cortex Magnoliae Officinalis 10～15, Pericarpium Citri Reticulatae 8～12, the Radix Astragali 10～15, Radix Angelicae Sinensis 10～20, Radix Rehmanniae 10～20, Radix Rehmanniae Preparata 10～20, Radix Clematidis 15～25, Semen Armeniacae Amarum 8～12, Semen Juglandis 8～12, Poria 10～15, the Radix Paeoniae Alba 25～30.
The Chinese medicine preparation of above-mentioned treatment chronic slow-transit constipation adds the crude drug of following unit of weight: the Radix Aucklandiae 4～8, Rhizoma Alismatis 8～12, Radix Ophiopogonis 10～15 in the composition.
The Chinese medicine preparation of above-mentioned treatment chronic slow-transit constipation adds the crude drug of following unit of weight: Pericarpium Citri Reticulatae Viride 15～25, Fructus Schisandrae Chinensis 10～20, Fructus Aurantii Immaturus 8～12, Semen Litchi 15～25 in the composition.
The Chinese medicine preparation of above-mentioned treatment chronic slow-transit constipation adds the crude drug of following unit of weight: Semen Cassiae 10～15 in the composition.
The Chinese medicine preparation of above-mentioned treatment chronic slow-transit constipation, described preparation are capsule, powder or pill.
The preparation method of the Chinese medicine preparation of above-mentioned treatment chronic slow-transit constipation, it is undertaken by following operation:
A. prepare burden: take by weighing each crude drug by the above-mentioned raw materials survival dose;
B. distill, extract: Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis, Semen Armeniacae Amarum, Pericarpium Citri Reticulatae Viride, Pericarpium Citri Reticulatae in the crude drug are put in the distillation extraction device, steam extraction, it is standby to reclaim distillate; Other crude drug and distilled medical material decocting in the lump extract twice, merge filtrate twice;
C. concentrated, dry: as above-mentioned filtrate to be concentrated into thick shape, to add ethanol to ethanol content and reach 60%, left standstill 48 hours, reclaim ethanol, add distilled water and left standstill 48 hours, be filtered to clear and brightly, again the distillate that reclaims in gained filtrate and the last process mixed, concentrate, low-temperature vacuum drying;
D. incapsulate: dried drug is ground into fine powder, makes powder, tablet or incapsulate.
Medicament of the present invention acts on the marrow of Chinese medicine, honor ancients''s " with sliding key of supporting " purport, in conjunction with the modern pharmacology achievement in research, abandon the thinking set that the treatment constipation must add cathartic, the physiological characteristics that takes into full account human body lung, liver,kidney,spleen, stomach is drafted prescription, make that it has that benefiting qi and nourishing blood is moisturized, purging heat to relax the bowels, the stagnant effect of dispelling, accomplish liver lung mutual causality of ascending and descending, spleen kidney dryness and dampness coordinating each other.Medicament of the present invention shows through animal experiment, can promote intestinal peristalsis promoting, has dual regulation, by changing cytotrophy and energy metabolism, reduce collagen content, increase cell vitality and resistance, and, promote the reparation of colon plexus nervorum by improving effects such as hemorheological property and microcirculation improvement, non-specific antiinflammatory and anti-inflammation.Clinical use shows that it has determined curative effect, the characteristics for the treatment of both the principal and secondary aspects of a disease, and its many index is better than the control drug group, and effective percentage reaches 100%.The present invention can be made into multiple dosage form, based on capsule, facilitates patients.
The specific embodiment
The disease of chronic slow-transit constipation surely belongs to the category of " obstipation " on the traditional Chinese medical science, and Chinese traditional treatment is from integral body, and people-oriented, debates the disease treatment.Find that through clinical research primary disease is the disease of deficiency in origin and excess in superficiality.Existing deficiency of YIN blood is dry, and the deficiency of vital energy is not transported, and also has the scorching stagnation of QI to be mingled with.Then the large intestine transmission is unable for the deficiency of vital energy, and it is difficult that stool is discharged; Blood deficiency then Tianjin is withered, or YIN fluid being insufficient, is difficult to down profit stool, and attains its drying, discharges not freely, and the patients on long-term is constipated obstructed, YANG QI deficiency, and warm having no right,, cold from interior life, sluggish the intestines and stomach conducts unablely, and body fluid is not all right and cause that defecation is difficult further.Point out just as " Jing Yue's complete work constipated a piece of writing ": " all part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels yang deficiency, then yang-energy is not all right, not all right then can not the transmission of yang-energy and cloudy coagulating in down, this yang deficiency and constipation of YIN type are also." yang deficiency being described and gas must not be gone, the YIN-cold part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels that stagnates causes constipation.Because it is the key that causes this disease that gas, blood, body fluid homology, healthy energy are lost empty conduction unable, the Therapeutic Principle should be benefiting qi and nourishing blood and moisturizes, circulation of qi promoting intestinal stasis relieving, purging heat to relax the bowels.
Based on above-mentioned Therapeutic Principle, prescription characteristic analysis of the present invention is as follows:
1. giving consideration to both the incidental and fundamental: the Radix Astragali, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Radix Rehmanniae, Radix Rehmanniae Preparata match benefiting qi and nourishing blood YIN nourishing Zhi Qiben in the side.Herba Cistanches, Semen Armeniacae Amarum, Semen Juglandis, Radix Ophiopogonis, Fructus Schisandrae Chinensis are moisturized; The sharp internal organs of Radix Clematidis relieving constipation, six medicines are 5 moistening dryness for relaxing bowels mutually, and assistant is controlled its mark with the Radix Aucklandiae, Pericarpium Citri Reticulatae Viride, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis circulation of qi promoting intestinal stasis relieving.
2. the nourishing kidney profit is just in the hope of it: the spleen being adverse to dampness, get Rhizoma Atractylodis Macrocephalae, Poria, Rhizoma Alismatis spleen reinforcing dampness removing, with compress body fluid.The kidney being adverse to tryness is got Radix Rehmanniae Preparata, Semen Juglandis kidney tonifying, essence replenishing with the profit stool.Inferior spleen renal function is normal, then normal defecation.
3. set about controlling for assistant from liver, kidney, lung: Semen Armeniacae Amarum is gone into lung meridian, the intestine moistening of lung qi dispersing promoting the circulation of QI.The gas of Pericarpium Citri Reticulatae conditioning viscera, two medicines phase 5 makes liver rise lung and falls, and QI movement being in harmonious way is the prerequisite that guarantees the large intestine conduction function.
All medicines share in the side, take mutually together, play benefiting qi and nourishing blood altogether and moisturize, circulation of qi promoting intestinal stasis relieving, the merit of purging heat to relax the bowels.Accomplish liver lung mutual causality of ascending and descending, spleen kidney dryness and dampness coordinating each other, not relieving constipation and just from logical.
In addition, show that all medicines for promoting intestinal peristalsis promoting, immunologic function to have dual regulation more among the side of the present invention through pharmacological research.Wherein, the Radix Astragali contains several amino acids, and pair cell has the promotion restitution, and can improve cytotrophy and energy metabolism, improves immune function of human body; Radix Angelicae Sinensis contains several amino acids, and the adjusting immunologic function is arranged, expansible blood vessel, microcirculation improvement; Radix Rehmanniae, Radix Rehmanniae Preparata have non-specific anti-inflammatory effect; That the Radix Paeoniae Alba has is antibiotic, blood vessel dilating and immunoregulation effect; Fructus Schisandrae Chinensis has excitation to smooth muscle, and its antioxidase system helps body and removes superoxide anion and hydrogen peroxide, the damage that alleviates these risk factor pair cells; Herba Cistanches has the effect of enhance immunity, can obviously promote the fibroblast growth of In vitro culture, promotes wound healing, animal experiment shows, Herba Cistanches can effectively resist atropine and suppress defecation, and suppresses the absorption of large intestine moisture content, has definite functions of loosening bowel relieving constipation; Radix Clematidis has tangible excitation to the rat intestinal tube, and has certain antibacterial action; Cortex Magnoliae Officinalis can make gastrointestinal peristalsis accelerate; The Rhizoma Atractylodis Macrocephalae promotes that obviously little Erepsin is synthetic, has the function of regulating the immunostimulant immunity, and Rhizoma Atractylodis Macrocephalae water decoction and ileum shrink and be the effect magnitude relation, and heavy dose of Rhizoma Atractylodis Macrocephalae can make gastrointestinal secretion vigorous, and defecating feces excretion is definite, so reuse it; The Radix Aucklandiae, Fructus Aurantii Immaturus have the enterokinesia of promotion effect; The main component of Pericarpium Citri Reticulatae has gentle facilitation to gastrointestinal tract, is beneficial to the eliminating gastrointestinal pneumatosis; Poria has direct relexation in to the test of rabbit intestine in vitro.
Several embodiments of the present invention below are provided:
Embodiment 1: Rhizoma Atractylodis Macrocephalae 15, Herba Cistanches 15, Cortex Magnoliae Officinalis 12, Pericarpium Citri Reticulatae 10, the Radix Astragali 12, Radix Angelicae Sinensis 20, Radix Rehmanniae 15, Radix Rehmanniae Preparata 15, Radix Clematidis 2D, Semen Armeniacae Amarum 10, Semen Juglandis 10, Poria 12, the Radix Paeoniae Alba 30.
Embodiment 2: Rhizoma Atractylodis Macrocephalae 6, Herba Cistanches 10, Cortex Magnoliae Officinalis 10, Pericarpium Citri Reticulatae 8, the Radix Astragali 10, Radix Angelicae Sinensis 10, Radix Rehmanniae 10, Radix Rehmanniae Preparata 10, Radix Clematidis 15, Semen Armeniacae Amarum 8, Semen Juglandis 8, Poria 10, the Radix Paeoniae Alba 25.
Embodiment 3: Rhizoma Atractylodis Macrocephalae 8, Herba Cistanches 20, Cortex Magnoliae Officinalis 15, Pericarpium Citri Reticulatae 12, the Radix Astragali 15, Radix Angelicae Sinensis 10, Radix Rehmanniae 20, Radix Rehmanniae Preparata 20, Radix Clematidis 25, Semen Armeniacae Amarum 12, Semen Juglandis 12, Poria 15, the Radix Paeoniae Alba 28.
Embodiment 4: Rhizoma Atractylodis Macrocephalae 15, Herba Cistanches 15, Cortex Magnoliae Officinalis 12, Pericarpium Citri Reticulatae 10, the Radix Astragali 12, Radix Angelicae Sinensis 20, Radix Rehmanniae 15, Radix Rehmanniae Preparata 15, Radix Clematidis 20, Semen Armeniacae Amarum 10, Semen Juglandis 10, Poria 12, the Radix Paeoniae Alba 30, the Radix Aucklandiae 6, Rhizoma Alismatis 10, Radix Ophiopogonis 12.
Embodiment 5: Rhizoma Atractylodis Macrocephalae 15, Herba Cistanches 15, Cortex Magnoliae Officinalis 12, Pericarpium Citri Reticulatae 10, the Radix Astragali 12, Radix Angelicae Sinensis 20, Radix Rehmanniae 15, Radix Rehmanniae Preparata 15, Radix Clematidis 20, Semen Armeniacae Amarum 10, Semen Juglandis 10, Poria 12, the Radix Paeoniae Alba 30, the Radix Aucklandiae 4, Rhizoma Alismatis 8, Radix Ophiopogonis 10.
Embodiment 6: Rhizoma Atractylodis Macrocephalae 15, Herba Cistanches 15, Cortex Magnoliae Officinalis 12, Pericarpium Citri Reticulatae 10, the Radix Astragali 12, Radix Angelicae Sinensis 20, Radix Rehmanniae 15, Radix Rehmanniae Preparata 15, Radix Clematidis 20, Semen Armeniacae Amarum 10, Semen Juglandis 10, Poria 12, the Radix Paeoniae Alba 30, the Radix Aucklandiae 8, Rhizoma Alismatis 12, Radix Ophiopogonis 15, Pericarpium Citri Reticulatae Viride 25, Fructus Schisandrae Chinensis 20, Fructus Aurantii Immaturus 12, Semen Litchi 25.
Embodiment 7: Rhizoma Atractylodis Macrocephalae 13, Herba Cistanches 12, Cortex Magnoliae Officinalis 10, Pericarpium Citri Reticulatae 12, the Radix Astragali 12, Radix Angelicae Sinensis 10, Radix Rehmanniae 10, Radix Rehmanniae Preparata 12, Radix Clematidis 20, Semen Armeniacae Amarum 10, Semen Juglandis 10, Poria 12, the Radix Paeoniae Alba 25, the Radix Aucklandiae 6, Rhizoma Alismatis 10, Radix Ophiopogonis 10, Pericarpium Citri Reticulatae Viride 15, Fructus Schisandrae Chinensis 10, Fructus Aurantii Immaturus 8, Semen Litchi 15.
Embodiment 8: Rhizoma Atractylodis Macrocephalae 15, Herba Cistanches 15, Cortex Magnoliae Officinalis 12, Pericarpium Citri Reticulatae 10, the Radix Astragali 12, Radix Angelicae Sinensis 10, Radix Rehmanniae 15, Radix Rehmanniae Preparata 15, Radix Clematidis 20, Semen Armeniacae Amarum 10, Semen Juglandis 10, Poria 12, the Radix Paeoniae Alba 30, the Radix Aucklandiae 4, Rhizoma Alismatis 12, Radix Ophiopogonis 12, Pericarpium Citri Reticulatae Viride 20, Fructus Schisandrae Chinensis 15, Fructus Aurantii Immaturus 10, Semen Litchi 20.
Embodiment 9: Rhizoma Atractylodis Macrocephalae 15, Herba Cistanches 15, Cortex Magnoliae Officinalis 12, Pericarpium Citri Reticulatae 10, the Radix Astragali 12, Radix Angelicae Sinensis 10, Radix Rehmanniae 15, Radix Rehmanniae Preparata 15, Radix Clematidis 20, Semen Armeniacae Amarum 10, Semen Juglandis 10, Poria 12, the Radix Paeoniae Alba 30, the Radix Aucklandiae 7, Rhizoma Alismatis 10, Radix Ophiopogonis 12, Pericarpium Citri Reticulatae Viride 25, Fructus Schisandrae Chinensis 20, Fructus Aurantii Immaturus 12, Semen Litchi 25, Semen Cassiae 12.
Embodiment 10: Rhizoma Atractylodis Macrocephalae 15, Herba Cistanches 15, Cortex Magnoliae Officinalis 12, Pericarpium Citri Reticulatae 10, the Radix Astragali 12, Radix Angelicae Sinensis 10, Radix Rehmanniae 15, Radix Rehmanniae Preparata 15, Radix Clematidis 20, Semen Armeniacae Amarum 10, Semen Juglandis 10, Poria 12, the Radix Paeoniae Alba 30, the Radix Aucklandiae 7, Rhizoma Alismatis 10, Radix Ophiopogonis 12, Pericarpium Citri Reticulatae Viride 25, Fructus Schisandrae Chinensis 20, Fructus Aurantii Immaturus 12, Semen Litchi, 25 Semen Cassiaes 15.
Preparation method:
A. prepare burden: take by weighing each crude drug by the above-mentioned raw materials survival dose;
B. distill, extract: Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis, Semen Armeniacae Amarum, Pericarpium Citri Reticulatae Viride, Pericarpium Citri Reticulatae in the crude drug are put in the distillation extraction device, steam extraction, it is standby to reclaim distillate; Other crude drug and distilled medical material decocting in the lump extract twice, each 1.5 hours, merge filtrate twice;
The present invention adopts steam distillation, is applicable to the extraction of the medicinal herb components that can not be destroyed with vapor distillation.The boiling point of specific examples of such components is many more than 100 ℃, the not miscible or slightly soluble only with water.When be heated to boiling with water together, steam is taken volatile material out of in the lump.The for example volatile oil in the Chinese herbal medicine, some micromolecule alkaloid, phenolic substance, or the like, all can extract.
C. concentrate: above-mentioned filtrate concentrating put thick shape, ethanol to the ethanol content of adding 95% reaches 60%, left standstill 48 hours, reclaim ethanol to solution and do not have the alcohol flavor, adding distilled water left standstill 48 hours, be filtered to clear and brightly, be condensed into thick paste, low-temperature vacuum drying after again the distillation liquid that reclaims in gained filtrate and the last process being mixed;
D. incapsulate: dried drug is ground into fine powder, the hollow capsule of packing into No. 0, every capsules medicated powder 0.3 gram of packing into approximately.
This preparation capsule is taken three every day, and each 5, one month is a course of treatment.The state of an illness alleviates after taking a period of time, and its consumption can take the circumstances into consideration to be decremented to every day twice, and each two, effective percentage reaches 100%.
Claims (6)
1. Chinese medicine preparation for the treatment of chronic slow-transit constipation, it is characterized in that: it adopts the crude drug of following unit of weight to make: Rhizoma Atractylodis Macrocephalae 6-15, Herba Cistanches 10-20, Cortex Magnoliae Officinalis 10-15, Pericarpium Citri Reticulatae 8-12, Radix Astragali 10-15, Radix Angelicae Sinensis 10-20, Radix Rehmanniae 10-20, Radix Rehmanniae Preparata 10-20, Radix Clematidis 15-25, Semen Armeniacae Amarum 8-12, Semen Juglandis 8-12, Poria 10-15, Radix Paeoniae Alba 25-30.
2. the Chinese medicine preparation of treatment chronic slow-transit constipation according to claim 1 is characterized in that: the crude drug that adds following unit of weight: Radix Aucklandiae 4-8, Rhizoma Alismatis 8-12, Radix Ophiopogonis 10-15.
3. the Chinese medicine preparation of treatment chronic slow-transit constipation according to claim 2 is characterized in that: the crude drug that adds following unit of weight: Pericarpium Citri Reticulatae Viride 15-25, Fructus Schisandrae Chinensis 10-20, Fructus Aurantii Immaturus 8-12, Semen Litchi 15-25.
4. the Chinese medicine preparation of treatment chronic slow-transit constipation according to claim 3 is characterized in that: the crude drug that adds following unit of weight: Semen Cassiae 10-15.
5. the Chinese medicine preparation of treatment chronic slow-transit constipation according to claim 4 is characterized in that: described preparation is capsule, powder or pill.
6. method for preparing as treatment chronic slow-transit constipation Chinese medicine preparation as described in the claim 1,2,3,4 or 5, it is characterized in that: it is undertaken by following operation:
A. prepare burden: take by weighing each crude drug by the above-mentioned raw materials consumption;
B. distill, extract: the Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis, Semen Armeniacae Amarum, Pericarpium Citri Reticulatae Viride, Pericarpium Citri Reticulatae in the crude drug are put in the distillation extraction device, steam extraction, it is standby to reclaim distillate; Other crude drug and distilled medical material decocting in the lump extract twice, merge filtrate twice.
C. concentrate: above-mentioned filtrate is concentrated into thick shape, adds ethanol to its content and reach 60%, left standstill 48 hours, reclaim ethanol, add distilled water and left standstill 48 hours, be filtered to clear and brightly, again the distillate that reclaims in gained filtrate and the last process mixed, concentrate, low-temperature vacuum drying;
D. incapsulate: dried drug is ground into fine powder, incapsulates.
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| CNB2005100126335A CN100336533C (en) | 2005-07-01 | 2005-07-01 | Traditional Chinese medicinal prepn. for treating constipation of slow-remove type, and its prepn. method |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101301375B (en) * | 2008-06-03 | 2011-09-21 | 李亚萍 | Decoction for treating intestinal obstruction |
| CN102293950B (en) * | 2011-08-23 | 2013-04-10 | 高朱荣 | Traditional Chinese medicine for treating constipation |
| CN102657722B (en) * | 2012-05-31 | 2014-06-04 | 北京中医药大学 | Traditional Chinese medicine composition for treating constipation, preparation containing same and application of the Traditional Chinese medicine composition |
| CN102697951B (en) * | 2012-06-15 | 2014-02-26 | 李良 | Cistanche traditional Chinese medicine decoction for treating astriction and preparation method for decoction |
| CN102940718B (en) * | 2012-12-08 | 2014-04-23 | 卞毓平 | Traditional Chinese medicine composition for treating constipation, preparation method and application |
| CN103405635A (en) * | 2013-08-30 | 2013-11-27 | 石欣 | Traditional Chinese medicine composition for treating middle and old aged constipation |
| CN104352722A (en) * | 2014-10-17 | 2015-02-18 | 郭云芳 | Traditional Chinese medicine granules for treating chronic constipation and preparation method thereof |
| CN105381226A (en) * | 2015-12-17 | 2016-03-09 | 济南昊泽环保科技有限公司 | Chinese herbal compound oral liquid for treating slow transit constipation |
| CN105617284A (en) * | 2016-03-14 | 2016-06-01 | 山东仁和堂药业有限公司 | Pharmaceutical composition for treating habitual and intractable constipation and preparation technology thereof |
| CN108434287B (en) * | 2018-06-07 | 2021-01-08 | 苏州市中医医院 | Traditional Chinese medicine composition and preparation method and application thereof |
| CN108714182A (en) * | 2018-08-17 | 2018-10-30 | 河南夕阳蓝食品科技有限公司 | Bowel relaxing oral liquid and preparation method |
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| CN1176128A (en) * | 1997-07-12 | 1998-03-18 | 迟经惠 | Duozhu oral liquid |
| CN1383846A (en) * | 2001-04-29 | 2002-12-11 | 王运景 | Heart-strengthening and blood circulation-promoting liquid medicine for treating heart diseases |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1176128A (en) * | 1997-07-12 | 1998-03-18 | 迟经惠 | Duozhu oral liquid |
| CN1383846A (en) * | 2001-04-29 | 2002-12-11 | 王运景 | Heart-strengthening and blood circulation-promoting liquid medicine for treating heart diseases |
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